scholarly journals Natural Bioactive Cinnamoyltyramine Alkylamides and Co-Metabolites

Biomolecules ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1765
Author(s):  
Antonio Evidente ◽  
Marco Masi
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Carbon Skeleton ◽  
The Other ◽  
Present Review ◽  
Natural Sources ◽  
Plant Kingdom ◽  
Structural Variability ◽  
Plant Families

Natural products are a vital source for agriculture, medicine, cosmetic and other fields. Among them alkylamides are a broad and expanding group found in at least 33 plant families. Frequently, they possess a simple carbon skeleton architecture but show broad structural variability and important properties such as immunomodulatory, antimicrobial, antiviral, larvicidal, insecticidal and antioxidant properties, amongst others. Despite to these several and promising biological activities, up to today, only two reviews have been published on natural alkylamides. One focuses on their potential pharmacology application and their distribution in the plant kingdom and the other one on the bioactive alkylamides specifically found in Annona spp. The present review is focused on the plant bioactive cinnamoyltyramine alkylamides, which are subject of several works reported in the literature. Furthermore, the co-metabolites isolated from the same natural sources and their biological activities are also reported.

Naturally occurring and synthetic polyyne glycosides

2009 ◽  
Vol 87 (11) ◽  
pp. 1565-1582 ◽  
Author(s):  
Yanqing Pan ◽  
Todd L. Lowary ◽  
Rik R. Tykwinski
Keyword(s):  
Natural Products ◽  
Marine Algae ◽  
Biological Activities ◽  
Terrestrial Plants ◽  
Natural Sources ◽  
Naturally Occurring

Polyyne glycosides are a class of natural products that have been found in terrestrial plants, fungi, and marine algae. Many display interesting and potentially useful biological activities, which in some cases has initiated synthetic efforts toward their formation. This review provides a comprehensive report of polyyne glycosides isolated from natural sources, as well as the synthesis of these molecules and their analogues.

The chemistry and biology of guanidine natural products

2016 ◽  
Vol 33 (3) ◽  
pp. 456-490 ◽  
Author(s):  
Roberto G. S. Berlinck ◽  
Stelamar Romminger
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Structure Determination ◽  
Biological Activities ◽  
Present Review ◽  
Guanidine Group

The present review discusses the isolation, structure determination, synthesis, biosynthesis and biological activities of secondary metabolites bearing a guanidine group.

scholarly journals Analysis of Flavonoid Metabolites in Citrus Peels (Citrus reticulata “Dahongpao”) Using UPLC-ESI-MS/MS

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2680 ◽  
Author(s):  
Fu Wang ◽  
Lin Chen ◽  
Hongping Chen ◽  
Shiwei Chen ◽  
Youping Liu
Keyword(s):  
Biological Activities ◽  
Antioxidant Properties ◽  
Principal Component ◽  
The Other ◽  
Citrus Reticulata ◽  
Flavonoid Content ◽  
Esi Ms ◽  
Medicinal Value ◽  
Citrus Peels ◽  
Citrus Varieties

Flavonoids are a kind of essential substance for the human body because of their antioxidant properties and extremely high medicinal value. Citrus reticulata “Dahongpao” (DHP) is a special citrus variety that is rich in flavonoids, however little is known about its systematic flavonoids profile. In the present study, the presence of flavonoids in five important citrus varieties, including DHP, Citrus grandis Tomentosa (HZY), Citrus ichangensis Swingle (YCC), Citrus sinensis (L.) Osbeck (TC), and Citrus reticulata ‘Buzhihuo’ (BZH), was determined using a UPLC-ESI-MS/MS-based, widely targeted metabolome. Results showed that a total of 254 flavonoid metabolites (including 147 flavone, 39 flavonol, 21 flavanone, 24 anthocyanins, 8 isoflavone, and 15 polyphenol) were identified. The total flavonoid content of peels from DHP was the highest. DHP could be clearly separated from other samples through clustering analysis and principal component analysis (PCA). Further, 169 different flavonoid metabolites were observed between DHP peels and the other four citrus peels, and 26 down-regulated differential metabolites displayed important biological activities in DHP. At the same time, a unique flavonoid component, tricin 4′-O-syringyl alcohol, was only found in DHP, which could be used as a marker to distinguish between other varieties. This work might facilitate a better understanding of flavonoid metabolites between DHP peels and the other four citrus peels and provide a reference for its sufficient utilization in the future.

scholarly journals The endemic plants – a valuable resource with vast potential in Bulgaria: A brief overview

2021 ◽  
Vol 13 (3) ◽  
pp. 219-233
Author(s):  
D.T. Petkova ◽  
D.Sp. Mihaylova
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Endemic Plants ◽  
Valuable Resource ◽  
Plant Kingdom ◽  
Mountainous Regions ◽  
Biological Compounds ◽  
Prevention And Treatment

Abstract. The plant kingdom with its natural products, both terrestrial and marine, has been widely studied. Plant-based products have long been used for the prevention and treatment of various diseases. Many natural compounds are reported to have a number of interesting and significant biological activities, such as antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, antidiabetic, antiatherogenic, antiproliferative, and cardioprotective and neuroprotective activities. In order to find a natural product, researchers often explore the possibilities given by nature. Special attention is paid to bioactive compounds synthesized by endemic plants as a specific resource of limited habitat. This review focuses on a brief overview of endemic plants in Bulgaria, most common in the mountainous regions of the country, with the aim to encourage the knowledge of these resources with vast potential for unique biological compounds and specific characteristics beneficial to humans for various purposes.

scholarly journals Electrochemical Organic Synthesis of Electron-Rich Biaryl Scaffolds: An Update

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6968
Author(s):  
Fabrizio Medici ◽  
Simonetta Resta ◽  
Alessandra Puglisi ◽  
Sergio Rossi ◽  
Laura Raimondi ◽  
...  
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Cross Coupling ◽  
Therapeutic Agents ◽  
The Other ◽  
Present Review ◽  
Single Class ◽  
Efficient Alternative ◽  
Privileged Class

Biaryl scaffolds are widely spread in biologically important natural products, in numerous therapeutic agents, but they are also considered a privileged class of ligands and (organo)catalysts; therefore, the development of efficient alternative methodologies to prepare such compounds is always attracting much attention. The present review discusses the organic electrosynthesis of biaryls starting from phenols, anilines, naphthols, and naphthylamines. The most significant examples of the works reported in the last decade are presented and classified according to the single class of molecules: after the introduction, the first three sections relate to the reactions of phenols, naphthols, and anilines, respectively; the other two sections refer to cross-coupling and miscellaneous reactions.

scholarly journals In vitro Methods to Study Antioxidant and Some Biological Activities of Essential Oils: a Review

2021 ◽  
Vol 12 (3) ◽  
pp. 3332-3347
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Biological Effects ◽  
The Other ◽  
Present Review ◽  
In Vitro Methods ◽  
Potential Benefits ◽  
Experimental Protocols ◽  
The One

As essential oils (EOs) represent a new source of efficient and safe agents for health nowadays, the present review brings together the in vitro methods widely used to evaluate the antioxidant and some biological activities especially, antidiabetic, anticancer, antimicrobial, and anti-inflammatory activities of EOs, in order to valorize these EOs and to highlight their potential benefits. Moreover, each method cited is along with its aim, principle, advantages and limitations, experimental protocols, and notes. Hence, this review will help researchers working on EOs, to save time while accessing this summary document on the one hand, and on the other hand, it will contribute to scientific approval of in vitro antioxidant and biological effects of EOs for future useful purposes.

scholarly journals Engineering of critical enzymes and pathways for improved triterpenoid biosynthesis in yeast

2020 ◽  
Author(s):  
Hao Guo ◽  
Huiyan Wang ◽  
Yi-xin Huo
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Natural Products ◽  
Biological Activities ◽  
Biosynthetic Pathways ◽  
Diverse Group ◽  
Heterologous Production ◽  
Scale Level ◽  
Yeast Metabolism ◽  
Plant Kingdom ◽  
Potential Strategy

AbstractTriterpenoids represent a diverse group of phytochemicals, widely distributed in the plant kingdom with many biological activities. Recently, the heterologous production of triterpenoids in Saccharomyces cerevisiae has been successfully implemented by introducing various triterpenoids biosynthetic pathways. By engineering related enzymes as well as yeast metabolism, the yield of various triterpenoids is significantly improved from milligram-scale per liter to gram-scale level per liter. This achievement demonstrates that engineering of critical enzymes is considered as a potential strategy to overcome the main hurdles of translation of these potent natural products into industry. Here, we review strategies for designing enzymes to improve the yield of triterpenoids in S. cerevisiae, which is mainly separated into three aspects: 1. elevating the supply of the precursor—2,3-oxidosqualene, 2. optimizing triterpenoid-involved reactions, 3. lowering the competition of the native sterol pathway. And then we provide challenges and prospects on further enhancing the triterpenoid production in S. cerevisiae.

Isolation of Phthalates and Terephthalates from Plant Material – Natural Products or Contaminants?

2021 ◽  
Vol 8 (1) ◽  
pp. 1-36
Author(s):  
Thies Thiemann
Keyword(s):  
Natural Products ◽  
Plant Material ◽  
The Other ◽  
Natural Sources ◽  
Small Weight ◽  
Anthropogenic Origin ◽  
Other Hand ◽  
Bona Fide ◽  
Bacteria And Fungi

Dialkyl phthalates have been used as plasticizers in polymers for decades. As mobile, small weight molecules, phthalates have entered the environment, where they have become ubiquitous. On the other hand, phthalates continue to be isolated from natural sources, plants, bacteria and fungi as bona fide natural products. Here, doubt remains as to whether the phthalates represent actual natural products or whether they should all be seen as contaminants of anthropogenic origin. The following article will review the material as presented in the literature.

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