scholarly journals Relevant Biological Effects of Varicocele Embolization with N-Butyl Cyanoacrylate Glue on Semen Parameters in Infertile Men

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1423
Author(s):  
Olivier Chevallier ◽  
Patricia Fauque ◽  
Carole Poncelet ◽  
Kévin Guillen ◽  
Pierre-Olivier Comby ◽  
...  
Keyword(s):  
Biological Effects ◽  
Semen Analysis ◽  
Semen Parameters ◽  
Embolic Agent ◽  
Cyanoacrylate Glue ◽  
Semen Parameter ◽  
Infertile Men ◽  
Embolic Agents ◽  
Before And After ◽  
The Impact

Surgical treatment or varicocele embolization (VE) with sclerosing or mechanical embolic agents have been shown to improve the semen parameters of infertile men. The aim of this study was to evaluate the impact of VE using N-butyl cyanoacrylate (NBCA) glue on semen parameters in infertile men. From January 2014 to June 2018, infertile adult patients with stage 3 varicocele and an initial semen analysis showing at least one abnormal semen parameter, and who were successfully embolized with NBCA Glubran®2 glue, were retrospectively recruited. The availability of a second semen analysis after VE was mandatory for patient inclusion. The primary endpoint was the change in total sperm number (TSN) after VE. The other parameters of interest were progressive and total sperm motilities (Smot) at 1 h (H1), sperm vitality (SV) and morphology (SMor). One hundred and two patients were included. Eight patients presented null TSN before and after VE. Among the remaining 94 patients, a significant improvement in the median TSN after VE was shown (31.79 × 106/ejaculate [IQR:11.10–127.40 × 106/ejaculate] versus 62.24 × 106/ejaculate [IQR:17.90–201.60 × 106/ejaculate], p= 0.0295). Significant improvement in TSN was found for the 60 oligo- or azoospermic patients (p = 0.0007), whereas no significant change was found for the 42 patients with normal initial TSN (p = 0.49). Other parameters, such as progressive and total SMot, SV and SMor, also significantly improved after VE (p = 0.0003, 0.0013, 0.0356 and 0.007, respectively). The use of NBCA glue as an embolic agent for VE in infertile men with stage 3 varicocele significantly improves the semen parameters.

scholarly journals Effects of Varicocelectomy on Abnormal Semen Parameters in Patients with Clinically Palpable Varicocele

2018 ◽  
Vol 43 (2) ◽  
pp. 94-100
Author(s):  
Md. Selim Morshed ◽  
AKM Khurshidul Alam ◽  
AKM Anwarul Islam ◽  
Sojib Bin Zaman ◽  
Mohammad Saruar Alam ◽  
...  
Keyword(s):  
Sperm Motility ◽  
Semen Analysis ◽  
Sperm Concentration ◽  
Surgical Correction ◽  
World Health ◽  
Semen Parameters ◽  
Semen Parameter ◽  
Quasi Experimental ◽  
Health Organization ◽  
The Impact

Prevalence of varicocele is approximately 15.1% of the general population. Studies showed that surgical correction of clinically palpable varicocele could improve the semen parameters. However, there is scarce of study to demonstrate post-operative outcome of varicocelectomy among the patients with abnormal semen parameter. Therefore, this study tried to compare the microscopic changes in sperm concentration, sperm motility, and sperm morphology before and after varicocelectomy. This quasi-experimental study was done in Urology Department of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from November 2014 to April 2016. Forty five patients with clinically palpable varicocele were finally includedin the study. Semen parameters of these patients were assessed by following the World Health Organization′s 5th manual of semen parameter, 2010. Subinguinal varicocelectomy was performed in every case. Follow up was done three months and six months after surgery. Data were analysed with statistical software SPSS 20 and level of significance was assessed by paired t-test.Almost 60.0% of patients were from 25 to 35 years age group. Of them, 87.1% patients were presented with left-sided varicocele, and 80% were grade III. All the patients showed oligospermia on semen analysis, whereas the number of abnormal sperm motility and abnormal morphology was 39, and 09, respectively. After surgical correction of varicocele, mean improvement of sperm concentration, motility and morphology found in 35 patients (77.7%), 31 patients (79.4%) and six patients (66.6%) respectively. The improvement was statistically significant (p<0.05). This study showed that surgical treatment could lead to the betterment of semen parameters in patients with clinically palpable varicocele, which will guide in deciding the management of varicocele patients presented with abnormal semen parameter. However, to recommend varicocelectomy as a most useful procedure in treating infertility cases; further longitudinal studies are recommended to establish the impact of varicocelectomy on

scholarly journals P–070 Evaluation of SARS-CoV–2 in human semen and effect on total sperm number: A prospective observational study

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
J Best ◽  
M Kuchakulla ◽  
K Khodamoradi ◽  
T Lima ◽  
F Frech ◽  
...  
Keyword(s):  
Semen Analysis ◽  
Epidemiological Data ◽  
Semen Parameters ◽  
Human Semen ◽  
Sperm Number ◽  
Rt Pcr ◽  
Sperm Analysis ◽  
Reproductive Techniques ◽  
The Impact

Abstract Study question Is the SARS-CoV–2 virus present in human semen and what is the impact on semen parameters following an infection? Summary answer SARS-CoV–2 infection, though not detected in semen of recovered men, can affect TSN in ejaculate in the acute setting. What is known already Early epidemiological data has suggested that the primary mode of transmission is through respiratory droplets, but the presence of SARS-CoV–2 has been identified in other bodily fluids such as feces, urine, and semen. Study design, size, duration We prospectively recruited thirty men diagnosed with acute SARS-CoV–2 infection using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) of pharyngeal swab specimens. Thirty semen samples from recovered men were obtained 11–64 days after testing positive for SAR-CoV–2 infection. The median duration between positive SAR-CoV–2 test and semen collection was 37 days (IQR=23). Participants/materials, setting, methods Semen samples were collected from each individual using mailed kits. Follow-up semen samples were done with mailed kits or in-person in office setting. Semen analysis and PCR was performed after samples were received. Main results and the role of chance The median total sperm number (TSN) in ejaculate was 12.5 million (IQR=53.1). When compared with age-matched SARS-CoV–2(-) men, TSN was lower among SARS-CoV–2(+) men (p = 0.0024). Five men completed a follow-up sperm analysis (median 3 months) and had a median TSN of 18 million (IQR=21.6). No RNA was detected by means of RT-PCR in the semen in 16 samples tested. Limitations, reasons for caution First, most of the semen samples came from non-severe men of whom were in the recovery stage and lacked symptoms. Additionally, our sample size was relatively small and overnight mail-in semen analysis kits were used during the acute phase of infection to minimize contact with positive subjects. Wider implications of the findings: Our findings suggest extremely low risk of viral transmission during sexual contact and assisted reproductive techniques, although further data need to be obtained. The impact on TSC in recovered men from SARS-CoV–2 infection is concerning, nevertheless long-term follow-up of these men is critical to determine the nadir of TSC. Trial registration number 20200401

Estimation of haemodynamic changes in varicocele testis and results after microsurgical sub-inguinal varicocelectomy

2021 ◽  
pp. 039156032110690
Author(s):  
Satyadeo Sharma ◽  
Rajendra K Shimpi
Keyword(s):  
Semen Analysis ◽  
Peak Systolic Velocity ◽  
Resistive Index ◽  
Semen Parameters ◽  
Medical Institute ◽  
Sperm Density ◽  
Doppler Study ◽  
Diastolic Velocity ◽  
Before And After ◽  
Haemodynamic Changes

Introduction: Varicocele is among the most frequently encountered, surgically correctable causes of male infertility. Since varicocele is a primary abnormality of testicular vessels, a thorough understanding of haemodynamic changes in the microcirculation of varicocele testis is needed. Objectives: To estimate changes in the microcirculation of varicocele testis and correlate them with symptomatic and semen parameters changes before and after varicocelectomy. Material and methods: This prospective, observational study includes 47 patients of age group 18–40 years who underwent microsurgical varicocelectomy during June 2016 to April 2018 at a tertiary medical institute. Testicular haemodynamic was evaluated using a colour spectral doppler study (PSV-Peak systolic velocity/ESV-End diastolic velocity/RI-Resistive index/PI-Pulsatility index). Semen analysis parameters and testicular blood flow were compared with pre-operative values. Results: RI in the capsular artery of varicocele affected testis, which was 0.61 ± 0.11 (mean ± SD), significantly reduced to 0.56 ± 0.09 (mean ± SD) in post-operative follow-up, indicating improved perfusion. Pre-operative sperm density was noted to be 15.94 ± 7.88 (mean ± SD), which improved to 28.41 ± 10.99, Progressive sperm motility from 33.81 ± 10.88 to 38.32 ± 9.21 and morphology from 36.13 ± 10.68 to 41.43 ± 9.29 on 6-month follow-ups ( p < 0.05). Conclusion: Varicocele testis is associated with altered testicular haemodynamic, which insults spermatogenesis. Microsurgical varicocelectomy with testicular artery and lymphatic preservation leads to correction of this altered haemodynamic state and improves the testicular microcirculation.

scholarly journals Benefit of varicocelectomy in infertile men with varicocele

2020 ◽  
Vol 9 (7) ◽  
pp. 2709
Author(s):  
Shreeharsha Mallappa Awati
Keyword(s):  
Cohort Study ◽  
Semen Analysis ◽  
Observational Cohort Study ◽  
Semen Parameters ◽  
Prospective Observational Cohort Study ◽  
College Hospital ◽  
Medical College ◽  
Infertile Men ◽  
Observational Cohort ◽  
Scrotal Imaging

Background: Varicocelectomy does improve semen parameters and pregnancy rates in men with infertility. Various studies have shown the extent of benefit and also shown that some may not benefit. It is important to counsel the patients about the same. The present study was done to determine how much varicocelectomy is beneficial to infertile men with varicocele.Methods: A prospective observational cohort study was conducted on 25 patients undergoing varicocelectomy for infertility at St. John Medical College Hospital, Bangalore from 1st June 2013 to 31st May 2014. Clinical data, semen analysis, scrotal imaging was done and postoperatively semen analysis was done after three months. The data was analysed to find out how much was the benefit of varicocelectomy.Results: Twenty-five patients underwent varicocelectomy, all of them showed improvement of semen parameters. Fifteen of them had more than 50% of improvement. This showed that varicocelectomy is beneficial to about 60% of patients.Conclusions: Varicocelectomy is beneficial to infertile men with palpable varicocele and abnormal semen parameters.

scholarly journals The serum inhibin B concentration and reference ranges in normozoospermia

2015 ◽  
Vol 172 (6) ◽  
pp. 669-676 ◽  
Author(s):  
Anne-Laure Barbotin ◽  
Caroline Ballot ◽  
Julien Sigala ◽  
Nassima Ramdane ◽  
Alain Duhamel ◽  
...  
Keyword(s):  
Reference Range ◽  
Reference Group ◽  
Semen Analysis ◽  
Inhibin B ◽  
World Health ◽  
Semen Parameters ◽  
Case Group ◽  
Reference Ranges ◽  
Semen Parameter ◽  
Health Organization

ObjectiveAlthough an inhibin B assay may be useful in the assessment of testicular function in a number of genital conditions, reliable reference ranges are still lacking. The present study sought to establish the reference range for serum inhibin B by applying the updated Gen II assay.DesignThis prospective study included 818 men referred for semen analysis: 377 were normozoospermic (reference group) and 441 presented at least one abnormal semen parameter (case group).MethodsSemen parameters were interpreted according to the 2010 World Health Organization manual and David's modified classification for normal morphology. The inhibin B concentration was determined with the current ELISA.ResultsIn the reference group, the 2.5th percentile for inhibin B was 92 pg/ml and the 97.5th percentile for FSH was 7.8 IU/l. In the overall population, an inhibin B level <92 pg/ml was associated with increased odds ratio (OR; 95% CI) for oligozoospermia (16.93 (9.82–29.18), P<0.0001), asthenozoospermia (4.87 (2.88–8.10), P<0.0001), and teratozoospermia (2.20 (1.31–3.68), P=0.0026). The combination of a FSH >7.8 IU/l and an inhibin B <92 pg/ml was associated with greater OR for oligozoospermia (98.74 (23.99–406.35), P<0.0001) than for each hormone considered separately.ConclusionsA new reference range for serum inhibin B was established by the use of updated immunoassay. The correlations between hormone levels and semen parameters highlighted the importance of establishing these values with respect to the spermogram. When combined with FSH assay, the inhibin B range may be of value in the evaluation of spermatogenesis in a number of male genital conditions.

scholarly journals SEMEN PARAMETERS

2018 ◽  
Vol 25 (07) ◽  
pp. 1024-1028
Author(s):  
Jahangir Sultan ◽  
Shafqat Husnain Khan ◽  
Munir Ahmed
Keyword(s):  
Semen Analysis ◽  
National Level ◽  
Cross Sectional Study ◽  
Conclusive Evidence ◽  
Semen Parameters ◽  
Regional Study ◽  
Cross Sectional ◽  
Infertile Men ◽  
Hormonal Levels

Objective: The objective of this study was to study the semen parameters and its relation to hormonal status in infertile men. Study Design: Cross sectional study. Period: March 2015 to April 2017. Setting: Jinnah Hospital Fertility Centre; Department of Obstetrics and Gynecology, Lahore. Method: A total of 70 infertile men were included in this study. Semen samples for semen analysis and serum for hormonal analysis were obtained and further tests were performed. Results: The results of our study show that 28.57% were Normospermic, 18.56% were azoospermic and 52.85% were Oligospermic. In Oligospermic and azoospermic patients significant low levels of testosterone and prolactin were noticed. The results indicate that along with semen parameters hormonal levels should also be assessed to diagnose the underlying cause of infertility. Conclusion: It is concluded from our study that both quality of semen and hormonal levels cause infertility in men. Therefore the patients should be properly investigated and should be treated accordingly to the underlying abnormality. This is a regional study and further studies should be conducted to have a conclusive evidence at national level.

scholarly journals The Effect of Human Chorionic Gonadotropin Therapy on Semen Parameters and Pregnancy Rate after Varicocelectomy

2017 ◽  
Vol 11 (2) ◽  
pp. 92-96
Author(s):  
Javanmard Babak ◽  
Fadavi Behruz ◽  
Yousefi Mohammadreza ◽  
Fallah-Karkan Morteza
Keyword(s):  
Pregnancy Rate ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Semen Analysis ◽  
Semen Parameters ◽  
Infertile Men ◽  
Hcg Therapy ◽  
Infertile Patients ◽  
Gonadotropin Therapy

Introduction: To study the stimulating effect of human chorionic gonadotropin (hCG) on spermatogenesis in patients with varicocele and infertility undergoing varicocelectomy. Materials and Methods: In the study, 188 infertile patients with varicocele were included. Open inguinal varicocelectomy was performed. They were randomized into 2 groups and hCG (91 patients) was administered intramuscularly by dosage of 5,000 international units every week for 3 months. A semen analysis was obtained at 6 months, post-operatively and cases were followed for 2 years for pregnancy report. Results: Semen analysis of the patients shows a significant improvement in all parameters 6 months after varicocelectomy without any superiority between the 2 groups. During the follow-up, 56 couples (61.5%) in hCG treated and 22 couples (22.7%) in the group treated only by varicocelectomy achieved pregnancy. Patients treated with varicocelectomy plus hCG therapy had a significant superior pregnancy rate compared to the other group (P=0.0001). Conclusion: Administration of hCG in this group of infertile patients might be helpful in order to enhance pregnancy rate. However some more conclusive studies are needed to be able to recommend such therapy for infertile men due to varicocele.

scholarly journals The Impact of Intense Exercise on Semen Quality

2016 ◽  
Vol 11 (3) ◽  
pp. 654-662 ◽  
Author(s):  
Paweł Jóźków ◽  
Marco Rossato
Keyword(s):  
Physical Activity ◽  
Semen Quality ◽  
Sperm Count ◽  
Semen Analysis ◽  
Semen Parameters ◽  
Male Factor ◽  
Recreational Athletes ◽  
Increasing Demand ◽  
Male Reproductive Health ◽  
The Impact

With expanding knowledge on the health benefits of exercise, there is an increasing demand for information on the andrological consequences of participating in sports. These consequences are especially important in the context of infertility problems worldwide. The so-called “male factor” is reported in up to 50% of couples having trouble with conception. The answer to the question, “Is physical activity good for male reproductive health?” is not straightforward. A number of studies have suggested that significant changes in semen parameters may occur due to sports training of certain types, intensities, and durations. The changes to these parameters vary in scope, direction, and magnitude. Findings in recreational athletes have also differed from those in professional athletes. This review of the current literature suggests that intense physical activity may affect the semen concentration, as well as the number of motile and morphologically normal spermatozoa. Training at higher intensities and with increased loads seems to be associated with more profound changes in semen quality. In recreational athletes, exercise has either a positive or neutral effect on semen parameters. Due to many limitations (e.g., global sperm count trends, concerns about the quality control of sperm evaluations, and new standards for semen analysis), comparisons among historical data and their interpretation are difficult.

scholarly journals Bacteriospermia and Its Impact on Basic Semen Parameters among Infertile Men

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Sangeetha Vilvanathan ◽  
Balan Kandasamy ◽  
Abiramy Lakshmy Jayachandran ◽  
Sarasa Sathiyanarayanan ◽  
Vijayalakshmi Tanjore Singaravelu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Semen Quality ◽  
Sperm Count ◽  
Semen Analysis ◽  
Surrogate Marker ◽  
Semen Parameters ◽  
Who Guidelines ◽  
E Coli ◽  
Infertile Men ◽  
Normal Sperm

Introduction. Semen analysis is considered as the surrogate marker for male fecundity while assessing infertile men. There are several reasons for altered semen quality and bacteriospermia could be one among them. Thereby the aim of our work is to study the semen culture and its impact on semen parameters among infertile men.Materials and Methods. Semen samples were collected from men attending infertility clinic. Semen parameters were analysed based on WHO guidelines. Also, samples were subjected to culture using standard bacteriological techniques.Results. A total of 85 samples were collected. A number of 47 (55.30%) had normal sperm count, 37 (43.50%) had oligozoospermia, and one (1.17%) had azoospermia. Teratozoospermia was the most common abnormality observed (81.17%) followed by asthenozoospermia (28.23%). The prevalence of bacteriospermia was 35.3%.Enterococcus faecalis(30%) was the most common organism isolated followed by Coagulase negativeStaphylococcus(23.33%),Staphylococcus aureus(20%), andE. coli(10%). Other less frequently isolated organisms wereKlebsiella pneumoniae(6.66%),Proteussp. (6.66%), andCitrobactersp. (3.33%).Conclusion. The presence of asymptomatic bacteriospermia did not correlate with abnormal semen parameters.

scholarly journals Improvement of semen parameters after coil embolization of varicoceles: a systematic review

2021 ◽  
Vol 20 ◽  
Author(s):  
Sergio Quilici Belczak ◽  
Vanessa Stefaniak ◽  
Leonardo Garcia Góes ◽  
Felipe Coelho Neto ◽  
Walter Jr. Boim de Araújo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Studies ◽  
Cost Effective ◽  
Semen Parameters ◽  
Semen Parameter ◽  
Cost Effective Method ◽  
Prisma Statement ◽  
Meta Analyses ◽  
The Impact

Abstract This systematic review was conducted in accordance with the 2009 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, including clinical studies in which one of the outcomes was semen parameter improvement after varicocele embolization using coils only. The objective of the review was to assess the evidence on the role of embolization using coils alone for semen parameter improvement in men with varicocele, since embolization using coils is the most cost-effective method of varicocele repair. Study quality was assessed using the methodological index for non-randomized studies (MINORS). Out of six retrospective and two prospective observational or comparative clinical studies involving 701 patients, semen concentration improved significantly in all five studies that assessed this parameter. Mean semen motility improved significantly in seven studies. The impact of embolization on semen density could not be analyzed.

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