Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases

There is a growing quantity of evidence on how skin and gut microbiome composition impacts the course of various dermatological diseases. The strategies involving the modulation of bacterial composition are increasingly in the focus of research attention. The aim of the present review was to analyze the literature available in PubMed (MEDLINE) and EMBASE databases on the topic of microbiome modulation in skin diseases. The effects and possible mechanisms of action of probiotics, prebiotics and synbiotics in dermatological conditions including atopic dermatitis (AD), psoriasis, chronic ulcers, seborrheic dermatitis, burns and acne were analyzed. Due to the very limited number of studies available regarding the topic of microbiome modulation in all skin diseases except for AD, the authors decided to also include case reports and original studies concerning oral administration and topical application of the pro-, pre- and synbiotics in the final analysis. The evaluated studies mostly reported significant health benefits to the patients or show promising results in animal or ex vivo studies. However, due to a limited amount of research and unambiguous results, the topic of microbiome modulation as a therapeutic approach in skin diseases still warrants further investigation.

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Optimization of Rheological Behaviour and Skin Penetration of Thermogelling Emulsions with Enhanced Substantivity for Potential Application in Treatment of Chronic Skin Diseases

Pharmaceutics ◽

10.3390/pharmaceutics11080361 ◽

2019 ◽

Vol 11 (8) ◽

pp. 361 ◽

Cited By ~ 1

Author(s):

Markus Schmidberger ◽

Ines Nikolic ◽

Ivana Pantelic ◽

Dominique Lunter

Keyword(s):

Droplet Size ◽

Skin Diseases ◽

Ex Vivo ◽

Methyl Cellulose ◽

Rheological Behaviour ◽

Skin Penetration ◽

Rheological Parameters ◽

Application Site ◽

Chronic Skin ◽

Chronic Skin Diseases

Topical formulations are an important pillar in the therapy of skin diseases. Nevertheless, after application the formulation will be exposed to environmental effects. Contact with other surfaces will reduce the available amount of formulation and drug substance. The resulting consequences for therapy range from reduced effects to therapeutic failure. The removed active ingredient also contaminates patients’ environment. The aim of this work was to develop preparations that remain at the application site. These will enhance safety and efficiency and thus improve of skin disease therapies. Therefore, we developed polymer-stabilised emulsions that show thermogelling properties. Emulsions with different methyl cellulose concentrations and macrogols of different molecular weights were investigated. The dispersed phase consisted of nonivamide as the active pharmaceutical ingredient, dissolved in medium-chain triglycerides. Rheological properties, droplet size, substantivity and ex vivo penetration experiments were performed to characterise the developed formulations. Droplet size and rheological parameters were affected by the composition of the preparations. The tested formulations showed benefits in their substantivity compared to a conventional semi-solid cream. We found a residual amount of up to 100% at the application site. The drug levels in viable epidermis were in a therapeutic range. The developed emulsions are a promising vehicle to improve therapy for chronic skin diseases.

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The Constructive Thinking Inventory: Factorial Structure in Healthy Individuals and Patients with Chronic Skin Diseases

European Journal of Psychological Assessment ◽

10.1027/1015-5759.14.3.226 ◽

1998 ◽

Vol 14 (3) ◽

pp. 226-233 ◽

Cited By ~ 3

Author(s):

Jürgen Hoyer ◽

Mechthild Averbeck ◽

Thomas Heidenreich ◽

Ulrich Stangier ◽

Karin Pöhlmann ◽

...

Keyword(s):

Skin Diseases ◽

Principal Component ◽

Initial Study ◽

Statistical Independence ◽

Constructive Thinking ◽

Global Factor ◽

Emotional Coping ◽

Factor Congruence ◽

Chronic Skin ◽

Chronic Skin Diseases

Epstein's “Constructive Thinking Inventory” (CTI) was developed to measure the construct of experiential intelligence, which is based on his cognitive-experiential self-theory. Inventory items were generated by sampling naturally occurring automatic cognitions. Using principal component analysis, the findings showed a global factor of coping ability as well as six main factors: Emotional Coping, Behavioral Coping, Categorical Thinking, Personal Superstitious Thinking, Esoteric Thinking, and Naive Optimism. We tested the replicability of this factor structure and the amount of statistical independence (nonredundancy) between these factors in an initial study of German students (Study 1, N = 439) and in a second study of patients with chronic skin disorders (Study 2, N = 187). Factor congruence with the original (American) data was determined using a formula proposed by Schneewind and Cattell (1970) . Our findings show satisfactory factor congruence and statistical independence for Emotional Coping and Esoteric Thinking in both studies, while full replicability or independence could not be found in both for the other factors. Implications for the use and further development of the CTI are discussed.

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167 Influence of Chronic Skin Diseases on Male Sexual Function in Upper Egypt

Journal of Sexual Medicine ◽

10.1016/j.jsxm.2016.12.155 ◽

2017 ◽

Vol 14 (2) ◽

pp. e69

Author(s):

H. Abdel Hafez ◽

A.A. Abdel-Motaleb ◽

H.D. Gaber ◽

G.S.T. Al-Attar

Keyword(s):

Sexual Function ◽

Skin Diseases ◽

Upper Egypt ◽

Male Sexual Function ◽

Chronic Skin ◽

Chronic Skin Diseases

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Quality of Life and Psychosocial Needs of Children Suffering from Chronic Skin Diseases

Alcoholism and psychiatry research Journal on psychiatric research and addictions ◽

10.20471/apr.2016.52.02.04 ◽

2016 ◽

Vol 52 (2) ◽

pp. 133-148 ◽

Cited By ~ 4

Author(s):

Mia Roje ◽

Ines Rezo ◽

Gordana Buljan Flander

Keyword(s):

Quality Of Life ◽

Skin Diseases ◽

Psychosocial Needs ◽

Chronic Skin ◽

Chronic Skin Diseases

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Influência de fatores emocionais nas doenças crônicas de pele: O estresse como gatilho para o desenvolvimento, reincidência ou agravamento da psoríase / Influence of emotional factors on chronic skin diseases: Stress as a trigger for development, recurrence or worsening of psoriasis

ID on line REVISTA DE PSICOLOGIA ◽

10.14295/idonline.v13i46.1914 ◽

2019 ◽

Vol 13 (46) ◽

pp. 584-608

Author(s):

Manuela Sobral Bentes de Melo ◽

Nara Freire Leão Rocha ◽

Stéfany Silva Magalhães ◽

Lais Landim Sousa

Keyword(s):

Skin Diseases ◽

Emotional Factors ◽

Chronic Skin ◽

Chronic Skin Diseases

Diversos estudos têm revelado a existência de uma relação entre aspectos psicossociais e o desenvolvimento ou agravamento de dermatoses crônicas, dentre as quais se encontra a psoríase. Fatores psicológicos, stress e outros eventos da vida são capazes de agravar de 40 e 80% dos casos. O estudo objetivou analisar a forma como esses aspectos podem ensejar o surgimento, a reincidência ou a acentuação do quadro clínico. Metodologia: Estudo de casos concretos com pacientes portadores da psoríase, além de uma vasta literatura bibliográfica acerca da temática. Conclusão: Ficou demonstrada a importância do tratamento psíquico e fisiológico, bem como a necessidade do desenvolvimento de estratégias de coping para enfretamento das situações sociais envolvidas.

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Comparison of Personality Traits among Patients with Psoriasis, Atopic Dermatitis, and Stress: A Pilot Study

Dermatology ◽

10.1159/000505543 ◽

2020 ◽

Vol 236 (4) ◽

pp. 324-328 ◽

Cited By ~ 2

Author(s):

Lynda Grine ◽

Giulia Tochtermann ◽

Hilde Lapeere ◽

Nele Maes ◽

Günther F.L. Hofbauer ◽

...

Keyword(s):

Atopic Dermatitis ◽

Pilot Study ◽

Personality Traits ◽

Skin Diseases ◽

Work Related Stress ◽

Work Related ◽

Chronic Skin ◽

Related Stress ◽

Chronic Skin Diseases ◽

The Impact

Background: Psoriasis and atopic dermatitis are chronic skin diseases that greatly affect the quality of life. Both diseases can be triggered or exacerbated by stress. Objective: We aimed to differentiate personality traits between patients with chronic skin conditions and people treated for stress in a pilot study. Methods: Patients participating voluntarily in educational programs in Belgium and Switzerland were recruited to complete personality trait questionnaires, including the Temperament and Character Inventory (TCI) and the Tridimensional Personality Questionnaire (TPQ). A comparison was made with patients treated for work-related stress. Results: A total of 48 and 91 patients suffering from skin diseases and work-related stress, respectively, were included in the study. Based on the questionnaires, we found that dermatology patients were less persistent and impulsive than those with work-related stress. Dermatology patients also exhibited more rigidness and less focus on performance. Finally, patients with work-related stress seem more likely to change in response to health-promoting programs than patients with chronic dermatoses. Conclusion: Patients with chronic skin diseases may perceive and cope with stress differently in comparison to patients with work-related stress due to inherent personality traits. Therefore, stress coping mechanisms may differ among different diseases. More research is needed into the design of educational interventions and the impact of personality traits in disease-specific groups.

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