scholarly journals Tuning of Hydrogel Architectures by Ionotropic Gelation in Microfluidics: Beyond Batch Processing to Multimodal Diagnostics

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1551
Author(s):  
Alessio Smeraldo ◽  
Alfonso Maria Ponsiglione ◽  
Paolo Antonio Netti ◽  
Enza Torino
Keyword(s):  
Multimodal Imaging ◽  
Polymer Nanoparticles ◽  
Fine Tuning ◽  
Batch Processes ◽  
Resonance Imaging ◽  
Gadolinium Contrast ◽  
Flow Rates ◽  
Ionotropic Gelation ◽  
Promising Tool ◽  
Gadolinium Contrast Agent

Microfluidics is emerging as a promising tool to control physicochemical properties of nanoparticles and to accelerate clinical translation. Indeed, microfluidic-based techniques offer more advantages in nanomedicine over batch processes, allowing fine-tuning of process parameters. In particular, the use of microfluidics to produce nanoparticles has paved the way for the development of nano-scaled structures for improved detection and treatment of several diseases. Here, ionotropic gelation is implemented in a custom-designed microfluidic chip to produce different nanoarchitectures based on chitosan-hyaluronic acid polymers. The selected biomaterials provide biocompatibility, biodegradability and non-toxic properties to the formulation, making it promising for nanomedicine applications. Furthermore, results show that morphological structures can be tuned through microfluidics by controlling the flow rates. Aside from the nanostructures, the ability to encapsulate gadolinium contrast agent for magnetic resonance imaging and a dye for optical imaging is demonstrated. In conclusion, the polymer nanoparticles here designed revealed the dual capability of enhancing the relaxometric properties of gadolinium by attaining Hydrodenticity and serving as a promising nanocarrier for multimodal imaging applications.

scholarly journals Effectiveness of low-field magnetic resonance imaging in diagnosing brachial plexus tumours in dogs – short communication

2015 ◽  
Vol 59 (2) ◽  
pp. 317-319
Author(s):  
Zbigniew Adamiak ◽  
Yauheni Zhalniarovich ◽  
Paulina Przyborowska ◽  
Joanna Głodek ◽  
Adam Przeworski
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brachial Plexus ◽  
Resonance Imaging ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent ◽  
Low Field ◽  
Mri Sequences ◽  
Magnetic Resonance Imaging Mri ◽  
Brachial Plexus Tumours

AbstractThe aim of the study was to identify magnetic resonance imaging (MRI) sequences that contribute to a quick and reliable diagnosis of brachial plexus tumours in dogs. The tumours were successfully diagnosed in 6 dogs by the MRI with the use of SE, FSE, STIR, Turbo 3 D, 3D HYCE, and GE sequences and the gadolinium contrast agent

Gadolinium contrast agent is of limited value for magnetic resonance imaging assessment of synovial hypertrophy in hemophiliacs

2007 ◽  
Vol 48 (5) ◽  
pp. 520-530 ◽  
Author(s):  
B. Lundin ◽  
E. Berntorp ◽  
H. Pettersson ◽  
R. Wirestam ◽  
K. Jonsson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Dynamic Mri ◽  
Time Interval ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Gadolinium Contrast ◽  
Synovial Hypertrophy ◽  
Gadolinium Contrast Agent

Purpose: To examine the influence of different doses of gadolinium contrast agent on synovial enhancement, to compare magnetic resonance imaging (MRI) findings of synovial hypertrophy and radiographic joint changes in hemophiliacs, and to investigate the value of gadolinium in MRI assessment of synovial hypertrophy in hemophiliacs using dynamic MRI and MRI scoring. Material and Methods: Twenty-one hemophiliacs on prophylactic factor treatment without recent bleeds were subjected to radiography and gadolinium contrast-enhanced dynamic and static MRI of the knee using a standard dose of 0.1 mmol/kg b.w. gadoteridol. In 17 of the patients, the MRI procedure was repeated after a triple dose of gadoteridol. Results: MRI findings of synovial hypertrophy were significantly correlated with Pettersson radiographic scores. In 19 of the 21 MRI investigated joints, administration of contrast agent did not alter the result of the evaluation of synovial hypertrophy. Conclusion: The optimal time interval for volume assessment of synovial hypertrophy after injection of gadolinium contrast agent is dose dependent. Hemophiliacs without recent bleeds have minor to abundant synovial hypertrophy in joints with pronounced radiographic changes. Dynamic MRI is not useful for evaluating hemophilic arthropathy, and gadolinium contrast agent is not routinely indicated for MRI scoring of joints in hemophiliacs.

Magnetic Resonance Imaging Demonstration of Pharmacologic-Induced Myocardial Vasodilatation Using a Macromolecular Gadolinium Contrast Agent

1992 ◽  
Vol 27 (11) ◽  
pp. 935-940 ◽  
Author(s):  
VLADIMIR S. VEXLER ◽  
YVES BERTHEZÈNE ◽  
CHRISTOPHER L. WOLFE ◽  
RICHARD SIEVERS ◽  
JEAN W. DUPON ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent

scholarly journals A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage

2015 ◽  
Vol 51 (56) ◽  
pp. 11166-11169 ◽  
Author(s):  
Jonathan D. Freedman ◽  
Hrvoje Lusic ◽  
Martin Wiewiorski ◽  
Michelle Farley ◽  
Brian D. Snyder ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Articular Cartilage ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent

A new cationic gadolinium contrast agent is described for imaging articular cartilage.

scholarly journals A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1513
Author(s):  
Fouzi Mouffouk ◽  
Hacene Serrai ◽  
Sourav Bhaduri ◽  
Rik Achten ◽  
Mozhdeh Seyyedhamzeh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Ph Sensitive ◽  
Resonance Imaging ◽  
Gadolinium Contrast ◽  
Tissue Ph ◽  
Gadolinium Contrast Agent ◽  
Magnetic Resonance Imaging Mri

Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the techniques developed so far suffer from inadequate accuracy, due to poor sensitivity at low concentration of the target or nonspecific interactions within the tissue matrix. To overcome these issues, we describe herein the development of a simple, yet reliable, way to estimate pH with high precision using a Gd(III)-DOTA-silyl-based acid-labile group as a pH-sensitive contrast agent with Magnetic Resonance Imaging (MRI). With this method, a change in T 1 weighted image intensity of the newly developed pH-sensitive contrast is directly linked to the proton concentration in the media. As a result, we were able estimate the pH of the target with 95% reliability.

scholarly journals Enhancement of subarachnoid space during magnetic resonance imaging of endolymphatic hydrops: a case report

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110297
Author(s):  
Milan Vajda ◽  
Jana Dědková ◽  
Maja Stříteská ◽  
Jiří Jandura ◽  
Pavel Ryška
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Intravenous Administration ◽  
Subarachnoid Space ◽  
Endolymphatic Hydrops ◽  
Clinical Signs ◽  
Resonance Imaging ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agent

Enhancement of the subarachnoid space after intravenous administration of gadolinium contrast agent is not common. Enhancement usually occurs in pathological conditions that increase the permeability of the blood–cerebrospinal fluid barrier, most notably in meningitis. We herein describe possible subarachnoid enhancement in patients with no apparent effect on the meninges. These patients had clinical signs of Meniere’s disease and underwent specific magnetic resonance imaging of the inner ear to possibly visualize endolymphatic hydrops. The endolymphatic space can be noninvasively imaged by intravenous administration of contrast agent, usually at a double dose, 4 hours before the scanning process. During this time, the contrast agent penetrates not only the perilymph but also the subarachnoid space, where the highest concentration occurs after 4 hours according to some studies.

scholarly journals Idiopathic Free-Floating Thrombus of the Common Carotid Artery

2002 ◽  
Vol 29 (1) ◽  
pp. 97-99 ◽  
Author(s):  
Brian Silver ◽  
Irene Gulka ◽  
Michael Nicolle ◽  
Ramesh Sahjpaul ◽  
Vladimir Hachinski
Keyword(s):  
Carotid Artery ◽  
Common Carotid Artery ◽  
Multimodal Imaging ◽  
Doppler Ultrasonography ◽  
Resonance Imaging ◽  
Wall Defect ◽  
Floating Thrombus ◽  
Weighted Magnetic Resonance Imaging ◽  
The Common ◽  
One Year

Background:The observation of an intraluminal common carotid artery thrombus overlying a wall defect at ultrasonography or angiography is unusual. To our knowledge, there are no previous reports of a free-floating thrombus in the common carotid artery.Case Report:A 45-year-old woman who was previously healthy and on no medications presented with acute hemiparesis and aphasia. Following testing that included carotid duplex and trancranial Doppler ultrasonography, diffusion-weighted magnetic resonance imaging, and digital subtraction angiography, the patient underwent emergency open embolectomy. No underlying wall defect was seen at the time of imaging or surgery. No obvious hypercoagulable state could be identified. Her NIH Stroke Scale score improved from 26 at admission to 2 at three months and 1 at one year.Conclusions:Multimodal imaging may have improved diagnosis and management in this patient with a unique finding. The source of the thrombus remains obscure.

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