scholarly journals Hypothetical Mechanism of Exercise-Induced Acute Kidney Injury Associated with Renal Hypouricemia

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1847
Author(s):  
Makoto Hosoyamada
Keyword(s):  
Acute Kidney Injury ◽  
Mammalian Target Of Rapamycin ◽  
Kidney Injury ◽  
Hereditary Disease ◽  
Exhaustive Exercise ◽  
Thick Ascending Limb ◽  
High Concentration ◽  
Renal Hypouricemia ◽  
Pyrin Domain ◽  
Exercise Induced

Renal hypouricemia (RHUC) is a hereditary disease that presents with increased renal urate clearance and hypouricemia due to genetic mutations in the urate transporter URAT1 or GLUT9 that reabsorbs urates in the renal proximal tubule. Exercise-induced acute kidney injury (EIAKI) is known to be a complication of renal hypouricemia. In the skeletal muscle of RHUC patients during exhaustive exercise, the decreased release of endothelial-derived hyperpolarization factor (EDHF) due to hypouricemia might cause the disturbance of exercise hyperemia, which might increase post-exercise urinary urate excretion. In the kidneys of RHUC patients after exhaustive exercise, an intraluminal high concentration of urates in the proximal straight tubule and/or thick ascending limb of Henle’s loop might stimulate the luminal Toll-like receptor 4–myeloid differentiation factor 88–phosphoinositide 3-kinase–mammalian target of rapamycin (luminal TLR4–MyD88–PI3K–mTOR) pathway to activate the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome and may release interleukin-1β (IL-1β), which might cause the symptoms of EIAKI.

scholarly journals Renal hypouricemia with exercise induced acute kidney injury-A case report

2020 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Srikanth Gundlapalli ◽  
Yogesh Gaur ◽  
MVenkateswar Rao ◽  
SujeethReddy Bande ◽  
P Sandhya
Keyword(s):  
Acute Kidney Injury ◽  
Case Report ◽  
Kidney Injury ◽  
Renal Hypouricemia ◽  
Exercise Induced

scholarly journals A Case of Acute Kidney Injury in a Patient with Renal Hypouricemia without Intense Exercise

2020 ◽  
Vol 10 (1) ◽  
pp. 26-34
Author(s):  
Daiki Aomura ◽  
Kosuke Sonoda ◽  
Makoto Harada ◽  
Koji Hashimoto ◽  
Yuji Kamijo
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Risk Factor ◽  
Conservative Treatment ◽  
Kidney Injury ◽  
Intense Exercise ◽  
Kidney Dysfunction ◽  
Renal Hypouricemia ◽  
Orthostatic Dysregulation ◽  
Exercise Induced

Exercise-induced acute kidney injury (EIAKI) frequently develops in patients with renal hypouricemia (RHUC). However, several cases of RHUC with acute kidney injury (AKI) but without intense exercise have been reported. We encountered a 15-year-old male with RHUC who experienced AKI. He reported no episodes of intense exercise and displayed no other representative risk factors of EIAKI, although a vasopressor had been administered for orthostatic dysregulation before AKI onset. His kidney dysfunction improved with discontinuation of the vasopressor and conservative treatment. Thus, AKI can develop in patients with RHUC in the absence of intense exercise, for which vasopressors may be a risk factor.

Exercise-Induced Acute Kidney Injury: A Case of Renal Hypouricemia

2015 ◽  
Vol 24 (2) ◽  
pp. 217-219
Author(s):  
Simge Bardak ◽  
Kenan Turgutalp ◽  
Ahmet Kiykim
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Renal Hypouricemia ◽  
Exercise Induced

scholarly journals Mutation in the SLC2A9 Gene: A New Family with Familial Renal Hypouricemia Type 2

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Christian Maalouli ◽  
Karin Dahan ◽  
Arnaud Devresse ◽  
Valentine Gillion
Keyword(s):  
Acute Kidney Injury ◽  
Genetic Disorder ◽  
Kidney Injury ◽  
Type Ii ◽  
Renal Hypouricemia ◽  
New Family ◽  
Exercise Induced ◽  
Renal Tubular ◽  
Work Up

Familial renal hypouricemia is a rare genetic disorder characterized by a defect in renal tubular urate reabsorption. Some patients present with exercise-induced acute kidney injury and nephrolithiasis. Type II is caused by mutations in the SLC2A9 gene. Here, we report the case of a young patient who developed acute kidney injury after exercise secondary to familial renal hypouricemia type II. The same mutation was found in other asymptomatic members of his family. We review the medical literature on this condition. This case highlights the importance of considering uric acid disorders in the work-up of acute kidney injury after exercise.

Two cases of renal hypouricemia in which dopamine infusion produced a good recovery from exercise-induced acute kidney injury

2011 ◽  
Vol 76 (08) ◽  
pp. 83-90 ◽  
Author(s):  
O. Saito ◽  
T. Sugase ◽  
T. Saito ◽  
T. Akimoto ◽  
M. Inoue ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Good Recovery ◽  
Renal Hypouricemia ◽  
Dopamine Infusion ◽  
Exercise Induced

scholarly journals Exercise-Induced Acute Kidney Injury in a Police Officer with Hereditary Renal Hypouricemia

2019 ◽  
Vol 9 (2) ◽  
pp. 92-101 ◽  
Author(s):  
Yoshio Shimizu ◽  
Keiichi Wakabayashi ◽  
Ayako Totsuka ◽  
Yoko Hayashi ◽  
Shusaku Nitta ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Uric Acid ◽  
Police Officer ◽  
Serum Uric Acid ◽  
Kidney Injury ◽  
Occupational Training ◽  
Renal Hypouricemia ◽  
Acid Clearance ◽  
Uric Acid Clearance ◽  
Exercise Induced

Hereditary renal hypouricemia is characterized by hypouricemia with hyper-uric acid clearance due to a defect in renal tubular transport. Patients with hereditary renal hypouricemia have a higher risk of exercise-induced acute kidney injury (EAKI) and reduced kidney function. Although the best preventive measure is avoiding exercise, there are many kinds of jobs that require occupational exercise. A 27-year-old male police officer suffered from stage 3 AKI after performing a 20-m multistage shuttle run test. His mother had previously been diagnosed as having renal hypouricemia at another facility. The patient had reported having hypouricemia during a health check at a previous police station, but his serum uric acid concentration was within the normal range at our hospital. After treatment, he recovered from EAKI and exhibited low serum uric acid and hyper-uric acid clearance. Since the patient desired to continue his career requiring strenuous exercise, it was difficult to establish a preventive plan against the recurrence of EAKI. Patients with hereditary renal hypouricemia who must undergo strenuous occupational anaerobic exercise are at higher risk of developing EAKI than other workers. The risks of EAKI among patients with hypouricemia should be considered when undergoing physical occupational training.

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