scholarly journals Thermoplastic Elastomer (TPE)–Poly(Methyl Methacrylate) (PMMA) Hybrid Devices for Active Pumping PDMS-Free Organ-on-a-Chip Systems

Biosensors ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 162
Author(s):  
Mathias Busek ◽  
Steffen Nøvik ◽  
Aleksandra Aizenshtadt ◽  
Mikel Amirola-Martinez ◽  
Thomas Combriat ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Drug Testing ◽  
Low Cost ◽  
Thermoplastic Elastomer ◽  
Bonding Process ◽  
Cell Alignment ◽  
Poly Methyl Methacrylate ◽  
Bonding Parameters ◽  
Organ On A Chip ◽  
Hybrid Devices

Polydimethylsiloxane (PDMS) has been used in microfluidic systems for years, as it can be easily structured and its flexibility makes it easy to integrate actuators including pneumatic pumps. In addition, the good optical properties of the material are well suited for analytical systems. In addition to its positive aspects, PDMS is well known to adsorb small molecules, which limits its usability when it comes to drug testing, e.g., in organ-on-a-chip (OoC) systems. Therefore, alternatives to PDMS are in high demand. In this study, we use thermoplastic elastomer (TPE) films thermally bonded to laser-cut poly(methyl methacrylate) (PMMA) sheets to build up multilayered microfluidic devices with integrated pneumatic micro-pumps. We present a low-cost manufacturing technology based on a conventional CO2 laser cutter for structuring, a spin-coating process for TPE film fabrication, and a thermal bonding process using a pneumatic hot-press. UV treatment with an Excimer lamp prior to bonding drastically improves the bonding process. Optimized bonding parameters were characterized by measuring the burst load upon applying pressure and via profilometer-based measurement of channel deformation. Next, flow and long-term stability of the chip layout were measured using microparticle Image Velocimetry (uPIV). Finally, human endothelial cells were seeded in the microchannels to check biocompatibility and flow-directed cell alignment. The presented device is compatible with a real-time live-cell analysis system.

A facile solvothermal polymerization approach to thermoplastic polymer-based nanocomposites as alternative anodes for high-performance lithium-ion batteries

2019 ◽  
Vol 7 (40) ◽  
pp. 23019-23027 ◽  
Author(s):  
Zongfeng Sha ◽  
Shengqiang Qiu ◽  
Qing Zhang ◽  
Zhiyong Huang ◽  
Xun Cui ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Lithium Ion Batteries ◽  
Anode Materials ◽  
High Performance ◽  
Low Cost ◽  
Lithium Ion ◽  
Thermoplastic Polymer ◽  
Lithium Storage ◽  
Poly Methyl Methacrylate

A solvothermal polymerization approach to graphene/poly(methyl methacrylate) thermoplastic nanocomposites as low-cost alternative anode materials with superior lithium storage capability.

Effect of laser beam truncation (pinhole), (ordered) dithering, and jitter on residual smoothness after poly(methyl methacrylate) ablations, using a close-to-Gaussian beam profile

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Shwetabh Verma ◽  
Juergen Hesser ◽  
Samuel Arba-Mosquera
Keyword(s):  
Laser Beam ◽  
Methyl Methacrylate ◽  
Gaussian Beam ◽  
Low Cost ◽  
Random Noise ◽  
Beam Profile ◽  
Negatively Associated ◽  
Poly Methyl Methacrylate ◽  
The Impact ◽  
Ordered Dithering

Abstract Smoother surfaces after laser vision correction have been widely accepted as a factor for improving visual recovery regardless of the used technique (PRK, LASIK, or even SMILE). We tested the impact of laser beam truncation, dithering (expressing a continuous profile on a basis of lower resolution causing pixels to round up/down the number of pulses to be placed), and jitter (a controlled random noise (up to ±20 µm in either direction) added to the theoretical scanner positions) on residual smoothness after Poly(methyl methacrylate) (PMMA) ablations, using a close-to-Gaussian beam profile. A modified SCHWIND AMARIS system has been used providing a beam profile with the following characteristics: close-to-Gaussian beam profile with full width at half maximum (FWHM) of 540 µm, 1050 Hz. Laser parameters have been optimized following Invest. Ophthalmol. Vis. Sci., vol. 58, no. 4, pp. 2021–2037, 2017, the pulse energy has been optimized following Biomed. Opt. Express vol. 4, pp. 1422–1433, 2013. For the PMMA ablations, two configurations (with a 0.7 mm pinhole and 0.75 mJ and without pinhole and 0.9 mJ (for fluences of 329 mJ/cm2 and 317 mJ/cm2 and corneal spot volumes of 174 and 188 pl)) were considered, along with two types of lattices (with and without ordered dithering to select the optimum pulse positions), and two types of spot placement (with and without jitter). Real ablations on PMMA (ranging from −12D to +6D with and without astigmatism of up to 3D) completed the study setup. The effect of the 2 × 2 × 2 different configurations was analyzed based on the roughness in ablation estimated from the root mean square error in ablation. Truncation of the beam is negatively associated to a higher level of residual roughness; ordered dithering to select the optimum pulse positions is positively associated to a lower level of residual roughness; jitter is negatively associated to a higher level of residual roughness. The effect of dithering was the largest, followed by truncation, and jitter had the lowest impact on results. So that: Dithering approaches help to further minimize residual roughness after ablation; minimum (or no) truncation of the beam is essential to minimize residual roughness after ablation; and jitter shall be avoided to minimize residual roughness after ablation. The proposed model can be used for optimization of laser systems used for ablation processes at relatively low cost and would directly improve the quality of results. Minimum (or no) truncation of the beam is essential to minimize residual roughness after ablation. Ordered dithering without jitter helps to further minimize residual roughness after ablation. Other more complex dithering approaches may further contribute to minimize residual roughness after ablation.

A General Nonlithographic Method for Producing Nanodots by RIE Etching

2007 ◽  
Vol 1059 ◽  
Author(s):  
Jacob H. Leach ◽  
Hadis Morkoç
Keyword(s):  
Methyl Methacrylate ◽  
Low Cost ◽  
Polymeric Materials ◽  
Thin Layers ◽  
Wet Etching ◽  
General Technique ◽  
Poly Methyl Methacrylate

ABSTRACTIn this work, thin layers of poly(methyl methacrylate) (PMMA) on Ni on silicon <111> substrates were etched almost completely away by oxygen RIE, leaving only the topmost portion of the roughness, generating nanodots of PMMA approximately 30-40nm or smaller in size. After sufficiently hard baking the samples to promote PMMA adhesion to the Ni and to increase the robustness of the PMMA, the nanodots were used as a mask to etch the thin Ni films, thus generating Ni nanodots on Si. The Ni nanodots were then used as a reactive ion (RIE) etch mask, thereby generating Si nanopillars. With further understanding of the mechanism of the generation of the roughness of the PMMA, or with the use of other polymeric materials suitable as wet etching masks, nanodots of varying size should be attainable. This method represents a very simple, low cost, scalable, and general technique to produce nanodots of various thin metals on various substrates.

ADSORPTION OF METHYLENE BLUE ON ALGINATE-GRAFTED-POLY (METHYL METHACRYLATE)

2015 ◽  
Vol 76 (13) ◽  
Author(s):  
Ahmed Salisu ◽  
Mohd Marsin Sanagi ◽  
Khairil Juhanni Abd Karim ◽  
Neda Pourmand ◽  
Wan Aini Wan Ibrahim
Keyword(s):  
Methylene Blue ◽  
Methyl Methacrylate ◽  
Low Cost ◽  
Order Kinetic ◽  
Adsorption Parameters ◽  
Poly Methyl Methacrylate ◽  
Initial Ph ◽  
Equilibrium Data ◽  
Order Kinetic Model ◽  
Langmuir Isotherm Model

In this study, the removal of methylene blue (MB) dye using alginate-graft-poly (methyl methacrylate) beads was investigated. The effects of adsorption parameters namely initial pH and initial dye concentration were studied. The removal efficiency of the beads has been found to be dependent on initial dye concentration and initial pH. The experimental equilibrium data was fitted successfully to Langmuir isotherm model with the maximum monolayer coverage of 5.25 mg g−1 and adsorption kinetics data has been well fitted by a pseudo-second-order kinetic model. The alginate based beads could be used as low-cost and eco-friendly adsorbent for removal of trace amount of methylene blue from aqueous solution.

Thermoplastic–elastomer composition based on an interpenetrating polymeric network of styrene butadiene rubber–poly(methyl methacrylate) as an efficient vibrational damper

2018 ◽  
Vol 42 (3) ◽  
pp. 1939-1951 ◽  
Author(s):  
Jose James ◽  
George V. Thomas ◽  
Pramoda K. P. ◽  
Nandakumar Kalarikkal ◽  
Sabu Thomas
Keyword(s):  
Methyl Methacrylate ◽  
Polymer Networks ◽  
Thermoplastic Elastomer ◽  
Interpenetrating Polymer Networks ◽  
Styrene Butadiene Rubber ◽  
Butadiene Rubber ◽  
Poly Methyl Methacrylate ◽  
Polymeric Network ◽  
Styrene Butadiene

A new series of interpenetrating polymer networks (IPNs) and semi-IPNs based on styrene butadiene rubber (SBR) and poly[methyl methacrylate] (PMMA) have been synthesized by sequential polymerization.

Three Dimensional Surface Patterning Atop Poly(methyl Methacrylate) (PMMA)

2012 ◽  
Vol 161 ◽  
pp. 292-295 ◽  
Author(s):  
Yong Zhao ◽  
Wei Min Huang ◽  
Hendra Purnawali
Keyword(s):  
Methyl Methacrylate ◽  
Shape Recovery ◽  
Compound Eye ◽  
Low Cost ◽  
Three Dimensional ◽  
Surface Patterning ◽  
Poly Methyl Methacrylate ◽  
Novel Approach ◽  
Surface Patterns ◽  
Pmma Sample

We demonstrate a novel approach to fabricate three dimensional (3-D) surface patterns atop poly(methyl methacrylate) (PMMA). This approach utilizes both shape recovery behavior and swelling phenomenon of the PMMA. The simplicity in the fabrication process affirms the low-cost nature of this approach. Moreover, as obtained 3-D patterned PMMA sample can be used as artificial compound eye.

Low-cost fabrication of poly(methyl methacrylate) microchips using disposable gelatin gel templates

Talanta ◽  
2010 ◽  
Vol 81 (4-5) ◽  
pp. 1325-1330 ◽  
Author(s):  
Zhi Chen ◽  
Zhengyin Yu ◽  
Gang Chen
Keyword(s):  
Methyl Methacrylate ◽  
Low Cost ◽  
Poly Methyl Methacrylate
Sign in / Sign up

Export Citation Format

Share Document