Computer Simulation of a Surface Charge Nanobiosensor with Internal Signal Integration

The ionized states of molecular analytes located on solid surfaces require profound investigation and better understanding for applications in the basic sciences in general, and in the design of nanobiosensors, in particular. Such ionized states are induced by the interactions of molecules between them in the analyzed substance and with the target surface. Here, computer simulations using COMSOL Multiphysics software show the effect of surface charge density and distribution on the output generation in a dynamic PIN diode with gate control. This device, having built-in potential barriers, has a unique internal integration of output signal generation. The identified interactions showed the possibility of a new design for implementing a nanobiosensor based on a dynamic PIN diode in a mode with surface charge control.

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Effect of surface charge on water film nanoconfined between hydrophilic solid surfaces

Journal of Applied Physics ◽

10.1063/1.3148290 ◽

2009 ◽

Vol 105 (12) ◽

pp. 124301 ◽

Cited By ~ 20

Author(s):

Shuhai Liu ◽

Jianbin Luo ◽

Guoxin Xie ◽

Dan Guo

Keyword(s):

Surface Charge ◽

Water Film ◽

Solid Surfaces ◽

Effect Of Surface

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PIN Diode-Triode with Embedded Gate-Control Potential Barrier: Surface Charge Effects

2018 IEEE International Conference on Electrical Engineering and Photonics (EExPolytech) ◽

10.1109/eexpolytech.2018.8564397 ◽

2018 ◽

Cited By ~ 1

Author(s):

Dmitry Dyubo ◽

Oleg Yu. Tsybin

Keyword(s):

Surface Charge ◽

Potential Barrier ◽

Pin Diode ◽

Control Potential ◽

Charge Effects ◽

Gate Control ◽

Barrier Surface

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EFFECTS OF POLYMERIC NANOPARTICLE SURFACE PROPERTIES ON INTERACTION WITH BRAIN TUMOR ENVIRONMENT

Nano LIFE ◽

10.1142/s1793984413430034 ◽

2013 ◽

Vol 03 (04) ◽

pp. 1343003 ◽

Cited By ~ 7

Author(s):

BRANDON MATTIX ◽

THOMAS MOORE ◽

OLGA UVAROV ◽

SAMUEL POLLARD ◽

LAUREN O'DONNELL ◽

...

Keyword(s):

Human Brain ◽

Surface Charge ◽

Cellular Uptake ◽

Drug Clearance ◽

Cellular Interaction ◽

Normal Tissues ◽

Poly Ethylene ◽

Uptake Studies ◽

Effect Of Surface

Current chemotherapy treatments are limited by poor drug solubility, rapid drug clearance and systemic side effects. Additionally, drug penetration into solid tumors is limited by physical diffusion barriers [e.g., extracellular matrix (ECM)]. Nanoparticle (NP) blood circulation half-life, biodistribution and ability to cross extracellular and cellular barriers will be dictated by NP composition, size, shape and surface functionality. Here, we investigated the effect of surface charge of poly(lactide)-poly(ethylene glycol) NPs on mediating cellular interaction. Polymeric NPs of equal sizes were used that had two different surface functionalities: negatively charged carboxyl ( COOH ) and neutral charged methoxy ( OCH 3). Cellular uptake studies showed significantly higher uptake in human brain cancer cells compared to noncancerous human brain cells, and negatively charged COOH NPs were uptaken more than neutral OCH 3 NPs in 2D culture. NPs were also able to load and control the release of paclitaxel (PTX) over 19 days. Toxicity studies in U-87 glioblastoma cells showed that PTX-loaded NPs were effective drug delivery vehicles. Effect of surface charge on NP interaction with the ECM was investigated using collagen in a 3D cellular uptake model, as collagen content varies with the type of cancer and the stage of the disease compared to normal tissues. Results demonstrated that NPs can effectively diffuse across an ECM barrier and into cells, but NP mobility is dictated by surface charge. In vivo biodistribution of OCH 3 NPs in intracranial tumor xenografts showed that NPs more easily accumulated in tumors with less collagen. These results indicate that a robust understanding of NP interaction with various tumor environments can lead to more effective patient-tailored therapies.

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