scholarly journals Molecular Imaging in Pediatric Brain Tumors

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1853 ◽  
Author(s):  
Agostino Chiaravalloti ◽  
Luca Filippi ◽  
Maria Ricci ◽  
Andrea Cimini ◽  
Orazio Schillaci
Keyword(s):  
Nuclear Medicine ◽  
Brain Tumors ◽  
Single Photon ◽  
Somatostatin Receptor ◽  
Photon Emission ◽  
Pediatric Brain Tumors ◽  
Emission Computed Tomography ◽  
Receptor Imaging ◽  
Preliminary Results ◽  
Pediatric Brain

In the last decade, several radiopharmaceuticals have been developed and investigated for imaging in vivo of pediatric brain tumors with the aim of exploring peculiar metabolic processes as glucose consumption, amino-acid metabolism, and protein synthesis with nuclear medicine techniques. Although the clinical shreds of evidence are limited, preliminary results are encouraging. In this review, we performed web-based and desktop research summarizing the most relevant findings of the literature published to date on this topic. Particular attention was given to the wide spectrum of nuclear medicine advances and trends in pediatric neurooncology and neurosurgery. Furthermore, the role of somatostatin receptor imaging through single-photon emission computed tomography (SPECT) and positron emission tomography (PET) probes, with reference to their potential therapeutic implications, was examined in the peculiar context. Preliminary results show that functional imaging in pediatric brain tumors might lead to significant improvements in terms of diagnostic accuracy and it could be of help in the management of the disease.

scholarly journals Modern methods for radionuclide diagnosis of tumors and non-tumor pathologies of the brain

2022 ◽  
Vol 20 (4) ◽  
pp. 131-142
Author(s):  
R. V. Zelchan ◽  
A. A. Medvedeva ◽  
O. D. Bragina ◽  
A. N. Ribina ◽  
A. I. Ryabova ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Brain Tumors ◽  
Single Photon ◽  
Photon Emission ◽  
Cochrane Library ◽  
Emission Computed Tomography ◽  
Advantages And Disadvantages ◽  
Scientific Schools ◽  
Radionuclide Diagnosis ◽  
The Brain

The review analyzes the global experience in the application of nuclear medicine techniques for diagnosis of tumors and non-tumor pathologies of the brain. The main groups of radiopharmaceuticals currently used for imaging of malignant brain tumors and diagnosis of cognitive impairments and neurotransmitter system disturbances by means of single-photon emission computed tomography and positron emission tomography are described.Modern approaches to the application of methods for radionuclide diagnosis in neuro-oncology and neurology are compared, and the main trends in production of new, more specific radiopharmaceuticals for visualizing brain tumors of various degrees of malignancy and diagnosing non-tumor pathologies of the brain are described. The review discusses the advantages and disadvantages of currently used techniques and radiopharmaceuticals for imaging of central nervous system disorders, depending on the clinical situation and specific diagnostic tasks.In addition, the review presents consolidated recommendations of the leading scientific schools in neuro-oncology on the use of nuclear medicine techniques in patients with brain tumors at the stages of treatment and follow-up. The presented article examines the experience of domestic scientific schools in the development of radiopharmaceuticals for neuro-oncology. The features of the development and use of new radiopharmaceuticals in patients with brain tumors and neurodegenerative diseases are highlighted. The review is based on the analysis of literature included in the Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, and RSCI databases. 

scholarly journals Recent applications of nuclear medicine in diagnostics: II part

2013 ◽  
pp. 159-166
Author(s):  
Giorgio Treglia ◽  
Ernesto Cason ◽  
Giorgio Fagioli
Keyword(s):  
Nuclear Medicine ◽  
Single Photon ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Cellular Level ◽  
Accurate Information ◽  
Emission Computed Tomography ◽  
Nuclear Medicine Imaging ◽  
Positron Emission ◽  
Artery Disease

Introduction: Positron-emission tomography (PET) and single photon emission computed tomography (SPECT) are effective diagnostic imaging tools in several clinical settings. The aim of this article (the second of a 2-part series) is to examine some of the more recent applications of nuclear medicine imaging techniques, particularly in the fields of neurology, cardiology, and infection/inflammation. Discussion: A review of the literature reveals that in the field of neurology nuclear medicine techniques are most widely used to investigate cognitive deficits and dementia (particularly those associated with Alzheimer disease), epilepsy, and movement disorders. In cardiology, SPECT and PET also play important roles in the work-up of patients with coronary artery disease, providing accurate information on the state of the myocardium (perfusion, metabolism, and innervation). White blood cell scintigraphy and FDG-PET are widely used to investigate many infectious/inflammatory processes. In each of these areas, the review discusses the use of recently developed radiopharmaceuticals, the growth of tomographic nuclear medicine techniques, and the ways in which these advances are improving molecular imaging of biologic processes at the cellular level.

scholarly journals Tc-99m HYNIC-TOC scintigraphy in dedifferentiated thyroid cancer

2019 ◽  
Vol 12 (4) ◽  
pp. e227910
Author(s):  
Kanhaiyalal Agrawal ◽  
P Sai Sradha Patro ◽  
C Preetam
Keyword(s):  
Thyroid Cancer ◽  
Single Photon ◽  
Somatostatin Receptor ◽  
Photon Emission ◽  
Peptide Receptor Radionuclide Therapy ◽  
Ct Imaging ◽  
Whole Body ◽  
Emission Computed Tomography ◽  
Serum Thyroglobulin ◽  
Pet Ct

There is literature evidence showing utility of somatostatin receptor (SSTR) positron emission tomography-CT (PET-CT) imaging in differentiated thyroid cancer with Thyroglobulin Elevated and Negative Iodine Scan (TENIS). These patients are less benefited with I-131 therapy and surgery remains only curable option if disease could be localised. If surgery is not feasible, other therapeutic options are not promising. However, if these patients show strongly positive SSTR imaging, then possibility of peptide receptor radionuclide therapy may be explored. As SSTR PET-CT imaging is expensive and not widely available, Technetium-99m (Tc-99m) hydrazinonicotinyl-Tyr3-octreotide (HYNIC-TOC), which is a Single photon emission computed tomography (SPECT) tracer, can be used. We are documenting a case of raised serum thyroglobulin antibody and negative I-131 whole body scan with disease recurrence localised on Tc-99m HYNIC-TOC scan.

scholarly journals New Radionuclides and Technological Advances in SPECT and PET Scanners

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6183
Author(s):  
Nicholas P. van der Meulen ◽  
Klaus Strobel ◽  
Thiago Viana Miranda Lima
Keyword(s):  
Nuclear Medicine ◽  
Single Photon ◽  
Photon Emission ◽  
Clinical Findings ◽  
Emission Computed Tomography ◽  
Silicon Photomultipliers ◽  
Positron Emission ◽  
Technological Advances ◽  
Total Body ◽  
Rubidium 82

Developments throughout the history of nuclear medicine have involved improvements in both instrumentation and radionuclides, which have been intertwined. Instrumentation developments always occurred during the search to improving devices’ sensitivity and included advances in detector technology (with the introduction of cadmium zinc telluride and digital Positron Emission Tomography—PET-devices with silicon photomultipliers), design (total body PET) and configuration (ring-shaped, Single-Photon Emission Computed Tomography (SPECT), Compton camera). In the field of radionuclide development, we observed the continual changing of clinically used radionuclides, which is sometimes influenced by instrumentation technology but also driven by availability, patient safety and clinical questions. Some areas, such as tumour imaging, have faced challenges when changing radionuclides based on availability, when this produced undesirable clinical findings with the introduction of unclear focal uptakes and unspecific uptakes. On the other end of spectrum, further developments of PET technology have seen a resurgence in its use in nuclear cardiology, with rubidium-82 from strontium-82/rubidium-82 generators being the radionuclide of choice, moving away from SPECT nuclides thallium-201 and technetium-99m. These continuing improvements in both instrumentation and radionuclide development have helped the growth of nuclear medicine and its importance in the ever-evolving range of patient care options.

scholarly journals 99MTc-PSMA – radionuclide imaging of prostate cancer: an innovative diagnostic direction in nuclear medicine

2020 ◽  
pp. 26-38
Author(s):  
P. Korol ◽  
M. Tkachenko ◽  
A. Voloshin
Keyword(s):  
Prostate Cancer ◽  
Nuclear Medicine ◽  
Single Photon ◽  
Photon Emission ◽  
General Concept ◽  
Emission Computed Tomography ◽  
Clinical Use ◽  
Clinical Workflow ◽  
Therapeutic Concepts ◽  
Total Body

The literature review considers the prospects for the use of SPECT and PET imaging with 99mTc-PSMA as an innovative method for diagnosing prostate cancer. SPECT studies with 111In-PSMA-I have further expanded the scope of modern therapeutic concepts aimed at PSMA. However, the inherent limitations associated with 111In preclude the wider clinical use of 111In-PSMA-I and T, in addition to studies confirming the concept, in small cohorts of patients. The total body clearance of 99mTc-PSMA-I and S is relatively slow, which results in a relatively late clearance in the abdominal region. However, the accumulation of the radiopharmaceutical in previously identified areas of tumor lesions steadily grows over time due to the prolonged presence of an intact indicator in the blood and its internalization into tumor cells with high PSMA expression. In a delayed period, an excellent lesion-background ratio is obtained due to the synergistic effect of stable uptake of 99mTc-PSMA-I and S in tumor tissue and the continuation of the clearance of background activity. Several alternative therapeutic approaches have been implemented to provide a universal molecular platform for labeling with diagnostic (123I / 124I, 68Ga) and therapeutic radionuclide (131I, 177Lu). Baseline data on endoradiotherapeutic use of 131I-MIP-1095, 177Lu-DKFZ-617 and 177Lu-PSMA-I and T in patients with metastatic prostate cancer demonstrate the prospects of molecular and morphological treatment. Thus, the aim of this work was to adapt the general concept of the indicator with the requirements of 99mTc. The availability and ease of preparation of 99mTc-PSMA indicators is fully compatible with the daily clinical workflow. In this regard, a lyophilized kit for the routine manufacture of 99mTc-PSMA-I and S appears to be available and reliable, which facilitates the distribution and production of new effective radiopharmaceuticals for clinical use in urology and, in particular, nuclear medicine. Key words: nuclear medicine, prostate cancer, single-photon emission computed tomography, prostate-specific membrane antigen.

scholarly journals Nuclear medicine imaging technique in the erectile dysfunction evaluation: a mini-review

2007 ◽  
Vol 50 (spe) ◽  
pp. 91-96 ◽  
Author(s):  
Camila Godinho Ribeiro ◽  
Regina Moura ◽  
Rosane de Figueiredo Neves ◽  
Jean Pierre Spinosa ◽  
Mario Bernardo-Filho
Keyword(s):  
Nuclear Medicine ◽  
Erectile Dysfunction ◽  
Sexual Arousal ◽  
Single Photon ◽  
Photon Emission ◽  
Brain Regions ◽  
Emission Computed Tomography ◽  
Nuclear Medicine Imaging ◽  
Positron Emission

Functional imaging with positron emission tomography and single photon emission computed tomography is capable of visualizing subtle changes in physiological function in vivo. Erectile dysfunction(ED) diminishes quality of life for affected men and their partners. Identification of neural substrates may provide information regarding the pathophysiology of types of sexual dysfunction originating in the brain. The aim of this work is to verify the approaches of the nuclear medicine techniques in the evaluation of the erectile function/disfunction. A search using the words ED and nuclear medicine, ED and scintigraphy, ED and spect and ED and pet was done in the PubMed. The number of citations in each subject was determined. Neuroimaging techniques offer insight into brain regions involved in sexual arousal and inhibition. To tackle problems such as hyposexual disorders or ED caused by brain disorders, it is crucial to understand how the human brain controls sexual arousal and penile erection.

Nuclear Medicine Applications in Pediatric Musculoskeletal Diseases: The Added Value of Hybrid Imaging

2018 ◽  
Vol 22 (01) ◽  
pp. 025-045 ◽  
Author(s):  
Ramesh Iyer ◽  
A. Stanescu ◽  
Marguerite Parisi
Keyword(s):  
Computed Tomography ◽  
Nuclear Medicine ◽  
Single Photon ◽  
Musculoskeletal Diseases ◽  
Photon Emission ◽  
Added Value ◽  
Whole Body ◽  
Response Monitoring ◽  
Emission Computed Tomography ◽  
Nuclear Medicine Procedures

AbstractThe introduction of diphosphonates in the 1970s revolutionized not only nuclear medicine but musculoskeletal imaging as well, providing functional assessment of entities such as osteomyelitis, trauma, and osseous metastatic disease. Although rarely the first-line imaging modality used today, nuclear medicine procedures continue to play a pivotal role in the evaluation of musculoskeletal diseases in children, providing whole-body assessment of disease involvement. More recently, the introduction of technologies such as single-photon emission computed tomography/computed tomography (SPECT/CT), as well as newer positron-emitting tracers such as 18fluorine-fluorodeoxyglucose and sodium 18F-fluorine, particularly when combined with CT (positron emission tomography/CT), have injected new life into the older established techniques and expanded the application of nuclear medicine imaging into new arenas. This article discusses the utility of standard nuclear medicine procedures as they apply to children with musculoskeletal disorders, focusing on the added value of and indications for SPECT/CT. Subsequently, we discuss the expanding role of positron-emitting agents in infection, trauma, and for the diagnosis, staging, and therapeutic response monitoring of children with malignant bone and soft tissue tumors. Differences between disease processes encountered in children as compared with adults are discussed; developmental variants that can, but should not, be confused with disease are illustrated. The need for pediatric-specific protocols is addressed.

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