scholarly journals High miR-30 Expression Associates with Improved Breast Cancer Patient Survival and Treatment Outcome

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2907
Author(s):  
Maral Jamshidi ◽  
Rainer Fagerholm ◽  
Taru A. Muranen ◽  
Sippy Kaur ◽  
Swapnil Potdar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Pathway Analysis ◽  
Patient Survival ◽  
Breast Cancer Cell Lines ◽  
Breast Cancer Patients ◽  
Her2 Positive ◽  
Cancer Pathogenesis ◽  
The Impact

Deregulated miRNA expression has been suggested in several stages of breast cancer pathogenesis. We have studied the miR-30 family, in particular miR-30d, in relation to breast cancer patient survival and treatment outcomes. With tumor specimens from 1238 breast cancer patients, we analyzed the association of miR-30d expression with tumor characteristics with the 5-year occurrence of breast cancer-specific death or distant metastasis (BDDM), and with 10-year breast cancer survival (BCS). We conducted a two-stage drug-screen to investigate the impact of miR-30 family members (miR-30a-30e) on sensitivity to doxorubicin and lapatinib in six breast cancer cell lines HCC1937, HCC1954, MDA-MB-361, MCF7, MDA-MB-436 and CAL-120, using drug sensitivity scores (DSS) to compare the miR-30 family mimics to their specific inhibitors. The study was complemented with Ingenuity Pathway Analysis (IPA) with the METABRIC data. We found that while high miR-30d expression is typical for aggressive tumors, it predicts better metastasis-free (pBDDM = 0.035, HR = 0.63, 95% CI = 0.4–0.9) and breast cancer-specific survival (pBCS = 0.018, HR = 0.61, 95% CI = 0.4–0.9), especially in HER2-positive (pBDDM = 0.0009), ER-negative (pBDDM = 0.003), p53-positive (pBDDM = 0.011), and highly proliferating (pBDDM = 0.0004) subgroups, and after adjuvant chemotherapy (pBDDM = 0.035). MiR-30d predicted survival independently of standard prognostic markers (pBDDM = 0.0004). In the drug-screening test, the miR-30 family sensitized the HER2-positive HCC1954 cell line to lapatinib (p < 10–2) and HCC1937, MDA-MB-361, MDA-MB-436 and CAL120 to doxorubicin (p < 10–4) with an opposite impact on MCF7. According to the pathway analysis, the miR-30 family has a suppressive effect on cell motility and metastasis in breast cancer. Our results suggest prognostic and predictive potential for the miR-30 family, which warrants further investigation.

Breast cancer patient access to social work

2016 ◽  
Vol 17 (5) ◽  
pp. 531-543
Author(s):  
Yuko K Abbott
Keyword(s):  
Breast Cancer ◽  
Social Work ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Clinical Area ◽  
Oncology Social Work ◽  
The Impact ◽  
Office Location

Summary This study was conducted to understand the impact of oncology social work office location on breast cancer patients’ access and utilization of social work services. It also explored the current status of oncology social work offices and the perceptions among Association of Oncology Social Work Listserv members. The frequency and types of interventions and referral time were determined retrospectively. Association of Oncology Social Work Listserv members were surveyed. Findings From 461 new breast cancer patient charts, 52 were referred to social work during study period. Face-to-face interventions decreased by 0.8 contact ( p = .0221) and telephone interventions increased by 1.8 contacts ( p = .0293) after social work office was relocated away from clinical area. Referral time to social work services decreased unexpectedly by 14.5 days ( p = .076) after office relocation. Association of Oncology Social Work Listserv survey results identify an office location as possible barrier, though most respondents have a private office in clinical area, accessible to patients. Survey finding is limited due to low response rate. Applications There are many challenges to ensuring timey and effective delivery of social work services to breast cancer patients. Social Ecological framework is used to understand the impacts of office location on access to social work services. Study results suggest that office relocation has had mix impacts on patients. Raising awareness of social worker services among patients early in cancer trajectory is needed for patient empowerment and to ensure access to social work services. Further research is needed to understand barriers, identify effective strategies in order to guide and improve clinical practice.

Repeated courses of radiation treatment in an HER2‐positive breast cancer patient with diffuse brain metastases: A case report

2020 ◽  
Vol 26 (7) ◽  
pp. 1370-1371
Author(s):  
Sonia Silipigni ◽  
Edy Ippolito ◽  
Paolo Matteucci ◽  
Bianca Santo ◽  
Emma Gangemi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Brain Metastases ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Radiation Treatment ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Diffuse Brain ◽  
Positive Breast Cancer

scholarly journals Interplay of tRNA-Derived Fragments and T Cell Activation in Breast Cancer Patient Survival

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2230 ◽  
Author(s):  
Nayang Shan ◽  
Ningshan Li ◽  
Qile Dai ◽  
Lin Hou ◽  
Xiting Yan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
T Cell ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cox Regression ◽  
Patient Survival ◽  
Significant Difference

Effector CD8+ T cell activation and its cytotoxic function are positively correlated with improved survival in breast cancer. tRNA-derived fragments (tRFs) have recently been found to be involved in gene regulation in cancer progression. However, it is unclear how interactions between expression of tRFs and T cell activation affect breast cancer patient survival. We used Kaplan–Meier survival and multivariate Cox regression models to evaluate the effect of interactions between expression of tRFs and T cell activation on survival in 1081 breast cancer patients. Spearman correlation analysis and weighted gene co-expression network analysis were conducted to identify genes and pathways that were associated with tRFs. tRFdb-5024a, 5P_tRNA-Leu-CAA-4-1, and ts-49 were positively associated with overall survival, while ts-34 and ts-58 were negatively associated with overall survival. Significant interactions were detected between T cell activation and ts-34 and ts-49. In the T cell exhaustion group, patients with a low level of ts-34 or a high level of ts-49 showed improved survival. In contrast, there was no significant difference in the activation group. Breast cancer related pathways were identified for the five tRFs. In conclusion, the identified five tRFs associated with overall survival may serve as therapeutic targets and improve immunotherapy in breast cancer.

The Impact of Primary Tumor Surgery on Survival in HER2 Positive Stage IV Breast Cancer Patients in the Current Era of Targeted Therapy

2020 ◽  
Vol 27 (8) ◽  
pp. 2711-2720 ◽  
Author(s):  
Ross Mudgway ◽  
Carlos Chavez de Paz Villanueva ◽  
Ann C. Lin ◽  
Maheswari Senthil ◽  
Carlos A. Garberoglio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Stage Iv ◽  
Tumor Surgery ◽  
Breast Cancer Patients ◽  
Her2 Positive ◽  
Stage Iv Breast Cancer ◽  
The Impact

scholarly journals A transcriptome-based signature of pathological angiogenesis predicts breast cancer patient survival

PLoS Genetics ◽  
2019 ◽  
Vol 15 (12) ◽  
pp. e1008482
Author(s):  
Rodrigo Guarischi-Sousa ◽  
Jhonatas S. Monteiro ◽  
Lilian C. Alecrim ◽  
Jussara S. Michaloski ◽  
Laura B. Cardeal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patient ◽  
Breast Cancer Patient ◽  
Patient Survival ◽  
Pathological Angiogenesis
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