scholarly journals Sex and Gender Differences in Kidney Cancer: Clinical and Experimental Evidence

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4588
Author(s):  
Anna Julie Peired ◽  
Riccardo Campi ◽  
Maria Lucia Angelotti ◽  
Giulia Antonelli ◽  
Carolina Conte ◽  
...  
Keyword(s):  
Kidney Cancer ◽  
Current Knowledge ◽  
Diagnostic Tools ◽  
Sex And Gender ◽  
Female Sex Hormones ◽  
Outcome Difference ◽  
Genetics And Genomics ◽  
Gender Based ◽  
And Gender ◽  
Sex And Gender Differences

Sex and gender disparities have been reported for different types of non-reproductive cancers. Males are two times more likely to develop kidney cancer than females and have a higher death rate. These differences can be explained by looking at genetics and genomics, as well as other risk factors such as hypertension and obesity, lifestyle, and female sex hormones. Examination of the hormonal signaling pathways bring further insights into sex-related differences. Sex and gender-based disparities can be observed at the diagnostic, histological and treatment levels, leading to significant outcome difference. This review summarizes the current knowledge about sex and gender-related differences in the clinical presentation of patients with kidney cancer and the possible biological mechanisms that could explain these observations. Underlying sex-based differences may contribute to the development of sex-specific prognostic and diagnostic tools and the improvement of personalized therapies.

scholarly journals Sex and gender differences in polypharmacy in persons with dementia: A scoping review

2019 ◽  
Vol 7 ◽  
pp. 205031211984571 ◽  
Author(s):  
Shanna C Trenaman ◽  
Megan Rideout ◽  
Melissa K Andrew
Keyword(s):  
Older Adults ◽  
Drug Use ◽  
Scoping Review ◽  
Medication Use ◽  
Potentially Inappropriate Medications ◽  
Sex And Gender ◽  
Gender Based ◽  
And Gender ◽  
Inappropriate Medications ◽  
Sex And Gender Differences

Purpose: To date, research studies in most disciplines have not made sex-based analysis a priority despite increasing evidence of its importance. We now understand that both sex and gender impact medication prescribing, use, and effect. This is particularly true for older adults with dementia who have alterations in drug metabolism, drug response, and the permeability of the blood–brain barrier. To better understand the influence of sex and gender on drug use in older adults with dementia, we conducted a scoping review. Methods: This scoping review systematically searched the Medline, Embase, Web of Science, CINAHL, and ProQuest databases to find published reports on polypharmacy in populations of older adults with dementia that included a sex- or gender-based analysis. Results: A total of 12 published reports were identified. Findings were cohort studies and case-control trials that commented on sex-related differences in medication use as a secondary analysis to the studies’ primary objective. These studies showed that community-dwelling women received more potentially inappropriate medications and more psychotropic medications, while nursing home dwelling men received more potentially inappropriate medications, cholinesterase inhibitors, and antipsychotics. None of the identified studies explicitly examined gender-related differences in medication use. Conclusion: This scoping review supports that there is inadequate understanding of both sex and gender differences in drug use in older men and women with dementia. To tailor medication-specific interventions to improve drug therapy for older adults with dementia, it is important that future work includes sex- or gender-based analysis of drug use.

scholarly journals Article Commentary: Sex- and Gender-Based Medicine: The Need for Precise Terminology

2017 ◽  
Vol 1 (3) ◽  
pp. 122-128 ◽  
Author(s):  
Tracy E. Madsen ◽  
Ghada Bourjeily ◽  
Memoona Hasnain ◽  
Marjorie Jenkins ◽  
Mary F. Morrison ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Health Professions ◽  
Sex And Gender ◽  
Medical Specialties ◽  
Health And Disease ◽  
Gender Based ◽  
And Gender ◽  
Based Medicine ◽  
The Impact ◽  
Sex And Gender Differences

As our knowledge of sex- and gender-based medicine (SGBM) continues to grow, attention to precision in the use of related terminology is critical. Unfortunately, the terms sex and gender are often used interchangeably and incorrectly, both within and outside of the typical binary construct. On behalf of the Sex and Gender Women's Health Collaborative (SGWHC), a national organization whose mission is the integration of SGBM into research, health professions education, and clinical practice, our objective was to develop recommendations for the accurate use of SGBM terminology in research and clinical practice across medical specialties and across health professions. In addition, we reviewed the origins and evolution of SGBM terminology and described terms used when referring to individuals outside the typical binary categorization of sex and gender. Standardization and precision in the use of sex and gender terminology will lead to a greater understanding and appropriate translation of sex and gender evidence to patient care along with an accurate assessment of the impact sex and gender have on patient outcomes. In addition, it is critical to acknowledge that SGBM terminology will continue to evolve and become more precise as our knowledge of sex and gender differences in health and disease progresses.

Sex and Gender Differences

2012 ◽  
Vol 220 (2) ◽  
pp. 57-60 ◽  
Author(s):  
Markus Hausmann ◽  
Barbara Schober
Keyword(s):  
Gender Differences ◽  
Sex And Gender ◽  
And Gender ◽  
Sex And Gender Differences

scholarly journals Influence of sex and gender on the management of late-stage knee osteoarthritis

2021 ◽  
Author(s):  
B. Moretti ◽  
A. Spinarelli ◽  
G. Varrassi ◽  
L. Massari ◽  
A. Gigante ◽  
...  
Keyword(s):  
Gender Differences ◽  
Knee Osteoarthritis ◽  
Healthcare Professionals ◽  
Pain Tolerance ◽  
Exact Nature ◽  
Sex And Gender ◽  
Physician Practices ◽  
Knee Oa ◽  
And Gender ◽  
Sex And Gender Differences

Abstract Purpose The exact nature of sex and gender differences in knee osteoarthritis (OA) among patient candidates for total knee arthroplasty (TKA) remains unclear and requires better elucidation to guide clinical practice. The purpose of this investigation was to survey physician practices and perceptions about the influence of sex and gender on knee OA presentation, care, and outcomes after TKA. Methods The survey questions were elaborated by a multidisciplinary scientific board composed of 1 pain specialist, 4 orthopedic specialists, 2 physiatrists, and 1 expert in gender medicine. The survey included 5 demographic questions and 20 topic questions. Eligible physician respondents were those who treat patients during all phases of care (pain specialists, orthopedic specialists, and physiatrists). All survey responses were anonymized and handled via remote dispersed geographic participation. Results Fifty-six physicians (71% male) accepted the invitation to complete the survey. In general, healthcare professionals expressed that women presented worse symptomology, higher pain intensity, and lower pain tolerance and necessitated a different pharmacological approach compared to men. Pain and orthopedic specialists were more likely to indicate sex and gender differences in knee OA than physiatrists. Physicians expressed that the absence of sex and gender-specific instruments and indications is an important limitation on available studies. Conclusions Healthcare professionals perceive multiple sex and gender-related differences in patients with knee OA, especially in the pre- and perioperative phases of TKA. Sex and gender bias sensitivity training for physicians can potentially improve the objectivity of care for knee OA among TKA candidates.

“I am an atypical mother”: Motherhood and maternal language in Giovanna Cristina Vivinetto’s poetry

2021 ◽  
pp. 001458582199184
Author(s):  
Danila Cannamela
Keyword(s):  
Symbolic Order ◽  
Sex And Gender ◽  
New Words ◽  
Poetic Discourse ◽  
Maternal Language ◽  
Queer Representation ◽  
Gender Based ◽  
And Gender ◽  
Relationship Of ◽  
Male To Female

In her debut book Dolore minimo, Giovanna Cristina Vivinetto engages in a reflection on motherhood to recount an autobiographical story of gender self-determination and male to female transition. This article explores Vivinetto’s poetry as the retelling of transformative moments in two mother–daughter relationships, which generate a reshaping of life and language. In the book, these two storylines intersect, blur, and even overlap, creating a poetic discourse in which the maternal acts simultaneously as powerful catalyzer and producer of meanings. In discussing how, in Dolore minimo, the relationship of two atypical mothers becomes the creative site of a new possible symbolic order, my analysis engages an atypical approach: it reads Vivinetto’s queer representation of motherhood via the theorization developed by the women of Diotima—including, in particular, Luisa Muraro, Chiara Zamboni, Diana Sartori, and Ida Dominijanni. These feminist thinkers have been generally criticized for reinforcing binary understandings of sex and gender, based on an essentialist view of the category of woman. Yet, what if the feminism forwarded by Diotima, by positioning the feminine as a creative producer and first-person narrator of change, could still offer a productive avenue for dialogue? The article begins with a discussion of Diotima’s key theorizations, which lays the groundwork for interpreting the maternal poetics of Dolore minimo. The subsequent sections examine in more depth how Vivinetto’s poetry has reinvented the figure of the mother as a teacher and learner of new words, and how, through this reinvention, she has crafted a maternal language that knits together new relations of contiguity and change. Ultimately, by redeploying the figure of the mother beyond cisgender norms, Vivinetto’s poetry is revealing the inexhaustible vitality of this character.

Rethinking an Assessment of Nicotine Dependence: A Sex, Gender and Diversity Analysis of the Fagerstrom Test for Nicotine Dependence

2007 ◽  
Vol 2 (2) ◽  
pp. 59-67 ◽  
Author(s):  
Lindsay Richardson ◽  
Lorraine Greaves ◽  
Natasha Jategaonkar ◽  
Kirsten Bell ◽  
Ann Pederson ◽  
...  
Keyword(s):  
Gender Differences ◽  
Nicotine Dependence ◽  
Diversity Analysis ◽  
Sex And Gender ◽  
Accurate Picture ◽  
And Gender ◽  
Diverse Groups ◽  
Sex And Gender Differences

AbstractThis article assesses whether the Fagerstrom Test for Nicotine Dependence (FTND), adequately reflects sex, gender and diversity related differences in nicotine dependence. Available studies on the FTND were reviewed and a sex, gender and diversity analysis (SGBA) of this instrument was conducted. Results indicate that sex and gender differences in nicotine dependence may undermine the ability of the FTND to present an adequate picture of dependence. Conducting a SGBA on this Fagerstrom test reveals that sex and gender differences likely limit the ability of this instrument to present an accurate picture of dependence in diverse groups. Further research is needed to enhance the sensitivity of the FTND.

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