scholarly journals Current Landscape of Sonodynamic Therapy for Treating Cancer

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6184
Author(s):  
Toshihiro Yamaguchi ◽  
Shuji Kitahara ◽  
Kaori Kusuda ◽  
Jun Okamoto ◽  
Yuki Horise ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Minimally Invasive ◽  
Focused Ultrasound ◽  
Cell Function ◽  
Unmet Need ◽  
High Intensity Focused Ultrasound ◽  
Sonodynamic Therapy ◽  
Curative Therapy ◽  
Current State ◽  
Cancer Tissues

Recent advancements have tangibly changed the cancer treatment landscape. However, curative therapy for this dreadful disease remains an unmet need. Sonodynamic therapy (SDT) is a minimally invasive anti-cancer therapy involving a chemical sonosensitizer and focused ultrasound. A high-intensity focused ultrasound (HIFU) beam is used to destroy or denature targeted cancer tissues. Some SDTs are based on unfocused ultrasound (US). In some SDTs, HIFU is combined with a drug, known as a chemical sonosensitizer, to amplify the drug’s ability to damage cancer cells preferentially. The mechanism by which US interferes with cancer cell function is further amplified by applying acoustic sensitizers. Combining multiple chemical sonosensitizers with US creates a substantial synergistic effect that could effectively disrupt tumorigenic growth, induce cell death, and elicit an immune response. Therefore, the minimally invasive SDT treatment is currently attracting attention. It can be combined with targeted therapy (double-targeting cancer therapy) and immunotherapy in the future and is expected to be a boon for treating previously incurable cancers. In this paper, we will consider the current state of this therapy and discuss parts of our research.

Cancer Therapy Combining High-Intensity Focused Ultrasound and Megavoltage Radiation

2014 ◽  
Vol 89 (4) ◽  
pp. 926-927 ◽  
Author(s):  
Giovanni Borasi ◽  
Andreas Melzer ◽  
Giorgio Russo ◽  
Alan Nahum ◽  
Qinghui Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound

scholarly journals Osteoblastoma: When the Treatment Is Not Minimally Invasive, an Overview

2021 ◽  
Vol 10 (20) ◽  
pp. 4645
Author(s):  
Carmine Zoccali ◽  
Mariangela Novello ◽  
Francesco Arrigoni ◽  
Alessandra Scotto di Uccio ◽  
Dario Attala ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Gold Standard ◽  
Bone Tumors ◽  
Focused Ultrasound ◽  
Surgical Excision ◽  
Late Complications ◽  
High Intensity Focused Ultrasound ◽  
Wide Resection ◽  
Primary Bone Tumors ◽  
Invasive Techniques

Background: osteoblastoma is a bone-forming tumor accounting for about 1% of all primary bone tumors and 3% of benign bone tumors. The gold-standard treatment is surgical excision; nevertheless, minimally invasive radiological techniques such as thermoablation and, more recently, high intensity focused ultrasound are gaining more importance. The aim of the present paper is to analyze surgical indications based on our experience and on the evidences in the literature. Methods: all patients affected by osteoblastoma who underwent surgical excision in January 2009 and December 2018 were reviewed; eleven patients were enrolled in the study. The epidemiological aspects, size of the disease and site of onset, symptoms, surgery type, indications, and results are reported for every case. Results: all treatments were based on a preoperative diagnosis; pain was constant in all cases. Intralesional surgeries were performed in 9 out of 11 cases; the remaining 2 cases underwent wide resection. No early or late complications occurred after the surgical procedure. The indications for surgery were lesions very close to nerves or joints, unclear diagnosis, risk of fracture, lesion too large for radiofrequency thermoablation, or failure of minimally invasive treatments. At a medium follow-up of 88 months, no local recurrences were verified. Conclusions: osteoblastoma is a rare tumor with difficult diagnosis. Identification is based on symptoms, imaging, and histology. When possible, minimally invasive techniques is preferred for treatment but surgery is still considered the gold standard.

scholarly journals Interventional Treatment of Endometriosis

2020 ◽  
Author(s):  
Yang Xiaomin ◽  
Han Jun ◽  
Feng Pin ◽  
Yang Xiaojun
Keyword(s):  
Minimally Invasive ◽  
High Intensity ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Ultrasound Treatment ◽  
Interventional Treatment ◽  
Artery Embolization ◽  
Plexus Block

Patients with endometriosis and adenomyosis naturally improve after menopause. Therefore, some patients only need to relieve symptoms, especially those near menopause, and they prefer to be treated by conservative methods. We summarized several minimally invasive interventional methods: uterine artery intervention (Uterine artery embolization, UAE), nerve intervention (upper and lower abdominal plexus block, SHPB), ultrasound intervention (puncture sclerotherapy; high intensity focused ultrasound treatment).

Applications of Micro/Nanotechnology in Ultrasound-Based Drug Delivery and Therapy for Tumors

2020 ◽  
Vol 27 ◽  
Author(s):  
Suhui Sun ◽  
Ping Wang ◽  
Sujuan Sun ◽  
Xiaolong Liang
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Tumor Therapy ◽  
High Intensity Focused Ultrasound ◽  
Nano Materials ◽  
Invasive Treatment ◽  
Sonodynamic Therapy ◽  
Non Invasive ◽  
Recent Developments

: Ultrasound has been broadly used in biomedicine for both tumor diagnosis as well as therapy. The applications of recent developments in micro/nanotechnology promote the development of ultrasound-based biomedicine, especially in the field of ultrasound-based drug delivery and tumor therapy. Ultrasound can activate nano-sized drug delivery systems by different mechanisms for ultrasound-triggered on-demand drug release targeted only at the tumor. Ultrasound targeted microbubble destruction (UTMD) technology can not only increase the permeability of vasculature and cell membrane via sonoporation effect but also achieve in situ conversion of microbubbles into nanoparticles to promote cellular uptake and therapeutic efficacy. Furthermore, high intensity focused ultrasound (HIFU), or sonodynamic therapy (SDT), is considered to be one of the most promising and representative non-invasive treatment for cancer. However, their application in the treatment process is still limited due to their critical treatment efficiency issues. Fortunately, recently developed micro/nanotechnology offer an opportunity to solve these problems, thus improving the therapeutic effect of cancer. This review summarizes and discusses the recent developments in the design of micro- and nano- materials for ultrasound-based biomedicine applications.

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