Prevalence and Spectrum of Second Primary Malignancies among People Living with HIV in the French Dat’AIDS Cohort

Background: We aimed to describe the prevalence and spectrum of second primary cancer (SPC) in HIV-positive cancer survivors. Methods: A multicenter retrospective study was performed using longitudinal data from the French Dat’AIDS cohort. Subjects who had developed at least two primary cancers were selected. The spectrum of SPCs was stratified by the first primary cancer type and by sex. Results: Among the 44,642 patients in the Dat’AIDS cohort, 4855 were diagnosed with cancer between 1 December 1983 and 31 December 2015, of whom 444 (9.1%) developed at least two primary cancers. The most common SPCs in men were non-Hodgkin lymphoma (NHL) (22.8%), skin carcinoma (10%) and Kaposi sarcoma (KS) (8.4%), and in women the most common SPCs were breast cancer (16%), skin carcinoma (9.3%) and NHL (8%). The pattern of SPCs differed according to first primary cancer and by sex: in men, NHL was the most common SPC after primary KS and KS was the most common SPC after primary NHL; while in women, breast cancer was the most common SPC after primary NHL and primary breast cancer. Conclusion: The frequency and pattern of subsequent cancers among HIV-positive cancer survivors differed according to the first primary cancer type and sex.

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Determinants of Second Primary Cancer Type in Survivors of Virus-Related and Non-Virus-Related Cancer Living With HIV in the French Dat’AIDS Cohort

Cancer Control ◽

10.1177/10732748211066310 ◽

2021 ◽

Vol 28 ◽

pp. 107327482110663

Author(s):

Isabelle Poizot-Martin ◽

Caroline Lions ◽

Clotilde Allavena ◽

Pierre Delobel ◽

Anne Fresard ◽

...

Keyword(s):

Cancer Survivors ◽

Hiv Transmission ◽

Hiv Positive ◽

Second Primary ◽

Cancer Type ◽

Primary Cancer ◽

Second Primary Cancer ◽

Hiv Diagnosis ◽

Monitoring Strategies ◽

Increased Risk

Objectives People who survive after primary cancer are at an increased risk for subsequent primary cancers. We aimed to investigate the possible determinants of second primary cancer (SPC) in HIV-positive cancer survivors. Methods This was a multicenter retrospective study using longitudinal data from the French Dat’AIDS cohort. Subjects who developed at least 2 primary cancers were selected. Cancer cases were identified using ICD10 codes and distributed in 3 cancer categories: AIDS-defining cancer (ADC), virus-related non-ADC (VR-NADC), and virus-unrelated-NADC (VU-NADC). The possible determinants considered were the first primary cancer category, sex, age, HIV transmission route, duration of HIV infection follow-up, duration of ART exposure, nadir CD4+ T cell count, and hepatitis C and hepatitis B serostatus. Results Among the 44642 patients in the Dat’AIDS cohort, 4855 were diagnosed with cancer between 1 December 1983 and 31 December 2015, of whom 444 (9.1%) developed at least 2 primary cancers: 130 ADCs, 85 VR-NADCs, and 229 VU-NADCs. A longer delay between the first primary cancer and the SPC was associated with an increased risk of occurrence of a VR-NADC rather than a secondary ADC. Having had a first primary VU-NADC, an older age, and a longer delay between the HIV diagnosis and the first primary cancer as well as between the first primary cancer and the SPC were associated with an increased risk of VU-NADC rather than ADC. Conclusion SPCs are now a major concern in HIV-positive cancer survivors justifying the development of monitoring strategies after a first cancer.

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A Path Analysis on Factors Influencing Second Primary Cancer Screening Practices in Stomach, Colon, and Breast Cancer Survivors

Journal of Korean Academy of Nursing ◽

10.4040/jkan.2014.44.2.139 ◽

2014 ◽

Vol 44 (2) ◽

pp. 139 ◽

Cited By ~ 5

Author(s):

Young Hee Yang

Keyword(s):

Breast Cancer ◽

Cancer Screening ◽

Cancer Survivors ◽

Path Analysis ◽

Breast Cancer Survivors ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer ◽

Screening Practices ◽

Factors Influencing

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Development of second primary cancers in breast cancer survivors.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.3_suppl.257 ◽

2016 ◽

Vol 34 (3_suppl) ◽

pp. 257-257

Author(s):

Hong Kyu Jung ◽

Jihyoun Lee ◽

Zisun Kim ◽

Min Hyuk Lee ◽

Ilkyun Lee

Keyword(s):

Breast Cancer ◽

Endometrial Cancer ◽

Thyroid Cancer ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer ◽

Breast Cancer Patients ◽

Second Primary Cancers

257 Background: Breast cancer survivors have slightly increased risk of second primary cancers. Importance of screening for second cancers has been raised due to increased survival in those populations. Not only having genetic risk such as BRCA mutation, but also treatment-related risk presents. The most common second primary cancer is breast cancer. Colon cancer, uterine cancer, and ovarian cancer showed increased cumulative incidence. In this study, we assessed development second primary cancers in breast cancer survivors. Methods: Medical record of breast cancer patients was reviewed retrospectively in three tertiary medical institutions. Available data of ICD-9 record after breast cancer diagnosis was evaluated. Diagnosis of second primary breast cancer was excluded in evaluation. Results: Since Jan 1989 to Jan 2014, available medical records were reviewed in breast cancer patients(N = 5880) in three institutions(one urban and the other two rural institutions). Cumulative incidence of overall second primary cancers was 4.57%. Among 269 second primary cancers, thyroid cancer(44.2%) was most common second primary cancer, followed by gastric cancer(10.0%). Gastric cancers were more common in rural institution than urban area(14.2 % vs 5.5%), while incidence of thyroid cancer is elevated in urban institution(57.8% vs 31.9%). Among 9 patients who has been diagnosed endometrial cancer, 7 patients had history of selective estrogen receptor modulator(tamoxifen or toremifen) treatment. Development of lung cancer was not related to breast cancer radiation treatment(4 of 15 patients). Leukemia after breast cancer treatment was diagnosed in 5 patients (8.5% of second primary cancers), three of them were adult T cell leukemia and two of them were acute myeloid leukemia. Conclusions: Incidence of cancer in general population was reflected to development of second primary cancer in breast cancer survivors. Endocrine treatment was related increased incidence of endometrial cancer, respectively. Application of personalized cancer screening plan would be important in this patient group.

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Risk factors and prediction of second primary cancer in primary female non-metastatic breast cancer survivors

Aging ◽

10.18632/aging.103939 ◽

2020 ◽

Vol 12 (19) ◽

pp. 19628-19640

Author(s):

Xiwen Qian ◽

Huixun Jia ◽

Yue Zhang ◽

Bingqing Ma ◽

Guoyou Qin ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Metastatic Breast Cancer ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Metastatic Breast ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer

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Development of second primary cancer in Korean breast cancer survivors

Annals of Surgical Treatment and Research ◽

10.4174/astr.2017.93.6.287 ◽

2017 ◽

Vol 93 (6) ◽

pp. 287 ◽

Cited By ~ 8

Author(s):

Hong Kyu Jung ◽

Suyeon Park ◽

Nam Won Kim ◽

Jong Eun Lee ◽

Zisun Kim ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Second Primary ◽

Primary Cancer ◽

Second Primary Cancer

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Incidence of second primary neoplasms among cancer survivors in the United States, 2000 through 2015.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.1586 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. 1586-1586 ◽

Cited By ~ 1

Author(s):

Eric Adjei Boakye ◽

Wiley D Jenkins ◽

Nosayaba Osazuwa-Peters ◽

Maggie Wang ◽

Min Jee Lee ◽

...

Keyword(s):

United States ◽

Cancer Survivors ◽

Survival Rates ◽

The United States ◽

Second Primary ◽

Primary Cancer ◽

Non Hodgkin Lymphoma ◽

Second Primary Neoplasms ◽

Increased Risk ◽

Index Cancer

1586 Background: The number of cancer survivors in the United States is projected to exceed 20 million by 2024. Survivors are at risk of developing a second primary neoplasm (SPN) – a leading cause of survivor death. We described the risk of developing a SPN among survivors of common cancers (smoking-related vs non-smoking-related) in the United States. Methods: We identified patients aged ≥18 years who were diagnosed with a primary cancer from the 10 sites with highest survival rates and stratified as smoking-related (urinary bladder, kidney & renal pelvis, uterine cervix, oral cavity & pharynx, and colon & rectum) and non-smoking related (prostate, thyroid, breast, corpus & uterus, and non-Hodgkin lymphoma) from Surveillance, Epidemiology, and End Results (2000-2015). SPN was defined as the first subsequent primary cancer occurring ≥2 months after first cancer diagnosis. Excess SPN risk was quantified using standardized incidence ratios (SIRs) stratified by sex. Results: A cohort of 2,908,349 patients (50.1% female) was identified and 260,267 (9.0%) developed SPN (7.6% of females and 10.3% of males). All index cancer sites were associated with a significant increase in SPN risk for females and males (except prostate cancer). Index smoking-related cancers (SIR range 1.20 – 2.17 for females and 1.12 – 1.91 for males) had higher increased risk of SPN than non-smoking-related cancers (SIR range 1.08 – 1.39 for females and 0.55 – 1.38 for males) relative to the general population. Conclusions: Nearly 10% of cancer survivors developed an SPN, and those with smoking-related cancers had higher risk. Given the increasing number of cancer survivors and importance of SPN as a cause of cancer death, these findings can improve secondary prevention and surveillance guidelines. [Table: see text]

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