scholarly journals Osteogenic Enhancement of Zirconia-Toughened Alumina with Silicon Nitride and Bioglass®

Ceramics ◽  
2019 ◽  
Vol 2 (4) ◽  
pp. 554-567 ◽  
Author(s):  
Pezzotti ◽  
Marin ◽  
Zanocco ◽  
Boschetto ◽  
Zhu ◽  
...  
Keyword(s):  
Surface Modification ◽  
Biological Testing ◽  
Powder Mixtures ◽  
Al2o3 Ceramic ◽  
Laser Patterning ◽  
Ceramic Implants ◽  
Surface Laser ◽  
Biological Environment ◽  
Zirconia Toughened Alumina

Alumina (Al2O3) ceramic implants do not stimulate osteoblasts in vivo. Surface alterations targeted at changing the chemistry or topography have been proposed to enhance the bioactivity of alumina. This surface modification is intended to improve oxide bioceramic’s ability to integrate with the biological environment and, in particular, to rapidly osteointegrate. In this study, the surface of zirconia-toughened alumina (ZTA) was functionalized using two methods: (i) Surface laser-patterning and successive filling of patterned wells with powder mixtures of bioglass and Si3N4; and, (ii) Si3N4 coating by pulse-laser sintering. Functionalized ZTA surfaces were characterized with vibrational spectroscopy, biological testing, and laser microscopy. Both enhancements resulted in osteoblast activation, a property that is relevant to osteosynthesis.

scholarly journals Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anne-Marie Pobloth ◽  
Max J. Mersiowsky ◽  
Luisa Kliemt ◽  
Hanna Schell ◽  
Anke Dienelt ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Sol Gel ◽  
Carbonate Apatite ◽  
Implant Surface ◽  
Bioactive Coatings ◽  
Bioactive Coating ◽  
Ceramic Implants ◽  
Push Out ◽  
Zirconia Toughened Alumina

Abstract Bioactive coatings have the potential to improve the bony integration of mechanically loaded orthopedic ceramic implants. Using the concept of mimicking the natural bone surface, four different coatings of varying thickness on a zirconia toughened alumina (ZTA) ceramic implant were investigated regarding their osseointegration in a drill-hole model in sheep. The hypothesis that a bioactive coating of ZTA ceramics would facilitate cancellous bone integration was investigated. The bioactive coatings consisted of either a layer of covalently bound multi phosphonate molecules (chemical modification = CM), a nano hydoxyapatite coating (HA), or two different bioactive glass (BG) coatings in micrometer thickness, forming a hydroxyl-carbonate apatite layer on the implant surface in vivo (dip-coated 45S5 = DipBG; sol-gel 70S30C = SGBG). Coated surfaces were characterized by scanning electron microscopy and X-ray photoelectron spectroscopy. After 12 weeks, osseointegration was evaluated via mechanical push-out testing and histology. HA enhanced the maximum push-out force (HA: mean 3573.85 ± 1119.91 N; SGBG: mean 1691.57 ± 986.76 N; p = 0.046), adhesive shear strength (HA: mean 9.82 ± 2.89 MPA; SGBG: mean 4.57 ± 2.65 MPA; p = 0.025), and energy release rate (HA: mean 3821.95 ± 1474.13 J/mm2; SGBG: mean 1558.47 ± 923.47 J/mm2; p = 0.032) compared to SGBG. The implant-bone interfacial stiffness increased by CM compared to SGBG coating (CM: mean 6258.06 ± 603.80 N/mm; SGBG: mean 3565.57 ± 1705.31 n/mm; p = 0.038). Reduced mechanical osseointegration of SGBG coated implants could be explained histologically by a foreign body reaction surrounding the implants.

Articulating Biomaterials

2015 ◽  
pp. 218-267 ◽  
Author(s):  
Vamsi Krishna Balla ◽  
Mitun Das ◽  
Someswar Datta ◽  
Biswanath Kundu
Keyword(s):  
Surface Modification ◽  
Clinical Performance ◽  
Decisive Role ◽  
Surface Characteristics ◽  
Surface Modification Techniques ◽  
Biological Environment ◽  
Surface Modified ◽  
In Vivo Effects

This chapter examines the importance of surface characteristics such as microstructure, composition, crystallographic texture, and surface free energy in achieving desired biocompatibility and tribological properties thereby improving in vivo life of artificial articulating implants. Current implants often fail prematurely due to inadequate mechanical, tribological, biocompatibility, and osseointegration properties, apart from issues related to design and surgical procedures. For long-term in vivo stability, artificial implants intended for articulating joint replacement must exhibit long-term stable articulation surface without stimulating undesirable in vivo effects. Since the implant's surface plays a vital and decisive role in their response to biological environment, and vice versa, surface modification of implants assumes a significant importance. Therefore, overview on important surface modification techniques, their capabilities, properties of modified surfaces/implants are presented in the chapter. The clinical performance of surface modified implants and new surfaces for potential next-generation articulating implant applications are discussed at the end.

Articulating Biomaterials

2018 ◽  
pp. 859-910
Author(s):  
Vamsi Krishna Balla ◽  
Mitun Das ◽  
Someswar Datta ◽  
Biswanath Kundu
Keyword(s):  
Surface Modification ◽  
Clinical Performance ◽  
Decisive Role ◽  
Surface Characteristics ◽  
Surface Modification Techniques ◽  
Biological Environment ◽  
Surface Modified ◽  
In Vivo Effects

This chapter examines the importance of surface characteristics such as microstructure, composition, crystallographic texture, and surface free energy in achieving desired biocompatibility and tribological properties thereby improving in vivo life of artificial articulating implants. Current implants often fail prematurely due to inadequate mechanical, tribological, biocompatibility, and osseointegration properties, apart from issues related to design and surgical procedures. For long-term in vivo stability, artificial implants intended for articulating joint replacement must exhibit long-term stable articulation surface without stimulating undesirable in vivo effects. Since the implant's surface plays a vital and decisive role in their response to biological environment, and vice versa, surface modification of implants assumes a significant importance. Therefore, overview on important surface modification techniques, their capabilities, properties of modified surfaces/implants are presented in the chapter. The clinical performance of surface modified implants and new surfaces for potential next-generation articulating implant applications are discussed at the end.

scholarly journals Erratum to: Surface modification-mediated biodistribution of 13C-fullerene C60 in vivo

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Chenglong Wang ◽  
Yitong Bai ◽  
Hongliang Li ◽  
Rong Liao ◽  
Jiaxin Li ◽  
...  
Keyword(s):  
Surface Modification ◽  
Fullerene C60

Clindamycin-loaded titanium prevents implant-related infection through blocking biofilm formation

2021 ◽  
pp. 088532822110511
Author(s):  
Youbin Li ◽  
Shaochuan Wang ◽  
Shidan Li ◽  
Jun Fei
Keyword(s):  
Surface Modification ◽  
Rat Model ◽  
Biofilm Formation ◽  
High Performance ◽  
Bacterial Colonization ◽  
Tissue Homogenate ◽  
Tartrate Resistant Acid Phosphatase ◽  
Layer By Layer

Implant-related infection is a disastrous complication. Surface modification of titanium is considered as an important strategy to prevent implant-related infection. However, there is no recognized surface modification strategy that can be applied in clinic so far. We explored a new strategy of coating. The clindamycin-loaded titanium was constructed by layer-by-layer self-assembly. The release of clindamycin from titanium was detected through high performance liquid chromatography. Different titanium was co-cultured with Staphylococcus aureus for 24 h in vitro, then the effect of different titanium on bacterial colonization and biofilm formation was determined by spread plate method and scanning electron microscopy. Cytotoxicity and cytocompatibility of clindamycin-loaded titanium on MC3T3-E1 cells were measured by CCK8. The antibacterial ability of clindamycin-loaded titanium in vivo was also evaluated using a rat model of osteomyelitis. The number of osteoclasts in bone defect was observed by tartrate-resistant acid phosphatase staining. Bacterial burden of surrounding tissues around the site of infection was calculated by tissue homogenate and colony count. Clindamycin-loaded titanium could release clindamycin slowly within 160 h. It reduced bacterial colonization by three orders of magnitude compare to control ( p < .05) and inhibits biofilm formation in vitro. Cells proliferation and adhesion were similar on three titanium surfaces ( p > .05). In vivo, clindamycin-loaded titanium improved bone healing, reduced microbial burden, and decreased the number of osteoclasts compared control titanium in the rat model of osteomyelitis. This study demonstrated that clindamycin-loaded titanium exhibited good biocompatibility, and showed antibacterial activity both in vivo and in vitro. It is promising and might have potential for clinical application.

Toxicity And Surface Modification Of Dendrimers: A Critical Review

2021 ◽  
Vol 18 ◽  
Author(s):  
Rohini Kharwade ◽  
Payal Badole ◽  
Nilesh Mahajan ◽  
Sachin More
Keyword(s):  
Surface Modification ◽  
Positive Charge ◽  
Haematological Toxicity ◽  
Three Dimensional ◽  
Different Types ◽  
Hemolytic Toxicity ◽  
High Degree ◽  
Core Functionality ◽  
Polymeric Structures

: As compared to other nano polymers, dendrimers have novel three dimensional, synthetic hyperbranched, nano-polymeric structures. The characteristic of these supramolecular dendritic structures has a high degree of significant surface as well as core functionality in the transportation of drugs for targeted therapy, specifically in host-guest response, gene transfer therapy and imaging of biological systems. However, there are conflicting shreds of evidence regarding biological safety and dendrimers toxicity due to their positive charge at the surface. It includes cytotoxicity, hemolytic toxicity, haematological toxicity, immunogenicity and in vivo toxicity. Therefore to resolve these problems surface modification of the dendrimer group is one of the methods. From that point, this review involves different strategies which reduce the toxicity and improve the biocompatibility of different types of dendrimers. From that viewpoint, we broaden the structural and safe characteristics of the dendrimers in the biomedical and pharmaceutical fields.

Surface Modification of Dispersed Phases Designed for In Vivo Removal of Overdosed Toxins

2005 ◽  
pp. 813-832
Author(s):  
J Flint ◽  
T Morey ◽  
E Powell ◽  
D Dennis ◽  
D-W Lee ◽  
...  
Keyword(s):  
Surface Modification ◽  
Dispersed Phases

scholarly journals Ratiometric Photoelectrochemical Microsensor Based on Small-Molecule Organic Semiconductor for Reliable in Vivo Analysis

2021 ◽  
Author(s):  
Yunhui Xiang ◽  
Yao Kong ◽  
Wenqi Feng ◽  
Xiaoxue Ye ◽  
Zhi-hong Liu
Keyword(s):  
Small Molecule ◽  
Organic Semiconductor ◽  
In Vivo Analysis ◽  
Biological Environment

Photoelectrochemical (PEC) sensing has been developing quickly in recent years, while its in vivo application is still in the infancy. The complexity of biological environment poses a high challenge to...

Surface modification of polyurethane towards promoting the ex vivo cytocompatibility and in vivo biocompatibility for hypopharyngeal tissue engineering

2012 ◽  
Vol 28 (4) ◽  
pp. 607-616 ◽  
Author(s):  
Zhisen Shen ◽  
Cheng Kang ◽  
Jingjing Chen ◽  
Dong Ye ◽  
Shijie Qiu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Surface Modification ◽  
Ex Vivo
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