scholarly journals Cyclosporine CsA—The Physicochemical Characterization of Liposomal and Colloidal Systems

2020 ◽  
Vol 4 (4) ◽  
pp. 46
Author(s):  
Agnieszka Ewa Wiącek ◽  
Małgorzata Jurak ◽  
Agata Ładniak ◽  
Kacper Przykaza ◽  
Klaudia Szafran
Keyword(s):  
Particle Size ◽  
Lipid Membranes ◽  
Physicochemical Characterization ◽  
Colloidal Systems ◽  
Drug Bioavailability ◽  
Individual Variations ◽  
The Stability ◽  
The Individual ◽  
Formulation Stability

This paper presents an overview of the possibilities of testing various cyclosporine (CsA) formulations with an emphasis on parameters that may be key to improving the stability and biocompatibility. The feasibility of CsA colloidal systems for oral (injection) administration were investigated using different techniques and compared with similar investigations of other researchers. The chosen CsA systems were developed using dipalmitoylphosphocholine (DPPC) and/or cholesterol as a lipid matrix, stabilized with ethanol, with soybean oil or n-tetradecane as oil phase in emulsions, under natural pH, room and physiological temperature. Their integrity was found to be strictly dependent on the stabilizers. The highest CsA penetrability with the system containing phospholipid in the context of its interactions with lipid membranes was shown. Also, the bioavailability of CsA can be enhanced with the biopolymer antibacterial chitosan. This mini-review suggests the suitability of liposome/microemulsion as promising vehicles for CsA delivery. The most hopeful proved to be formulation with the smaller particle size facilitating absorption, but when safety is assessed, relying on just the particle size cannot be the only criteria. Reassumed, the CsA formulation stability known on the basis of the size and zeta potential measurements guarantees a decrease of the individual variations in the drug bioavailability, toxicity and minimizes rejection.

scholarly journals Synthesis and characterization of the aluminium phosphates modified with ammonium, calcium and molybdenum by hydrothermal method

2016 ◽  
Vol 18 (2) ◽  
pp. 131-139
Author(s):  
Kinga Łuczka ◽  
Barbara Grzmil ◽  
Bogumił Kic ◽  
Krzysztof Kowalczyk
Keyword(s):  
Particle Size ◽  
Physicochemical Parameters ◽  
Average Particle Size ◽  
Synthesis And Characterization ◽  
Average Particle ◽  
Influence Of Process Parameters ◽  
Molar Ratios ◽  
Aluminum Phosphates ◽  
The Individual

Abstract Synthesis and characterization of the aluminum phosphates modified with ammonium, calcium and molybdenum were conducted. The influence of process parameters (reactive pressure and molar ratios) in the reaction mixture were studied. The contents of the individual components in the products were in the range of: 10.97–17.31 wt% Al, 2.65–13.32 wt% Ca, 0.70–3.11 wt% Mo, 4.36–8.38 wt% NH3, and 35.12–50.54 wt% P2O5. The materials obtained in the experiments were characterized by various physicochemical parameters. The absorption oil number was in the range from 67 to 89 of oil/100 g of product, the surface area was within the range of 4–76 m2/g, whereas the average particle size of products reached 282–370 nm. The Tafel tests revealed comparable anticorrosive properties of aluminum phosphates modified with ammonium, calcium, molybdenum in comparison with commercial phosphate.

scholarly journals Preparation and characterization of oyster shell powder-treated rice husk ash adsorbent pellet for As(III) removal

2018 ◽  
Vol 192 ◽  
pp. 01003
Author(s):  
Pichnipa Khownpurk ◽  
Walairat Chandra-ambhorn
Keyword(s):  
Particle Size ◽  
Rice Husk ◽  
Rice Husk Ash ◽  
Oyster Shell ◽  
Maximum Adsorption Capacity ◽  
Oyster Shell Powder ◽  
The Stability ◽  
Precursor Powders ◽  
Shell Powder

The adsorbent pellet for As(III) removal was prepared from ground oyster shell and rice husk ash. The effects of particle size of oyster shell powder (OS) and the ratio between the OS and Treated rice husk ash (TRHA) on the stability of the adsorbent pellet were studied. The adsorbent pellet was characterized by XRD, XRF and SEM. The solubility and As(III) adsorption tests were performed. The results showed that the adsorbent pellet prepared from OS size <106 μm with OS:TRHA ratio of 0.7:0.3 could provide As(III) maximum adsorption capacity of approximately 26.20 mg/g. Furthermore, the XRD and SEM results indicated that the adsorbent pellet could consist of two parts i.e. CaO that could adsorb As(III) in the form of Ca-As-O and the CaSiO3 and C-S-H compounds which behaved as a binder to bind the precursor powders to be stable adsorbent pellet without cracking.

scholarly journals Development and Physicochemical Characterization of Desonide-Loaded Nanocapsule Suspensions

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
M. B. Antonow ◽  
R. Lorenzoni ◽  
G. M. Barbosa ◽  
A. F. Ourique ◽  
P. Gomes ◽  
...  
Keyword(s):  
Particle Size ◽  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Release Kinetics ◽  
Physicochemical Characterization ◽  
Eudragit S100 ◽  
Franz Diffusion Cells ◽  
Negative Zeta Potential

Desonide is a topical corticosteroid that has been used for more than 30 years; however, its prolonged use can induce several side effects, affecting dermis and epidermis. The present work consists of development desonide-loaded nanocapsule suspensions (D-NC) using different polymers (Eudragit S100® or Eudragit L100®) and desonide-loaded lipid-core nanocapsules (D-LNC). They were formulated by interfacial deposition using the preformed polymer method and all formulations showed negative zeta potential and adequate nanotechnological characteristics (particle size 161–202 nm, polydispersity index < 0.20). Simple and sensitive methods using high-performance liquid chromatography (HPLC) were developed to quantify desonide in LNC and to study its release kinetics. The method was linear, specific, precise, and exact and therefore can be applied in quantification of D-NC and D-LNC. We evaluatedin vitromethods for drug release (dissolution, Franz diffusion cells, and dialysis sac) and we use mathematical models (monoexponential, biexponential, and Korsmeyer-Peppas) to show release kinetics from this system.

scholarly journals Physicochemical characterization of mesquite flours

2018 ◽  
Author(s):  
S. Sandoval Torres ◽  
L. Reyes López ◽  
L. Méndez Lagunas ◽  
J. Rodríguez Ramírez ◽  
G. Barriada Bernal
Keyword(s):  
Thermal Stability ◽  
Particle Size ◽  
Physicochemical Characterization ◽  
Chemical Properties ◽  
Sorption Isotherms ◽  
Nutritional Composition ◽  
Gluten Free ◽  
Sieving Process ◽  
Thermal Stability Of

Ethnic foods are healthy products interesting for the new societies. Mesquite flour offers another option for making gluten-free recipes as part of a diet for people with celiac disease. The physicochemical properties of mesquite flours (Prosopis laevigata) were characterized. The mesquite pods were dried at 60°C, 15% RH and 2 m/s airflow; then a grinding and sieving process were applied. The nutritional composition and the sorption isotherms were obtained at 30, 35, 40 and 45°C  for  water activities of 0.07-0.9. The particle-size distribution, morphology and thermal stability of the flours were determined by different methods. Keywords: Mesquite Flours; drying; isotherms; chemical properties; morphology

scholarly journals PHYSICOCHEMICAL CHARACTERIZATION OF PITUITARY FOLLICLE-STIMULATING HORMONE

1952 ◽  
Vol 35 (4) ◽  
pp. 629-637 ◽  
Author(s):  
Choh Hao Li ◽  
Kai O. Pedersen
Keyword(s):  
Molecular Weight ◽  
Amino Acid ◽  
Amino Acid Composition ◽  
Follicle Stimulating Hormone ◽  
Physicochemical Characterization ◽  
Single Protein ◽  
Pituitary Glands ◽  
The Stability ◽  
Stimulating Hormone

The physiochemical characteristics of the follicle-stimulating hormone (FSH) from whole sheep pituitary glands have been studied. The hormone behaves as a single protein in electrophoresis, diffusion, and ultracentrifugation. It has an isoelectric point at pH 4.5 and a molecular weight of 67,000 and contains 1.23 per cent hexose and 1.51 per cent hexosamine. The amino acid composition has also been determined in large part. The stability of the hormone to acid and heat has been investigated.

Input and Characterization of Sediments in Urban Sewer Systems

1992 ◽  
Vol 25 (8) ◽  
pp. 21-28 ◽  
Author(s):  
C. Xanthopoulos ◽  
A. Augustin
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Analysis Method ◽  
Sewer System ◽  
Detention Basin ◽  
Sewer Systems ◽  
Separate System ◽  
Simplified Analysis ◽  
The Individual

This paper discusses informative data on the particle size distribution in sewer sediments including data on the contamination of the individual fractions with micropollutants. For this purpose, two low-gradient sewer systems, a combined and a separate system, were sampled. This paper will show the differences between the two systems' sediments characteristics. Furthermore the sewer sediments will be compared to settleable solids introduced by street runoff into the sewer system and deposits found in a detention basin of the combined sewage. Finally, we will propose a simplified analysis method based on the observed data to describe the cohesivity of the sewer sediments.

scholarly journals Extraction and Physicochemical Characterization of Oil from Unripe Plantain (Musa Paradisiaca) Peels

2020 ◽  
pp. 151-155
Author(s):  
Orodu Victor Enearepuadoh ◽  
Igara Evawere Abigail
Keyword(s):  
Physicochemical Properties ◽  
Physicochemical Characterization ◽  
Iodine Content ◽  
Acid Value ◽  
Physicochemical Analysis ◽  
Human Consumption ◽  
Musa Paradisiaca ◽  
The Mean ◽  
The Stability

Extraction and physicochemical analysis of oil from unripe plantain (Musa paradisiaca) peels was carried out using cold extraction method. The peels were washed with distilled water, sun dried for 3 hours and oven dried for 6 hours at 85oC. It was then ground thoroughly. 700g of the sample was weighed and 1.20 liter of n-hexane was added for 72 hours. It was placed in a water bath for the evaporation of the solvent. The physicochemical properties determined were Saponification Value (SV), Iodine Value (IV), Free Fatty Acid Value (FFA), Peroxide Value (PV), Acid Value (AV) the mean results obtained SV 335.18mg/KOH/g, IV 7.16gI2/100g, FFA 338.76mg/KOH/g, AV 696.35mg/KOH/g and PV 328.46meq/kg. In comparing these physicochemical properties with the standard given by WHO/FAO, it was observed that IV and PV were below the range, SV, AV and FFA was above the range. Hence, the oil obtained from unripe plantain (Musa paradisiaca) peels is not fit for human consumption because AV, SV and FFA are higher than the standard given by WHO/FAO rather it can be used for making of soap and shampoos, PV showed the stability of the oil and IV indicates it’s nondrying quality which will not be suitable for ink and paint making due to its low iodine content.

Determination of the Stability of Asphaltenes Through Physicochemical Characterization of Asphaltenes

2016 ◽  
Author(s):  
Andreas Prakoso ◽  
Abhishek Punase ◽  
Kristina Klock ◽  
Estrella Rogel ◽  
Cesar Ovalles ◽  
...  
Keyword(s):  
Physicochemical Characterization ◽  
The Stability
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