scholarly journals Optimal Breast Density Characterization Using a Three-Dimensional Automated Breast Densitometry System

2021 ◽  
Vol 28 (6) ◽  
pp. 5384-5394
Author(s):  
Reika Yoshida ◽  
Takenori Yamauchi ◽  
Sadako Akashi-Tanaka ◽  
Misaki Matsuyanagi ◽  
Kanae Taruno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diagnostic Accuracy ◽  
Mammographic Density ◽  
Breast Density ◽  
Three Dimensional ◽  
Density Measurement ◽  
Case Series ◽  
Breast Cancer Surgery ◽  
Detection Rates ◽  
Case Series Study

Dense breasts are a risk factor for breast cancer. Assessment of breast density is important and radiologist-dependent. We objectively measured mammographic density using the three-dimensional automatic mammographic density measurement device Volpara™ and examined the criteria for combined use of ultrasonography (US). Of 1227 patients who underwent primary breast cancer surgery between January 2019 and April 2021 at our hospital, 441 were included. A case series study was conducted based on patient age, diagnostic accuracy, effects of mammography (MMG) combined with US, size of invasion, and calcifications. The mean density of both breasts according to the Volpara Density Grade (VDG) was 0–3.4% in 2 patients, 3.5–7.4% in 55 patients, 7.5–15.4% in 173 patients, and ≥15.5% in 211 patients. Breast density tended to be higher in younger patients. Diagnostic accuracy of MMG tended to decrease with increasing breast density. US detection rates were not associated with VDG on MMG and were favorable at all densities. The risk of a non-detected result was high in patients without malignant suspicious calcifications. Supplementary use of US for patients without suspicious calcifications on MMG and high breast density, particularly ≥25.5%, could improve the breast cancer detection rate.

Design and fabrication of anisotropic textile brace for exerting corrective forces on spinal curvature

2021 ◽  
pp. 152808372110326
Author(s):  
Queenie Fok ◽  
Joanne Yip ◽  
Kit-lun Yick ◽  
Sun-pui Ng
Keyword(s):  
Medical Condition ◽  
Three Dimensional ◽  
Case Series ◽  
The Body ◽  
Spinal Curvature ◽  
Radiographic Examination ◽  
Interface Pressure ◽  
Pressure System ◽  
Case Series Study ◽  
Point Pressure

This study focuses on the fabrication of an anisotropic textile brace that exerts corrective forces based on the three-point pressure system to treat scoliosis, which is a medical condition that involves deformity of the spine. The design and material properties of the proposed anisotropic textile brace are discussed in detail here. A case series study with 5 scoliosis patients has been conducted to investigate the immediate in-brace effect and biomechanics of the proposed brace. Radiographic examination, three-dimensional scanning of the body and interface pressure measurements have been used to evaluate the immediate effect of the proposed brace on reducing the spinal curvature and asymmetry of the body contours and its biomechanics. The results show that the proposed brace on average reduces the spinal curvature by 11.7° and also increases the symmetry of the posterior trunk by 14.1% to 43.2%. The interface pressure at the corrective pad ranges from 6.0 to 24.4 kPa. The measured interface pressure shows that a sufficient amount of pressure has been exerted and a three-point pressure distribution is realized to reduce the spinal curvature. The obtained results indicate the effectiveness of this new approach which uses elastic textile material and a hinged artificial backbone to correct spinal deformity.

scholarly journals Semi-automated and fully automated mammographic density measurement and breast cancer risk prediction

2014 ◽  
Vol 116 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Rafael Llobet ◽  
Marina Pollán ◽  
Joaquín Antón ◽  
Josefa Miranda-García ◽  
María Casals ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Risk Prediction ◽  
Mammographic Density ◽  
Density Measurement

scholarly journals Diagnostic accuracy of repeat placental growth factor measurements in women with suspected preeclampsia: A case series study

2020 ◽  
Vol 99 (8) ◽  
pp. 994-1002 ◽  
Author(s):  
Kate E. Duhig ◽  
Louise M. Webster ◽  
Andrew Sharp ◽  
Carolyn Gill ◽  
Paul T. Seed ◽  
...  
Keyword(s):  
Growth Factor ◽  
Diagnostic Accuracy ◽  
Case Series ◽  
Placental Growth Factor ◽  
Case Series Study ◽  
Series Study

Pattern of breast diseases in Kuwait Cancer Control Center, Kuwait

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10754-10754 ◽  
Author(s):  
S. A. Alawadi ◽  
M. D. Delvadiya
Keyword(s):  
Breast Cancer ◽  
Hormone Replacement ◽  
Case Series ◽  
Breast Diseases ◽  
Age At Menarche ◽  
Female Breast ◽  
N2 Disease ◽  
Case Series Study ◽  
History Of ◽  
Second Degree

10754 Background: The aim of this case series study is to evaluate the outline and pattern of female breast cancers in Kuwait. Methods: Our study consisted of data from 300 cases of female breast cancer seen in our outpatient department. Data on profile of their disease at presentation and known risk factors was retrieved. The analysis indented to examine the pattern of the disease and risk factor profile of the patients. Results: Out of 300 patients, 52% were Kuwaiti citizens, 24% were Arabs from other countries, 23% were of Asian origin and 1% was of other nationality. Their median age ± SD (Standard Deviation) was 50 ± 9.7 years. Most patients were younger than 55 years (77.4%) and were predominantly premenopausals (63%). Only 18% had stage I disease at presentation, whilst 54 %, 24 %, and 4% had stage II, III and IV disease, respectively. Among patients with known axillary nodal status (298 patients) 44.3% were node-negative whilst 39.6% and 16.8% had N1 and N2 disease, respectively. History of benign breast disease was positive in 9% and only 1% had breast biopsy done before the biopsy which diagnosed cancer. In 20.7% there was family history of breast cancer. Among them 11.7% had first degree relative with breast cancer, 3.3%, 7.3% and 1% patients had either mother, sister or both with history of breast cancer. Whilst 12% patients had second degree relatives with breast cancer, 3% patients out of them had both first and second degree relatives with breast cancer. History of alcohol ingestion was rare, only 0.7% patients were taking alcohol. 9.7% patients were nulliparous, while 10.7% patients had their first child after the age of 30 years. Breast feeding was common, 80 % patients breast fed their children and 43.3 % did that for more than 6 months. Age at menarche was 12 years or less in 34 % patients and age at menopause was more than 55 years in only 6.3% patients. Oral contraceptives were used by 38.7% patients, 12%, 9.3% and 17.3% patients used them for 2 or less, 2 to 5 or more than 5 years, respectively. Only 3% patients took hormone replacement therapy, 7 of them took that fore more than 2 years. Only 6 % patients gave history of smoking and only half of them were currently smoking. Conclusions: This data analysis suggested that pattern of breast cancer in Kuwait is similar to other countries in this region. No significant financial relationships to disclose.

Correlation of mammographic breast density with Ki-67 expression in benign breast epithelial cells obtained by random periareolar fine needle aspiration of high risk women

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 1011-1011
Author(s):  
Q. J. Khan ◽  
B. F. Kimler ◽  
E. J. Smith ◽  
A. P. O’Dea ◽  
P. Sharma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Mammographic Density ◽  
Breast Density ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Mammographic Breast Density ◽  
Ki 67 ◽  
Fine Needle ◽  
Cytologic Atypia

1011 
 >Background: Known risk factors for breast cancer development include elements incorporated into the Gail risk model, mammographic breast density and cytologic atypia detected by Random Periareolar Fine Needle Aspiration (RPFNA). Ki-67 expression is a possible risk biomarker and is currently being used as a response biomarker in chemoprevention trials. We have previously shown that Ki-67 expression is higher in RPFNA specimens of benign breast cells exhibiting cytologic atypia. It is not known whether there is a correlation between mammographic density and Ki-67 expression in benign breast ductal cells obtained by RPFNA. Methods: 344 women at high risk of developing breast cancer (based on personal or family history) seen at The University of Kansas Medical Center high risk breast clinic, who underwent RPFNA with cytomorphology and Ki-67 assessment, plus a mammogram were included in the study. Mammographic breast density was assessed using the Cumulus program. Categorical variables were analyzed by Chi-square test and continuous variables were analyzed by non-parametric test and linear regression. Results: 40% of women were premenopausal, 7% perimenopausal and 53% were postmenopausal. Median age was 49 years, median 5 year Gail Risk was 2.2%, and median Ki-67 was 1.9%. Median mammographic breast density was 37%. Ki-67 expression increased with cytologic abnormality and number of cells collected, but was unrelated to Gail risk (as observed previously). Breast density was higher in pre-menopausal women (p=0.001), those with lower BMI (p< 0.001), and lower 5-year Gail risk (p=0.012); Breast density showed no correlation with Ki-67 expression or cytomorphology. Conclusion: Given the lack of correlation of mammographic breast density with either cytomorphology or Ki-67 expression in RPFNA specimens, mammographic density and Ki-67 expression should be considered as potentially complementary response biomarkers for breast cancer chemoprevention trials. No significant financial relationships to disclose.

scholarly journals Long-term excess risk of breast cancer after a single breast density measurement

2019 ◽  
Vol 117 ◽  
pp. 41-47 ◽  
Author(s):  
Matejka Rebolj ◽  
Oleg Blyuss ◽  
Kee Seng Chia ◽  
Stephen W. Duffy
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Density Measurement ◽  
Excess Risk ◽  
Breast Density Measurement

Sarcoidosis as a paraneoplastic syndrome for breast cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e12587-e12587
Author(s):  
Pamela Barletta ◽  
Mukunthan Murthi ◽  
Douglas Salguero ◽  
Mehdi Mirsaeidi
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Case Series ◽  
Breast Cancer Diagnosis ◽  
Pulmonary Sarcoidosis ◽  
Unknown Etiology ◽  
Time Interval ◽  
Case Series Study ◽  
Increased Risk ◽  
Study Population

e12587 Background: Sarcoidosis is a multisystem granulomatous disease of unknown etiology. The pathogenesis of sarcoidosis is believed to be a result from a cellular immune reaction from exposure to occupational, environmental, or infectious elements that lead to the formation of noncaseating granulomas. Non-caseating granulomas are also present in cancer , and it is well known that the cancer cells carry neo-antigens, leading to a possible association between cancer and sarcoidosis. Several studies have shown an increased risk of breast cancer , in particular, in patients with sarcoidosis, but only a few studies have analyzed the incidence of sarcoidosis following breast cancer diagnosis. The present study aimed to identify patients with sarcoidosis following a diagnosis of breast cancer in our cohort of sarcoidosis. Methods: This is a retrospective case-series study between 2008-2018 of patients with sarcoidosis in the University of Miami Sarcoidosis Program. Sarcoidosis was defined per the World Association for Sarcoidosis and other Granulomatous Disorders guidelines. Breast cancer diagnosis was confirmed through pathology. We collected demographic data of age, gender, ethnicity and the time between diagnosis of breast cancer and sarcoidosis by chart review. Clincial data including clinical manifestations, laboratories, staging, and treatment were also collected. Results: Among 125 patients in our registry, 26 patients had a diagnosis of both cancer and sarcoidosis. In this, 12 (46%) developed sarcoidosis after the diagnosis of breast cancer and are the study population. Among them, 12(100%) were female. The most common ethnic group in the study population was European American with 8(67%) followed by African Americans 2(16.7%) and Hispanic 2(16.7%). Eight (67%) patients were treated with chemotherapy, 7(58%) with radiotherapy, of this, 6 (50%) received both. Mean (SD) age of onset of sarcoidosis was 61.9 ( 10.8) years . The mean time interval between breast cancer diagnosis and the onset of sarcoidosis was 5.58 ( 5.24) years ( (see Figure 1). Nine (75%) had pulmonary sarcoidosis and 3(25%) cardiac sarcoidosis. Among the subjects with pulmonary sarcoidosis 1(11.1%) had Stage 4, 4(44.4%) had Stage 2 and 4(44.4%) had stage 1. Conclusions: Our findings suggest sarcoidosis may be a paraneoplastic characteristic of breast cancer. The mechanism of granuloma development remains unclear. Cancer mediated immune dysregulation could be a potential contributing factor. Further studies are warranted to establish a definitive association.

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