scholarly journals Ocular Involvement in Friedreich Ataxia Patients and Its Relationship with Neurological Disability, a Follow-Up Study

Diagnostics ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 75
Author(s):  
Pilar Rojas ◽  
Ana I. Ramírez ◽  
Rosa de Hoz ◽  
Manuel Cadena ◽  
Antonio Ferreras ◽  
...  
Keyword(s):  
Friedreich Ataxia ◽  
P Value ◽  
Ocular Involvement ◽  
Ganglion Cell Complex ◽  
Optic Coherence Tomography ◽  
Fiber Layer ◽  
Neurological Disability ◽  
Follow Up Study ◽  
Best Parameter

Background: This study compared functional and structural visual changes in Friedreich ataxia (FRDA) patients with healthy controls (HC) and correlated these changes with neurological disability. Methods: Eight FRDA Spanish patients and eight HC were selected from 2014 to 2018. Best corrected visual acuity (BCVA), visual field (VF), optic coherence tomography (OCT), and neurological disability measured by “scale for the assessment and rating of ataxia” (SARA) were taken in a basal exploration and repeated after 6 months. A linear mixed analysis and Bonferroni p-value correction were performed. Results: FRDA baseline and follow-up patients showed statistically significant decreases in BCVA, VF, and OCT parameters compared with the HC. Some of the VF measurements and most of the OCT parameters had an inverse mild-to-strong correlation with SARA. Moreover, the analysis of the ROC curve demonstrated that the peripapillary retinal nerve fiber layer (pRNFL) average thickness was the best parameter to discriminate between FRDA patients and HC. Conclusions: The follow-up study showed a progression in OCT parameters. Findings showed a sequential effect in pRNFL, ganglion cell complex (GCC), and macula. The VF and the OCT could be useful biomarkers in FRDA, both for their correlation with neurological disease as well as for their ability to evaluate disease progression.

scholarly journals Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study

2019 ◽  
Vol 9 (12) ◽  
pp. 337 ◽  
Author(s):  
Pilar Rojas ◽  
Rosa de Hoz ◽  
Ana I. Ramírez ◽  
Antonio Ferreras ◽  
Elena Salobrar-Garcia ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Rating Scale ◽  
P Value ◽  
Ophthalmological Examination ◽  
Fiber Layer ◽  
Neurological Disability ◽  
Als Patients ◽  
Lateral Sclerosis ◽  
Visual Changes

Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disability. Methods: All patients underwent a comprehensive neurological and ophthalmological examination. A linear mixed analysis and Bonferroni p-value correction were performed, testing four comparisons as follows: Control baseline vs. control follow-up, control baseline vs. ALS baseline, control follow-up vs. ALS follow-up, and ALS baseline vs. ALS follow-up. Results: The mean time from the diagnosis was 10.80 ± 5.5 months. The analysis of the optical coherence tomography (OCT) showed: (1) In ALS baseline vs. control baseline, a macular significantly increased thickness of the inner macular ring temporal and inferior areas; (2) in ALS follow-up vs. ALS baseline, a significant macular thinning in the inner and outer macular ring inferior areas; (3) in ALS follow-up vs. ALS baseline, a significant peripapillary retinal nerve fiber layer (pRNFL) thinning in the superior and inferior quadrants; and (4) ALS patients showed a moderate correlation between some OCT pRNFL parameters and Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score. Conclusion: The OCT showed retinal changes in patients with motoneuron disease and could serve as a complementary tool for studying ALS.

scholarly journals Ganglion cell complex scan in the early prediction of glaucoma

2012 ◽  
Vol 4 (2) ◽  
pp. 236-241
Author(s):  
S Ganekal
Keyword(s):  
Ganglion Cell ◽  
Cell Complex ◽  
P Value ◽  
Ganglion Cell Complex ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Fiber Layer ◽  
Color Code ◽  
Rnfl Thickness ◽  
Significant Difference

Objective: To compare the macular ganglion cell complex (GCC) with peripapillary retinal fiber layer (RNFL) thickness map in glaucoma suspects and patients. Subjects and methods: Forty participants (20 glaucoma suspects and 20 glaucoma patients) were enrolled. Macular GCC and RNFL thickness maps were performed in both eyes of each participant in the same visit. The sensitivity and specificity of a color code less than 5% (red or yellow) for glaucoma diagnosis were calculated. Standard Automated Perimetry was performed with the Octopus 3.1.1 Dynamic 24-2 program. Statistics: The statistical analysis was performed with the SPSS 10.1 (SPSS Inc. Chicago, IL, EUA). Results were expressed as mean ± standard deviation and a p value of 0.05 or less was considered significant. Results: Provide absolute numbers of these findings with their units of measurement. There was a statistically significant difference in average RNFL thickness (p=0.004), superior RNFL thickness (p=0.006), inferior RNFL thickness (p=0.0005) and average GCC (p=0.03) between the suspects and glaucoma patients. There was no difference in optic disc area (p=0.35) and vertical cup/disc ratio (p=0.234) in both groups. While 38% eyes had an abnormal GCC and 13% had an abnormal RNFL thickness in the glaucoma suspect group, 98% had an abnormal GCC and 90% had an abnormal RNFL thickness in the glaucoma group.Conclusion: The ability to diagnose glaucoma with macular GCC thickness is comparable to that with peripapillary RNFL thickness. Macular GCC thickness measurements may be a good alternative or a complementary measurement to RNFL thickness assessment in the clinical evaluation of glaucoma.DOI: http://dx.doi.org/10.3126/nepjoph.v4i2.6538 Nepal J Ophthalmol 2012; 4 (2): 236-241 

scholarly journals Incidence and predictors of lost to follow-up among women under Option B+ PMTCT program in western Ethiopia: a retrospective follow-up study

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Tadesse Tolossa ◽  
Getachew Mullu Kassa ◽  
Habtamu Chanie ◽  
Amanuel Abajobir ◽  
Diriba Mulisa
Keyword(s):  
Proportional Hazards ◽  
Previous History ◽  
Cox Proportional Hazards ◽  
Hiv Disclosure ◽  
Outcome Variable ◽  
P Value ◽  
Pmtct Program ◽  
Follow Up Study ◽  
Western Ethiopia

Abstract Objective Although Ethiopia has been implementing Option B+ program, LTFU of women from the Option B+ program is one of the challenges that minimizes its implementation. Thus, this study assessed the incidence and predictors of LTFU among women under Option B+ PMTCT program in western Ethiopia. An institution-based retrospective follow-up study was conducted. A cox proportional hazards regression model was fitted to identify predictors of LTFU. A Hazard ratios with 95% confidence CI was computed and all predictors that were associated with the outcome variable at p-value ≤ 0.05 in the multivariable cox proportional hazards were declared as a significance predictor of the outcome. Results A total of 330 women were followed for a mean follow up time of 16.9 (± 7.6) months. An overall incidence rate of LTFU was 9/1000 person-months. Women’s educational status, residence, HIV-disclosure status, the status of women at enrollment, previous history of HIV and ART adherence were significant predictors of LTFU. The incidence of LTFU from Option B+ PMTCT is lower as compared to evidence from sub-Saharan African and strengthening linkage and referral system between clinics as well as establishing appropriates tracing mechanisms would retain pregnant women in the program.

Early retinal and retinal nerve fiber layer effects of hydroxychloroquine: a follow up study by sdOCT

2013 ◽  
Vol 32 (3) ◽  
pp. 204-209 ◽  
Author(s):  
Fatma Yülek ◽  
Nagihan Uğurlu ◽  
Emine Akçay ◽  
Sücattin İlker Kocamıs¸ ◽  
Sıdıka Gerçeker ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Follow Up Study ◽  
Retinal Nerve Fiber

scholarly journals A 22-Year Follow-up Study of Long-term Cardiac Outcome and Predictors of Survival in Friedreich Ataxia

2015 ◽  
Vol 72 (11) ◽  
pp. 1334 ◽  
Author(s):  
Francoise Pousset ◽  
Lise Legrand ◽  
Marie-Lorraine Monin ◽  
Claire Ewenczyk ◽  
Perrine Charles ◽  
...  
Keyword(s):  
Friedreich Ataxia ◽  
Follow Up Study ◽  
Cardiac Outcome

A follow-up study of Nordic multiple sclerosis candidate gene regions

2007 ◽  
Vol 13 (5) ◽  
pp. 584-589
Author(s):  
P. Datta ◽  
H.F. Harbo ◽  
L.P. Ryder ◽  
E. Akesson ◽  
J. Benedikz ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Linkage Disequilibrium ◽  
Microsatellite Markers ◽  
Candidate Gene ◽  
Hla Class Ii ◽  
P Value ◽  
Class Iii ◽  
Follow Up Study ◽  
Sample Set

In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value <0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected =0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), D1S2627 (1p22), D6S273 (6p21.33, HLA class III) and D12S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population. Multiple Sclerosis 2007; 13: 584-589. http://msj.sagepub.com

scholarly journals A follow up study of postpartum intrauterine device insertion in a tertiary health care centre

2017 ◽  
Vol 6 (7) ◽  
pp. 2800
Author(s):  
. Ranjana ◽  
Anita Verma ◽  
Indu Chawla
Keyword(s):  
Family Planning ◽  
Removal Rate ◽  
Post Partum ◽  
Intrauterine Device ◽  
Uterine Cavity ◽  
P Value ◽  
Expulsion Rate ◽  
Follow Up Study ◽  
Uterine Anomalies

Background: In view of high rate of unintended pregnancy in our country, particularly in post-partum women, there is a need for reliable, effective and long-term contraception such as intrauterine device (IUCD) in post-partum women. This study was done to determine the efficacy and safety of Post-Partum Intrauterine Device (PPIUCD) and to compare the outcomes of PPIUCD insertion after vaginal delivery and caesarean section.Methods: This follow up study was carried out in the department of Obstetrics and Gynecology, Dr. R.M.L Hospital, PGIMER, New Delhi over a period of 7 month from January 2016 to July 2016. PPIUCD (cu T- 380 A) insertions were done in 136 women who fulfilled the inclusion criteria. Women having haemoglobin less than 8 gm%, rupture of membranes more than 18 hours, obstructed labour, Uterine anomalies, distorted uterine cavity by fibroid, significant postpartum haemorrhage, coagulation disorders, fever or clinical symptoms of infection during labour were excluded from the study. Post insertion counselling was done, and these women were advised to follow up at 6 weeks and then after 6 months postpartum in the family planning O.P.D. At the follow-up visit, the women were asked for any symptoms of unusual vaginal discharge, irregular or heavy bleeding per vagina, and any expulsions if noticed.Results: Total number of cases that reported for follow up in family planning OPD was 118. Therefore, 18 patients were lost in the follow up. In 58.47% women, there was no complaint. Heavy menstrual bleeding was found in 17.79% women and pelvic pain in 16.10% women. The expulsion rate was 5.08% and IUCD removal was done in 12.71% women. Though, the incidence of expulsion and removal rate was more in vaginal insertions than in caesarean insertions but this difference was not statistically significant, while the incidence of missing threads were found more in intra caesarean insertion (28% vs. 11.76% with p value <0.05). Continuation rate at 6 month was 82.20%.Conclusions: PPIUCD insertion is a safe, convenient and effective method of contraception. Although the expulsion rate and removal rate was more in vaginal PPIUCD insertions, the benefits of providing highly effective contraception immediately after delivery outweigh this disadvantage, particularly in our country where most of the women do not come for contraceptive advice after delivery.

scholarly journals ”Hvis man havde set mig som menneske fremfor bare min skade” – Indefra-perspektiver på dansk neurorehabilitering

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Chalotte Glintborg
Keyword(s):  
Brain Injury ◽  
Empirical Data ◽  
Acquired Brain Injury ◽  
Human Being ◽  
Study Analysis ◽  
Neurological Disability ◽  
Rehabilitation Process ◽  
Follow Up Study ◽  
Master Status

Øvrig forfatter: Dorthe Birkmose, cand.psych., selvstændig psykolog og kursusleder.  ResuméFormålet med denne artikel er at se nærmere på, hvordan mennesker oplever at blive mødt i hjerneskaderehabiliteringen i Danmark. Empirisk trækkes der på interviews med de 82 personer, der indgik i ph.d.-afhandlingen ”Grib mennesket” (Glintborg, 2015) samt et opfølgningsstudie efter 5 år. Analyserne trækker på diskurspsykologi og narrativ teori til at udforske fortællinger og diskurser om personer med erhvervede hjerneskader. Analyserne viser, at det individuelle aspekt kan blive skubbet til side af et for stort fokus på hjerneskaden. Konklusionen er, at der er et behov for en professionalisme, der i højere grad balancerer den neurofaglige viden med indefra-perspektivet hos det enkelte menneske.AbstraktThe aim of this study was to explore how Danish adults with an acquired brain injury (ABI) experience encounters with professionals during their rehabilitation process. The study draws on empirical data from 82 adults with moderate to severe ABI collected as part of a Ph.D. project (Glintborg, 2015) and a 5-year follow up study. Analysis reveal that once diagnosed with ABI, this label can take a master status in encounters with professionals. Professionals' reification of the diagnosis of brain injury can be oppressive because it subjugates humanity such that everything a person does can be interpreted as part of the neurological disability. We conclude that there is a need for a new kind of professionalism that balance the diagnostic lens with a lens on the person as a human being.

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