Automated Assessment of Thoracic-Abdominal Asynchrony in Patients with Morquio Syndrome

Morquio syndrome is a rare disease caused by a disorder in the storage of mucopolysaccharides that affects multiple organs, including musculoskeletal, respiratory, cardiovascular, and digestive systems. Respiratory failure is one of the leading causes of mortality in Morquio patients; thus, respiratory function testing is vital to the management of the disease. An automated respiratory assessment methodology using the pneuRIP device and a machine-learning algorithm was developed. pneuRIP is a noninvasive approach that uses differences between thoracic and abdominal movements (thoracic-abdominal asynchrony) during respiration to assess respiratory status. The technique was evaluated on 17 patients with Morquio (9 females and 8 males) between the ages of 2 and 57 years. The results of the automated technique agreed with the clinical assessment in 16 out of the 17 patients. It was found that the inverse cumulative percentage representation of the time delay between the thorax and abdomen was the most critical variable for accurate evaluation. It was demonstrated that the technique could be successfully used on patients with Morquio who have difficulty breathing with 100% compliance. This technique is highly accurate, portable, noninvasive, and easy to administer, making it suitable for a variety of settings, such as outpatient clinics, at home, and emergency rooms.

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Acute, medium and long-term effects of yellow sand and air pollutants on allergy and biomarker search

Impact ◽

10.21820/23987073.2020.3.63 ◽

2020 ◽

Vol 2020 (3) ◽

pp. 63-65

Author(s):

Tomomi Higashi

Keyword(s):

Air Pollutants ◽

Genetic Factors ◽

Long Term Effects ◽

Emergency Rooms ◽

Improve Treatment ◽

Treatment And Prevention ◽

Chronic Effects ◽

Difficulty Breathing ◽

Acute And Chronic Effects

Talk to any allergy sufferer and they will tell you how awful it can be. Runny noses, itchy eyes, coughing and difficulties breathing. For many these symptoms rise only to the level of annoyance and can be avoided by steering clear of the source of their allergy. What many people don't realise though is that allergies can become a far more serious issue for a large segment of the population. Shortness of breath and difficulty breathing due to allergies bring many people to emergency rooms and these are just the acute symptoms. Along with the potential for an allergic attack during a windy or dusty day, researchers and medical professionals are beginning to recognise that there are chronic, long term effects associated with allergies. In order to mitigate both the acute and chronic effects of allergies a better understanding of how genetic factors combine with environmental conditions to produce the ranges of symptoms and effects of allergy suffers is needed. Professor Tomomi Higashi, from the Department of Hygiene at Kanazawa University in Japan, is an expert in this field and is currently working to improve treatment and prevention of allergic disease.

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Metered-Dose Inhalers for Young Athletes With Exercise-Induced Asthma

PEDIATRICS ◽

10.1542/peds.94.1.129 ◽

1994 ◽

Vol 94 (1) ◽

pp. 129-130 ◽

Cited By ~ 3

Author(s):

Keyword(s):

Pulmonary Function ◽

Physical Exertion ◽

Pulmonary Function Testing ◽

Dose Inhaler ◽

Metered Dose Inhalers ◽

Metered Dose ◽

Difficulty Breathing ◽

Exercise Induced ◽

Function Testing

Bronchoconstriction can occur in association with exercise in up to 15% of the general population, including nearly 100% of people with asthma, 35% to 40% of those with allergic rhinitis, and some who have no other evidence of allergy.1 This phenomenon, termed exercise-induced asthma (EIA), is manifested by coughing, choking, chest pain, easy fatigability, shortness of breath, wheezing, chest tightness, or any combination of these symptoms during, or especially after, exercise. In a child known to have asthma or nasal allergies, the diagnosis of EIA can usually be made on the basis of history alone. Repeated episodes of increased difficulty breathing or cough in association with physical exertion should be assumed to be EIA until proved otherwise. Sophisticated pulmonary function testing is not necessary in the majority of cases. In the atypical case, pulmonary function testing, often in conjunction with an exercise challenge, can confirm the diagnosis. Exercise-induced asthma is less likely to occur in a child whose asthma is well controlled,1 a goal accomplished best with attention to the role of airway inflammation as well as bronchoconstriction.2 Fortunately, EIA can be controlled in most athletes by the inhalation of a β2-agonist bronchodilator (eg, albuterol), cromolyn sodium, or both 15 to 30 minutes before exercise. These safe medications come in several different forms, but the most convenient for patients older than 2 or 3 years is the pressurized metered-dose inhaler (MDI), which is especially easy to use with the addition of a spacing device. Cromolyn has never been thought to be effective as an ergogenic (performance-enhancing) aid,3 and only two studies have suggested the possibility that albuterol is ergogenic.4,5

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Survey of Penetration Injuries Caused to Major Operation on Patients Refer to Tonekabon Shahid Rajaee Hospital, Mazandaran North of Iran during 2015-2016

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v17i3.37005 ◽

2018 ◽

Vol 17 (3) ◽

pp. 484-488

Author(s):

M Pouya ◽

Babak Khodadadi ◽

V Khodadadi

Keyword(s):

Significant Relationship ◽

Medical Science ◽

Penetrating Trauma ◽

Emergency Rooms ◽

Common Causes ◽

Major Operation ◽

North Of Iran ◽

Causes Of Mortality ◽

Specific Reason

Introduction: Trauma is considered as one of the major causes of mortality in the World and in Iran. Which, many people die each year. The aim of study we evaluated penetrating traumas as Specific reason of deaths among affected patients.Materials and Methods: In this crosssectional retrospective study, 73patients with penetrating traumas visiting Shahid Rajaee hospital of Tonekabon in 2015-16were evaluated, then, the files were extracted from hospital archive files and information of patients such as age, sex, The type of agent and the cause of the injury, the reasons for the surgery and the type of surgery were recorded from the archived files, then, The data were statistically analyzed by the SPSS software.Results: Based on the findings, over the 60 (80 %) of patients were males, that was a significant relationship between sex and penetrating trauma. Also, the most common were penetrating trauma in the age group of 21-35 years old. There was a significant relationship between age and penetrating traumas (p<0.05), it should be noted that, other variables in this studies were not related significantly withthepenetrating trauma in patients. (p>0.05).Conclusion: The more common causes of penetrating traumas among young are Damage from driving accidents which require better Facilities to manage them. Also, the role of emergency rooms and the provision of equipment to reduce mortality from penetrating trauma can be mentioned.Bangladesh Journal of Medical Science Vol.17(3) 2018 p.484-488

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