Reply to Jue et al. Value of MRI to Improve Deep Learning Model That Identifies High-Grade Prostate Cancer. Comment on “Gentile et al. Optimized Identification of High-Grade Prostate Cancer by Combining Different PSA Molecular Forms and PSA Density in a Deep Learning Model. Diagnostics 2021, 11, 335”

Prostate-specific antigen (PSA) has been criticized for its low specificity for prostate cancer, which has led to the increased adoption of additional biomarkers, PSA density (PSAD), and multiparametric magnetic resonance imaging (mpMRI) to increase the localization, risk stratification, and diagnosis of prostate cancer [...]

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Classification of Clinically Significant Prostate Cancer on Multi-Parametric MRI: A Validation Study Comparing Deep Learning and Radiomics

Cancers ◽

10.3390/cancers14010012 ◽

2021 ◽

Vol 14 (1) ◽

pp. 12

Author(s):

Jose M. Castillo T. ◽

Muhammad Arif ◽

Martijn P. A. Starmans ◽

Wiro J. Niessen ◽

Chris H. Bangma ◽

...

Keyword(s):

Prostate Cancer ◽

Deep Learning ◽

Characteristic Curve ◽

Model Development ◽

Learning Model ◽

Multiparametric Mri ◽

Data Sets ◽

Data Set ◽

Test Sets ◽

Deep Learning Model

The computer-aided analysis of prostate multiparametric MRI (mpMRI) could improve significant-prostate-cancer (PCa) detection. Various deep-learning- and radiomics-based methods for significant-PCa segmentation or classification have been reported in the literature. To be able to assess the generalizability of the performance of these methods, using various external data sets is crucial. While both deep-learning and radiomics approaches have been compared based on the same data set of one center, the comparison of the performances of both approaches on various data sets from different centers and different scanners is lacking. The goal of this study was to compare the performance of a deep-learning model with the performance of a radiomics model for the significant-PCa diagnosis of the cohorts of various patients. We included the data from two consecutive patient cohorts from our own center (n = 371 patients), and two external sets of which one was a publicly available patient cohort (n = 195 patients) and the other contained data from patients from two hospitals (n = 79 patients). Using multiparametric MRI (mpMRI), the radiologist tumor delineations and pathology reports were collected for all patients. During training, one of our patient cohorts (n = 271 patients) was used for both the deep-learning- and radiomics-model development, and the three remaining cohorts (n = 374 patients) were kept as unseen test sets. The performances of the models were assessed in terms of their area under the receiver-operating-characteristic curve (AUC). Whereas the internal cross-validation showed a higher AUC for the deep-learning approach, the radiomics model obtained AUCs of 0.88, 0.91 and 0.65 on the independent test sets compared to AUCs of 0.70, 0.73 and 0.44 for the deep-learning model. Our radiomics model that was based on delineated regions resulted in a more accurate tool for significant-PCa classification in the three unseen test sets when compared to a fully automated deep-learning model.

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Volumetric modulated arc therapy dose prediction and deliverable treatment plan generation for prostate cancer patients using a densely connected deep learning model

Physics and Imaging in Radiation Oncology ◽

10.1016/j.phro.2021.07.008 ◽

2021 ◽

Vol 19 ◽

pp. 112-119

Author(s):

Michael Lempart ◽

Hunor Benedek ◽

Mikael Nilsson ◽

Niklas Eliasson ◽

Sven Bäck ◽

...

Keyword(s):

Prostate Cancer ◽

Deep Learning ◽

Cancer Patients ◽

Treatment Plan ◽

Volumetric Modulated Arc Therapy ◽

Learning Model ◽

Plan Generation ◽

Dose Prediction ◽

Arc Therapy ◽

Deep Learning Model

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Combination possibility and deep learning model as clinical decision-aided approach for prostate cancer

Health Informatics Journal ◽

10.1177/1460458219855884 ◽

2019 ◽

Vol 26 (2) ◽

pp. 945-962 ◽

Cited By ~ 3

Author(s):

Okyaz Eminaga ◽

Omran Al-Hamad ◽

Martin Boegemann ◽

Bernhard Breil ◽

Axel Semjonow

Keyword(s):

Prostate Cancer ◽

Deep Learning ◽

Gleason Score ◽

Clinical Decision ◽

Learning Model ◽

Classification Performance ◽

Study Data ◽

Learning Approaches ◽

Tumor Stages ◽

Deep Learning Model

This study aims to introduce as proof of concept a combination model for classification of prostate cancer using deep learning approaches. We utilized patients with prostate cancer who underwent surgical treatment representing the various conditions of disease progression. All possible combinations of significant variables from logistic regression and correlation analyses were determined from study data sets. The combination possibility and deep learning model was developed to predict these combinations that represented clinically meaningful patient’s subgroups. The observed relative frequencies of different tumor stages and Gleason score Gls changes from biopsy to prostatectomy were available for each group. Deep learning models and seven machine learning approaches were compared for the classification performance of Gleason score changes and pT2 stage. Deep models achieved the highest F1 scores by pT2 tumors (0.849) and Gls change (0.574). Combination possibility and deep learning model is a useful decision-aided tool for prostate cancer and to group patients with prostate cancer into clinically meaningful groups.

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Optimized Identification of High-Grade Prostate Cancer by Combining Different PSA Molecular Forms and PSA Density in a Deep Learning Model

Diagnostics ◽

10.3390/diagnostics11020335 ◽

2021 ◽

Vol 11 (2) ◽

pp. 335

Author(s):

Francesco Gentile ◽

Matteo Ferro ◽

Bartolomeo Della Ventura ◽

Evelina La Civita ◽

Antonietta Liotti ◽

...

Keyword(s):

Prostate Cancer ◽

Prostate Biopsy ◽

Specific Antigen ◽

Molecular Forms ◽

Psa Density ◽

Prostate Specific Antigen Test ◽

Free Psa ◽

Artificial Neuronal Networks ◽

Total Psa ◽

Deep Learning Model

After skin cancer, prostate cancer (PC) is the most common cancer among men. The gold standard for PC diagnosis is based on the PSA (prostate-specific antigen) test. Based on this preliminary screening, the physician decides whether to proceed with further tests, typically prostate biopsy, to confirm cancer and evaluate its aggressiveness. Nevertheless, the specificity of the PSA test is suboptimal and, as a result, about 75% of men who undergo a prostate biopsy do not have cancer even if they have elevated PSA levels. Overdiagnosis leads to unnecessary overtreatment of prostate cancer with undesirable side effects, such as incontinence, erectile dysfunction, infections, and pain. Here, we used artificial neuronal networks to develop models that can diagnose PC efficiently. The model receives as an input a panel of 4 clinical variables (total PSA, free PSA, p2PSA, and PSA density) plus age. The output of the model is an estimate of the Gleason score of the patient. After training on a dataset of 190 samples and optimization of the variables, the model achieved values of sensitivity as high as 86% and 89% specificity. The efficiency of the method can be improved even further by training the model on larger datasets.

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Deep Learning Model Selection of Suboptimal Complexity

Автоматика и телемеханика ◽

10.31857/s000523100001252-1 ◽

2018 ◽

pp. 129-147

Author(s):

Oleg Bakhteev ◽

◽

Vadim Strijov ◽

Keyword(s):

Deep Learning ◽

Model Selection ◽

Learning Model ◽

Deep Learning Model ◽

Selection Of

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Improving Sentiment Analysis using Hybrid Deep Learning Model

Recent Advances in Computer Science and Communications ◽

10.2174/2213275912666190328200012 ◽

2020 ◽

Vol 13 (4) ◽

pp. 627-640 ◽

Cited By ~ 1

Author(s):

Avinash Chandra Pandey ◽

Dharmveer Singh Rajpoot

Keyword(s):

Neural Network ◽

Deep Learning ◽

Sentiment Analysis ◽

Classification Accuracy ◽

Short Term Memory ◽

Computational Cost ◽

Extraction Process ◽

Learning Model ◽

Sentiment Classification ◽

Deep Learning Model

Background: Sentiment analysis is a contextual mining of text which determines viewpoint of users with respect to some sentimental topics commonly present at social networking websites. Twitter is one of the social sites where people express their opinion about any topic in the form of tweets. These tweets can be examined using various sentiment classification methods to find the opinion of users. Traditional sentiment analysis methods use manually extracted features for opinion classification. The manual feature extraction process is a complicated task since it requires predefined sentiment lexicons. On the other hand, deep learning methods automatically extract relevant features from data hence; they provide better performance and richer representation competency than the traditional methods. Objective: The main aim of this paper is to enhance the sentiment classification accuracy and to reduce the computational cost. Method: To achieve the objective, a hybrid deep learning model, based on convolution neural network and bi-directional long-short term memory neural network has been introduced. Results: The proposed sentiment classification method achieves the highest accuracy for the most of the datasets. Further, from the statistical analysis efficacy of the proposed method has been validated. Conclusion: Sentiment classification accuracy can be improved by creating veracious hybrid models. Moreover, performance can also be enhanced by tuning the hyper parameters of deep leaning models.

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