scholarly journals Combination possibility and deep learning model as clinical decision-aided approach for prostate cancer

2019 ◽  
Vol 26 (2) ◽  
pp. 945-962 ◽  
Author(s):  
Okyaz Eminaga ◽  
Omran Al-Hamad ◽  
Martin Boegemann ◽  
Bernhard Breil ◽  
Axel Semjonow
Keyword(s):  
Prostate Cancer ◽  
Deep Learning ◽  
Gleason Score ◽  
Clinical Decision ◽  
Learning Model ◽  
Classification Performance ◽  
Study Data ◽  
Learning Approaches ◽  
Tumor Stages ◽  
Deep Learning Model

This study aims to introduce as proof of concept a combination model for classification of prostate cancer using deep learning approaches. We utilized patients with prostate cancer who underwent surgical treatment representing the various conditions of disease progression. All possible combinations of significant variables from logistic regression and correlation analyses were determined from study data sets. The combination possibility and deep learning model was developed to predict these combinations that represented clinically meaningful patient’s subgroups. The observed relative frequencies of different tumor stages and Gleason score Gls changes from biopsy to prostatectomy were available for each group. Deep learning models and seven machine learning approaches were compared for the classification performance of Gleason score changes and pT2 stage. Deep models achieved the highest F1 scores by pT2 tumors (0.849) and Gls change (0.574). Combination possibility and deep learning model is a useful decision-aided tool for prostate cancer and to group patients with prostate cancer into clinically meaningful groups.

scholarly journals An Efficient DenseNet-Based Deep Learning Model for Malware Detection

Entropy ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 344
Author(s):  
Jeyaprakash Hemalatha ◽  
S. Abijah Roseline ◽  
Subbiah Geetha ◽  
Seifedine Kadry ◽  
Robertas Damaševičius
Keyword(s):  
Deep Learning ◽  
Detection System ◽  
Malware Detection ◽  
Class Imbalance ◽  
Learning Model ◽  
Computational Time ◽  
Learning Approaches ◽  
Security Threat ◽  
Static And Dynamic Analysis ◽  
Deep Learning Model

Recently, there has been a huge rise in malware growth, which creates a significant security threat to organizations and individuals. Despite the incessant efforts of cybersecurity research to defend against malware threats, malware developers discover new ways to evade these defense techniques. Traditional static and dynamic analysis methods are ineffective in identifying new malware and pose high overhead in terms of memory and time. Typical machine learning approaches that train a classifier based on handcrafted features are also not sufficiently potent against these evasive techniques and require more efforts due to feature-engineering. Recent malware detectors indicate performance degradation due to class imbalance in malware datasets. To resolve these challenges, this work adopts a visualization-based method, where malware binaries are depicted as two-dimensional images and classified by a deep learning model. We propose an efficient malware detection system based on deep learning. The system uses a reweighted class-balanced loss function in the final classification layer of the DenseNet model to achieve significant performance improvements in classifying malware by handling imbalanced data issues. Comprehensive experiments performed on four benchmark malware datasets show that the proposed approach can detect new malware samples with higher accuracy (98.23% for the Malimg dataset, 98.46% for the BIG 2015 dataset, 98.21% for the MaleVis dataset, and 89.48% for the unseen Malicia dataset) and reduced false-positive rates when compared with conventional malware mitigation techniques while maintaining low computational time. The proposed malware detection solution is also reliable and effective against obfuscation attacks.

scholarly journals Classification of Clinically Significant Prostate Cancer on Multi-Parametric MRI: A Validation Study Comparing Deep Learning and Radiomics

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 12
Author(s):  
Jose M. Castillo T. ◽  
Muhammad Arif ◽  
Martijn P. A. Starmans ◽  
Wiro J. Niessen ◽  
Chris H. Bangma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Deep Learning ◽  
Characteristic Curve ◽  
Model Development ◽  
Learning Model ◽  
Multiparametric Mri ◽  
Data Sets ◽  
Data Set ◽  
Test Sets ◽  
Deep Learning Model

The computer-aided analysis of prostate multiparametric MRI (mpMRI) could improve significant-prostate-cancer (PCa) detection. Various deep-learning- and radiomics-based methods for significant-PCa segmentation or classification have been reported in the literature. To be able to assess the generalizability of the performance of these methods, using various external data sets is crucial. While both deep-learning and radiomics approaches have been compared based on the same data set of one center, the comparison of the performances of both approaches on various data sets from different centers and different scanners is lacking. The goal of this study was to compare the performance of a deep-learning model with the performance of a radiomics model for the significant-PCa diagnosis of the cohorts of various patients. We included the data from two consecutive patient cohorts from our own center (n = 371 patients), and two external sets of which one was a publicly available patient cohort (n = 195 patients) and the other contained data from patients from two hospitals (n = 79 patients). Using multiparametric MRI (mpMRI), the radiologist tumor delineations and pathology reports were collected for all patients. During training, one of our patient cohorts (n = 271 patients) was used for both the deep-learning- and radiomics-model development, and the three remaining cohorts (n = 374 patients) were kept as unseen test sets. The performances of the models were assessed in terms of their area under the receiver-operating-characteristic curve (AUC). Whereas the internal cross-validation showed a higher AUC for the deep-learning approach, the radiomics model obtained AUCs of 0.88, 0.91 and 0.65 on the independent test sets compared to AUCs of 0.70, 0.73 and 0.44 for the deep-learning model. Our radiomics model that was based on delineated regions resulted in a more accurate tool for significant-PCa classification in the three unseen test sets when compared to a fully automated deep-learning model.

scholarly journals Comparison between Deep Learning and Tree-Based Machine Learning Approaches for Landslide Susceptibility Mapping

Water ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 2664
Author(s):  
Sunil Saha ◽  
Jagabandhu Roy ◽  
Tusar Kanti Hembram ◽  
Biswajeet Pradhan ◽  
Abhirup Dikshit ◽  
...  
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Deep Learning ◽  
Landslide Susceptibility ◽  
Learning Model ◽  
Susceptibility Mapping ◽  
Landslide Susceptibility Mapping ◽  
Learning Approaches ◽  
Statistical Measures ◽  
Deep Learning Model

The efficiency of deep learning and tree-based machine learning approaches has gained immense popularity in various fields. One deep learning model viz. convolution neural network (CNN), artificial neural network (ANN) and four tree-based machine learning models, namely, alternative decision tree (ADTree), classification and regression tree (CART), functional tree and logistic model tree (LMT), were used for landslide susceptibility mapping in the East Sikkim Himalaya region of India, and the results were compared. Landslide areas were delimited and mapped as landslide inventory (LIM) after gathering information from historical records and periodic field investigations. In LIM, 91 landslides were plotted and classified into training (64 landslides) and testing (27 landslides) subsets randomly to train and validate the models. A total of 21 landslide conditioning factors (LCFs) were considered as model inputs, and the results of each model were categorised under five susceptibility classes. The receiver operating characteristics curve and 21 statistical measures were used to evaluate and prioritise the models. The CNN deep learning model achieved the priority rank 1 with area under the curve of 0.918 and 0.933 by using the training and testing data, quantifying 23.02% and 14.40% area as very high and highly susceptible followed by ANN, ADtree, CART, FTree and LMT models. This research might be useful in landslide studies, especially in locations with comparable geophysical and climatological characteristics, to aid in decision making for land use planning.

scholarly journals ECOVNet: a highly effective ensemble based deep learning model for detecting COVID-19

2021 ◽  
Vol 7 ◽  
pp. e551
Author(s):  
Nihad Karim Chowdhury ◽  
Muhammad Ashad Kabir ◽  
Md. Muhtadir Rahman ◽  
Noortaz Rezoana
Keyword(s):  
Deep Learning ◽  
Detection System ◽  
Learning Model ◽  
Classification Performance ◽  
Data Sets ◽  
X Rays ◽  
Proposed Model ◽  
Highly Effective ◽  
Chest X Ray ◽  
Deep Learning Model

The goal of this research is to develop and implement a highly effective deep learning model for detecting COVID-19. To achieve this goal, in this paper, we propose an ensemble of Convolutional Neural Network (CNN) based on EfficientNet, named ECOVNet, to detect COVID-19 from chest X-rays. To make the proposed model more robust, we have used one of the largest open-access chest X-ray data sets named COVIDx containing three classes—COVID-19, normal, and pneumonia. For feature extraction, we have applied an effective CNN structure, namely EfficientNet, with ImageNet pre-training weights. The generated features are transferred into custom fine-tuned top layers followed by a set of model snapshots. The predictions of the model snapshots (which are created during a single training) are consolidated through two ensemble strategies, i.e., hard ensemble and soft ensemble, to enhance classification performance. In addition, a visualization technique is incorporated to highlight areas that distinguish classes, thereby enhancing the understanding of primal components related to COVID-19. The results of our empirical evaluations show that the proposed ECOVNet model outperforms the state-of-the-art approaches and significantly improves detection performance with 100% recall for COVID-19 and overall accuracy of 96.07%. We believe that ECOVNet can enhance the detection of COVID-19 disease, and thus, underpin a fully automated and efficacious COVID-19 detection system.

scholarly journals Reply to Jue et al. Value of MRI to Improve Deep Learning Model That Identifies High-Grade Prostate Cancer. Comment on “Gentile et al. Optimized Identification of High-Grade Prostate Cancer by Combining Different PSA Molecular Forms and PSA Density in a Deep Learning Model. Diagnostics 2021, 11, 335”

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1214
Author(s):  
Francesco Gentile ◽  
Matteo Ferro ◽  
Bartolomeo Della Ventura ◽  
Evelina La Civita ◽  
Antonietta Liotti ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Deep Learning ◽  
Learning Model ◽  
Molecular Forms ◽  
Model Diagnostics ◽  
High Grade ◽  
Psa Density ◽  
Deep Learning Model

In their comment “Value of MRI to Improve Deep Learning Model That Identifies High-Grade Prostate Cancer [...]

scholarly journals Using deep learning for trajectory classification in imbalanced dataset

2021 ◽  
Vol 34 (1) ◽  
Author(s):  
Nicksson Ckayo Arrais de Freitas ◽  
Ticiana L. Coelho Da Silva ◽  
José Antônio Fernandes De Macêdo ◽  
Leopoldo Melo Júnioer
Keyword(s):  
Deep Learning ◽  
Classification Problem ◽  
Learning Model ◽  
Learning Approaches ◽  
Imbalanced Dataset ◽  
Imbalanced Datasets ◽  
Learning Techniques ◽  
Trajectory Classification ◽  
Low Performance ◽  
Deep Learning Model

Deep learning has gained much popularity in the past years due to GPU advancements, cloud computing improvements, and its supremacy, considering the accuracy results when trained on massive datasets. As with machine learning, deep learning models may experience low performance when handled with imbalanced datasets. In this paper, we focus on the trajectory classification problem, and we examine deep learning techniques for coping with imbalanced class data. We extend a deep learning model, called DeepeST (Deep Learning for Sub-Trajectory classification), to predict the class or label for sub-trajectories from imbalanced datasets. DeepeST is the first deep learning model for trajectory classification that provides approaches for coping with imbalanced dataset problems from the authors' knowledge. In this paper, we perform the experiments with three real datasets from LBSN (Location-Based Social Network) trajectories to identify who is the user of a sub-trajectory (similar to the Trajectory-User Linking problem). We show that DeepeST outperforms other deep learning approaches from state-of-the-art concerning the accuracy, precision, recall, and F1-score.

scholarly journals Value of MRI to Improve Deep Learning Model That Identifies High-Grade Prostate Cancer. Comment on Gentile et al. Optimized Identification of High-Grade Prostate Cancer by Combining Different PSA Molecular Forms and PSA Density in a Deep Learning Model. Diagnostics 2021, 11, 335

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1213
Author(s):  
Joshua S. Jue ◽  
David Mikhail ◽  
Javier González ◽  
Mahmoud Alameddine
Keyword(s):  
Prostate Cancer ◽  
Deep Learning ◽  
Specific Antigen ◽  
Learning Model ◽  
Molecular Forms ◽  
Model Diagnostics ◽  
High Grade ◽  
Resonance Imaging ◽  
Psa Density ◽  
Deep Learning Model

Prostate-specific antigen (PSA) has been criticized for its low specificity for prostate cancer, which has led to the increased adoption of additional biomarkers, PSA density (PSAD), and multiparametric magnetic resonance imaging (mpMRI) to increase the localization, risk stratification, and diagnosis of prostate cancer [...]

scholarly journals An Efficient Method for Capturing the High Peak Concentrations of PM2.5 Using Gaussian-Filtered Deep Learning

2021 ◽  
Vol 13 (21) ◽  
pp. 11889
Author(s):  
Inchoon Yeo ◽  
Yunsoo Choi
Keyword(s):  
Deep Learning ◽  
Learning Model ◽  
High Peak ◽  
Environmental Research ◽  
Quality Data ◽  
Learning Approaches ◽  
Gaussian Filter ◽  
High Concentration ◽  
Concentration Data ◽  
Deep Learning Model

This paper proposes a deep learning model that integrates a convolutional neural network with a gate circulation unit that captures patterns of high-peak PM2.5 concentrations. The purpose is to accurately predict high-peak PM2.5 concentration data that cannot be trained in general deep learning models. For the training of the proposed model, we used all available weather and air quality data for three years from 2015 to 2017 from 25 stations of the National Institute of Environmental Research (NIER) and the Korea Meteorological Administration (KMA) observatory in Seoul, South Korea. Our model trained three years of data and predicted high-peak PM2.5 concentrations for the year 2018. In addition, we propose a Gaussian filter algorithm as a preprocessing method for capturing high concentrations of PM2.5 in the Seoul area and predicting them more accurately. This model overcomes the limitations of conventional deep learning approaches that are unable to predict high peak PM2.5 concentrations. Comparing model measurements at each of the 25 monitoring sites in 2018, we found that the deep learning model with a Gaussian filter achieved an index of agreement of 0.73–0.89 and a proportion of correctness of 0.89–0.96, and compared to the conventional deep learning method (average POC = 0.85), the Gaussian filter algorithm (average POC = 0.94) improved the accuracy of high-concentration PM2.5 prediction by an average of about 9%. Applying this algorithm in the preprocessing stage could be updated to predict the risk of high PM2.5 concentrations in real time.

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