scholarly journals Argon Bioactivation of Implants Installed Simultaneously to Maxillary Sinus Lifting without Graft. An Experimental Study in Rabbits

2021 ◽  
Vol 9 (9) ◽  
pp. 105
Author(s):  
Yuki Omori ◽  
Daniele Botticelli ◽  
Mauro Ferri ◽  
Rafael Delgado-Ruiz ◽  
Vitor Ferreira Balan ◽  
...  
Keyword(s):  
Experimental Studies ◽  
Argon Plasma ◽  
Titanium Implants ◽  
Implant Surface ◽  
Sinus Augmentation ◽  
Bone Apposition ◽  
Sinus Lifting ◽  
Almost All ◽  
And Control ◽  
Sinus Mucosa

Background: The treatment of the surface of titanium implants with argon plasma improved its hydrophilicity and cell adhesion, resulting in higher bone apposition on implant and graft surfaces. The spontaneous perforation over time of the sinus mucosa after sinus augmentation has been documented in experimental studies at both implants and graft particles. The aim of the present study was to evaluate the influence of plasma argon treatment of the implant surface on bone apposition and on the rate of sinus mucosa perforations. Methods: A sinus lifting procedure was performed bilaterally in sixteen rabbits, and implants, either treated with argon plasma or left without treatment (control), were placed simultaneously without grafts. After 8 weeks, histological analyses were carried out. Results: A collapse of the sinus mucosa was observed at all implants. Twenty-four out of thirty-two implants presented sinus mucosa perforations at the apex. Several perforations were also found at the threads. Thinned mucosa sites (width < 40 µm) were found around almost all implants. About 2.6–2.9 mm of the apical regions of the implant did not present signs of osseointegration and about 1.3 mm were exposed to the sinus cavity. No statistically significant differences were found between plasma and control sites. Conclusions: In conclusion, the sinus mucosa was damaged and perforated by direct contact with treated and non-treated implant surfaces. The treatment of the implant surface with argon plasma did not affect the outcomes.

scholarly journals Sinus Mucosa Thinning and Perforations after Sinus Lifting Performed with Different Xenografts: A Histological Analysis in Rabbits

2021 ◽  
Vol 10 (1) ◽  
pp. 2
Author(s):  
Riccardo Favero ◽  
Karol Alí Apaza Alccayhuaman ◽  
Daniele Botticelli ◽  
Samuel Porfirio Xavier ◽  
Vitor Ferreira Balan ◽  
...  
Keyword(s):  
Histological Analysis ◽  
Experimental Studies ◽  
The Other ◽  
Bovine Bone ◽  
Sinus Augmentation ◽  
Different Types ◽  
Sinus Lifting ◽  
Sinus Mucosa ◽  
New Zealand Rabbits ◽  
Deproteinized Bovine Bone

Background: Experimental studies have shown a progressive thinning and perforations of the sinus mucosa associated with sharpened edges and the cutting projections of graft particles used simultaneously for maxillary sinus augmentation. Hence, the aim of the present study was to evaluate the damaging effects of two different bovine grafts on the sinus mucosa after sinus augmentation. Methods: Twenty New Zealand rabbits received a bilateral sinus lifting using, as fillers, two different types of deproteinized bovine bone in granules, one processed at low temperature (low-T group), and the other at high temperature (high-T group). Thinned mucosa sites (<40 µm) and perforations were evaluated in the sinus mucosa that were in contact with graft granules after 2 and 10 weeks, in ten animals per period. Results: After 2 weeks of healing, the number of thinned mucosa sites was 118 in the low-T group, and 149 in the high-T group (p = 0.191). At the 10-week assessment, the thinned sites increased to 237 and 195 sites, respectively. The numbers of sinus mucosa perforations after 2 weeks were eight and three in the low-T and high-T group, respectively. At the 10-week evaluation, the perforations increased to 19 in the low-T group, and to 14 in the high-T group. Conclusions: The contact with bovine xenografts yielded thinning and perforations of the sinus mucosa. Despite the differences in characteristics and dimensions, no differences were found between the two xenografts in the numbers of thinning mucosa sites and perforations. However, a trend of more events was found in the low-T compared to the high-T group.

scholarly journals Effect of Plasma of Argon Treated Implants on Bone Density: A Randomized, Controlled, Histomorphometric Study in Dogs

2018 ◽  
Vol 12 (1) ◽  
pp. 937-945
Author(s):  
Kazushige Tanaka ◽  
Erick Ricardo Silva ◽  
Shunsuke Kawakami ◽  
Luigi Canullo ◽  
Daniele Botticelli ◽  
...  
Keyword(s):  
Bone Density ◽  
Argon Plasma ◽  
Surface Characteristics ◽  
Titanium Implants ◽  
Treatment Control ◽  
Implant Surface ◽  
Randomized Controlled ◽  
Histomorphometric Study ◽  
Short Time ◽  
And Control

Background: Altering surface characteristics by increasing its energy and hydrophilicity will accelerate the interaction between cells and implant surface. Energy and hydrophilicity tend to disappear over a short time. The implant surface may be reactivated by the use of argon plasma Objective: To assess bone density at cleaned and activated titanium implants using argon plasma. Methods: Mandibular premolars and first molars were extracted bilaterally in eight Beagle dogs. After three months, four implants, two treated with argon plasma (test; plasma) and two left without treatment (control), were randomly installed in one side of the mandible. Abutments were applied on the implants and a non-submerged healing was allowed. After one month, the same surgical procedures were adopted on the opposite side of the mandible. The animals were euthanized after one month and ground sections representing the healing after 1 and 2 months were obtained for histological examination. Results: No statistically significant differences were found between test and control sites (p < 0.05). After 1 month of healing, new bone was 32.5 ± 12.2% and 33.8 ± 8.8% at the plasma and control sites, respectively. After 2 months, the respective values were 50.8 ± 21.5% and 47.6 ± 15.6%. Conclusion: The treatment of the implant surface with argon plasma did not have a significant effect on bone density around implants.

Histologic Evaluation of a Provisional Implant Retrieved From Man 7 Months After Placement in a Sinus Augmented With Calcium Sulphate: A Case Report

2007 ◽  
Vol 33 (2) ◽  
pp. 89-95 ◽  
Author(s):  
Giovanna Iezzi ◽  
Elisabetta Fiera ◽  
Antonio Scarano ◽  
Gabriele Pecora ◽  
Adriano Piattelli
Keyword(s):  
Close Contact ◽  
Calcium Sulphate ◽  
Titanium Implants ◽  
Implant Surface ◽  
Sinus Augmentation ◽  
Bone Implant ◽  
Native Bone ◽  
Osteocyte Lacunae ◽  
Histologic Evaluation

Abstract Little is known about the in vivo healing processes at the interface of implants placed in different grafting materials. For optimal sinus augmentation, a bone graft substitute that can regenerate high-quality bone and enable the osseointegration of load-bearing titanium implants is needed in clinical practice. Calcium sulphate (CaS) is one of the oldest biomaterials used in medicine, but few studies have addressed its use as a sinus augmentation material in conjunction with simultaneous implant placement. The aim of the present study was to histologically evaluate an immediately loaded provisional implant retrieved 7 months after simultaneous placement in a human sinus grafted with CaS. During retrieval bone detached partially from one of the implants which precluded its use for histologic analysis. The second implant was completely surrounded by native and newly formed bone, and it underwent histologic evaluation. Lamellar bone, with small osteocyte lacunae, was present and in contact with the implant surface. No gaps, epithelial cells, or connective tissues were present at the bone–implant interface. No residual CaS was present. Bone–implant contact percentage was 55% ± 8%. Of this percentage, 40% was represented by native bone and 15% by newly formed bone. CaS showed complete resorption and new bone formation in the maxillary sinus; this bone was found to be in close contact with the implant surface after immediate loading.

scholarly journals Bone-Healing Pattern on the Surface of Titanium Implants at Cortical and Marrow Compartments in Two Topographic Sites: an Experimental Study in Rabbits

Materials ◽  
2018 ◽  
Vol 12 (1) ◽  
pp. 85 ◽  
Author(s):  
David Soto-Peñaloza ◽  
Marco Caneva ◽  
José Viña-Almunia ◽  
José Martín-de-Llano ◽  
David Peñarrocha-Oltra ◽  
...  
Keyword(s):  
Bone Healing ◽  
Titanium Implants ◽  
New Bone Formation ◽  
Implant Surface ◽  
Bone Apposition ◽  
Bone Morphometry ◽  
Implantation Sites ◽  
Healing Bone ◽  
New Zealand Rabbits ◽  
Better Than

This study evaluates the bone-healing patterns on the surface of titanium implants at the cortical and marrow compartments of bicortically-installed implants in the diaphysis and metaphysis of rabbit tibiae. In 27 New Zealand rabbits, two implants, one for each macro-design and with equal resorbable blasted media (RBM) implant surfaces, were randomly implanted in the diaphysis or metaphysis of each tibia. The flaps were sutured to allow submerged healing. The animals were sacrificed after two, four, or eight weeks, with nine weeks used for the period of healing. Ground sections were prepared and analyzed. No statistically significant differences were found between the two groups for newly formed bone in contact with the implant surface after two, four, and eight weeks of healing. Bone apposition in the marrow compartment was slightly higher in the diaphysis compared to metaphysis regions across healing stages. Despite the limitations of the present study, it can be concluded that new bone apposition was better than average in the cortical compartment as compared to the marrow compartments. Bone morphometry and density may affect bone apposition onto the implant surface. The apposition rates were slightly better at both the cortical and marrow compartments in diaphysis as compared to metaphysis sites. The new bone formation at the marrow compartment showed slightly better increasing values at diaphysis compared to metaphysis implantation sites.

scholarly journals Maxillary Sinus Augmentation with Deproteinized Bovine Bone (Bio-Oss®) and Impladent® Dental Implant System Part II. Evaluation of Deprotienized Bovine Bone (Bio-Oss®) and Implant Surface

2002 ◽  
Vol 45 (4) ◽  
pp. 167-171 ◽  
Author(s):  
Samer Kasabah ◽  
Antonín Šimůnek ◽  
Jiří Krug ◽  
Miguel Cevallos Lecaro
Keyword(s):  
Maxillary Sinus ◽  
Titanium Implants ◽  
Autogenous Bone ◽  
Bovine Bone ◽  
Implant Surface ◽  
Sinus Augmentation ◽  
Suitable Material ◽  
Group 2 ◽  
Group 1 ◽  
Deproteinized Bovine Bone

The objective of this clinical study was to determine the predictability of endosseous implant placed in a maxillary sinus augmented with deproteinized bovine bone (Bio-Oss®). A total of 185 implants (109 titanium and 76 hydroxyapatite- coated) were placed in 77 patients representing 92 sinuses either a one- or two-stage surgical technique. A mixture of venous patient’s blood and Bio-Oss® was used alone within 20 sinuses (Group 1), or in combination with autogenous bone within 72 sinuses (Group 2). Thirty-nine implants were placed in Group 1 and 147 implants were inserted in Group 2. The grafted sinuses were evaluated clinically and radiographically at second stage surgery. According to certain criteria, of the implants placed, only two titanium implants (1.08 %) failed with 98.91 % implant survival. There was no statistically variable difference for the use of hydroxyapatite-coated or titanium implants. The two failed implants were from Group 2. No clinical benefit has been achieved from the combination with autogenous bone (P<0.05). All the grafted sinuses were sufficient to place dental implants of at least 12 mm length (100 % graft success). The results of this short-term study support the hypothesis that Bio-Oss® can be a suitable material for sinus augmentation.

scholarly journals Surface Treatment of the Dental Implant with Hyaluronic Acid: An Overview of Recent Data

2021 ◽  
Vol 18 (9) ◽  
pp. 4670
Author(s):  
Gabriele Cervino ◽  
Agron Meto ◽  
Luca Fiorillo ◽  
Alessandra Odorici ◽  
Aida Meto ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Host Response ◽  
Experimental Studies ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Positive Interaction ◽  
Implant Surface ◽  
Early Loading ◽  
Proliferation And Differentiation ◽  
Secondary Stability

Recently, interest has grown by focusing on the evaluation of a molecule already produced in the human body such as hyaluronic acid (HA), as an application to the surface of the titanium implant. Its osteo-conductive characteristics and positive interaction with the progenitor cells responsible for bone formation, consequently, make it responsible for secondary stability. The aim of this work was to analyze the various surface treatments in titanium implants, demonstrating that the topography and surface chemistry of biomaterials can correlate with the host response; also focusing on the addition of HA to the implant surface and assessing the biological implications during early stages of recovery. Used as a coating, HA acts on the migration, adhesion, proliferation and differentiation of cell precursors on titanium implants by improving the connection between implant and bone. Furthermore, the improvement of the bioactivity of the implant surfaces through HA could therefore facilitate the positioning of the dental prosthesis precisely in the early loading phase, thus satisfying the patients’ requests. It is important to note that all the findings should be supported by further experimental studies in animals as well as humans to evaluate and confirm the use of HA in any field of dentistry.

scholarly journals Histologic and Histomorphometric Evaluation of a New Bioactive Liquid BBL on Implant Surface: A Preclinical Study in Foxhound Dogs

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 6217
Author(s):  
Eduard Ferrés-Amat ◽  
Ashraf Al Madhoun ◽  
Elvira Ferrés-Amat ◽  
Saddam Al Demour ◽  
Mera A. Ababneh ◽  
...  
Keyword(s):  
Bone Loss ◽  
Test Group ◽  
Fold Increase ◽  
Preclinical Study ◽  
Titanium Implants ◽  
Control Group ◽  
Implant Surface ◽  
Chemical Surface ◽  
Crestal Bone Loss ◽  
And Control

Background: Bioactive chemical surface modifications improve the wettability and osseointegration properties of titanium implants in both animals and humans. The objective of this animal study was to investigate and compare the bioreactivity characteristics of titanium implants (BLT) pre-treated with a novel bone bioactive liquid (BBL) and the commercially available BLT-SLA active. Methods: Forty BLT-SLA titanium implants were placed in in four foxhound dogs. Animals were divided into two groups (n = 20): test (BLT-SLA pre-treated with BBL) and control (BLT-SLA active) implants. The implants were inserted in the post extraction sockets. After 8 and 12 weeks, the animals were sacrificed, and mandibles were extracted, containing the implants and the surrounding soft and hard tissues. Bone-to-implant contact (BIC), inter-thread bone area percentage (ITBA), soft tissue, and crestal bone loss were evaluated by histology and histomorphometry. Results: All animals were healthy with no implant loss or inflammation symptoms. All implants were clinically and histologically osseo-integrated. Relative to control groups, test implants demonstrated a significant 1.5- and 1.7-fold increase in BIC and ITBA values, respectively, at both assessment intervals. Crestal bone loss was also significantly reduced in the test group, as compared with controls, at week 8 in both the buccal crests (0.47 ± 0.32 vs 0.98 ± 0.51 mm, p < 0.05) and lingual crests (0.39* ± 0.3 vs. 0.89 ± 0.41 mm, p < 0.05). At week 12, a pronounced crestal bone loss improvement was observed in the test group (buccal, 0.41 ± 0.29 mm and lingual, 0.54 ± 0.23 mm). Tissue thickness showed comparable values at both the buccal and lingual regions and was significantly improved in the studied groups (0.82–0.92 mm vs. 33–48 mm in the control group). Conclusions: Relative to the commercially available BLT-SLA active implants, BLT-SLA pre-treated with BBL showed improved histological and histomorphometric characteristics indicating a reduced titanium surface roughness and improved wettability, promoting healing and soft and hard tissue regeneration at the implant site.

Convergence in norming and control of modern wireless technologies electromagnetic fields

2020 ◽  
Vol 60 (9) ◽  
pp. 610-613
Author(s):  
Michail Yu. Maslov ◽  
Yuri M. Spodobaev
Keyword(s):  
Wireless Communication ◽  
Electromagnetic Fields ◽  
Communication Systems ◽  
Communication Technologies ◽  
Telecommunications Industry ◽  
High Tech ◽  
Wireless Technologies ◽  
Almost All ◽  
Network Technologies ◽  
And Control

Telecommunications industry evolution shows the highest rates of transition to high-tech systems and is accompanied by a trend of deep mutual penetration of technologies - convergence. The dominant telecommunication technologies have become wireless communication systems. The widespread use of modern wireless technologies has led to the saturation of the environment with technological electromagnetic fields and the actualization of the problems of protecting the population from them. This fundamental restructuring has led to a uniform dense placement of radiating fragments of network technologies in the mudflow areas. The changed parameters of the emitted fields became the reason for the revision of the regulatory and methodological support of electromagnetic safety. A fragmented structural, functional and parametric analysis of the problem of protecting the population from the technological fields of network technologies revealed uncertainty in the interpretation of real situations, vulnerability, weakness and groundlessness of the methodological basis of sanitary-hygienic approaches. It is shown that this applies to all stages of the electromagnetic examination of the emitting fragments of network technologies. Distrust arises on the part of specialists and the population in not only the system of sanitary-hygienic control, but also the safety of modern network technologies is being called into question. Growing social tensions and radio phobia are everywhere accompanying the development of wireless communication technologies. The basis for solving almost all problems of protecting the population can be the transfer of subjective methods and means of monitoring and sanitary-hygienic control of electromagnetic fields into the field of IT.

RELEVÂNCIA DA UTILIZAÇÃO DO PLASMA RICO EM PLAQUETAS ASSOCIADO AO BIO-OSS® EM LEVANTAMENTO DE SEIO MAXILAR: REVISÃO SISTEMÁTICA

2016 ◽  
Author(s):  
Gustavo V. O. Fernandes
Keyword(s):  
Platelet Rich Plasma ◽  
Sinus Lift ◽  
Sinus Augmentation ◽  
Sinus Lifting

RESUMO O advento da osseointegração e dos implantes dentários revolucionaram o tratamento e a reabilitação protética de pacientes edêntulos totais e parciais. Obstáculos anatômicos tais como o seio maxilar pneumatizado impediam a instalação imediata de implantes. Com o avanço da implantodontia, técnicas cirúrgicas para a reconstrução de rebordos, tais como o levantamento de seio maxilar, foram introduzidas, ampliando as possibilidades de tratamento. Esta técnica consiste no ganho ósseo a partir do assoalho do seio maxilar com a colocação de um material de enxertia. Para melhorar a reparação óssea, diversos estudos avaliaram os efeitos dos fatores de crescimento e de diferenciação tais como PDGF, VEGF, TGF, EGF, entre outros. Estes fatores são produzidos pelas plaquetas. O plasma rico em plaquetas (PRP), um concentrado autógeno de plaquetas humanas, vem sendo utilizado com destaque na prática clínica há mais de 15 anos a fim de otimizar a neoformação óssea quando associado aos enxertos. No entanto, ainda existe uma grande controvérsia acerca de sua eficácia. Assim, o objetivo deste estudo foi realizar a revisão sistemática da literatura sobre a eficácia do PRP associado ao xenoenxerto Bio-Oss® (osso bovino desproteinizado) em cirurgias de levantamento de seio maxilar. A busca com palavras-chaves [(PRP) OR (Platelet-Rich Plasma) AND Sinus Lift) OR (Sinus Lifting) OR (Sinus Augmentation) AND (Bio-Oss)] na base de dados PubMed retornou 189 artigos dos quais inicialmente foram encontrados 9 artigos sobre o tema em questão. Destes, apenas 2 artigos foram enquadrados nos critérios de elegibilidade e foram incluídos para análise final e discussão. Constatou-se que diversos estudos apresentaram falhas metodológicas comprometendo a confiabilidade dos resultados. Nos artigos considerados, observou-se que os resultados são contraditórios. Em uma avaliação de qualidade dos estudos enquadrados para análise, um foi classificado como de baixo risco de viés e o outro foi classificado como de alto risco de viés. Conclui-se que há grande carência de artigos sobre este assunto e que novos estudos clínicos que há grande carência de artigos sobre este assunto que há grande carência de artigos sobre este assunto e que novos estudos clínicos devem ser realizados com metodologias que considerem, por exemplo, randomização dos grupos e cegamento das análises. Palavras-Chave: PRP, plaquetas, Bio-Oss, Levantamento de seio maxilar, Revisão Sistemática

Drug policy and control at the international level

2018 ◽  
Author(s):  
Thomas F. Babor ◽  
Jonathan Caulkins ◽  
Benedikt Fischer ◽  
David Foxcroft ◽  
Keith Humphreys ◽  
...  
Keyword(s):  
Low Income ◽  
Low Income Countries ◽  
Drug Control ◽  
Prescription Medications ◽  
Access To Treatment ◽  
Illicit Markets ◽  
Pain Medications ◽  
Almost All ◽  
And Control ◽  
Illicit Trafficking

International drug control efforts are designed to coordinate domestic laws with international activities that regulate or limit the supply of psychoactive substances. These efforts are organized around three main drug control treaties that almost all countries have ratified in order to prevent illicit trafficking and other drug-related crime, while at the same time allowing access to prescription medications. The effects of the system have been evaluated mostly in terms of the ability to eliminate illicit markets and supply. The gross imbalance in world consumption of legal opiates is a pointer to the limited availability of effective pain medications in many low-income countries, with 80% of the world’s population having either no or inadequate access to treatment for moderate or severe pain.

Sign in / Sign up

Export Citation Format

Share Document