3’-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women

As life expectancy increases, the prevalence of osteoporosis is increasing. In addition to vitamin D which is well established to have an association with osteoporosis, B vitamins, such as thiamine, folate (vitamin B9), and cobalamin (vitamin B12), could affect bone metabolism, bone quality, and fracture risk in humans by influencing homocysteine/folate metabolism. Despite the crucial role of B vitamins in bone metabolism, there are few studies regarding associations between B vitamin-related genes and osteoporosis. In this study, we investigated the genetic association of four single nucleotide polymorphisms (SNPs) within the 3’-untranslated regions of vitamin B-related genes, including TCN2 (encodes transcobalamin II), CD320 (encodes transcobalamin II receptor), SLC19A1 (encodes reduced folate carrier protein 1), and SLC19A2 (encodes thiamine carrier 1), with osteoporosis and osteoporotic vertebral compression fracture (OVCF). We recruited 301 postmenopausal women and performed genotyping of CD320 rs9426 C>T, TCN2 rs10418 C>T, SLC19A1 rs1051296 G>T, and SLC19A2 rs16862199 C>T using a polymerization chain reaction-restriction fragment length polymorphism assay. There was a significantly higher incidence of both osteoporosis (AOR 5.019; 95% CI, 1.533–16.430, p < 0.05) and OVCF (AOR, 5.760; 95% CI, 1.480–22.417, p < 0.05) in individuals with genotype CD320 CT+TT and high homocysteine concentrations. Allele combination analysis revealed that two combinations, namely CD320 C-TCN2 T-SLC19A1 T-SLC19A2 C (OR, 3.244; 95% CI, 1.478–7.120, p < 0.05) and CD320 T-TCN2 C-SLC19A1 G-SLC19A2 C (OR, 2.287; 95% CI, 1.094–4.782, p < 0.05), were significantly more frequent among the osteoporosis group. Our findings suggest that SNPs within the CD320 gene in 3´-UTR may contribute to osteoporosis and OVCF occurrences in some individuals. Furthermore, specific allele combinations of CD320, TCN2, SLC19A1, and SLC19A2 may contribute to increased susceptibility to osteoporosis and OVCF.

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Thoracolumbar flexion dysfunction and thoracolumbar compression fracture in postmenopausal women: a single-center retrospective study

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-021-02857-w ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Zhirong Zheng ◽

Chao Liu ◽

Zhen Zhang ◽

Wenhao Hu ◽

Meng Gao ◽

...

Keyword(s):

Computed Tomography ◽

Postmenopausal Women ◽

Demographic Data ◽

Quantitative Computed Tomography ◽

Compression Fracture ◽

Threshold Value ◽

Vertebral Compression Fractures ◽

Control Group ◽

Compression Fractures ◽

The Difference

Abstract Objective To investigate whether thoracolumbar flexion dysfunctions increase the risk of thoracolumbar compression fractures in postmenopausal women. Methods The records of postmenopausal women with thoracolumbar vertebral compression fractures and without vertebral compression fractures were surveyed. Demographic data, clinical data, and quantitative computed tomography (QCT) findings were compared between the groups. Chi-squared tests, unpaired t-tests, Spearman, and Mann–Whitney U were used to assess the group characteristics and proportions. The relationship between the risk of fracture and the difference of Cobb’s angle of thoracolumbar segment (DCTL) was evaluated by logistic regression. DCTL was calculated by subtracting thoracolumbar Cobb’s angles (TLCobb’s) from thoracolumbar hyperflexion Cobb’s angles (TLHCobb’s). Quantitative computed tomography (QCT) values and spinal osteoarthritis (OA) of postmenopausal women in the two groups were compared. Results 102 of 312 were enrolled to the study group of postmenopausal women with the fracture, and 210 of 312 were enrolled to the control group of postmenopausal women without the fracture. There were significant differences in QCT values and spinal OA including disc narrowing (DSN) and osteophytes (OPH) between the two groups (p < 0.001 for all four). The risk of thoracolumbar compression fractures in the postmenopausal women with DCTL ≤ 8.7° was 9.95 times higher (95% CI 5.31–18.64) than that with > 8.7° after adjusting for age, BMI, and QCT values. Conclusion Low DCTL may be a risk factor of thoracolumbar compression fractures in postmenopausal women, and a DCTL ≤ 8.7° can be a threshold value of thoracolumbar compression fractures.

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A Study on Vertebral Compression Fracture in Postmenopausal Women with Back Pain in Two Medical College Hospitals of Bangladesh

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v18i2.47777 ◽

2020 ◽

Vol 18 (2) ◽

pp. 49-53

Author(s):

Khairul Anam ◽

Sumia Ahmed Tazri ◽

Fairzu Faiza ◽

AKM Maruf Raza

Keyword(s):

Back Pain ◽

Rural Communities ◽

Postmenopausal Women ◽

Social Life ◽

Vertebral Compression Fracture ◽

Compression Fracture ◽

Cross Sectional Study ◽

Vertebral Compression Fractures ◽

Cross Sectional ◽

Medical College

Background: To determine the prevalence and nature of the vertebral compression fracture in postmenopausal women suffering from back pain in the rural communities of Bangladesh. Materials and methods: Cross sectional study was conducted for the period January to December 2018 which included all postmenopausal women aged 55 years and above presented with back pain in the Obstetrics and Gynaecology and Orthopedic outpatient Departments of Jahurul Islam Medical College and North Bengal Medical College Hospitals. Vertebral fractures were diagnosed by X-Ray scanning of the spine based on predefined criteria. Results: Prevalence of vertebral compression fracture was 30.6%. Most of the subjects were highly active, of poor nutritional status and undergraduate. Majority (35.7%) of the patients belonged to 55-59 years group but prevalence was highest in 70-75 years of age. Maximum patients (48.1%) sustained fracture at only one vertebra. Highest number of fracture (61.1%) was found in the dorsolumbar region. Most of the fracture (44.8%) was of biconcave shape. Most of the wedge deformities were present from 12th thoracic and above and majority of the biconcave deformities were from 11th thoracic and below. Conclusion: Although the prevalence was low in comparison to other studies, it showed a great burden on our social life. The most important step in treating vertebral compression fractures is prevention and treatment of osteoporosis. Chatt Maa Shi Hosp Med Coll J; Vol.18 (2); July 2019; Page 49-53

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The analgesic efficacy of extracorporeal shock wave combined with percutaneous vertebroplasty in the treatment of osteoporotic thoracolumbar compression fractures in postmenopausal women

BioMedical Engineering OnLine ◽

10.1186/s12938-021-00894-4 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Xiaowei Liu ◽

Hui Wang ◽

Yang Zhang ◽

Mingling Wang ◽

Yujin Qiu ◽

...

Keyword(s):

Shock Wave ◽

Postmenopausal Women ◽

Percutaneous Vertebroplasty ◽

Reduction Rate ◽

Compression Fracture ◽

Analgesic Efficacy ◽

Small Sample ◽

Compression Fractures ◽

Extracorporeal Shock Wave ◽

Post Operation

Abstract Background To explore the analgesic efficacy of extracorporeal shock wave (ESW) combined with percutaneous vertebroplasty (PVP) after reduction in overextension position in the treatment of osteoporotic thoracolumbar compression fractures in postmenopausal women. Methods The data of postmenopausal women with osteoporotic thoracolumbar compression fracture admitted in our department from January 2017 to October 2019 were analyzed retrospectively. They were divided into groups of unipedicular percutaneous kyphoplasty (U-PKP n = 21), bipedicular PKP (B-PKP n = 20), and ESW combined with PVP after reduction in overextension position (EP-PVP n = 18). The improvement of pain and vertebral height in three groups was compared. Results Postoperative compression rate and Cobb angle of vertebral fractures in the three groups were all lower than those before surgery, and the differences between pre-operation and post-operation were statistically significant (P < 0.05). The visual analog scale (VAS) and Oswestry dysfunction index (ODI) scores of the three groups decreased significantly after the operation (P < 0.05). The ODI scores of the EP-PVP group in the third months after the operation were significantly improved compared with the other two groups, and the difference was statistically significant (P < 0.05). Conclusions In our small-sample study, all three treatment schemes can treat osteoporotic compression fracture of thoracolumbar vertebrae in postmenopausal women, relieve pain, and improve quality of life. ESW combined with PVP after reduction in overextension position could achieve a good vertebral reduction rate and improve kyphosis, and may reduce the application of analgesic drugs.

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Characteristics of bone metabolism in postmenopausal women with newly diagnosed type 2 diabetes mellitus

Clinical Endocrinology ◽

10.1111/cen.14501 ◽

2021 ◽

Author(s):

Huijuan Li ◽

Yuhua Wen ◽

Peipei Liu ◽

Liya Zhang ◽

Xiaoya Zhang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Bone Metabolism ◽

Postmenopausal Women ◽

Newly Diagnosed

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The benefits of a high-intensity aquatic exercise program (HydrOS) for bone metabolism and bone mass of postmenopausal women

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-013-0509-y ◽

2013 ◽

Cited By ~ 3

Author(s):

Linda Denise Fernandes Moreira ◽

Fernanda Cerveira A. O. Fronza ◽

Rodrigo Nolasco dos Santos ◽

Patrícia Lins Zach ◽

Ilda S. Kunii ◽

...

Keyword(s):

Bone Mass ◽

Bone Metabolism ◽

Postmenopausal Women ◽

High Intensity ◽

Exercise Program ◽

Aquatic Exercise

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Common variants in MAEA gene contributed the susceptibility to osteoporosis in Han Chinese postmenopausal women

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-020-02140-4 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Xuan Cai ◽

Jun Dong ◽

Teng Lu ◽

Liqiang Zhi ◽

Xijing He

Keyword(s):

Postmenopausal Women ◽

Chinese Women ◽

Han Chinese ◽

Blood Levels ◽

Nucleotide Polymorphisms ◽

Mineral Density ◽

Association Analyses ◽

Metabolism Disorder ◽

Increased Risk ◽

Chinese Postmenopausal Women

Abstract Background Osteoporosis (OP) is a complex bone metabolism disorder characterized by the loss of bone minerals and an increased risk of bone fracture. A recent study reported the relationship of the macrophage erythroblast attacher gene (MAEA) with low bone mineral density in postmenopausal Japanese women. Our study aimed to investigate the association of MAEA with postmenopausal osteoporosis (PMOP) in Han Chinese individuals. Methods A total of 968 unrelated postmenopausal Chinese women comprising 484 patients with PMOP and 484 controls were recruited. Four tag single nucleotide polymorphisms (SNPs) that covered the gene region of MAEA were chosen for genotyping. Single SNP and haplotypic association analyses were performed, and analysis of variance was conducted to test the correlation between blood MAEA protein level and genotypes of associated SNPs. Results SNP rs6815464 was significantly associated with the risk of PMOP. The C allele of rs6815464 was strongly correlated with the decreased risk of PMOP in our study subjects (OR[95% CI]=0.75[0.63-0.89], P=0.0015). Significant differences in MAEA protein blood levels among genotypes of SNP rs6815464 were identified in both the PMOP (F=6.82, P=0.0012) and control groups (F=11.5, P=0.00001). The C allele was positively associated with decreased MAEA protein levels in blood. Conclusion This case-control study on Chinese postmenopausal women suggested an association between SNP rs6815464 of MAEA and PMOP. Further analyses showed that genotypes of SNP rs6815464 were also associated with the blood level of MAEA protein.

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