scholarly journals APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population

Genes ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1768
Author(s):  
Stephanie Lozano ◽  
Victoria Padilla ◽  
Manuel Lee Avila ◽  
Mario Gil ◽  
Gladys Maestre ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Rio Grande Valley ◽  
Rio Grande ◽  
Initial Study ◽  
Apoe Gene ◽  
Hispanic Population ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Apoe Genotypes ◽  
First Time

Genetic variants in the apolipoprotein E (APOE) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the APOE gene and hypercholesterolemia in the Hispanic population; therefore, our aim for this study is to examine the APOE gene’s associations with cholesterol level and its related phenotypes. The APOE gene consists of three different alleles, ε2, ε3, and ε4, with ε4 being associated with dementia and cardiovascular diseases. A total of 1,382 subjects were collected from the Texas Alzheimer’s Research and Care Consortium (TARCC, N = 1320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, N = 62). Questionnaires on demographics, medical history, and blood/saliva samples were collected and APOE genotypes were performed. We observed allele frequencies of the APOE ε3 (96.7%), ε4 (22.6%) and ε2 (6.8%) alleles, respectively. Multivariable logistic regression revealed a significant association between the APOE ε4 allele and hypercholesteremia (p = 1.8 × 10−4) in our studied Hispanic population. We prove for the first time, that the APOE ε4 allele increases the risk for hypercholesterol in Hispanics. Further research is needed to confirm and supports our current findings.

scholarly journals Association of ApoE Gene Polymorphisms With Cardio-cerebrovascular Complications in Type 2 Diabetes Mellitus in the Chinese Population

2021 ◽  
Author(s):  
Lulu Kong ◽  
Yinting Gao ◽  
Wei Li ◽  
Bimin Shi
Keyword(s):  
Type 2 Diabetes ◽  
Carotid Plaque ◽  
Apoe Genotype ◽  
Apoe Gene ◽  
Control Group ◽  
Case Group ◽  
Cerebrovascular Complications ◽  
Ε4 Allele ◽  
Apoe Genotypes

Abstract Objective To analyze and study the relationship between ApoE gene polymorphism and cardio-cerebrovascular complications in type 2 diabetes mellitus(T2DM) in the Chinese Population.Methods From January 2018 to January 2019, 1140 patients with type 2 diabetes admitted to the Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University were selected as the case group, including 590 patients with coronary heart disease(CHD) and 550 patients with cerebral infarction(CI), and 1198 patients with type 2 diabetes without complications during the same period were selected as the control group. General baseline data of the two groups were collected, such as gender, age, course of disease, lipid profile, HbA1C, BMI, blood pressure, carotid plaque and complications. ApoE genotypes were identified in all participants who participated in the study.Results This study showed that the ApoE genotypes in both the case group and the control group had the highest frequency of E3/E3. The E3/E4 genotype frequency and ε4 allele frequency in the case group were higher than those in the control group (P<0.05). In the case group, the frequency of E2/E3 and E3/E4 genotypes of CI group was lower than that of CHD group, while the frequency of E3/E3 genotype was higher than that of CHD group. TC and LDL-c levels were significantly increased in patients with ApoE E3/E4 genotype(P<0.05). ApoE genotype E3/E4 was more associated with carotid plaque than E2/E3. ApoE genotype and ApoE allele were positively correlated with TC and LDL-c levels (P<0.05).Logistic regression results show that carotid plaque, diabetes duration and ApoE E3/E4 genotype are independent risk factors of cardio-cerebrovascular complications of T2DM(P< 0.05). ApoE E3/E4 genotype and allele ε4 may be risk factors for T2DM patients with cardio-cerebrovascular complications.Conclusion ApoE E3/E4 genotypes and T2DM patients carrying ε4 allele have a higher risk of cardio-cerebrovascular complications than other genotypes. ApoE ε2 allele has a certain protective effect , however ε4 allele may be a risk factor for cardio-cerebrovascular complications in T2DM patients, and its mechanism may be related to the effect of ApoE gene on lipid metabolism.

scholarly journals APOE-ε4 Carrier Status and Gut Microbiota Dysbiosis in Patients With Alzheimer Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Min Hou ◽  
Gaolian Xu ◽  
Maosheng Ran ◽  
Wei Luo ◽  
Hui Wang
Keyword(s):  
Alzheimer Disease ◽  
Gut Microbiota ◽  
Genetic Variants ◽  
16S Rrna Gene Sequencing ◽  
Gut Bacteria ◽  
Rrna Gene ◽  
Carrier Status ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Rrna Gene Sequencing

BackgroundAlternations in gut microbiota and a number of genes have been implicated as risk factors for the development of Alzheimer disease (AD). However, the interactions between the altered bacteria and risk genetic variants remain unclear.ObjectiveWe aimed to explore associations of the risk genetic variants with altered gut bacteria in the onset of AD.MethodsWe collected baseline data and stool and blood samples from 30 AD patients and 47 healthy controls in a case-control study. The rs42358/rs4512 (ApoE), rs3851179 (PICALM), rs744373 (BIN1), rs9331888 (CLU), rs670139 (MS4A4E), rs3764650 (ABCA7), rs3865444 (CD33), rs9349407 (CD2AP), rs11771145 (EPHA1), and rs3818361/rs6656401 (CR1) were sequenced, and microbiota composition was characterized using 16S rRNA gene sequencing. The associations of the altered gut bacteria with the risk genetics were analyzed.ResultsApolipoprotein ε4 allele and rs744373 were risk loci for the AD among 12 genetic variants. Phylum Proteobacteria; orders Enterobacteriales, Deltaproteobacteria, and Desulfovibrionales; families Enterobacteriaceae and Desulfovibrionaceae; and genera Escherichia–Shigella, Ruminococcaceae_UCG_002, Shuttleworthia, Anaerofustis, Morganelia, Finegoldia, and Anaerotruncus were increased in AD subjects, whereas family Enterococcaceae and genera Megamonas, Enterococcus, and Anaerostipes were more abundant in controls (P &lt; 0.05). Among the altered microbiota, APOE ε4 allele was positively associated with pathogens: Proteobacteria.ConclusionThe interaction of APOE ε4 gene and the AD-promoting pathogens might be an important factor requiring for the promotion of AD. Targeting to microbiota might be an effective therapeutic strategy for AD susceptible to APOE ε4 allele. This needs further investigation.

AFRICANIZED HONEY BEES FOUND IN ARIZONA

PEDIATRICS ◽  
1994 ◽  
Vol 94 (1) ◽  
pp. 117-117
Author(s):  
S. Hawthorne
Keyword(s):  
United States ◽  
Honey Bees ◽  
Rio Grande Valley ◽  
Rio Grande ◽  
The United States ◽  
Washington Dc ◽  
Department Of Agriculture ◽  
Africanized Honey Bees ◽  
First Time ◽  
North And South

Washington, DC, July 13, 1993—Africanized honey bees have been found in Arizona, the second state where the "killer bees" have migrated into this country, according to the Agriculture Department. A swarm was found in a state Department of Agriculture trap 2 miles north of Sasabe, AZ. The bees were destroyed. The fierce and unmanageable bees are descendants of honey bees imported from Africa to Brazil in 1956. They have been spreading north and south from Brazil since their release in 1957. They tend to sting with less provocation and in greater numbers than other honey bees. They migrated for the first time into the United States in 1990, near Hildago, TX, in the Rio Grande Valley. They have also entered the country on ships.

Molecular Genetics of Early- and Late-Onset Alzheimer’s Disease

2020 ◽  
Vol 20 ◽  
Author(s):  
Md. Sahab Uddin ◽  
Sharifa Hasana ◽  
Md. Farhad Hossain ◽  
Md. Siddiqul Islam ◽  
Tapan Behl ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Massively Parallel Sequencing ◽  
Late Onset ◽  
Current Knowledge ◽  
The Elderly ◽  
Apoe Ε4 ◽  
Sequencing Technologies ◽  
Genetic Components ◽  
Ε4 Allele

: Alzheimer’s disease (AD) is the most common form of dementia in the elderly and this complex disorder is associated with environmental as well as genetic components. Early-onset AD (EOAD) and late-onset AD (LOAD, more common) are major identified types of AD. The genetics of EOAD is extensively understood with three genes variants such as APP, PSEN1, and PSEN2 leading to disease. On the other hand, some common alleles including APOE are effectively associated with LOAD identified but the genetics of LOAD is not clear to date. It has been accounted that about 5% to 10% of EOAD patients can be explained through mutations in the three familiar genes of EOAD. The APOE ε4 allele augmented the severity of EOAD risk in carriers, and APOE ε4 allele was considered as a hallmark of EOAD. A great number of EOAD patients, who are not genetically explained, indicate that it is not possible to identify disease- triggering genes yet. Although several genes have been identified through using the technology of next-generation sequencing in EOAD families including SORL1, TYROBP, and NOTCH3. A number of TYROBP variants were identified through exome sequencing in EOAD patients and these TYROBP variants may increase the pathogenesis of EOAD. The existence of ε4 allele is responsible for increasing the severity of EOAD. However, several ε4 allele carriers live into their 90s that propose the presence of other LOAD genetic as well as environmental risk factors that are not identified yet. It is urgent to find out missing genetics of EOAD and LOAD etiology to discover new potential genetics facets which will assist to understand the pathological mechanism of AD. These investigations should contribute to developing a new therapeutic candidate for alleviating, reversing and preventing AD. This article based on current knowledge represents the overview of the susceptible genes of EOAD, and LOAD. Next, we represent the probable molecular mechanism which might elucidate the genetic etiology of AD and highlight the role of massively parallel sequencing technologies for novel gene discoveries.

scholarly journals Crustacea, Isopoda, Oniscidea Latreille, 1802: new continent record and distribution extension in Brazil

Check List ◽  
2010 ◽  
Vol 6 (2) ◽  
pp. 217 ◽  
Author(s):  
Mariana Juventina Magrini ◽  
Paula Beatriz Araujo ◽  
Marcio Uehara-Prado
Keyword(s):  
Rio Grande ◽  
Sao Paulo ◽  
The State ◽  
Southeastern Brazil ◽  
Pitfall Traps ◽  
São Paulo ◽  
Undescribed Species ◽  
Rio Grande Do Sul ◽  
Serra Do Mar ◽  
First Time

Terrestrial Isopods were sampled in four protected Atlantic Forest areas located in Serra do Mar, state of São Paulo, southeastern Brazil. A total of 2,217 individuals of six species (Atlantoscia sp., Benthana werneri, Pseudodiploexochus tabularis, Pudeoniscus obscurus, Styloniscus spinosus and Trichorhina sp.) were captured in pitfall traps. The exotic species S. spinosus is recorded for the first time for the Americas. Another introduced species, P. tabularis, previously recorded only from the state of Rio Grande do Sul, had its geographic distribution extended to the state of São Paulo. The most abundant isopods in this study belong to an undescribed species of Atlantoscia.

scholarly journals Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41636 ◽  
Author(s):  
Cheryl A. Hawkes ◽  
Patrick M. Sullivan ◽  
Sarah Hands ◽  
Roy O. Weller ◽  
James A. R. Nicoll ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Human Apoe ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Perivascular Drainage
Sign in / Sign up

Export Citation Format

Share Document