scholarly journals Meta-Prediction of MTHFR Gene Polymorphism and Air Pollution on the Risks of Congenital Heart Defects Worldwide: A Transgenerational Analysis

2018 ◽  
Vol 15 (8) ◽  
pp. 1660 ◽  
Author(s):  
Hsiao-Ling Yang ◽  
Ya-Ling Yang ◽  
Chong Yu ◽  
S. Shiao
Keyword(s):  
Air Pollution ◽  
Congenital Heart ◽  
Heart Defects ◽  
Mthfr C677t ◽  
Study Groups ◽  
Mthfr Gene ◽  
Mthfr Polymorphisms ◽  
Mthfr Gene Polymorphism ◽  
Related Enzyme ◽  
Genetic And Environmental Factors

Congenital heart disease (CHD) is the leading cause of death in children, and is affected by genetic and environmental factors. To investigate the association of air pollution with methylene-tetrahydrofolate reductase (MTHFR) polymorphisms and the risk of CHD, we included 58 study groups of children and parents, with 12,347 cases and 18,106 controls worldwide. Both MTHFR C677T (rs 1801133) and A1298C (rs 1801131) gene polymorphisms were risks for CHD in children with transgenerational effects from their parents. Countries with greater risks of CHD with a pooled risk ratio (RR) > 2 from MTHFR 677 polymorphisms included Germany, Portugal, China, and Egypt for children; and Brazil, Puerto Rico, Mexico, China, and Egypt for mothers. Whereas, countries with greater risk of CHD with RR > 2 from MTHFR 1298 polymorphisms included Taiwan, Turkey, and Egypt for children; and Brazil, China, and Egypt for mothers. Additionally, meta-prediction analysis revealed that the percentages of MTHFR 677TT and TT plus CT polymorphisms together were increased in countries with higher levels of air pollution, with a trend of increased CHD risks with higher levels of air pollution for children (p = 0.07). Our findings may have significant implications for inflammatory pathways in association with MTHFR polymorphisms and future intervention studies to correct for folate-related enzyme deficits resulted from MTHFR polymorphisms to prevent CHDs for future generations.

Methylenetetrahydrofolate reductase polymorphisms as risk factors for retinal venous occlusive disease: A literature review

2021 ◽  
pp. 112067212110006
Author(s):  
Manuel Marques ◽  
Francisco Alves ◽  
Miguel Leitão ◽  
Catarina Rodrigues ◽  
Joana Tavares Ferreira
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Methylenetetrahydrofolate Reductase ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Mthfr Polymorphisms ◽  
Vein Occlusion ◽  
C677t Mutation ◽  
Retinal Vascular Disease

The role of polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene in retinal vein occlusion (RVO) is a theme of discussion since the first reports of RVO in patients with MTHFR C677T mutation and without classic acquired risk factors for retinal vascular disease. The association between MTHFR polymorphisms and RVO has been studied over the last 20 years producing conflicting results. This review aims to summarize the literature concerning the role MTHFR polymorphisms as risk factors for RVO.

Time-Series Analysis of Air Pollution and Congenital Heart Defects

Epidemiology ◽  
2006 ◽  
Vol 17 (Suppl) ◽  
pp. S270
Author(s):  
M Strickland ◽  
A Correa ◽  
M Reller ◽  
W Mahle ◽  
L Botto ◽  
...  
Keyword(s):  
Air Pollution ◽  
Time Series ◽  
Time Series Analysis ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Series Analysis

scholarly journals MTHFR Gene Polymorphism-Mutations and Air Pollution as Risk Factors for Breast Cancer

2017 ◽  
Vol 66 (2) ◽  
pp. 152-163 ◽  
Author(s):  
Mildred C. Gonzales ◽  
Pojui Yu ◽  
S. Pamela K. Shiao
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Air Pollution ◽  
Gene Polymorphism ◽  
Mthfr Gene ◽  
Mthfr Gene Polymorphism

scholarly journals Meta-prediction of MTHFR gene polymorphism-mutations, air pollution, and risks of leukemia among world populations

Oncotarget ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 4387-4398 ◽  
Author(s):  
Shin-Yu A. Lien ◽  
Lufei Young ◽  
Bih-Shya Gau ◽  
S. Pamela K. Shiao
Keyword(s):  
Air Pollution ◽  
Gene Polymorphism ◽  
Mthfr Gene ◽  
Mthfr Gene Polymorphism

Cohort Analysis of Congenital Heart Defects and Air Pollution in Lanzhou, China

2014 ◽  
Vol 2014 (1) ◽  
pp. 1757
Author(s):  
Lan Jin* ◽  
Michelle Bell ◽  
Qing Liu ◽  
Yaqun Zhang ◽  
Jie Qiu ◽  
...  
Keyword(s):  
Air Pollution ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Cohort Analysis

MTHFR C677T and A1298C polymorphisms as a risk factor for congenital heart defects in Down syndrome

2011 ◽  
Vol 53 (4) ◽  
pp. 546-550 ◽  
Author(s):  
Ivana Babić Božović ◽  
Jadranka Vraneković ◽  
Nada StarčevićČizmarević ◽  
Vesna Mahulja-Stamenković ◽  
Igor Prpić ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Risk Factor ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Mthfr C677t

scholarly journals INVESTIGATION THE ASSOCIATION BETWEEN MTHFR GENE POLYMORPHISM AND HOMOCYSTEINE IN IRANIAN PREGNANT WOMEN

2017 ◽  
Vol 10 (12) ◽  
pp. 411
Author(s):  
Elham Sadat Sonbolestan ◽  
Hossein Sazegar ◽  
Noosha Zia-jahromi ◽  
Farzaneh Mohamadi Farsani
Keyword(s):  
Folic Acid ◽  
Pregnant Women ◽  
Homocysteine Level ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Healthy Individuals ◽  
Mthfr Polymorphism ◽  
Mthfr Gene Polymorphism ◽  
Significant Difference ◽  
In Pregnancy

  Objective: This study was aimed to investigate the association between polymorphisms in MTHFR gene and Vitamin B12-dependent homocysteine metabolism.Methods: Hyperhomocysteinemia has been implicated as a risk factor for complications in pregnancy including abortion, preeclampsia, and placental abruption. Several epidemiological studies have investigated the associations of MTHFR C677T polymorphism with hypertension or hypertension in pregnancy. However, the results were controversial. Numbers of 100 samples from healthy pregnant women as control criteria and 100 samples from fertile women have been collected. Due to research on MTHFR polymorphism, special primers have been designed. The research on MTHFR polymorphism has been done by restriction fragment length polymorphism assay.Results: The results demonstrated 9.26% have been registered for heterozygous individuals and the homocysteine level of homozygous individuals was 41.18% (higher than the normal level). The results showed a significant difference in the homocysteine levels of homozygous individuals and the homocysteine levels of healthy individuals (p=0.004). Furthermore, there was no significant difference in the homocysteine levels of heterozygous individuals and the homocysteine levels of healthy individuals (p=0.34). Similarly, a significant difference in the B12 levels in blood of homozygous individuals and the homocysteine levels of healthy individuals have been showed (p=0.00).Conclusion: The mutation of gene MTHFR C677T causes an increase of the homocysteine level, decrease of the level of folic acid and B12 vitamin in heterozygous individuals but a relationship among homocysteine level, the level of folic acid and B12 vitamin not found.

scholarly journals Maternal exposure to ambient air pollution and congenital heart defects in China

2021 ◽  
Vol 153 ◽  
pp. 106548
Author(s):  
Bo-Yi Yang ◽  
Yanji Qu ◽  
Yuming Guo ◽  
Iana Markevych ◽  
Joachim Heinrich ◽  
...  
Keyword(s):  
Air Pollution ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Ambient Air ◽  
Maternal Exposure ◽  
Ambient Air Pollution

scholarly journals Selected environmental risk factors and congenital heart defects

Medicina ◽  
2008 ◽  
Vol 44 (11) ◽  
pp. 827 ◽  
Author(s):  
Renata Kučienė ◽  
Virginija Dulskienė
Keyword(s):  
Risk Factors ◽  
Congenital Heart Defects ◽  
Environmental Risk ◽  
Congenital Heart ◽  
Heart Defects ◽  
Maternal Diabetes ◽  
Epidemiological Studies ◽  
Environmental Risk Factors ◽  
Congenital Heart Malformations ◽  
Genetic And Environmental Factors

The aim of the article is to review the published scientific literature and epidemiological studies about the effect of selected environmental risk factors on congenital heart defects in infants. According to recent reports, the prevalence of congenital heart defects is around 1% of live births. Congenital heart malformations are the leading cause of infant mortality. Unfortunately, the majority of the causes of heart defects remain unknown. These malformations are caused by interaction of genetic and environmental factors. The article reviews selected environmental risk factors: maternal illnesses and conditions associated with metabolic disorder (maternal diabetes, obesity, phenylketonuria), maternal lifestyle factors (alcohol use, smoking), which may increase the risk of congenital heart defects.

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