scholarly journals Prevalence of Arterial Hypertension and Characteristics of Nocturnal Blood Pressure Profile of Asthma Patients According to Therapy and Severity of the Disease: The BADA Study

2020 ◽  
Vol 17 (18) ◽  
pp. 6925
Author(s):  
Domenico Di Raimondo ◽  
Gaia Musiari ◽  
Alida Benfante ◽  
Salvatore Battaglia ◽  
Giuliana Rizzo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Blood Pressure Monitoring ◽  
Pressure Profile ◽  
Control Group ◽  
Cardiovascular Comorbidities ◽  
Cardiovascular Damage ◽  
Increased Risk ◽  
Asthma Patients ◽  
Severity Of The Disease

Background: several studies report an increased risk for asthmatic subjects to develop arterial hypertension and the relationship between these two diseases, frequently co-existing, still has some unclear aspects. Methods: The BADA (blood pressure levels, clinical features and markers of subclinical cardiovascular damage of asthma patients) study is aimed to evaluate the prevalence of the cardiovascular comorbidities of asthma and their impact on the clinical outcome. The main exclusion criteria were the presence of other respiratory diseases, current smoking, any contraindication to ambulatory blood pressure monitoring (ABPM). Results: The overall percentage of asthmatics having also hypertension was 75% (30 patients) vs. 45% (18 patients) of the control group (p: 0.012). Reduced level of FEV1 (but not inhaled steroid therapy) was associated to newly-diagnosed hypertension (p: 0.0002), higher day SBP levels (p: 0.003), higher day DBP levels (p: 0.03), higher 24 h-SBP levels (p: 0.005) and higher 24h-DBP levels (p: 0.03). The regression analysis performed taking into account sex, age, diabetes, fasting glucose, and body mass index confirms the independent role played by asthma: odds ratio (OR): 3.66 (CI: 1.29–11.1). Conclusions: hypertension is highly prevalent in asthma; the use of ABPM has allowed the detection of a considerable number of unrecognized hypertensives.

scholarly journals Endothelial function in patients with asthma according to circadian blood pressure profile

2010 ◽  
Vol 16 (4) ◽  
pp. 390-394
Author(s):  
N. A. Karoli ◽  
A. A. Roschina ◽  
A. P. Rebrov
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Arterial Hypertension ◽  
Bronchial Asthma ◽  
Blood Pressure Monitoring ◽  
Pressure Profile ◽  
Control Group ◽  
Essential Arterial Hypertension ◽  
Functional Features

Objective. The aim of study is asses of the endothelial functional features in patient with bronchial asthma with different types of blood pressure (BP) circadial rhythm. Design and methods. 62 patients with bronchial asthma (from 25 to 60 years old) were included in our study. Control group was represented by 30 healthy people for examination of endothelial function and 77 patients with essential arterial hypertension for 24-h blood pressure rhythm analysis. We described 2 groups of patients («dippers» and «non-dippers») by ambulatory 24-h blood pressure monitoring. Results. «Non-dipper» type was significantly prevalent in patient with asthma in comparative with patients with essential arterial hypertension (51,6% opposite 33,7%). The flow-depended endothelial dysfunction is most common in patient with asthma (dippers and non-dippers) than in control group. Negative correlation between nitroglycerin-depended vasodilatation and night-depressing systolic and diastolic blood pressure degree was presented in the study. Conclusion. We founded associations between endothelial dysfunction and BP circadial rhythm in patients with bronchial asthma, especially in «non-dippers».

scholarly journals Blood pressure profile, structural and functional cardiac parameters, renal function and metabolic status in hypertensive patients with chronic secondary pyelonephritis

2010 ◽  
Vol 16 (3) ◽  
pp. 256-260 ◽  
Author(s):  
M. E. Statsenko ◽  
M. V. Derevjanchenko
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Arterial Hypertension ◽  
Blood Pressure Monitoring ◽  
Close Relation ◽  
Pressure Profile ◽  
Upper Urinary Tract ◽  
Chronic Pyelonephritis ◽  
Metabolic Status ◽  
Hypertensive Patients

Objective. To study the blood pressure variability, morphofunctional parameters of the heart, kidney and metabolic status in hypertensive patients with secondary chronic pyelonephritis. Design and methods. The study included 110 patients: 55 patients with arterial hypertension and secondary chronic pyelonephritis, who underwent surgery for upper urinary tract, and 55 patients with essential arterial hypertension. All patients underwent 24-hour blood pressure monitoring, echocardiography; relative urine density in the morning urine portion, microalbuminuria, blood creatinine were assessed, glomerular fi ltration rate was calculated using MDRD formula. Results. Patients with arterial hypertension and chronic pyelonephritis have signifi cant changes of the blood pressure profi le, and hypertrophy and diastolic left ventricle dysfunction are more frequently observed in this group. A close relation between renal function and the state of the cardiovascular system is established. We also found higher numbers of total cholesterol, the most atherogenic fractions of cholesterol and triglycerides in this group compared to patients with essential hypertension.

Comparative analysis of daily blood pressure profile in patients with recurrent and primary ischemic stroke

2017 ◽  
pp. 18-27
Author(s):  
N. Svyrydova ◽  
O. Mykytei
Keyword(s):  
Blood Pressure ◽  
Ischemic Stroke ◽  
Comparative Analysis ◽  
Blood Pressure Monitoring ◽  
Pressure Profile ◽  
Hypertensive Encephalopathy ◽  
Control Group ◽  
Blood Pressure Profile ◽  
Significant Difference ◽  
The Difference

To conduct a comparative analysis of daily blood pressure profile in patients with recurrent and primary ischemic stroke. We were examined 124 patients, of which 94 patients with ischemic stroke in acute period, which came to the hospital in up to 2 days after the onset of the disease and were observed in the neurological department. The control group consisted of 30 patients with hypertensive encephalopathy. The conducted analysis of daily blood pressure monitoring in patients with recurrent and primary ischemic stroke indicates the importance of using this diagnostic method as a reliable difference in many indicators of arterial pressure is obtained. The difference averages of daily monitoring of blood pressure for all periods day informative confirms the difference in blood pressure in patients with primary and repeated ischemic stroke, as observed significant difference of values: the day indices of systolic, diastolic, blood pressure pulse heart rate parameters. The study allowed to increase the effectiveness of the diagnosis of recurrent ischemic stroke by studying the characteristics of central hemodynamics.

scholarly journals The condition of parameters of memory, attention and thinking at men of young age officers under the contractwith arterial hypertension.

2009 ◽  
Vol 6 (4) ◽  
pp. 59-63
Author(s):  
Il'ya Mikhaylovich Davidovich ◽  
Oleg Vladimirovich Afonaskov ◽  
Yuliya Konstantinovna Staroverova
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Blood Pressure Monitoring ◽  
Control Group ◽  
Military Officers ◽  
Pressure Data ◽  
Pressure Profiles ◽  
Blood Pressure Data ◽  
Stage 1 ◽  
Made In

Aim: to evaluate memory, attention and thinking functions indices in young hired military officers depending on their 24-hours blood pressure profiles. Materials and methods. The study was made in 49 patients with stage 1-2 arterial hypertension, aged 39,3±0,8, who did not take hypotensive medicines or took them occasionally. 24-hours blood pressure monitoring was performed with assessment of cognitive functions (memory, attention) depending on the stage, degree and duration of the disease. The control group included 12 men with no signs of arterial hypertension. Results. Comparing with the controls the memory, attention and thinking indices in hypertonic patients were found to be lower .even in those who had the first degree of hypertension and duration of the disease less than 5 years. The hypertonic patients showed lowering of attention and semantic memory scopes irrespective of duration of the disease. There was a negative correlation between monitored blood pressure data and memory, attention and thinking indices. Conclusions. Light cognitive dysfunctions can be found in young hired military officers with initial arterial hypertension but they are more typical for stage 2 of the disease

Blood pressure time load formation in patients with arterial hypertension without metabolic syndrome

2021 ◽  
Vol 25 (4) ◽  
pp. 282-289
Author(s):  
Tatjana Yu. Zotova ◽  
Anastasiya A. Lukanina ◽  
Mikhail L. Blagonravov
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Pressure Profile ◽  
Control Group ◽  
Double Product ◽  
Nocturnal Blood Pressure ◽  
Blood Pressure Profile ◽  
Pressure Time ◽  
Structural Point

Relevance . The study of the daily dynamics of blood pressure in arterial hypertension both on the basis of the daily index and on the basis of the time load is a relevant task, since, these indicators are associated in the literature with stable changes in the neurohumoral regulation of the cardiovascular system in arterial hypertension . The aim of the study was to compare data of the time load in patients with arterial hypertension , depending on the nocturnal blood pressure profile, with integrative indicators of the activity of the cardiovascular system in the form of a Circadian index, a structural point of blood pressure, double product. Materials and Methods. The study included 72 patients who were treated at the City Clinical Hospital No 13 in Moscow and signed a voluntary consent to participate in the research and the processing of personal data. Inclusion criteria: arterial hypertension. Exclusion criteria: metabolic syndrome, secondary forms of arterial hypertension and concomitant pathology. Depending on the daily index (DI10% and DI10%) patients were divided into 2 groups: 1 group (N= 32): patients with arterial hypertension without nocturnal decrease in blood pressure (non-dippers and night-pickers100%); Group 2 (N = 40): patients with arterial hypertension who had a nocturnal decrease in blood pressure (dippers and over dippers 100%). All patients and members of the control group (N=15) underwent daily monitoring of blood pressure (24-hour Arterial Blood Pressure Monitoring). The data were statistically processed to determine the 5% level of significance of differences (p0.05) (Students test). In the comparative analysis of integrative indicators at day and at night, a variance analysis was applied. Results and Discussion . As a result of the study, it was found that the values of Circadian Index for blood pressure vary depending on the type of night decrease in blood pressure and the blood pressure time load, while daily index and structural point of blood pressure remain on the same level as a reflection of the hemodynamic allostasis existing in both groups. Conclusion. Reflection of the allostatic load on hemodynamics is change of values of double product and of the structural point of blood pressure compared with the control group. These changes are not associated with the peculiarities of the nocturnal blood pressure profile in patients with hypertension without metabolic syndrome.

scholarly journals Comparison of circadian blood pressure profile in Stage 2-3 arterial hypertension patients receiving different antihypertensive combinations

2011 ◽  
Vol 10 (6) ◽  
pp. 30-34
Author(s):  
S. D. Mayanskaya ◽  
E. V. Malysheva ◽  
M. V. Potapova ◽  
E. B. Frolova ◽  
O. Yu. Mikhoparova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Blood Pressure Monitoring ◽  
Antihypertensive Agents ◽  
Pressure Profile ◽  
Circadian Blood Pressure ◽  
Blood Pressure Profile ◽  
Group I ◽  
First Choice ◽  
Circadian Blood Pressure Profile

Aim. To compare the dynamics of various parameters of circadian blood pressure profile (BP CP) and to assess the selection criteria for two combinations of the first-choice antihypertensive agents (AHA): angiotensin-converting enzyme (ACE) inhibitor plus thiazide diuretic (TD) or angiotensin II receptor antagonist (ARA) and calcium antagonist (CA) in patients with moderate to severe arterial hypertension (AH). Material and methods. This randomised study included 66 men aged 35-60 years with Stage 2-3 AH. Group I (n=37) received the combination of enalapril and hydrochlorothiazide (ENP + HCT; 20/12,5 mg/d), while Group II (n=29) was administered the combination of valsartan and S-amlodipine (VAL + S-AMD; 160/5 mg/d). All medications were taken daily, once a day. At baseline and after 12 weeks of the treatment, all participants underwent 24-hour blood pressure monitoring (BPM). The analysed parameters included: mean values and variability of systolic and diastolic BP (SBP, DBP), time index and pressure load index for SBP and DBP over 24 hours, dayand night-time, magnitude and velocity of SBP and DBP morning surge (MS), and diurnal/nocturnal BP ratio. Results. Twelve-week therapy with combinations significantly reduced mean SBP and DBP levels in patients with moderate to severe AH, regardless of the time of the day/night. It was also associated with reduced BP variability, mostly during the day-time. The ENP+HCT combination was more effective in terms of SBP MS reduction, while the VAL+S-AMD combination effect was more pronounced for DBP MS prevention. The VAL+S-AMD combination significantly improved diurnal/nocturnal BP ratio. Conclusion. The results obtained should be considered in the design of the antihypertensive combination therapy for Stage 2-3 AH patients with “non-dipper”, “night-peaker”, and “over-dipper” types of the two-phase BP CP.

scholarly journals An approach to antihypertensive therapy in sleep deprivation conditions

2012 ◽  
Vol 18 (3) ◽  
pp. 199-205
Author(s):  
A. Z. Tsfasman ◽  
D. V. Alpaev ◽  
V. D. Gorokhov
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Sleep Deprivation ◽  
Antihypertensive Drugs ◽  
Blood Pressure Monitoring ◽  
Night Shift ◽  
Pressure Profile ◽  
Diurnal Rhythms ◽  
Corrective Effect ◽  
Design And Methods

Objective. To assess the effects of several antihypertensive drugs on diurnal rhythms of blood pressure (BP) in sleep deprivation. Design and methods. The research included 58 patients with initial stages and levels of arterial hypertension (AH) divided into four groups (no medication, lisinopril, metoprolol, anaprilin before night with sleep deprivation). All patients underwent 24-hour blood pressure monitoring during the day with and without sleep deprivation. Results. Sleep deprivation was found to cause either inversion of daily blood pressure profile (DBPP) with higher night BP values, or at least reduction of night BP dipping. Among all mentioned medications only Anaprilin had some corrective effect on DBPP in sleep deprivation, and it can be recommended for night workers with arterial hypertension immediately before a night shift.

scholarly journals Clinical-hemodynamic efficiency of fixed combined hypotensin therapy for patients with heavy arterial hypertension

2019 ◽  
Vol 21 (2) ◽  
pp. 48-51
Author(s):  
N R Gizi Azayeva
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Diastolic Pressure ◽  
Blood Pressure Monitoring ◽  
Systolic Pressure ◽  
Clinical Manifestations ◽  
Pressure Profile ◽  
Left Ventricular ◽  
Combination Drug ◽  
Efficacy Of Treatment

The efficacy of treatment was evaluated by the fixed combination drug «Exforge-H» in 40 patients suffering from grade 3 arterial hypertension. All patients underwent general clinical and laboratory and instrumental examination (electrocardiography, echocardiography, 24-hour blood pressure monitoring) before and after 6 months of treatment. It was established that treatment with «Exforge-H» statistically reliably reduces the level of blood pressure, normalizes the variability and daily blood pressure profile. So, two weeks after the start of treatment, the systolic and diastolic pressure levels during clinical measurement decreased by 32,1±2,7 and 30,4±1,9 mm Hg. Art. respectively. After 3 months of treatment, 60% of patients showed achievement of the target level of blood pressure, and after 6 months - 96%. High hypotensive efficacy of treatment was also demonstrated during the daily monitoring of blood pressure in all its indicators. A significant decrease in systolic and diastolic pressure was observed during the day and night hours. The amplitudes of systolic and diastolic pressure variability have also been improved. At the same time, the variability of systolic pressure during the day was reduced by 46%, diastolic - by 49%, and at night by 59,3 and 52,8%, respectively, indicating a normalization of blood pressure during the day. All this was also accompanied by a decrease in the clinical manifestations of the disease. So, after 6 months of treatment, 84% of patients had positive clinical dynamics: a decrease in cardiac and cerebral symptoms, as well as emotional lability, which positively correlated with a decrease in the level of clinical blood pressure. The cardioprotective effect of the drug is expressed in the form of regression of left ventricular hypertrophy. In general, the use of the three-component fixed drug «Exforge-H» (valsartan - 80 mg, amlodipine - 5 mg and hydrochlorothiazide - 12,5 mg) is manifested by an increased antihypertensive effect due to the influence of its constituents side effects and the development of metabolic changes.

scholarly journals The use of telmisartan in patients with refractory arterial hypertension and obesity

2019 ◽  
Vol 18 (1) ◽  
pp. 73-81 ◽  
Author(s):  
I. Е. Deneka ◽  
A. V. Rodionov ◽  
V. V. Fomin
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Ace Inhibitor ◽  
Enzyme Inhibitor ◽  
Blood Pressure Monitoring ◽  
Main Group ◽  
Control Group ◽  
Angiotensin Ii Receptor Blocker ◽  
End Point

Aim.To evaluate the effectiveness of telmisartan as a component of triple antihypertensive therapy in patients with obesity and refractory arterial hypertension.Material and methods.The study included 30 patients with obesity and refractory arterial hypertension. All patients received an angiotensin II receptor blocker (ARB) or an angiotensin-converting enzyme inhibitor (ACE inhibitor) in an adequate dosage as part of a triple antihypertensive therapy that also includes a calcium antagonist and thiazide diuretic. Participants were randomly divided into two equal groups. In the main group, telmisartan (Dr. Reddy’s Laboratories) was prescribed at a dosage of 80 mg/day instead of the previously taken ARB or ACE inhibitor. In the control group, patients continued to receive a previously prescribed ARB or an ACE inhibitor. The primary end point was a decrease in mean daily systolic and/or diastolic blood pressure (SBP and DBP) according to 24-hour blood pressure monitoring at 10 mm Hg and more than 20 weeks after the start of the study. The secondary end point was a decrease in the concentration of inflammatory markers and an increase in the level of adiponectin by 15%.Results.After 20 weeks, in the telmisartan group, we noted a significant decrease in the average daily SBP and DBP: in the main group from 145,9±5,4/95,6±4,8 mm Hg to 134,8±3,0/84,9±4,2 mm Hg, in the control group with 147,2±4,9/96,4±5,6 mm Hg to 142,4±4,3/96,9±62 mm Hg. We also determined an increase in the serum adiponectin concentration from 9,3±5,6 μg/ml to 13,4±6,6 μg/ml in the main group and a decrease from 8,8±5,2 μg/ml to 8,6±5,6 μg/ml in the control group, as well as a decrease in the concentration of highly sensitive C-reactive protein (main group from 8,8±3,0 to 6,0±2,8 mg/l and the control group from 7,4±3,8 to 6,9±4,9 mg/l) and interleukin-6 (main group from 16,2±6,1 to 12,3±2,8 pg/ml, control group from 22,5±4,2 to 19,9±5,2 pg/ml).Conclusion.Telmisartan can be considered as a drug of choice as part of multi-component therapy in the treatment of patients with obesity and refractor arterial hypertension.

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