scholarly journals Association between Dietary Fibre Intake and Colorectal Adenoma: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (8) ◽  
pp. 4168
Author(s):  
Daniele Nucci ◽  
Cristina Fatigoni ◽  
Tania Salvatori ◽  
Mariateresa Nardi ◽  
Stefano Realdon ◽  
...  
Keyword(s):  
Protective Effect ◽  
Colorectal Adenoma ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Fibre Intake ◽  
Negative Linear Correlation ◽  
Statistical Heterogeneity ◽  
Dietary Fibre Intake ◽  
Meta Regression Analysis ◽  
Meta Analyses

PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus were searched in January 2021 in order to retrieve evidence assessing the association between dietary fibre intake and the risk of colorectal adenoma in adults. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for the reporting of results. Only primary observational studies were included. Publication bias was estimated through the Egger’s test and the visual inspection of the funnel plot. Heterogeneity between studies was calculated with I2 statistics. The search strategy identified 683 papers, 21 of which were included in our meta-analysis. Having evaluated a total of 157,725 subjects, the results suggest a protective effect of dietary fibre intake against colorectal adenoma. Effect Size (ES) was [0.71 (95% CI = 0.68–0.75), p = 0.000)]. Moderate statistical heterogeneity (Chi2 = 61.68, df = 23, I2 = 62.71%, p = 0.000) was found. Findings show a statistically significant (p = 0.000) and robust association between a higher intake of dietary fibre and a lower risk of colorectal adenoma, considering both the prevalent and incident risk. Moreover, the meta-regression analysis showed a borderline significant negative linear correlation between the amount of dietary fibre intake and colorectal adenoma. Lastly, we performed a subgroup analysis by sex, showing a higher protective effect for men.

scholarly journals Rectal Cancer: 20% Risk Reduction Thanks to Dietary Fibre Intake. Systematic Review and Meta-Analysis

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1579 ◽  
Author(s):  
Vincenza Gianfredi ◽  
Daniele Nucci ◽  
Tania Salvatori ◽  
Giulia Dallagiacoma ◽  
Cristina Fatigoni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Publication Bias ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
P Value ◽  
Computer Search ◽  
Fibre Intake ◽  
Statistical Heterogeneity ◽  
Dietary Fibre Intake

The aim of this systematic review and meta-analysis was to evaluate the association between dietary fibre intake and rectal cancer (RC) risk. In January 2019, a structured computer search on PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus was performed for studies reporting the results of primary research evaluating dietary fibre intake in women and men as well as the risk of developing RC. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations were followed. Highest vs. lowest fibre concentrations was compared. The Egger test was used to estimate publication bias. Heterogeneity between studies was evaluated with I2 statistics. The search strategy identified 912 papers, 22 of which were included in our meta-analysis. Having evaluated a total of 2,876,136 subjects, the results suggest a protective effect of dietary fibre intake on RC prevention. The effect Size (ES) was [0.77 (95% CI = 0.66–0.89), p-value = 0.001)]. Moderate statistical heterogeneity (Chi2 = 51.36, df = 21, I2 = 59.11%, p-value = 0.000) was found. However, no publication bias was found, as confirmed by Egger’s linear regression test (Intercept −0.21, t = −0.24, p = 0.816). The findings suggest that dietary fibre intake could be protective against RC, with a clinically relevant reduction of RC risk. Identifying preventive measures to avoid the development of RC, especially by following a healthy lifestyle including healthy diet, is pivotal.

scholarly journals Association of dietary fibre intake and gut microbiota in adults

2018 ◽  
Vol 120 (9) ◽  
pp. 1014-1022 ◽  
Author(s):  
Daniel Lin ◽  
Brandilyn A. Peters ◽  
Charles Friedlander ◽  
Hal J. Freiman ◽  
James J. Goedert ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Gut Microbiota ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Microbiota Composition ◽  
Fibre Intake ◽  
Dietary Fibre Intake ◽  
The Relationship ◽  
Gut Microbiota Composition

AbstractIncreasing evidence indicates that gut microbiota may influence colorectal cancer risk. Diet, particularly fibre intake, may modify gut microbiota composition, which may affect cancer risk. We investigated the relationship between dietary fibre intake and gut microbiota in adults. Using 16S rRNA gene sequencing, we assessed gut microbiota in faecal samples from 151 adults in two independent study populations: National Cancer Institute (NCI), n 75, and New York University (NYU), n 76. We calculated energy-adjusted fibre intake based on FFQ. For each study population with adjustment for age, sex, race, BMI and smoking, we evaluated the relationship between fibre intake and gut microbiota community composition and taxon abundance. Total fibre intake was significantly associated with overall microbial community composition in NYU (P=0·008) but not in NCI (P=0·81). In a meta-analysis of both study populations, higher fibre intake tended to be associated with genera of class Clostridia, including higher abundance of SMB53 (fold change (FC)=1·04, P=0·04), Lachnospira (FC=1·03, P=0·05) and Faecalibacterium (FC=1·03, P=0·06), and lower abundance of Actinomyces (FC=0·95, P=0·002), Odoribacter (FC=0·95, P=0·03) and Oscillospira (FC=0·96, P=0·06). A species-level meta-analysis showed that higher fibre intake was marginally associated with greater abundance of Faecalibacterium prausnitzii (FC=1·03, P=0·07) and lower abundance of Eubacterium dolichum (FC=0·96, P=0·04) and Bacteroides uniformis (FC=0·97, P=0·05). Thus, dietary fibre intake may impact gut microbiota composition, particularly class Clostridia, and may favour putatively beneficial bacteria such as F. prausnitzii. These findings warrant further understanding of diet–microbiota relationships for future development of colorectal cancer prevention strategies.

scholarly journals Dietary fibre intake and risk of stroke: A systematic review and meta-analysis of prospective studies

2012 ◽  
Vol 71 (OCE3) ◽  
Author(s):  
D. E. Threapleton ◽  
D. C. Greenwood ◽  
C. E. Evans ◽  
C. L. Cleghorn ◽  
C. Nykjaer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prospective Studies ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Dietary fibre intake and cardiovascular disease: A systematic review and meta-analysis of prospective studies

2012 ◽  
Vol 71 (OCE3) ◽  
Author(s):  
D. E. Threapleton ◽  
D. C. Greenwood ◽  
C. Evans ◽  
C. L. Cleghorn ◽  
C. Nykjaer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Prospective Studies ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Dietary fibre intake and diabetes risk: a systematic review and meta-analysis of prospective studies

2013 ◽  
Vol 72 (OCE4) ◽  
Author(s):  
D. E. Threapleton ◽  
D. C. Greenwood ◽  
C. Evans ◽  
C. L. Cleghorn ◽  
C. Nykjaer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Prospective Studies ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Diabetes Risk ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Dietary fibre intake and risk of breast cancer: A systematic review and meta-analysis of epidemiological studies

Oncotarget ◽  
2016 ◽  
Vol 7 (49) ◽  
pp. 80980-80989 ◽  
Author(s):  
Sumei Chen ◽  
Yuanyuan Chen ◽  
Shenglin Ma ◽  
Ruzhen Zheng ◽  
Pengjun Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis

BMJ ◽  
2013 ◽  
Vol 347 (dec19 2) ◽  
pp. f6879-f6879 ◽  
Author(s):  
D. E. Threapleton ◽  
D. C. Greenwood ◽  
C. E. L. Evans ◽  
C. L. Cleghorn ◽  
C. Nykjaer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiovascular Disease ◽  
Dietary Fibre ◽  
Meta Analysis ◽  
Fibre Intake ◽  
Dietary Fibre Intake

scholarly journals Intake of dietary fibre and lifetime non-steroidal anti-inflammatory drug (NSAID) use and the incidence of colorectal polyps in a population screened for colorectal cancer

2017 ◽  
Vol 71 (10) ◽  
pp. 961-969 ◽  
Author(s):  
Eileen Shaw ◽  
Matthew T Warkentin ◽  
S Elizabeth McGregor ◽  
Susanna Town ◽  
Robert J Hilsden ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dietary Fibre ◽  
Cross Sectional Study ◽  
Colorectal Polyps ◽  
Cross Sectional ◽  
Fibre Intake ◽  
Screening Population ◽  
Lifestyle Questionnaire ◽  
Dietary Fibre Intake ◽  
Anti Inflammatory

BackgroundThere is suggestive evidence that increased intake of dietary fibre and the use of non-steroidal anti-inflammatory drugs (NSAIDs) are generally associated with decreased colorectal cancer risk. However, the effects on precursors of colorectal cancer, such as adenomatous polyps, are mixed. We present the associations between dietary fibre intake and NSAID use on the presence and type of colorectal polyps in a screening population.MethodsA cross-sectional study of 2548 individuals undergoing colonoscopy at the Forzani & MacPhail Colon Cancer Screening Centre (Calgary, Canada) was conducted. Dietary fibre intake and NSAID use were assessed using the Diet History Questionnaire I or II and the Health and Lifestyle Questionnaire. Colorectal outcomes were documented as a polyp or high-risk adenomatous polyp (HRAP; villous histology, high-grade dysplasia, ≥10 mm or ≥3 adenomas). Crude and ORs and 95% CIs were estimated using unconditional logistic regression.ResultsThere were 1450 negative colonoscopies and 1098 patients with polyps, of which 189 patients had HRAPs. Total dietary fibre intake was associated with a decreased presence of HRAPs (OR=0.50, 95% CI: 0.29 to 0.86) when comparing the highest to lowest quartiles and was observed with both soluble (OR=0.51, 95% CI: 0.30 to 0.88) and insoluble (OR=0.51, 95% CI: 0.30 to 0.86) fibres. Ever use of NSAIDs was also inversely associated with HRAPs (OR=0.65, 95% CI: 0.47 to 0.89), observed with monthly (OR=0.60, 95% CI: 0.37 to 0.95) and daily (OR=0.53, 95% CI: 0.32 to 0.86) use.ConclusionsDietary fibre intake and NSAID use were associated with a decreased risk of having a HRAP at screening.

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