scholarly journals Health Status Is Affected, and Phase I/II Biotransformation Activity Altered in Young Women Using Oral Contraceptives Containing Drospirenone/Ethinyl Estradiol

2021 ◽  
Vol 18 (20) ◽  
pp. 10607
Author(s):  
Gerda Venter ◽  
Carien L. van der van der Berg ◽  
Francois H. van der van der Westhuizen ◽  
Elardus Erasmus
Keyword(s):  
Oxidative Stress ◽  
Health Status ◽  
Phase I ◽  
Young Women ◽  
Ethinyl Estradiol ◽  
Subjective Health ◽  
Subjective Health Status ◽  
Glucuronide Conjugation ◽  
Health Related

Combined oral contraceptive (COC) use has been associated with various adverse effects. Formulations containing drospirenone (DRSP) and ethinyl estradiol (EE) are generally regarded as milder COCs. Whether long term use of these pills indeed has a low health risk remains questionable. COC use may affect the biotransformation balance by increasing the toxic load or by interfering with the pharmacokinetics of other drugs. This may negatively impact overall health via the production of toxic biotransformation metabolites and induction of oxidative stress. Although individual enzymes involved in biotransformation are known to be regulated by COCs, the effect of COC use on the overall liver biotransformation efficiency has not been reported. Here, we evaluated the general subjective health status and overall liver biotransformation efficiency of healthy young women who were either long term chronic users of COCs containing DRSP/EE, or who were not using any hormonal products. COC users suffered from moderate to severe fatigue and reported more health-related symptoms. Furthermore, phase I (CYP1A2) activity was reduced whereas phase II conjugation reactions (glucuronide conjugation and glycine conjugation) were increased in COC users. Finally, serum peroxide levels were markedly elevated and antioxidant capacity of plasma was reduced in COC users. COCs containing DRSP/EE may, therefore, adversely affect health status and disturb the balance between phase I and II biotransformation reactions. These effects may be mediated by oxidative stress.

Long-Term Follow-Up of Controlled Acromegalic Patients: Radiotherapy Is Associated with Impaired Subjective Health Status (SF-36)

2011 ◽  
pp. P3-285-P3-285
Author(s):  
Sandra Schindler ◽  
Matthias Mohlig ◽  
Natalia Kremenevskaya ◽  
Michael Buchfelder ◽  
Christof Schofl
Keyword(s):  
Health Status ◽  
Subjective Health ◽  
Subjective Health Status ◽  
Sf 36 ◽  
Long Term Follow Up

Pyridostigmine Bromide and the Long-Term Subjective Health Status of a Sample of Female Reserve Component Gulf War Veterans: A Brief Report

2001 ◽  
Vol 88 (1) ◽  
pp. 306-308 ◽  
Author(s):  
Walter R. Schumm ◽  
Earl Jay Reppert ◽  
Anthony P. Jurich ◽  
Stephan R. Bollman ◽  
Carlos Castelo ◽  
...  
Keyword(s):  
Health Status ◽  
Subjective Health ◽  
Gulf War ◽  
Conclusive Evidence ◽  
Pyridostigmine Bromide ◽  
Subjective Health Status ◽  
War Veterans ◽  
Gulf War Veterans ◽  
Reserve Component

The role of pyridostigmine bromide (PB) pills in explaining the long-term subjective health status of a sample of over 100 female Reserve Component Gulf War veterans was examined through regression analysis. Results fell just short of significance ( p < .06) for the prediction of subjective health approximately six years after the war and were clearly not significant for the prediction of subjective health at previous times. Results parallel Golomb's 1999 RAND report, which found suggestive but not conclusive evidence for the possible adverse effects of Gulf War veterans' consumption of pyridostigmine bromide pills. Our data suggest that use of more than 10 pills may have been especially risky with respect to long-term subjective health.

scholarly journals Lifestyle and Living Standards of Elderly Men in Eastern Hungary

2011 ◽  
Vol 52 (1) ◽  
pp. 69-79
Author(s):  
Zsuzsanna Balogh ◽  
József Bognár ◽  
Judit Lakó ◽  
Judit Plachy ◽  
Magdolna Kovách
Keyword(s):  
Health Status ◽  
Sex Education ◽  
Decisive Role ◽  
Subjective Health ◽  
Living Standards ◽  
Elderly Men ◽  
Subjective Health Status ◽  
Physical Activity Change ◽  
Elderly Males ◽  
Health Related

Lifestyle and Living Standards of Elderly Men in Eastern HungaryThis present study intends to deal with the lifestyles and living standards of elderly men. The health-related lifestyle was examined including a closer look at how elderly people value their own living standards, and how it is connected to the present state of their condition and activities. Our main goal was to highlight all lifestyle elements, because such an age, lifestyle has a decisive role in improving living standards. It seems reasonable to take several aspects - physical activity, change of lifestyle, and age differences - into consideration when health-cultural behaviour is examined because all of them can influence elderly people's lifestyles and quality of life. Data were collected in eastern Hungary, in Hajdú-Bihar County, among elderly males above 60 years old (N=1,269; M=70.23; min: 60; max: 99; SD±7.095) through questionnaires. Our survey contained questions in three main topics: demographic profile (age, sex, education, financial status, living conditions, and occupation), health status (subjective health status, health awareness, mental health status), and health behaviour (physical exercise, smoking, and alcohol consumption). Different sub-patterns were examined during the analysis: different qualifications, age, and settlement types.

Influencing Factors on Health-Related Quality of Life in Middle-Aged Adults With Hypertension

2018 ◽  
Vol 9 (4) ◽  
pp. 40-49
Author(s):  
Eunjoo Lee
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Subjective Health ◽  
Health Related Quality ◽  
Middle Aged ◽  
Subjective Health Status ◽  
Related Quality ◽  
Health Related ◽  
Middle Aged Adults

This article aims to examine the influencing factors on health-related quality of life (HRQOL) in middle-aged adults with hypertension. HRQOL was assessed using EQ-5D from 263 middle-aged adults (40-60 years) with hypertension who participated in the 6th Korean National Health and Nutrition Examination Survey (2014). There were statistically significant differences in health-related quality of life according to income, education, subjective health status, experience of discomfort, activity limitation, stress, and aerobic physical activity. Factors influencing on health-related quality of life in middle-aged adults with hypertension were subjective health status, experience of discomfort, activity limitation, depression, and stress, which explained about 50% of total variance. These factors should be included in the nursing intervention, and psychological aspects such as depression should be emphasized.

Pyridostigmine Bromide and the Long-Term Subjective Health Status of a Sample of over 700 Male Reserve Component Gulf War Era Veterans

2002 ◽  
Vol 90 (3) ◽  
pp. 707-721 ◽  
Author(s):  
Walter R. Schumm ◽  
Earl J. Reppert ◽  
Anthony P. Jurich ◽  
Stephan R. Bollman ◽  
Farrell J. Webb ◽  
...  
Keyword(s):  
Health Status ◽  
Subjective Health ◽  
Pyridostigmine Bromide ◽  
Minority Status ◽  
Subjective Health Status ◽  
Male Veterans ◽  
Status Number ◽  
Reserve Component ◽  
Military Rank

Data from a 1996–1997 survey of approximately 700 Reserve Component male veterans indicate that the consumption of pyridostigmine bromide pills, used as a pretreatment for potential exposure to the nerve agent Soman, was a significant predictor of declines in reported subjective health status after the war, even after controlling for a number of other possible factors. Reported reactions to vaccines and other medications also predicted declines in subjective health. While higher military rank generally predicted better health during and after the war, educational attainment, minority status, number of days in theater, and age generally did not predict changes in subjective health. Although servicemembers were directed to take three pills a day, veterans reported a range of compliance—less than a fourth (24%) followed the medical instructions compared to 61% who took fewer than three pills daily and 6% who took six or more pills a day. Implications for use of pyridostigmine bromide are discussed.

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