Correction: Kang, K.A.; et al., Myricetin Protects Cells against Oxidative Stress-Induced Apoptosis via Regulation of PI3K/Akt and MAPK Signaling Pathways. Int. J. Mol. Sci. 2010, 11,  4348–4360

MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus. In this review, we present the main pro- and anti-apoptotic mechanisms regulated by MAPKs, as well as the crosstalk observed between some MAPKs. We also describe the basic signaling properties of MAPKs (ultrasensitivity, hysteresis, digital response), and the presence of different positive feedback loops in apoptosis. We provide a simple guide to predict MAPKs’ behavior, based on the intensity and duration of the stimulus. Finally, we consider the role of MAPKs in osmostress-induced apoptosis by using Xenopus oocytes as a cell model. As we will see, apoptosis is plagued with multiple positive feedback loops. We hope this review will help to understand how MAPK signaling pathways engage irreversible cellular decisions.

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Oxidative Stress Inhibits Insulin-like Growth Factor-I Induction of Chondrocyte Proteoglycan Synthesis through Differential Regulation of Phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK Signaling Pathways

Journal of Biological Chemistry ◽

10.1074/jbc.m109.056838 ◽

2009 ◽

Vol 284 (46) ◽

pp. 31972-31981 ◽

Cited By ~ 99

Author(s):

Weihong Yin ◽

Jong-In Park ◽

Richard F. Loeser

Keyword(s):

Oxidative Stress ◽

Growth Factor ◽

Signaling Pathways ◽

Mapk Signaling ◽

Differential Regulation ◽

Proteoglycan Synthesis ◽

Insulin Like Growth Factor ◽

Phosphatidylinositol 3 Kinase ◽

Factor I ◽

Mapk Signaling Pathways

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Bag-1 silencing enhanced chemotherapeutic drug-induced apoptosis in MCF-7 breast cancer cells affecting PI3K/Akt/mTOR and MAPK signaling pathways

Molecular Biology Reports ◽

10.1007/s11033-018-4540-x ◽

2019 ◽

Vol 46 (1) ◽

pp. 847-860 ◽

Cited By ~ 6

Author(s):

Pelin Ozfiliz Kilbas ◽

Izzet Mehmet Akcay ◽

Gizem Dinler Doganay ◽

Elif Damla Arisan

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Signaling Pathways ◽

Breast Cancer Cells ◽

Mapk Signaling ◽

Chemotherapeutic Drug ◽

Drug Induced ◽

Induced Apoptosis ◽

Mapk Signaling Pathways ◽

Mcf 7

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Weaning Induced Hepatic Oxidative Stress, Apoptosis, and Aminotransferases through MAPK Signaling Pathways in Piglets

Oxidative Medicine and Cellular Longevity ◽

10.1155/2016/4768541 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 26

Author(s):

Zhen Luo ◽

Wei Zhu ◽

Qi Guo ◽

Wenli Luo ◽

Jing Zhang ◽

...

Keyword(s):

Oxidative Stress ◽

Signaling Pathways ◽

Redox Status ◽

Mapk Signaling ◽

Mitogen Activated Protein Kinase ◽

Control Group ◽

Hepatic Oxidative Stress ◽

Mitogen Activated Protein ◽

D 20 ◽

Mapk Signaling Pathways

This study investigated the effects of weaning on the hepatic redox status, apoptosis, function, and the mitogen-activated protein kinase (MAPK) signaling pathways during the first week after weaning in piglets. A total of 12 litters of piglets were weaned at d 21 and divided into the weaning group (WG) and the control group (CG). Six piglets from each group were slaughtered at d 0 (d 20, referred to weaning), d 1, d 4, and d 7 after weaning. Results showed that weaning significantly increased the concentrations of hepatic free radicals H2O2and NO, malondialdehyde (MDA), and 8-hydroxy-2′-deoxyguanosine (8-OHdG), while significantly decreasing the inhibitory hydroxyl ability (IHA) and glutathione peroxidase (GSH-Px), and altered the level of superoxide dismutase (SOD). The apoptosis results showed that weaning increased the concentrations of caspase-3, caspase-8, caspase-9 and the ratio of Bax/Bcl-2. In addition, aspartate aminotransferase transaminase (AST) and alanine aminotransferase (ALT) in liver homogenates increased after weaning. The phosphorylated JNK and ERK1/2 increased, while the activated p38 initially decreased and then increased. Our results suggested that weaning increased the hepatic oxidative stress and aminotransferases and initiated apoptosis, which may be related to the activated MAPK pathways in postweaning piglets.

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