scholarly journals Enhanced Protection of Biological Membranes during Lipid Peroxidation. Study of the Interactions between Flavonoid Loaded Mesoporous Silica Nanoparticles and Model Cell Membranes

2019 ◽  
Author(s):  
Anja Sadžak ◽  
Lucija Mandić ◽  
Vida Strasser ◽  
Goran Baranović ◽  
Darija Domazet Jurašin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
High Potential ◽  
Bioactive Molecules ◽  
Oxidative Activity ◽  
Model Cell

Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress i.e. lipid peroxidation induced by addition of hydrogen peroxide and/or Cu2+ ions. Among investigated flavonoids, quercetin showed the most enhanced and prolonged protective anti-oxidative activity. The nanomechanical (Young modulus) measurement of the MSNs treated DOPC membranes during lipid peroxidation confirmed attenuated membrane damage. By applying combination of experimental techniques (AFM, force spectroscopy, ELS, DLS), this work generated detailed knowledge about the effects of flavonoid loaded MSNs on the elasticity of model membranes, especially under oxidative stress conditions. Results from this study will pave the way towards the development of innovative and improved markers for oxidative stress-associated neurological disorders. In addition, the obtained could be extended to designing effective delivery systems of other high potential bioactive molecules with an aim to improve human health in general.

scholarly journals Enhanced Protection of Biological Membranes during Lipid Peroxidation: Study of the Interactions between Flavonoid Loaded Mesoporous Silica Nanoparticles and Model Cell Membranes

2019 ◽  
Vol 20 (11) ◽  
pp. 2709 ◽  
Author(s):  
Lucija Mandić ◽  
Anja Sadžak ◽  
Vida Strasser ◽  
Goran Baranović ◽  
Darija Domazet Jurašin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Light Scattering ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
High Potential ◽  
Oxidative Activity ◽  
Model Cell

Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics for neurodegenerative disease, but their applicability is rendered by their poor water solubility and chemical instability under physiological conditions. In this study, this is overcome by delivering flavonoids to model cell membranes (unsaturated DOPC) using prepared and characterized biodegradable mesoporous silica nanoparticles, MSNs. Quercetin, myricetin and myricitrin have been investigated in order to determine the relationship between flavonoid structure and protective activity towards oxidative stress, i.e., lipid peroxidation induced by the addition of hydrogen peroxide and/or Cu2+ ions. Among investigated flavonoids, quercetin showed the most enhanced and prolonged protective anti-oxidative activity. The nanomechanical (Young modulus) measurement of the MSNs treated DOPC membranes during lipid peroxidation confirmed attenuated membrane damage. By applying a combination of experimental techniques (atomic force microscopy—AFM, force spectroscopy, electrophoretic light scattering—ES and dynamic light scattering—DLS), this work generated detailed knowledge about the effects of flavonoid loaded MSNs on the elasticity of model membranes, especially under oxidative stress conditions. Results from this study will pave the way towards the development of innovative and improved markers for oxidative stress-associated neurological disorders. In addition, the obtained could be extended to designing effective delivery systems of other high potential bioactive molecules with an aim to improve human health in general.

scholarly journals Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3337
Author(s):  
Sara Hooshmand ◽  
Sahar Mollazadeh ◽  
Negar Akrami ◽  
Mehrnoosh Ghanad ◽  
Ahmed El-Fiqi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Skin Regeneration ◽  
Bioactive Molecules ◽  
Wound Management ◽  
Bioactive Glasses ◽  
Wide Range

Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

scholarly journals pH-responsive delivery of H2 through ammonia borane-loaded mesoporous silica nanoparticles improves recovery after spinal cord injury by moderating oxidative stress and regulating microglial polarization

2021 ◽  
Author(s):  
Yi Liu ◽  
Yeying Wang ◽  
Bing Xiao ◽  
Guoke Tang ◽  
Jiangming Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ammonia Borane ◽  
Neural Regeneration ◽  
Dependent Manner ◽  
Cord Injury

Abstract Imbalance of oxidative and inflammatory regulation is the main contributor to neurofunctional deterioration and failure of rebuilding spared neural networks after spinal cord injury (SCI). As an emerging biosafe strategy for protecting against oxidative and inflammatory damage, hydrogen (H2) therapy is a promising approach for improving the microenvironment to allow neural regeneration. However, achieving release of H2 at sufficient concentrations specifically into the injured area is critical for the therapeutic effect of H2. Thus, we assembled SiO2@mSiO2 mesoporous silica nanoparticles and loaded them with ammonia borane (AB), which has abundant capacity and allows controllable release of H2 in an acid-dependent manner. The release of H2 from AB/SiO2@mSiO2 was satisfactory at pH 6.6, which is approximately equal to the microenvironmental acidity after SCI. After AB/SiO2@mSiO2 were intrathecally administered to rat models of SCI, continuous release of H2 from these nanoparticles synergistically enhanced neurofunctional recovery, reduced fibrotic scar formation and promoted neural regeneration by suppressing oxidative stress reaction. Furthermore, in the subacute phase of SCI, microglia were markedly polarized toward the M2 phenotype by H2 via inhibition of TLR9 expression in astrocytes. In conclusion, H2 delivery through AB/SiO2@mSiO2 has the potential to efficiently treat SCI through comprehensive modulation of the oxidative and inflammatory imbalance in the microenvironment.

Smart mesoporous silica nanoparticles for controlled-release drug delivery

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Mahdi Karimi ◽  
Hamed Mirshekari ◽  
Masoumeh Aliakbari ◽  
Parham Sahandi-Zangabad ◽  
Michael R. Hamblin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Capacity ◽  
Bioactive Molecules ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Stimulus Responsive ◽  
External Stimuli

AbstractStimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

scholarly journals Mesoporous Silica Nanoparticles in Chemical Detection: From Small Species to Large Bio-Molecules

Sensors ◽  
2021 ◽  
Vol 22 (1) ◽  
pp. 261
Author(s):  
Margarita Parra ◽  
Salvador Gil ◽  
Pablo Gaviña ◽  
Ana M. Costero
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Hybrid Materials ◽  
Mesoporous Silica Nanoparticles ◽  
High Potential ◽  
Chemical Detection ◽  
Small Species

A recompilation of applications of mesoporous silica nanoparticles in sensing from the last five years is presented. Its high potential, especially as hybrid materials combined with organic or bio-molecules, is shown. Adding to the multiplying effect of loading high amounts of the transducer into the pores, the selectivity attained by the interaction of the analyte with the layer decorating the material is described. Examples of the different methodologies are presented.

Implications for blood-brain-barrier permeability, in vitro oxidative stress and neurotoxicity potential induced by mesoporous silica nanoparticles: effects of surface modification

RSC Advances ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 2800-2809 ◽  
Author(s):  
Ming Zhou ◽  
Linlin Xie ◽  
Chen-Jie Fang ◽  
Hua Yang ◽  
Yan-Jie Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Surface Modification ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Brain Barrier ◽  
Neuronal Damage ◽  
Mesoporous Silica Nanoparticles ◽  
Barrier Permeability ◽  
Brain Barrier Permeability

MSNs are shown to have the potential to overcome the BBB and cause neuronal damage. However, the neurotoxicity potential could be mediated with surface modification.

scholarly journals Fabrication of Heparinized Mesoporous Silica Nanoparticles as Multifunctional Drug Carriers

2013 ◽  
Vol 2013 ◽  
pp. 1-10
Author(s):  
Yongxiang Zhang ◽  
Xinmin Liu ◽  
Yizhong Lu ◽  
Jincai Wang ◽  
Tingfang Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Bioactive Molecules ◽  
Promising Candidate ◽  
Silica Materials ◽  
New Material ◽  
Mesoporous Silica Materials

In this study, heparinized multifunctional mesoporous silica nanoparticles were successfully synthesized and characterized. The new material not only maintains intrinsic functions of bare magnetic and fluorescent mesoporous silica materials such as targeting, imaging, and sustained release of drugs, but also generates several novel activities such as the enhancement of biocompatibility, selective loading drugs, and dual loading of anticancer drug and bFGF, rendering it a promising candidate to be used as a multifunctional carrier. The strategy of combination of multifunctional mesoporous silica materials with bioactive molecules could be a new effective approach to improve their capabilities in the drug delivery.

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