scholarly journals Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni

2019 ◽  
Vol 20 (19) ◽  
pp. 4830 ◽  
Author(s):  
Fábia Daniela Lobo de Sá ◽  
Eduard Butkevych ◽  
Praveen Kumar Nattramilarasu ◽  
Anja Fromm ◽  
Soraya Mousavi ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Curcuma Longa ◽  
Epithelial Barrier ◽  
Protective Agent ◽  
Protective Effects ◽  
Barrier Dysfunction ◽  
Natural Polyphenol ◽  
Electrophysiological Measurements ◽  
Medical Plant ◽  
Epithelial Barrier Dysfunction

Campylobacter jejuni (C. jejuni) is the most common cause of foodborne gastroenteritis worldwide. The bacteria induce diarrhea and inflammation by invading the intestinal epithelium. Curcumin is a natural polyphenol from turmeric rhizome of Curcuma longa, a medical plant, and is commonly used in curry powder. The aim of this study was the investigation of the protective effects of curcumin against immune-induced epithelial barrier dysfunction in C. jejuni infection. The indirect C. jejuni-induced barrier defects and its protection by curcumin were analyzed in co-cultures with HT-29/B6-GR/MR epithelial cells together with differentiated THP-1 immune cells. Electrophysiological measurements revealed a reduction in transepithelial electrical resistance (TER) in infected co-cultures. An increase in fluorescein (332 Da) permeability in co-cultures as well as in the germ-free IL-10−/− mouse model after C. jejuni infection was shown. Curcumin treatment attenuated the C. jejuni-induced increase in fluorescein permeability in both models. Moreover, apoptosis induction, tight junction redistribution, and an increased inflammatory response—represented by TNF-α, IL-1β, and IL-6 secretion—was observed in co-cultures after infection and reversed by curcumin. In conclusion, curcumin protects against indirect C. jejuni-triggered immune-induced barrier defects and might be a therapeutic and protective agent in patients.

scholarly journals The Protective Effects of a Synthetic Geranyl Acetophenone in a Cellular Model of TNF-α-Induced Pulmonary Epithelial Barrier Dysfunction

Molecules ◽  
2018 ◽  
Vol 23 (6) ◽  
pp. 1355 ◽  
Author(s):  
Tee Sim ◽  
Hanis Harith ◽  
Chau Tham ◽  
Nur Md Hashim ◽  
Khozirah Shaari ◽  
...  
Keyword(s):  
Epithelial Barrier ◽  
Protective Effects ◽  
Cellular Model ◽  
Barrier Dysfunction ◽  
Tnf Α ◽  
Epithelial Barrier Dysfunction

scholarly journals Protective effects of lactic acid bacteria on gut epithelial barrier dysfunction are Toll like receptor 2 and protein kinase C dependent

2020 ◽  
Vol 11 (2) ◽  
pp. 1230-1234
Author(s):  
Chengcheng Ren ◽  
Qiuxiang Zhang ◽  
Bart J. de Haan ◽  
Marijke M. Faas ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Epithelial Barrier ◽  
Protective Effects ◽  
Toll Like Receptor ◽  
Bacterial Strains ◽  
Barrier Dysfunction ◽  
Barrier Integrity ◽  
Kinase C ◽  
Toll Like Receptor 2 ◽  
Epithelial Barrier Dysfunction

TLR2-signalling lactic acid bacterial strains specifically inhibit PKC-dependent gut epithelial barrier integrity loss but cannot dampen MAPK-dependent epithelial barrier disruption.

NAD+ Ameliorates Inflammation-Induced Epithelial Barrier Dysfunction in Cultured Enterocytes and Mouse Ileal Mucosa

2003 ◽  
Vol 307 (2) ◽  
pp. 443-449 ◽  
Author(s):  
Xiaonan Han ◽  
Takashi Uchiyama ◽  
Penny L. Sappington ◽  
Arino Yaguchi ◽  
Runkuan Yang ◽  
...  
Keyword(s):  
Epithelial Barrier ◽  
Barrier Dysfunction ◽  
Ileal Mucosa ◽  
Epithelial Barrier Dysfunction

scholarly journals Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Linda Chia-Hui Yu
Keyword(s):  
Mast Cell ◽  
Cell Surface ◽  
Critical Role ◽  
Mast Cell Activation ◽  
Epithelial Barrier ◽  
Intestinal Epithelial ◽  
Barrier Dysfunction ◽  
Intestinal Epithelial Barrier ◽  
Food Antigens ◽  
Epithelial Barrier Dysfunction

Intestinal epithelial barrier plays a critical role in the maintenance of gut homeostasis by limiting the penetration of luminal bacteria and dietary allergens, yet allowing antigen sampling for the generation of tolerance. Undigested proteins normally do not gain access to the lamina propria due to physical exclusion by tight junctions at the cell-cell contact sites and intracellular degradation by lysosomal enzymes in enterocytes. An intriguing question then arises: how do macromolecular food antigens cross the epithelial barrier? This review discusses the epithelial barrier dysfunction in sensitized intestine with special emphasis on the molecular mechanism of the enhanced transcytotic rates of allergens. The sensitization phase of allergy is characterized by antigen-induced cross-linking of IgE bound to high affinity FcεRI on mast cell surface, leading to anaphylactic responses. Recent studies have demonstrated that prior to mast cell activation, food allergens are transported in large quantity across the epithelium and are protected from lysosomal degradation by binding to cell surface IgE and low-affinity receptor CD23/FcεRII. Improved immunotherapies are currently under study including anti-IgE and anti-CD23 antibodies for the management of atopic disorders.

Correlation between cyclical epithelial barrier dysfunction and bacterial translocation in the relapses of intestinal inflammation

2006 ◽  
Vol 12 (9) ◽  
pp. 843-852 ◽  
Author(s):  
Monica Porras ◽  
Maria Teresa Martín ◽  
Ping-Chang Yang ◽  
Jennifer Jury ◽  
Mary H. Perdue ◽  
...  
Keyword(s):  
Bacterial Translocation ◽  
Intestinal Inflammation ◽  
Epithelial Barrier ◽  
Barrier Dysfunction ◽  
Epithelial Barrier Dysfunction
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