scholarly journals Cationic Surfactants: Self-Assembly, Structure-Activity Correlation and Their Biological Applications

2019 ◽  
Vol 20 (22) ◽  
pp. 5534 ◽  
Author(s):  
Zakharova ◽  
Pashirova ◽  
Doktorovova ◽  
Fernandes ◽  
Sanchez-Lopez ◽  
...  
Keyword(s):  
Self Assembly ◽  
Cationic Surfactants ◽  
Structural Diversity ◽  
Modern Trend ◽  
Biological Applications ◽  
Mixed Composition ◽  
Cleavable Surfactants ◽  
Amphiphilic Compounds ◽  
Head Groups ◽  
Main Emphasis

The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction.

Contrasting effect of 1-butanol and 1, 4-butanediol on the triggered micellar self-assemblies of C16-type cationic surfactants

2021 ◽  
Author(s):  
Vinod Kumar ◽  
Rajni Verma ◽  
Dwarkesh Satodia ◽  
Debes Ray ◽  
Ketan Kuperkar ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Cationic Surfactant ◽  
Self Assembly ◽  
Cationic Surfactants ◽  
Alkyl Chain ◽  
Cetylpyridinium Bromide ◽  
Quaternary Salts ◽  
Head Groups ◽  
Contrasting Effect ◽  
Cetyltrimethylammonium Tosylate

Self-assembly in aqueous solutions of three quaternary salts based C16-type cationic surfactant with different polar head groups and identical carbon alkyl chain viz., cetylpyridinium bromide (CPB), cetyltrimethylammonium tosylate (CTAT), and...

Steric and Counterion Effects on Cationic Surfactant Self-Assembly into Micelles and Liquid Crystals

2003 ◽  
Vol 56 (10) ◽  
pp. 1065 ◽  
Author(s):  
Marta A. Cassidy ◽  
Gregory G. Warr
Keyword(s):  
Liquid Crystals ◽  
Cationic Surfactant ◽  
Group Size ◽  
Self Assembly ◽  
Cationic Surfactants ◽  
Head Group ◽  
Ion Flotation ◽  
Head Groups ◽  
Aggregate Morphology ◽  
Spherical Micelles

The roles of head-group size and counterion association on aggregate morphology in solution and lyotropic phases of cationic surfactants (tetradecyl trimethyl-, tetradecyl triethyl-, and tetradecyl tripropylammonium) are examined, using salicylate as a strongly binding counterion. Larger head groups are found to inhibit the formation of low-curvature structures such as bilayers, and salicylate binding excludes spherical micelles, so that both effects tend to favour locally cylindrical aggregates. Interfacial probes and ion flotation show that the binding of salicylate is reduced by increasing head-group size. In addition, a novel demixing is observed with features similar to lower consolute behaviour of other cationic surfactant systems.

Self-assembly of the mixed systems based on cationic surfactants and different types of polyanions: The influence of structural and concentration factors

2018 ◽  
Vol 272 ◽  
pp. 892-901 ◽  
Author(s):  
E.A. Vasilieva ◽  
D.A. Samarkina ◽  
G.A. Gaynanova ◽  
S.S. Lukashenko ◽  
D.R. Gabdrakhmanov ◽  
...  
Keyword(s):  
Self Assembly ◽  
Cationic Surfactants ◽  
Different Types ◽  
Concentration Factors ◽  
Mixed Systems

scholarly journals Poly(ADP-ribose): An organizer of cellular architecture

2014 ◽  
Vol 205 (5) ◽  
pp. 613-619 ◽  
Author(s):  
Anthony K.L. Leung
Keyword(s):  
Dna Repair ◽  
Self Assembly ◽  
Structural Diversity ◽  
Low Complexity ◽  
Cellular Organization ◽  
Rna Granules ◽  
Cellular Architecture ◽  
Spindle Poles ◽  
Granule Proteins

Distinct properties of poly(ADP-ribose)—including its structural diversity, nucleation potential, and low complexity, polyvalent, highly charged nature—could contribute to organizing cellular architectures. Emergent data indicate that poly(ADP-ribose) aids in the formation of nonmembranous structures, such as DNA repair foci, spindle poles, and RNA granules. Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADP-ribose) could direct cellular organization.

Modelling the dynamics of a minimal protocell container

2005 ◽  
Vol 4 (1) ◽  
pp. 81-91 ◽  
Author(s):  
Martin Nilsson Jacobi ◽  
Steen Rasmussen ◽  
Kolbjørn Tunstrøm
Keyword(s):  
Self Assembly ◽  
Large Scale ◽  
Lattice Gas ◽  
Three Dimensional ◽  
Initial Distribution ◽  
Energy Potential ◽  
Time Dynamics ◽  
Amphiphilic Molecules ◽  
Head Groups ◽  
Simplifying Assumptions

This paper is a discussion on how reaction kinetics and three-dimensional (3D) lattice simulations can be used to elucidate the dynamical properties of micelles as a possible minimal protocell container. We start with a general discussion on the role of molecular self-assembly in prebiotic and contemporary biological systems. A simple reaction kinetic model of a micellation process of amphiphilic molecules in water is then presented and solved analytically. Amphiphilic molecules are polymers with hydrophobic (water-fearing), e.g. hydrocarbon tail groups, and hydrophilic (water-loving) head groups, e.g. fatty acids. By making a few simplifying assumptions an analytical expression for the size distribution of the resulting micelles can be derived. The main part of the paper presents and discusses a lattice gas technique for a more detailed 3D simulation of molecular self-assembly of amphiphilic polymers in aqueous environments. Water molecules, hydrocarbon tail groups and hydrophilic head groups are explicitly represented on a three-dimensional discrete lattice. Molecules move on the lattice proportional to their continuous momentum. Collision rules preserve momentum and kinetic energy. Potential energy from molecular interactions are also included explicitly. The non-trivial thermodynamics of large-scale and long-time dynamics are studied. In this paper we specifically demonstrate how, from a random initial distribution, micelles are formed and grow until they destabilize and can divide. Eventually a steady state of growing and dividing micelles is formed. Towards the end of the paper we discuss the relevance of the presented results to the design of a minimal artificial protocell.

scholarly journals Exploring the Self-Assembled Tacticity in Aurophilic Polymeric Arrangements of Diphosphanegold(I) Fluorothiolates

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4422 ◽  
Author(s):  
Moreno-Alcántar ◽  
Salazar ◽  
Romo-Islas ◽  
Flores-Álamo ◽  
Torrens
Keyword(s):  
Solid State ◽  
Self Assembly ◽  
Structural Diversity ◽  
Supramolecular Structures ◽  
X Ray Diffraction ◽  
Ligand Effects ◽  
Rational Control ◽  
Solid State Structures ◽  
Further Development ◽  
Aurophilic Interactions

Despite the recurrence of aurophilic interactions in the solid-state structures of gold(I) compounds, its rational control, modulation, and application in the generation of functional supramolecular structures is an area that requires further development. The ligand effects over the aurophilic-based supramolecular structures need to be better understood. This paper presents the supramolecular structural diversity of a series of new 1,3-bis(diphenylphosphane)propane (dppp) gold(I) fluorinated thiolates with the general formula [Au2(SRF)2(μ-dppp)] (SRF = SC6F5 (1); SC6HF4-4 (2); SC6H3(CF3)2-3,5 (3); SC6H4CF3-2 (4); SC6H4CF3-4 (5); SC6H3F2-3,4 (6); SC6H3F2-3,5 (7); SC6H4F-2 (8); SC6H4F-3 (9); SC6H4F-4 (10)). These compounds were synthesized and characterized, and six of their solid-state crystalline structures were determined using single-crystal X-ray diffraction. In the crystalline arrangement, they form aurophilic-bridged polymers. In these systems, the changes in the fluorination patterns of the thiolate ligands tune the aurophilic-induced self-assembly of the compounds causing tacticity and chiral differentiation of the monomers. This is an example of the use of ligand effects on the tune of the supramolecular association of gold complexes.

scholarly journals The effect of surfactant structure on ribonuclease A–surfactant interactions

1973 ◽  
Vol 135 (3) ◽  
pp. 547-549 ◽  
Author(s):  
Cecilia Blinkhorn ◽  
Malcolm N. Jones
Keyword(s):  
Anionic Surfactant ◽  
Cationic Surfactants ◽  
Ribonuclease A ◽  
Enzymic Activity ◽  
Head Groups ◽  
Surfactant Interactions ◽  
Dodecylamine Hydrochloride

The enzymic activity of ribonuclease A was measured in the presence of several surfactants at pH7.2. Cationic surfactants with trimethylammonium and pyridinium head groups do not deactivate or denature the enzyme, whereas n-dodecylamine hydrochloride, like the anionic surfactant sodium n-dodecyl sulphate, deactivates and denatures ribonuclease A.

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