scholarly journals Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain

2020 ◽  
Vol 21 (1) ◽  
pp. 345 ◽  
Author(s):  
Eugenia B. Manukhina ◽  
Vadim E. Tseilikman ◽  
Marina N. Karpenko ◽  
Nina S. Pestereva ◽  
Olga B. Tseilikman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Glycogen Content ◽  
Stress Disorder ◽  
Preventive Treatment ◽  
Monoamine Oxidase A ◽  
Post Traumatic Stress ◽  
Neuroprotective Effects ◽  
Norepinephrine Concentration ◽  
Somatic Diseases ◽  
Structural Injury

Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. This higher AI was associated with reduced glycogen content and histological signs of metabolic and hypoxic damage and of impaired contractility. The livers of PTSD rats had reduced glycogen content. Liver and blood alanine and aspartate aminotransferase activities of PTSD rats were significantly increased. PTSD rats had increased norepinephrine concentration and decreased monoamine oxidase A activity in cerebral cortex. The PTSD-induced elevation of carbonylated proteins and lipid peroxidation products in these organs reflects oxidative stress, a known cause of organ pathology. IHC alleviated PTSD-induced metabolic and structural injury and reduced oxidative stress. Therefore, IHC is a promising preventive treatment for PTSD-related morphological and functional damage to organs, due, in part, to IHC’s reduction of oxidative stress.

Serum total oxidant and antioxidant status in earthquake survivors with post-traumatic stress disorder

2015 ◽  
Vol 27 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Pinar Guzel Ozdemir ◽  
İbrahim Kaplan ◽  
Cem Uysal ◽  
Mahmut Bulut ◽  
Abdullah Atli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Antioxidant Status ◽  
Stress Disorder ◽  
Total Antioxidant Status ◽  
Post Traumatic Stress ◽  
Total Antioxidant ◽  
Post Traumatic ◽  
Earthquake Survivors

ObjectiveOxidative stress has been shown to play an important role in the pathogenesis of post-traumatic stress disorder (PTSD). Although there are some studies on oxidative stress and PTSD, there is no report available on the serum total oxidant and antioxidant status in earthquake survivors with PTSD. Therefore, this study aimed to investigate the serum total oxidant and antioxidant status in earthquake survivors with chronic PTSD.Material and MethodsThe study group included 45 earthquake survivors with PTSD and 40 earthquake survivors without PTSD. The oxidative status was determined using the total antioxidant status and total oxidant status (TOS) measurements and by calculating the oxidative stress index (OSI).ResultsThere were no statistically significant differences in the total antioxidant status, TOS, or OSI when comparing individuals with and without PTSD (all,p>0.05). There were no correlations between Clinician-Administered PTSD Scale scores and oxidant and antioxidant stress markers (all,p>0.05).ConclusionsOur results suggest that the total oxidant and antioxidant status may not affect earthquake survivors with PTSD. This is the first study to evaluate the oxidative status in earthquake survivors with PTSD. Further studies are necessary to confirm these findings.

scholarly journals Potential Biomarkers of Posttraumatic Stress Disorder

Psychiatry ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 90-99
Author(s):  
N. N. Petrova ◽  
B. G. Butoma ◽  
M. V. Dorofeikova
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Mental Disorders ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Molecular Genetic ◽  
Risk Groups ◽  
Post Traumatic Stress ◽  
Current State ◽  
State Of Research ◽  
Somatic Diseases

Background: although the search for biomarkers of mental disorders that is aimed at improving diagnosis, individualizing therapy based on knowledge of pathophysiological processes and preventing the development of mental illness is actively underway for endogenous mental disorders, the study of biological markers in non-endogenous mental disorders and posttraumatic stress disorder (PTSD) in particular has received much less attention. Aim: to analyze current state of research dedicated to genetic and biochemical biomarkers that can be used to identify high risk groups and clarify the diagnosis of PTSD. Material and method: keywords “biomarkers”, “post-traumatic stress disorder”, “pathogenesis” have been used to fi nd in PubMed articles published in 2010–2020. Conclusion: research methods for elucidating the mechanisms of PTSD are actively developing, however, the identifi cation of specifi c biomarkers (biochemical, molecular, genetic, epigenetic, neuroimaging, psychophysiological) is a complicated task. This complexity is associated with numerous pathogenic mechanisms of PTSD and frequent comorbidity with mental disorders (depression, anxiety) and somatic diseases, as well as lack of specifi city of detected biomarkers.

L-Carnitine prevents memory impairment induced by post-traumatic stress disorder

2021 ◽  
pp. 1-9
Author(s):  
Karem H. Alzoubi ◽  
Arwa M. Al-Dekah ◽  
Saied Jaradat ◽  
Nasr Alrabadi
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Memory Impairment ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Short And Long Term ◽  
Post Traumatic

Background: Post-traumatic stress disorder (PTSD) is a genuine obstructing mental disorder. As indicated by the name, it is related to the patients’ stress augmented by life-threatening conditions or accidents. The PTSD has linked to oxidative stress that can result in neurodegeneration. L-carnitine (L-CAR) is known for its antioxidant properties, which can protect against neuronal damage. Objective: In the current study, we investigated the beneficial effects of L-CAR on the memory impairment induced by PTSD using a rat model. Methods: A model of single-prolonged stress (a cycle of restraining, forced swimming, rest, and finally diethyl ether exposure for 2 h, 20 min, 15 min, and 1–2 min, respectively) was used to induce PTSD-like behavior. Intraperitoneal L-CAR treatment (300 mg/kg/day) was introduced for four weeks. Both memory and special learning were evaluated utilizing the radial arm water maze (RAWM). Moreover, the levels of glutathione peroxidase (GPx), glutathione reduced (GSH), and glutathione oxidized (GSSG) were assessed as biomarkers oxidative stress in the hippocampus. Results: The results demonstrated that both the short and long-term memories were impaired by PTSD/SPS model (P <  0.05), while L-CAR treatment prevented this memory impairment in PTSD rats. Besides, L-CAR prevented the reduction in GPx activity and increase in GSSG, which were altered in the hippocampus of the PTSD/SPS rats (P <  0.05). Levels of GSH were not changed in PTSD and/or L-CAR rats. Conclusions: L-CAR administration prevented short- and long-term memories’ impairments induced in the PTSD/SPS rat model. This is probably related to its antioxidant effects in the hippocampus.

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