scholarly journals Lipidomic Biomarkers in Polycystic Ovary Syndrome and Endometrial Cancer

2020 ◽  
Vol 21 (13) ◽  
pp. 4753 ◽  
Author(s):  
Mohamad Nasir Shafiee ◽  
Catharine A. Ortori ◽  
David A. Barrett ◽  
Nigel P. Mongan ◽  
Jafaru Abu ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Polycystic Ovary Syndrome ◽  
Molecular Mechanisms ◽  
High Resolution Mass Spectrometry ◽  
Polycystic Ovary ◽  
Capric Acid ◽  
Endometrial Tissue ◽  
University Hospital ◽  
Ovary Syndrome ◽  
Tissue Samples

Women with polycystic ovary syndrome (PCOS) are more likely to develop endometrial cancer (EC). The molecular mechanisms which increase the risk of EC in PCOS are unclear. Derangements in lipid metabolism are associated with EC, but there have been no studies, investigating if this might increase the risk of EC in PCOS. This was a cross-sectional study of 102 women in three groups of 34 (PCOS, EC and controls) at Nottingham University Hospital, UK. All participants had clinical assessments, followed by obtaining plasma and endometrial tissue samples. Lipidomic analyses were performed using liquid chromatography (LC) coupled with high resolution mass spectrometry (HRMS) and the obtained lipid datasets were screened using standard software and databases. Using multivariate data analysis, there were no common markers found for EC and PCOS. However, on univariate analyses, both PCOS and EC endometrial tissue samples showed a significant decrease in monoacylglycerol 24:0 and capric acid compared to controls. Further studies are required to validate these findings and investigate the potential role of monoacylglycerol 24:0 and capric acid in the link between PCOS with EC.

scholarly journals Molecular Mechanisms of Insulin Resistance in Polycystic Ovary Syndrome: Unraveling the Conundrum in Skeletal Muscle?

2019 ◽  
Vol 104 (11) ◽  
pp. 5372-5381 ◽  
Author(s):  
Nigel K Stepto ◽  
Alba Moreno-Asso ◽  
Luke C McIlvenna ◽  
Kirsty A Walters ◽  
Raymond J Rodgers
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Polycystic Ovary Syndrome ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Polycystic Ovary ◽  
Evidence Synthesis ◽  
Basic Research ◽  
Future Research ◽  
Ovary Syndrome

Abstract Context Polycystic ovary syndrome (PCOS) is a common endocrine condition affecting 8% to 13% of women across the lifespan. PCOS affects reproductive, metabolic, and mental health, generating a considerable health burden. Advances in treatment of women with PCOS has been hampered by evolving diagnostic criteria and poor recognition by clinicians. This has resulted in limited clinical and basic research. In this study, we provide insights into the current and future research on the metabolic features of PCOS, specifically as they relate to PCOS-specific insulin resistance (IR), that may affect the most metabolically active tissue, skeletal muscle. Current Knowledge PCOS is a highly heritable condition, yet it is phenotypically heterogeneous in both reproductive and metabolic features. Human studies thus far have not identified molecular mechanisms of PCOS-specific IR in skeletal muscle. However, recent research has provided new insights that implicate energy-sensing pathways regulated via epigenomic and resultant transcriptomic changes. Animal models, while in existence, have been underused in exploring molecular mechanisms of IR in PCOS and specifically in skeletal muscle. Future Directions Based on the latest evidence synthesis and technologies, researchers exploring molecular mechanisms of IR in PCOS, specifically in muscle, will likely need to generate new hypothesis to be tested in human and animal studies. Conclusion Investigations to elucidate the molecular mechanisms driving IR in PCOS are in their early stages, yet remarkable advances have been made in skeletal muscle. Overall, investigations have thus far created more questions than answers, which provide new opportunities to study complex endocrine conditions.

The prevalence of endometrial hyperplasia and endometrial cancer in women with polycystic ovary syndrome or hyperandrogenism

2012 ◽  
Vol 91 (10) ◽  
pp. 1173-1176 ◽  
Author(s):  
NINA SOFIE LILLEGAARD HOLM ◽  
DORTE GLINTBORG ◽  
MARIANNE SKOVSAGER ANDERSEN ◽  
DORIS SCHLEDERMANN ◽  
PERNILLE RAVN
Keyword(s):  
Endometrial Cancer ◽  
Polycystic Ovary Syndrome ◽  
Endometrial Hyperplasia ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Endometrial cancer combined with polycystic ovary syndrome in 9 women under 40‑years old: A case report

2020 ◽  
Vol 13 (5) ◽  
pp. 1-1
Author(s):  
Xibiao Jia ◽  
Lingyun Yang ◽  
Pan Xu ◽  
Ningwei Li ◽  
Cen Chen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Case Report ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Polycystic Ovary Syndrome and Risk of Endometrial Cancer: a Mini-Review

2014 ◽  
Vol 15 (17) ◽  
pp. 7011-7014 ◽  
Author(s):  
Aytekin Tokmak ◽  
Mahmut Kuntay Kokanali ◽  
Ali Irfan Guzel ◽  
Aydan Kara ◽  
Hasan Onur Topcu ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome

A Case of Endometrial Cancer with Polycystic Ovary Syndrome

2000 ◽  
Vol 11 (4) ◽  
pp. 416
Author(s):  
Sang Tae Ahn ◽  
Young Han Park ◽  
Hee Sug Ryu ◽  
Hee Jae Joo ◽  
Jung Pil Lee ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Endocrine Risk Factors of Endometrial Cancer: Polycystic Ovary Syndrome, Oral Contraceptives, Infertility, Tamoxifen

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1766 ◽  
Author(s):  
Atanas Ignatov ◽  
Olaf Ortmann
Keyword(s):  
Endometrial Cancer ◽  
Polycystic Ovary Syndrome ◽  
Oral Contraceptives ◽  
Polycystic Ovary ◽  
Gynecologic Cancer ◽  
Age At Menarche ◽  
Published Data ◽  
Ovary Syndrome ◽  
Increased Risk

Endometrial cancer is the most common gynecologic cancer and is predominantly endocrine-related. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. Different reproductive factors such as younger age at menarche, late age at menopause, infertility, nulliparity, age of birth of the first child, and long-term use of unopposed estrogens during hormone replacement therapy have been associated with an increased risk of endometrial cancer. In contrast, there is a growing body of evidence for a protective role of oral contraceptives. Most of the published data on the association between infertility and polycystic ovary syndrome are inconclusive, whereas the effect of tamoxifen on the risk of endometrial cancer has been well established. With this review, we aim to summarize the evidence on the association between infertility, polycystic ovary syndrome, oral contraceptives, and tamoxifen and the development of endometrial cancer.

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