scholarly journals The Lactate Receptor HCA1 Is Present in the Choroid Plexus, the Tela Choroidea, and the Neuroepithelial Lining of the Dorsal Part of the Third Ventricle

2020 ◽  
Vol 21 (18) ◽  
pp. 6457 ◽  
Author(s):  
Alena Hadzic ◽  
Teresa D. Nguyen ◽  
Makoto Hosoyamada ◽  
Naoko H. Tomioka ◽  
Linda H. Bergersen ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Fluorescent Protein ◽  
Third Ventricle ◽  
Ependymal Cells ◽  
Dorsal Part ◽  
Brain Physiology ◽  
The Third ◽  
Tela Choroidea ◽  
Csf Lactate ◽  
Lactate Levels

The volume, composition, and movement of the cerebrospinal fluid (CSF) are important for brain physiology, pathology, and diagnostics. Nevertheless, few studies have focused on the main structure that produces CSF, the choroid plexus (CP). Due to the presence of monocarboxylate transporters (MCTs) in the CP, changes in blood and brain lactate levels are reflected in the CSF. A lactate receptor, the hydroxycarboxylic acid receptor 1 (HCA1), is present in the brain, but whether it is located in the CP or in other periventricular structures has not been studied. Here, we investigated the distribution of HCA1 in the cerebral ventricular system using monomeric red fluorescent protein (mRFP)-HCA1 reporter mice. The reporter signal was only detected in the dorsal part of the third ventricle, where strong mRFP-HCA1 labeling was present in cells of the CP, the tela choroidea, and the neuroepithelial ventricular lining. Co-labeling experiments identified these cells as fibroblasts (in the CP, the tela choroidea, and the ventricle lining) and ependymal cells (in the tela choroidea and the ventricle lining). Our data suggest that the HCA1-containing fibroblasts and ependymal cells have the ability to respond to alterations in CSF lactate in body–brain signaling, but also as a sign of neuropathology (e.g., stroke and Alzheimer’s disease biomarker).

Rat placental lactogen-I binds to the choroid plexus and hypothalamus of the pregnant rat

1993 ◽  
Vol 139 (2) ◽  
pp. 235-NP ◽  
Author(s):  
C. Pihoker ◽  
M. C. Robertson ◽  
M. Freemark
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rat Brain ◽  
Choroid Plexus ◽  
Binding Sites ◽  
Third Ventricle ◽  
Placental Lactogen ◽  
Ependymal Cells ◽  
Pregnant Rat ◽  
The Third

ABSTRACT Recent findings suggest that placental lactogen has a role in the regulation of hypothalamic function during pregnancy. To explore the mechanisms by which placental hormones may exert effects in the maternal central nervous system, we have examined the binding of rat placental lactogen-I (rPL-I) to brain slices from pregnant rats at mid- and late gestation. The binding of rPL-I to maternal rat brain was compared with that of human GH (hGH). Radiolabelled rPL-I bound specifically to ependymal cells of the choroid plexus in the lateral ventricles and in the roof of the third ventricle. The binding of 125I-labelled rPL-I was inhibited by unlabelled rPL-I, hGH or rat prolactin but not by rat GH, indicating that rPL-I and rat prolactin interact with a common binding site in maternal rat brain. Radiolabelled hGH bound to the choroid plexus and to ependymal cells lining the third ventricle in the region of the arcuate nucleus. In addition, hGH bound specifically to the ventromedial nuclei and to the medial preoptic area of the hypothalamus. The binding of radiolabelled hGH to all brain regions was inhibited by unlabelled rPL-I as well as hGH, indicating that rPL-I competes for lactogenic binding sites in the hypothalamus as well as the choroid plexus of the pregnant rat. These findings suggest potential mechanisms by which placental hormones may exert direct effects on the maternal central nervous system during pregnancy. The precise functions and roles of the PL-I binding sites in maternal choroid plexus and hypothalamus remain to be explored. Journal of Endocrinology (1993) 139, 235–242

Choroid plexus papilloma of the third ventricle

Neurosurgery ◽  
1983 ◽  
Vol 12 (2) ◽  
pp. 217???20 ◽  
Author(s):  
W C Gradin ◽  
C Taylon ◽  
A H Fruin
Keyword(s):  
Choroid Plexus ◽  
Third Ventricle ◽  
Choroid Plexus Papilloma ◽  
The Third ◽  
Plexus Papilloma

General concepts of hypothalamus-pituitary anatomy

2011 ◽  
pp. 71-81
Author(s):  
Ignacio Bernabeu ◽  
Monica Marazuela ◽  
Felipe F. Casanueva
Keyword(s):  
Median Eminence ◽  
Third Ventricle ◽  
Optic Chiasm ◽  
Perivascular Space ◽  
Ependymal Cells ◽  
The Third ◽  
Long Time ◽  
Central Grey Matter ◽  
Imaginary Line ◽  
The Brain

The hypothalamus is the part of the diencephalon associated with visceral, autonomic, endocrine, affective, and emotional behaviour. It lies in the walls of the third ventricle, separated from the thalamus by the hypothalamic sulcus. The rostral boundary of the hypothalamus is roughly defined as a line through the optic chiasm, lamina terminalis, and anterior commissure, and an imaginary line extending from the posterior commissure to the caudal limit of the mamillary body represents the caudal boundary. Externally, the hypothalamus is bounded rostrally by the optic chiasm, laterally by the optic tract, and posteriorly by the mamillary bodies. Dorsolaterally, the hypothalamus extends to the medial edge of the internal capsule (Fig. 2.1.1) (1). The complicated anatomy of this area of the central nervous system (CNS) is the reason why, for a long time, little was known about its anatomical organization and functional significance. Even though the anatomy of the hypothalamus is well established it does not form a well-circumscribed region. On the contrary, it is continuous with the surrounding parts of the CNS: rostrally, with the septal area of the telencephalon and anterior perforating substance; anterolaterally with the substantia innominata; and caudally with the central grey matter and the tegmentum of the mesencephalon. The ventral portion of the hypothalamus and the third ventricular recess form the infundibulum, which represents the most proximal part of the neurohypophysis. A bulging region posterior to the infundibulum is the tuber cinereum, and the zone that forms the floor of the third ventricle is called the median eminence. The median eminence represents the final point of convergence of pathways from the CNS on the peripheral endocrine system and it is supplied by primary capillaries of the hypophyseal portal vessels. The median eminence is the anatomical interface between the brain and the anterior pituitary. Ependymal cells lining the floor of the third ventricle have processes that traverse the width of the median eminence and terminate near the portal perivascular space; these cells, called tanycytes, provide a structural and functional link between the cerebrospinal fluid (CSF) and the perivascular space of the pituitary portal vessels. The conspicuous landmarks of the ventral surface of the brain can be used to divide the hypothalamus into three parts: anterior (preoptic and supraoptic regions), middle (tuberal region), and caudal (mamillary region). Each half of the hypothalamus is also divided into a medial and lateral zone. The medial zone contains the so-called cell-rich areas with well-defined nuclei. The scattered cells of the lateral hypothalamic area have long overlapping dendrites, similar to the cells of the reticular formation. Some of these neurons send axons directly to the cerebral cortex and others project down into the brainstem and spinal cord.

Choroid Plexus Carcinoma in Adults: Literature Review and First Report of a Location into the Third Ventricle

2020 ◽  
Vol 133 ◽  
pp. 302-307 ◽  
Author(s):  
Antonio Crea ◽  
Andrea Bianco ◽  
Christian Cossandi ◽  
Sara Forgnone ◽  
Riccardo Fornaro ◽  
...  
Keyword(s):  
Literature Review ◽  
Choroid Plexus ◽  
Third Ventricle ◽  
Choroid Plexus Carcinoma ◽  
First Report ◽  
The Third

Detectability of the choroid plexus of the third ventricle with magnetic resonance ventriculography

2019 ◽  
Vol 37 (6) ◽  
pp. 449-457
Author(s):  
Ken Sato ◽  
Masanori Awaji ◽  
Shoichi Inagawa ◽  
Yuichiro Yoneoka ◽  
Junichi Yoshimura ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Choroid Plexus ◽  
Third Ventricle ◽  
The Third

Histology and fine structure of the pre-optic nucleus and hypothalamic tracts of the European eel Anguilla anguilla L

1969 ◽  
Vol 256 (804) ◽  
pp. 135-145 ◽  
Keyword(s):  
Electron Microscopy ◽  
Anterior Margin ◽  
Third Ventricle ◽  
Anguilla Anguilla ◽  
Structural Features ◽  
Ependymal Cells ◽  
European Eel ◽  
The Third ◽  
Secretory Products

The pre-optic nucleus and hypothalamic tracts of intact and hypophysectomized specimens of the European eel Anguilla anguilla L. have been studied in situ and by optical and electron microscopy. The in situ technique reveals a hitherto unsuspected degree of segregation of the neurosecretory axons which form up to five discrete tracts having separate origins and following distinct paths before converging, at the level of the anterior margin of the pituitary, to form a median tract. The structure of the pre-optic neurons, as revealed by several different techniques, is described and it is shown that their synthetic poles, identified by a prominent cap of endoplasmic reticulum, are precisely orientated towards the third ventricle and are separated from it by, at most, two or three layers of ependymal cells. Electron microscopy shows that the secretory products lie mainly in the axonal ends of the cells though in Bouin-fixed, wax-embedded material the entire perikaryon stains with neurosecretory dyes and this, and their proximity to the third ventricle, gives the impression that they secrete into the latter, as well as centripetally. This may well be so, but from the work described below it seems more likely that these neurons receive nutrients, or stimuli, or both, from the third ventricle. Two types of pre-optic neurons, separable by structural features as well as by the size of the elementary granules they contain have been identified; these probably give rise to two of the fibre types identified in the neurohypophysis of the eel by Knowles & Vollrath. Aggregations of neurosecretion, common in the fish pre-optic nucleus, and also, much rarer, colloid vesicles, are described and discussed.

Lateral Ventricle Choroid Plexus Papilloma Extending into the Third Ventricle

2004 ◽  
Vol 40 (6) ◽  
pp. 314-316 ◽  
Author(s):  
Federico Di Rocco ◽  
Massimo Caldarelli ◽  
Giovanni Sabatino ◽  
Gianpiero Tamburrini ◽  
Concezio Di Rocco
Keyword(s):  
Choroid Plexus ◽  
Lateral Ventricle ◽  
Third Ventricle ◽  
Choroid Plexus Papilloma ◽  
The Third ◽  
Plexus Papilloma

scholarly journals III. Contributions to the anatomy of the central nervous system in vertebrated animals. Part I.—Ichthyopsida. Section I.—Pisces. Subsection III.—Dipnoi. On the brain of the Ceratodus forsteri

1888 ◽  
Vol 43 (258-265) ◽  
pp. 420-423
Keyword(s):  
Fourth Ventricle ◽  
Third Ventricle ◽  
Pia Mater ◽  
The Third ◽  
Lateral Ventricles ◽  
Large Size ◽  
General Arrangement ◽  
Tela Choroidea ◽  
The Central Nervous System ◽  
The Brain

The brain of Ceratodus has the following general arrangement:—The membrane which represents the pia mater is of great thickness and toughness; there are two regions where a tela choroidea is developed: one where it covers in the fourth ventricle, and the other where it penetrates through the third ventricle and separates the lateral ventricles from each other. The ventricles are all of large size, and the walls of the lateral ventricles are not completed by nervous tissue. The thalamence-phalon and the mesencephalon are narrow, and the medulla oblongata is wide.

scholarly journals Endoscopic treatment of a third ventricle choroid plexus cyst

2013 ◽  
Vol 34 (v1supplement) ◽  
pp. 1 ◽  
Author(s):  
Danielle de Lara ◽  
Leo F. S. Ditzel Filho ◽  
Jun Muto ◽  
Daniel M. Prevedello
Keyword(s):  
Choroid Plexus ◽  
Obstructive Hydrocephalus ◽  
Adult Population ◽  
Third Ventricle ◽  
Postoperative Recovery ◽  
Current Treatment ◽  
Posterior Portion ◽  
Cerebrospinal Fluid Flow ◽  
Patient Reports ◽  
The Third

Choroid plexus cysts are frequent benign intraventricular lesions that infrequently cause symptoms, usually in the form of obstructive hydrocephalus. These instances are even less common in the adult population. When warranted, treatment seeks to reestablish cerebrospinal fluid flow and does not necessarily require resection of the cyst itself. Hence, endoscopic exploration of the ventricles with subsequent cyst ablation is the current treatment of choice for these lesions.Herein we present the case of a 25-year-old female patient with a 3-week history of intermittent headaches. Investigation with computerized tomography (CT) of the head detected supratentorial hydrocephalus, with enlargement of the lateral and third ventricles. Magnetic resonance imaging revealed a homogeneous cystic lesion in the third ventricle. A right-sided, pre-coronal burr hole was carried out, followed by endoscopic exploration of the ventricular system. A third-ventriclostomy was performed. With the aid of the 30-degrees endoscope, a cyst arising from the choroid plexus was visualized along the posterior portion of the third ventricle, obstructing the aqueduct opening. The cyst was cauterized until significant reduction of its dimensions was achieved and the aqueduct opening was liberated. Postoperative recovery was without incident and resolution of the hydrocephalus was confirmed by CT imaging. The patient reports complete improvement of her headaches and has been uneventfully followed since surgery.The video can be found here: http://youtu.be/XBtj_SqY07Q.

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