Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats

Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close to LOAEL (lowest observed adverse effect level), or even to NOAEL (no observed adverse effect level). At the same time, the experiment revealed genotoxic and allergic effects as early as in the first weeks of exposure, suggesting that these effects may have no threshold at all.

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About the threshold concentration of nickel oxide nanoparticles in long-term inhalation exposure of rats

Токсикологический вестник ◽

10.36946/0869-7922-2021-29-5-34-42 ◽

2021 ◽

Vol 29 (5) ◽

pp. 34-42

Author(s):

Boris Aleksandrovich Katsnelson ◽

Ivan Nikolaevich Chernyshov ◽

Svetlana Nikolaevna Solovyeva ◽

Ilzira Amirovna Minigalieva ◽

Vladimir Borisovich Gurvich ◽

...

Keyword(s):

Nickel Oxide ◽

Inhalation Exposure ◽

Exposure Period ◽

Threshold Concentration ◽

Engineered Nanoparticles ◽

Oxide Nanoparticles ◽

Nickel Oxide Nanoparticles ◽

Inhaled Nanoparticles ◽

Welding Materials

Introduction. Nickel oxide nanoparticles are of interest for toxicological science, not only as engineered nanoparticles, producing for industrial and scientific needs, but also as spontaneous pollutants of the atmosphere and the working area in industrial processes related to metallurgy and welding. Materials and methods. Rats were exposed to nickel-oxide aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a “nose only” inhalation setup for 4 hours at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Results. Of the several dozen examined parameters, only a few statistically significant manifestations associated with the reaction of the deep airways to inhaled nanoparticles were noted. However, in the biochemical and morphometric parameters of the lungs, even at the longest periods of exposure, the intergroup differences were insignificant. At the same time, even from the first weeks of the exposure period, genotoxic and allergic indices shifts are detected. Conclusion. For most of the evaluated effects, this level of exposure to nickel oxide nanoparticles may be considered as close to LOAEL, or even to NOAEL. However, according to some indicators, there are effects that suggest a non-threshold nature.

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Acuteβ-N-Methylamino-L-alanine Toxicity in a Mouse Model

Journal of Toxicology ◽

10.1155/2015/739746 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 13

Author(s):

Maitham Ahmed Al-Sammak ◽

Douglas G. Rogers ◽

Kyle D. Hoagland

Keyword(s):

Adverse Effect ◽

Lethal Dose ◽

Naturally Occurring ◽

Adverse Effect Level ◽

Effect Level ◽

Outbred Mice ◽

Nih Swiss ◽

And Control ◽

Lateral Sclerosis

The cyanobacterial neurotoxinβ-N-methylamino-L-alanine (BMAA) is considered to be an “excitotoxin,” and its suggested mechanism of action is killing neurons. Long-term exposure to L-BMAA is believed to lead to neurodegenerative diseases including Parkinson’s and Alzheimer’s diseases and amyotrophic lateral sclerosis (Lou Gehrig’s disease). Objectives of this study were to determine the presumptive median lethal dose (LD50), the Lowest-Observed-Adverse-Effect Level (LOAEL), and histopathologic lesions caused by the naturally occurring BMAA isomer, L-BMAA, in mice. Seventy NIH Swiss Outbred mice (35 male and 35 female) were used. Treatment group mice were injected intraperitoneally with 0.03, 0.3, 1, 2, and 3 mg/g body weight L-BMAA, respectively, and control mice were sham-injected. The presumptive LD50of L-BMAA was 3 mg/g BW and the LOAEL was 2 mg/g BW. There were no histopathologic lesions in brain, liver, heart, kidney, lung, or spleen in any of the mice during the 14-day study. L-BMAA was detected in brains and livers in all of treated mice but not in control mice. Males injected with 0.03 mg/g BW, 0.3 mg/g BW, and 3.0 mg/g BW L-BMAA showed consistently higher concentrations (P< 0.01) in brain and liver samples as compared to females in those respective groups.

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In VitroandIn VivoToxicity ofGarciniaor Hydroxycitric Acid: A Review

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/197920 ◽

2012 ◽

Vol 2012 ◽

pp. 1-12 ◽

Cited By ~ 23

Author(s):

Li Oon Chuah ◽

Swee Keong Yeap ◽

Wan Yong Ho ◽

Boon Kee Beh ◽

Noorjahan Banu Alitheen

Keyword(s):

Adverse Effect ◽

Weight Control ◽

Scientific Evidence ◽

Potential Toxicity ◽

Hydroxycitric Acid ◽

Diet Supplements ◽

Adverse Effect Level ◽

History Of ◽

Effect Level

Obesity is one of the pandemic chronic diseases commonly associated with health disorders such as heart attack, high blood pressure, diabetes or even cancer. Among the current natural products for obesity and weight control,Garciniaor more specifically hydroxycitric acid (HCA) extracted fromGarciniahas been widely used. The evaluation of the potential toxicity of weight control supplement is of the utmost importance as it requires long term continuous consumption in order to maintain its effects. Majority of reports demonstrated the efficacy ofGarcinia/HCA without any toxicity found. However, a few clinical toxicity reports on weight-loss diet supplements of which some were combinations that includedGarcinia/HCA as an active ingredient showed potential toxicity towards spermatogenesis. Nonetheless, it cannot be concluded thatGarcinia/HCA is unsafe. Those products which have been reported to possess adverse effects are either polyherbal or multi-component in nature. To date, there is no case study or report showing the direct adverse effect of HCA. The structure, mechanism of action, long history of the use ofGarcinia/HCA and comprehensive scientific evidence had shown “no observed adverse effect level (NOAEL)” at levels up to 2800 mg/day, suggesting its safety for use.

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Long-term effects of nickel oxide nanoparticles on performance, microbial enzymatic activity, and microbial community of a sequencing batch reactor

Chemosphere ◽

10.1016/j.chemosphere.2016.10.139 ◽

2017 ◽

Vol 169 ◽

pp. 387-395 ◽

Cited By ~ 10

Author(s):

Sen Wang ◽

Zhiwei Li ◽

Mengchun Gao ◽

Zonglian She ◽

Liang Guo ◽

...

Keyword(s):

Microbial Community ◽

Enzymatic Activity ◽

Nickel Oxide ◽

Sequencing Batch Reactor ◽

Batch Reactor ◽

Oxide Nanoparticles ◽

Long Term Effects ◽

Nickel Oxide Nanoparticles

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Comparative assessment of the effects of short-term inhalation exposure to Nickel oxide nanoparticles and microdispersed Nickel oxide

Nanotechnologies in Russia ◽

10.1134/s1995078016050219 ◽

2016 ◽

Vol 11 (9-10) ◽

pp. 671-677 ◽

Cited By ~ 3

Author(s):

N. V. Zaitseva ◽

M. A. Zemlyanova ◽

V. N. Zvezdin ◽

A. A. Dovbysh ◽

T. S. Ulanova ◽

...

Keyword(s):

Nickel Oxide ◽

Inhalation Exposure ◽

Comparative Assessment ◽

Oxide Nanoparticles ◽

Short Term ◽

Nickel Oxide Nanoparticles

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TOXIC EFFECTS ASSESSMENT OF NICKEL OXIDE NANOPARTICLES BY INHALATION

ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT ◽

10.35627/2219-5238/2018-309-12-24-30 ◽

2018 ◽

pp. 24-29 ◽

Cited By ~ 2

Author(s):

B.A. Katsnelson ◽

M.P. Sutunkova ◽

L.I. Privalova ◽

S.N. Solovjeva ◽

V.B. Gurvich ◽

...

Keyword(s):

Nickel Oxide ◽

Redox Balance ◽

Systemic Toxicity ◽

Laboratory Animals ◽

Oxide Nanoparticles ◽

Nickel Oxide Nanoparticles ◽

White Rats ◽

Liver And Kidney ◽

Stimulation Of Erythropoiesis ◽

Nio Nps

The article presents in an experiment obtained principal results based on repeated low-level inhalation exposures of laboratory animals (white rats, outbred) to nickel oxide nanoparticles with a diameter of (23 ± 5) nm, 4 hours a day, 5 times a week for up to 10 months in a «nose only» installation. It was shown that non-specific body reactions to the action of NiO NPs include: diverse manifestations of systemic toxicity with a particularly pronounced influence on liver and kidney function, redox balance, damage to some areas of brain tissue, associated with proven movement of the nanoparticles themselves from the nasal mucosa along the olfactory tract; some cytological signs of probable development for allergic syndrome; paradoxically low severity of pulmonary pathology by pneumoconiotic type explained by a small chronic delay of nanoparticles in the lungs; the genotoxic effect of the organismal level, even at those low levels of chronic exposure, at which systemic toxicity is rather poorly. Along with that, NiO NPs also induce phase-stimulation of erythropoiesis, which is relatively specific for the toxic nickel effects.

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