scholarly journals Multifaced Roles of HDL in Sepsis and SARS-CoV-2 Infection: Renal Implications

2021 ◽  
Vol 22 (11) ◽  
pp. 5980
Author(s):  
Alessandra Stasi ◽  
Rossana Franzin ◽  
Marco Fiorentino ◽  
Enrico Squiccimarro ◽  
Giuseppe Castellano ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Renal Involvement ◽  
Kidney Injury ◽  
High Density Lipoproteins ◽  
Cholesterol Transport ◽  
The Novel ◽  
Risk Of Mortality ◽  
Pleiotropic Functions ◽  
Relationship Of

High-density lipoproteins (HDLs) are a class of blood particles, principally involved in mediating reverse cholesterol transport from peripheral tissue to liver. Omics approaches have identified crucial mediators in the HDL proteomic and lipidomic profile, which are involved in distinct pleiotropic functions. Besides their role as cholesterol transporter, HDLs display anti-inflammatory, anti-apoptotic, anti-thrombotic, and anti-infection properties. Experimental and clinical studies have unveiled significant changes in both HDL serum amount and composition that lead to dysregulated host immune response and endothelial dysfunction in the course of sepsis. Most SARS-Coronavirus-2-infected patients admitted to the intensive care unit showed common features of sepsis disease, such as the overwhelmed systemic inflammatory response and the alterations in serum lipid profile. Despite relevant advances, episodes of mild to moderate acute kidney injury (AKI), occurring during systemic inflammatory diseases, are associated with long-term complications, and high risk of mortality. The multi-faceted relationship of kidney dysfunction with dyslipidemia and inflammation encourages to deepen the clarification of the mechanisms connecting these elements. This review analyzes the multifaced roles of HDL in inflammatory diseases, the renal involvement in lipid metabolism, and the novel potential HDL-based therapies.

scholarly journals Long-term risk of mortality after acute kidney injury in patients with sepsis: a contemporary analysis

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
José António Lopes ◽  
Paulo Fernandes ◽  
Sofia Jorge ◽  
Cristina Resina ◽  
Carla Santos ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Risk Of Mortality

scholarly journals Long-term risk of mortality for acute kidney injury in HIV-infected patients: a cohort analysis

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
José António Lopes ◽  
Maria João Melo ◽  
Mário Raimundo ◽  
André Fragoso ◽  
Francisco Antunes
Keyword(s):  
Acute Kidney Injury ◽  
Cohort Analysis ◽  
Kidney Injury ◽  
Risk Of Mortality

The patient with sarcoidosis

2015 ◽  
Author(s):  
Ravindra Rajakariar ◽  
Muhammad M. Yaqoob
Keyword(s):  
Acute Kidney Injury ◽  
Renal Impairment ◽  
Renal Disease ◽  
Low Dose ◽  
Clinical Presentation ◽  
Tubulointerstitial Nephritis ◽  
Renal Involvement ◽  
Kidney Injury ◽  
Chronic Renal Impairment

Renal involvement in sarcoidosis is common and often under-recognized. The most frequent manifestation is acute kidney injury secondary to hypercalcaemia and granulomatous tubulointerstitial nephritis. The latter can lead to both acute kidney injury and to slowly progressive chronic renal impairment with concomitant chronic damage seen on histology. This chapter describes the types of renal disease that may occur in sarcoidosis and the pathogenesis, clinical presentation, diagnosis, and treatment of the patient with sarcoidosis. Corticosteroid therapy is the cornerstone of therapy. In patients with granulomatous tubulointerstitial nephritis, the authors recommend long-term, low-dose maintenance steroids.

scholarly journals Phenomenon of Suicide in Russian Stories by V. Nabokov

2020 ◽  
pp. 153-173
Author(s):  
V. Yu. Lebedeva
Keyword(s):  
Scientific Knowledge ◽  
Fairy Tale ◽  
Russian Language ◽  
Overwhelming Majority ◽  
The Novel ◽  
Christian Culture ◽  
Relationship Of ◽  
The Relationship ◽  
Acute Crisis

The results of the analysis of suicidal issues in the stories of V. Nabokov “Blow of a Wing”, “Fairy Tale”, “Accident”, “Lycus”, “Notification”, “Letter to Russia”, “Vasily Shishkov” are presented in the article. The relevance of the study is due to the fact that it makes it possible to clarify the writer’s ideas about being and the otherworldly, as well as to contribute to the development of such an interdisciplinary branch of scientific knowledge as thanatology. It is argued that the suicidal situations in the stories are similar: the characters take this step in a state of acute crisis as a result of long-term indulgence of weaknesses and passions (including addictions). The problem of the environment is also noted — despite the fact that the heroes are surrounded by people, they are in an atmosphere of misunderstanding and loneliness. Attention is also paid to the relationship of a number of characters with God and infernal forces (in particular, an intertextual parallel with the novel “Demons” is drawn). It is proved that suicide in the overwhelming majority of texts is a consequence of the metaphysical disintegration of heroes prone to irresponsibility, consumerism, escapism, and in some cases to the fight against God. It is concluded that the phenomenon of suicide in Russian-language Nabokov’s stories is devoid of a romantic and / or heroic halo — the writer comprehends it within the framework of European-Christian culture.

scholarly journals Relationship of Kidney Injury Biomarkers with Long-Term Cardiovascular Outcomes after Cardiac Surgery

2017 ◽  
Vol 28 (12) ◽  
pp. 3699-3707 ◽  
Author(s):  
Chirag R. Parikh ◽  
Jeremy Puthumana ◽  
Michael G. Shlipak ◽  
Jay L. Koyner ◽  
Heather Thiessen-Philbrook ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Kidney Injury ◽  
Cardiovascular Outcomes ◽  
Relationship Of

COVID-19 infection and the kidney

2020 ◽  
Vol 81 (10) ◽  
pp. 1-8
Author(s):  
Lucas Alvarez-Belon ◽  
Alexander Sarnowski ◽  
Lui G Forni
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Renal Involvement ◽  
Kidney Injury ◽  
Urinary Sediment ◽  
Reporting Practices ◽  
Kidney Replacement Therapy ◽  
Few Data ◽  
Multiorgan Dysfunction Syndrome

Despite initial reports, renal involvement, including acute kidney injury, has emerged as a serious complication of COVID-19 disease, particularly in critically ill patients. The reported prevalence varies considerably, which may reflect reporting practices, although differences in pre-existing comorbidities and socioeconomic factors, and differences between ethnic groups, almost certainly contribute. Renal involvement may present as an active urinary sediment or as changes in serum creatinine levels and urine output leading to acute kidney injury. In common with acute kidney injury complicating critical illness, the cause is often multifactorial and often presents as part of a multiorgan dysfunction syndrome. Treatment is, in the main, supportive, with kidney replacement therapy required in nearly 25% of reported cases. Few data currently exist as to the long-term burden of COVID-19-associated acute kidney injury but evidence suggests that only approximately one-third of patients are discharged with recovered renal function.

scholarly journals Long-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis

2009 ◽  
Vol 53 (6) ◽  
pp. 961-973 ◽  
Author(s):  
Steven G. Coca ◽  
Bushra Yusuf ◽  
Michael G. Shlipak ◽  
Amit X. Garg ◽  
Chirag R. Parikh
Keyword(s):  
Systematic Review ◽  
Acute Kidney Injury ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Adverse Outcomes ◽  
Risk Of Mortality

Long-Term Risk of Mortality and Acute Kidney Injury During Hospitalization After Major Surgery

2009 ◽  
Vol 249 (5) ◽  
pp. 851-858 ◽  
Author(s):  
Azra Bihorac ◽  
Sinan Yavas ◽  
Sophie Subbiah ◽  
Charles E. Hobson ◽  
Jesse D. Schold ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Major Surgery ◽  
Risk Of Mortality

scholarly journals Severe postoperative hyperbilirubinemia in congenital heart disease

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 1276-1285
Author(s):  
Xiaolan Chen ◽  
Ming Bai ◽  
Shiren Sun ◽  
Xiangmei Chen
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Hospital Mortality ◽  
Congenital Heart ◽  
Kidney Injury ◽  
Term Survival ◽  
Risk Of Mortality ◽  
Long Term Mortality

Abstract Purpose The purpose of our present study was to explore the characteristics and outcomes of congenital heart disease (CHD) patients with severe postoperative hyperbilirubinemia. Methods All patients who underwent cardiopulmonary bypass surgical treatment for CHD and had severe postoperative hyperbilirubinemia (total bilirubin [TB] ≥85.5 μmol/L) in our center between January 2015 and December 2018 were retrospectively screened. Univariate and multivariate analyses were employed to identify risk factors for the study endpoints, including postoperative acute kidney injury (AKI), in-hospital mortality, and long-term mortality. Results After screening, 86 patients were included in our present study. In-hospital mortality was 10.9%. Fifty-one (59.3%) patients experienced AKI, and four (4.7%) patients received continuous renal replacement therapy. Multivariate analysis identified that the peak TB concentration (P = 0.002) and duration of mechanical ventilation (P = 0.008) were independent risk factors for in-hospital mortality, and stage 3 AKI was an independent risk factor for long-term mortality. The optimal cutoff value for peak TB concentration was 125.9 μmol/L. Patients with a postoperative TB level ≥125.9 μmol/L had worse long-term survival. Conclusion Hyperbilirubinemia was a common complication after CHD surgery. CHD patients with severe postoperative hyperbilirubinemia ≥125.9 μmol/L and AKI had a higher risk of mortality.

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