scholarly journals Effects of a Novel Cold Atmospheric Plasma Treatment of Titanium on the Proliferation and Adhesion Behavior of Fibroblasts

2021 ◽  
Vol 23 (1) ◽  
pp. 420
Author(s):  
Ming Yan ◽  
Philip Hartjen ◽  
Martin Gosau ◽  
Tobias Vollkommer ◽  
Audrey Laure Céline Grust ◽  
...  

Cold plasma treatment increases the hydrophilicity of the surfaces of implants and may enhance their integration with the surrounding tissues. The implaPrep prototype device from Relyon Plasma generates cold atmospheric plasma via dielectric barrier discharge (DBD). In this study, titanium surfaces were treated with the implaPrep device for 20 s and assessed as a cell culture surface for fibroblasts. One day after seeding, significantly more cells were counted on the surfaces treated with cold plasma than on the untreated control titanium surface. Additionally, the viability assay revealed significantly higher viability on the treated surfaces. Morphological observation of the cells showed certain differences between the treated and untreated titanium surfaces. While conventional plasma devices require compressed gas, such as oxygen or argon, the implaPrep device uses atmospheric air as the gas source. It is, therefore, compact in size and simple to handle, and may provide a safe and convenient tool for treating the surfaces of dental implants, which may further improve the implantation outcome.

2021 ◽  
Author(s):  
Chenchen Zhang ◽  
Jun Zhao ◽  
Yamei Gao ◽  
Jing Gao ◽  
Yongmei Lv

2014 ◽  
Vol 34 (4) ◽  
pp. 941-946 ◽  
Author(s):  
RAFAEL GUERRERO-PRESTON ◽  
TAKENORI OGAWA ◽  
MAMORU UEMURA ◽  
GARY SHUMULINSKY ◽  
BLANCA L. VALLE ◽  
...  

2018 ◽  
Vol 400 (1) ◽  
pp. 111-122 ◽  
Author(s):  
Christin Schneider ◽  
Stephanie Arndt ◽  
Julia L. Zimmermann ◽  
Yangfang Li ◽  
Sigrid Karrer ◽  
...  

AbstractPlasma oncology is a relatively new field of research. Recent developments have indicated that cold atmospheric plasma (CAP) technology is an interesting new therapeutic approach to cancer treatment. In this study, p53 wildtype (LoVo) and human p53 mutated (HT29 and SW480) colorectal cancer cells were treated with the miniFlatPlaSter – a device particularly developed for the treatment of tumor cells – that uses the Surface Micro Discharge (SMD) technology for plasma production in air. The present study analyzed the effects of plasma on colorectal cancer cellsin vitroand on normal colon tissueex vivo. Plasma treatment had strong effects on colon cancer cells, such as inhibition of cell proliferation, induction of cell death and modulation of p21 expression. In contrast, CAP treatment of murine colon tissueex vivofor up to 2 min did not show any toxic effect on normal colon cells compared to H2O2positive control. In summary, these results suggest that the miniFlatPlaSter plasma device is able to kill colorectal cancer cells independent of their p53 mutation status. Thus, this device presents a promising new approach in colon cancer therapy.


2015 ◽  
Vol 13 (4) ◽  
pp. 410-418 ◽  
Author(s):  
Elliot A. J. Bartis ◽  
Pingshan Luan ◽  
Andrew J. Knoll ◽  
David B. Graves ◽  
Joonil Seog ◽  
...  

2019 ◽  
Vol 301 ◽  
pp. 125281 ◽  
Author(s):  
Ewa Wielogorska ◽  
Yusuf Ahmed ◽  
Julie Meneely ◽  
William G. Graham ◽  
Christopher T. Elliott ◽  
...  

2020 ◽  
Author(s):  
N. Redzuan ◽  
M. R. Rabbi ◽  
L. Agun ◽  
N. Ahmad ◽  
K. Zakaria ◽  
...  

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