scholarly journals Laser Therapy for the Treatment of Morphea: A Systematic Review of Literature

2021 ◽  
Vol 10 (15) ◽  
pp. 3409
Author(s):  
Paulina Szczepanik-Kułak ◽  
Małgorzata Michalska-Jakubus ◽  
Dorota Krasowska
Keyword(s):  
Systematic Review ◽  
Laser Therapy ◽  
Web Of Science ◽  
Skin Diseases ◽  
Google Scholar ◽  
Localized Scleroderma ◽  
Psychosocial Impairment ◽  
Beneficial Effects ◽  
Limited Effectiveness ◽  
Life Therapy

Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients’ quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects. Due to the advances in the application of lasers and their possible beneficial effects, the aim of this study is to review the reported usage of laser in morphea. We present a systematic review of available literature, performed with MEDLINE, Cinahl, Central, Scopus, Web of Science, and Google Scholar databases. We identified a total of twenty relevant studies (MEDLINE n = 10, Cinahl n = 1, Central n = 0, Scopus n = 2, Web of Science n = 5, Google Scholar n = 2) using laser therapy for LoS. Eight studies were focused on the use of PDL, six on fractional lasers (CO2 and Er:YAG), four on excimer, and two on either alexandrite or Nd:YAG.

scholarly journals Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 256
Author(s):  
Amir Vahedian-Azimi ◽  
Mitra Abbasifard ◽  
Farshid Rahimi-Bashar ◽  
Paul C. Guest ◽  
Muhammed Majeed ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Clinical Settings ◽  
Curcumin Treatment ◽  
Partial Restoration ◽  
Beneficial Effects ◽  
Disease Outcomes ◽  
Duration Of Hospitalization ◽  
Anti Inflammatory ◽  
Related Compounds

Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (p < 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (p < 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.

scholarly journals NIGELLA SATIVA HAS BENEFICIAL EFFECT ON OSTEOPOROSIS AND BONE HEALING. IS IT FACT OR FICTION? A SYSTEMATIC REVIEW

2017 ◽  
Vol 10 (5) ◽  
pp. 41
Author(s):  
Muhamed T Osman
Keyword(s):  
Systematic Review ◽  
Bone Healing ◽  
Web Of Science ◽  
Nigella Sativa ◽  
Experimental Studies ◽  
Molecular Targets ◽  
The Elderly ◽  
Potential Effect ◽  
Beneficial Effects ◽  
Black Seed

Osteoporosis is the most common reason for a broken bone among the elderly. Several experimental studies have been reported that Nigella sativa(NS) and/or its major component thymoquinone (TQ) have good effects on osteoporosis and bone healing. We conducted this systematic review toevaluate these relevant studies to prove whether NS and/or TQ has potential effect on osteoporosis and can stop pathogenesis of this disease or thismatter still just a fiction. A search on published studies was done using databases including Scopus, PubMed, Google Scholar, Web of Science, andCINAHIL. Terms searched included “Nigella sativa, black seed, TQ, osteoporosis, bone healing.” Initially, 213 articles were extracted. After reviewing their titles and abstracts, 124 articles (Medline, 43; Scopus, 67; EBSCO, 14) were retrieved for further evaluation. However, after excluding the clinical trial studies, human reviews, removal of abstracts and unrelated studies, seven studies were considered finally as eligible for our review. Finally, seven studies were considered eligible for our review. The total number of animals used was 220 (150 rats and 70 rabbits) from different experimental study. Based on the results of this systematic review, we conclude that NS or TQ extract therapy for osteoporosis cannot be recommended yet and these data will not suffice to exclude the beneficial effects of NS on bone turnover reliably. Therefore, more studies are required to explore the specific cellular and molecular targets of NS or TQ using animal osteoporosis models. Once the anti-osteoporotic effectiveness of NS or TQ will be established, human studies can be carried out.Keywords: Nigella sativa, Black seed, Thymoquinone, Osteoporosis, Bone healing.

The effect of soya consumption on inflammatory biomarkers: a systematic review and meta-analysis of clinical trials

2020 ◽  
pp. 1-12
Author(s):  
Mahsa Rezazadegan ◽  
Fatemeh Mirjalili ◽  
Cain C. T. Clark ◽  
Mohammad Hossein Rouhani
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Web Of Science ◽  
Meta Analysis ◽  
Inflammatory Biomarkers ◽  
Beneficial Effects ◽  
Isi Web Of Science ◽  
Subgroup Analyses ◽  
Study Heterogeneity ◽  
High Doses

Abstract Inflammation is a major cause of chronic diseases. Several studies have investigated the effects of soya intake on inflammatory biomarkers; however, the results are equivocal. The aim of this study was to conduct a systematic review and meta-analysis of clinical trials that evaluated the effect of soya consumption on inflammatory biomarkers. Medline, Scopus, ISI Web of Science and Google Scholar were systematically searched, up to and including May 2020, for clinical trials that evaluated the effects of soya and soya products on TNF-α, IL-6, IL-2, IL-1β and interferon γ (IFN-γ) in adults. A random effects method was used to calculate overall effects, and subgroup analyses were performed to discern probable sources of inter-study heterogeneity. A total of twenty-eight clinical trials were included. Although soya consumption reduced TNF-α (Hedges’ g = –0·28; 95 % CI –0·49, –0·07), it had no significant effect on IL-6 (Hedges’ g = 0·07, 95 % CI –0·14, 0·28), IL-2 (mean difference (MD) = –1·38 pg/ml; 95 % CI –3·07, 0·31), IL-1β (MD = –0·02 pg/ml; 95 % CI –0·08, 0·03) and IFN-γ (MD = 1685·82 pg/ml; 95 % CI –1604·86, 4976·50). Subgroup analysis illustrated a reduction in TNF-α in parallel designed studies, at dosages ≥100 mg of isoflavones, and in unhealthy subjects. The present study showed that high doses of isoflavones in unhealthy subjects may yield beneficial effects on TNF-α.

scholarly journals Ethnic Variations Are Still Underrepresented In Neuropharmacogenomics: A Systematic Review

2021 ◽  
Vol 30 (1) ◽  
pp. 91-103
Author(s):  
Fabricio González-Andrade ◽  
Stephanie Michelena ◽  
Ronny Pibaque ◽  
Gabriela Aguinaga-Romero
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Google Scholar ◽  
Palabras Clave ◽  
Salud Mental ◽  
Ethnic Variations ◽  
Trastorno Bipolar

Contexto: Existe una cantidad creciente de evidencia que sugiere que la respuesta a ciertos medicamentos puede estar relacionada con la estructura genética de cada individuo. El advenimiento de la genómica rápida y la genética más precisa solo han impulsado la investigación para comprender ese vínculo. Esto ha abierto apasionantes campos de investigación, a saber, la farmacogenética y la farmacogenómica. Los estudios sobre la respuesta al tratamiento a las afecciones de salud mental que utilizan nuevas herramientas han llamado mucho la atención, especialmente para afecciones como el trastorno bipolar (BP), la esquizofrenia (SP), la manía y la hipomanía, en las que la respuesta al tratamiento puede variar significativamente entre los pacientes. Una forma de asociar la genética del paciente y su respuesta al tratamiento es recordando la etnia del paciente. Se han encontrado resultados interesantes para diferentes grupos étnicos donde las poblaciones asiáticas y caucásicas son las más estudiadas. Sin embargo, hay una profunda falta de estudios sobre poblaciones africanas y latinoamericanas. El propósito de este artículo es mostrar algunos estudios de farmacogenética / genómica de enfermedades de salud mental y contrastar la gran diferencia entre los estudios poblacionales al respecto. Métodos: Siguiendo una metodología PRISMA, se realizó una búsqueda no sistemática en PubMed, Medline, Web of Science, Scopus y Google Scholar tomando en consideración cualquier tipo de estudios publicados en ellos en cualquier momento hasta el 30 de noviembre de 2019. La búsqueda contenía los siguientes términos: farmacogenética, farmacogenómica, etnia y grupos étnicos combinados con su tratamiento respectivo (antidepresivos, litio, anticonvulsivantes y varios tipos de antipsicóticos) y la condición (trastorno bipolar (BP), esquizofrenia (SP), manía, hipomanía y trastornos depresivos mayores (MDD) En cada base de datos, una entrada contenía términos como: farmacogenética O farmacogenómica Y etnia O “grupos étnicos” Y “trastornos bipolares” Y “litio.” Resultados: Solo encontramos 29 estudios sobre estudios de farmacogenética/ farmacogenómica y etnicidad/grupos étnicos, 14 relacionados con la esquizofrenia, 7 relacionados con la manía y el trastorno depresivo mayor y 8 con los trastornos bipolares. La farmacogenética y la farmacogenómica se han utilizado ampliamente para estudiar el vínculo entre la genética de un individuo y los efectos secundarios del tratamiento. Aunque casi veinte genes se asociaron con la respuesta al tratamiento, pequeños cambios, como un polimorfismo de un solo nucleótido, también pueden influir en la respuesta al tratamiento. La clozapina fue el fármaco más utilizado para explorar su farmacogenética/genómica. Más de la mitad de los estudios encontrados se realizaron en europeos y más de las tres cuartas partes en asiáticos. Conclusión: Encontramos solo cinco estudios sobre farmacogenética de la manía, así como del trastorno depresivo mayor y la etnia que involucra los genes SLC6A4, ABCB1, NTRK2, SLC6A2, BDNF, PDE11A y PDE9A, genes relacionados con el uso de fluoxetina y desipramina. Algunos estudios sugirieron que la precisión del uso de Polimorfismo de Nucléotido Único (SNP) como marcadores farmacogenómicos del resultado del tratamiento, si se usa adecuadamente, podría representar un avance significativo en la medicina personalizada, ya que dos SNP que se encuentran en el mismo gen pueden producir resultados de tratamiento diferentes. Un resultado esperado fue que la gran cantidad de información encontrada reflejaba principalmente estudios realizados en Europa y Asia. Sin embargo, se puede observar que los estudios en etnias latinas o hispanas son muy escasos, lo que constituye un sesgo importante a la hora de elegir el fármaco adecuado en el tratamiento de las enfermedades neuropsiquiátricas, especialmente para entender las respuestas farmacológicas étnicas y aprovechar esta creciente y emocionante campo. Palabras clave: desórdenes psiquiátricos, Esquizofrenia, farmacogenómica, fármacos antipsicóticos, neurología, revisión no sistemática, trastorno bipolar, variaciones étnicas

scholarly journals Cytomegalovirus seroprevalence among blood donors: a systematic review and meta-analysis

2021 ◽  
Vol 49 (8) ◽  
pp. 030006052110346
Author(s):  
Tiruneh Adane ◽  
Solomon Getawa
Keyword(s):  
Systematic Review ◽  
Confidence Interval ◽  
Blood Donors ◽  
Web Of Science ◽  
Meta Analysis ◽  
Google Scholar ◽  
Cochrane Library ◽  
Blood Products ◽  
Specific Antibodies

Background Screening for cytomegalovirus (CMV)-specific antibodies is not routine in some settings. Thus, transfusion of blood products poses risks for susceptible individuals. Objectives To investigate the global pooled CMV seroprevalence among volunteer blood donors. Methods This systematic review and meta-analysis was performed according to PRISMA guidelines. The databases searched included Embase, Google Scholar, Medline, PubMed, Web of Science, and Cochrane Library. Data were extracted independently and analyzed using STATA version 11. Results The global seroprevalence of CMV IgG, CMV IgM, and both CMV IgM and IgG was 83.16% (95% confidence interval [CI]: 78.55–87.77%, I2 = 99.5%), 13.77% (95% CI: 11.59–15.95%, I2 = 98.8%), and 23.78% (95% CI: 10.50–37.06%, I2 = 98.7), respectively. Conclusion The global seroprevalence of CMV was high among blood donors. Therefore, regular CMV screening should be conducted to identify CMV-seronegative blood donors.

scholarly journals A systematic review of leadership styles, work engagement and organizational support

2020 ◽  
Vol 9 (4) ◽  
pp. 66-77
Author(s):  
Aida Mehrad ◽  
Jordi Fernández-Castro ◽  
Maria Pau González Gómez de Olmedo
Keyword(s):  
Systematic Review ◽  
Transformational Leadership ◽  
Leadership Styles ◽  
Transactional Leadership ◽  
Work Engagement ◽  
Organizational Support ◽  
Web Of Science ◽  
Organizational Factors ◽  
Google Scholar ◽  
Critical Factors

Work engagement is one of the critical factors at an organization, so considering some factors such as leadership styles and organizational support is important. Lack of attention to these factors can lead to undesirable environments for workers. The purpose of this study is to conduct a systematic review based on these variables. Data for this research were gathered from databases of Web of Knowledge, psycarticles, Scopus, psycinfo, Web of Science, and Google Scholar. A total of 165 records were identified in databases. 15 records were discovered in other sources. 149 records remained after deleting duplicates. 117 of these records were examined, 52 registers excluded. 65 complete articles were chosen to be evaluated, and after 10 completed articles had been excluded, 55 studies ultimately remained for inclusion in the synthesis. Overall, leadership styles (transformational leadership and transactional leadership) and organizational support were found as two imperative organizational factors to access better outcomes at the workplace.

scholarly journals The Safety of Laparoscopic Cholecystectomy in the Day Surgery Unit Comparing with That in the Inpatient Unit: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Wei Xiong ◽  
Ming Li ◽  
Ming Wang ◽  
Shu Zhang ◽  
Qin Yang
Keyword(s):  
Systematic Review ◽  
Laparoscopic Cholecystectomy ◽  
Web Of Science ◽  
Meta Analysis ◽  
Day Surgery ◽  
Inpatient Unit ◽  
Google Scholar

We aimed to perform a systematic review and meta-analysis on the safety of laparoscopic cholecystectomy performed in the day surgery unit versus those performed in the inpatient unit. Several databases including Ovid Embase, Medline Ovid, Cochrane Central, Web of Science, and Google Scholar were searched from inception through February 2019. Our results revealed that laparoscopic cholecystectomy can be conducted safely and effectively in day surgery units, helping bed shortage.

scholarly journals Mindfulness for patients with rheumatoid arthritis: systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. e2610212047
Author(s):  
Ledjane Neves Oliveira ◽  
André Telis de Vilela Araújo ◽  
João Nelson Rodrigues Branco ◽  
João Carlos Marchiori de Claudio ◽  
Jeanne Liliane Marlene Michel ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Clinical Practice ◽  
Web Of Science ◽  
Well Being ◽  
Complementary Therapy ◽  
Assessment Instrument ◽  
Controlled Trials ◽  
Beneficial Effects ◽  
Randomized Controlled

Objectives: To evaluate the effectiveness of mindfulness as a complementary therapy in patients with rheumatoid arthritis. Method: Protocol numbered CRD42017080108 on the PROSPERO platform. Manual searches and the Cochrane Collation assessment instrument were performed for systematic reviews in the databases CENTRAL, MEDLINE, PEDro, PsycoINFO, LILACS, Web of Science, clinical trials.gov, WHO-ICTRP and Open Gray. Randomized controlled trials were included without language restrictions or mindfulness temporality compared to placebo, psychotherapy or another equivalent strategy in patients with rheumatoid arthritis. Results: Four primary studies included (249 participants), which compared mindfulness with waiting lists, cognitive therapy and education. They presented better scores of disease activities, depressive symptoms, psychological distress, well-being, pain catastrophization, although they were classified as having a high risk of occurrence in at least one domain of the instrument used, presenting the need for robust clinical trials, proving the effectiveness of mindfulness in clinical practice. Conclusions: Beneficial effects of mindfulness in patients with rheumatoid arthritis are shown to present important results of changes in outcomes that affect the biopsychosocial dimensions in patients with. However, the evidence from the studies evaluated is of low quality, making it difficult to recommend intervention in clinical practice.

scholarly journals Injury rate in professional football: A systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. 52-63
Author(s):  
Mirza Ibrahimović ◽  
Emir Mustafović ◽  
Denis Causevic ◽  
Haris Alić ◽  
Eldin Jelešković ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Injury Rate ◽  
Google Scholar ◽  
Football Players ◽  
Professional Football ◽  
Exclusion Criteria ◽  
National Team ◽  
Frequency Rate ◽  
Injury Frequency

The goal of this paper is to determine the injury frequency rate in professional football players in leagues and national competitions by analyzing existing papers. We have chosen 21 articles according to the PRISMA method from the Google Scholar, ResearchGate Scopus, and Web of Science databases that fit both inclusion and exclusion criteria. We have discussed the following four segments based on the content of the selected papers: 1) An analysis of the injury frequency rate on the level of national teams, 2) An analysis of the injury frequency rate in club leagues, 3) A comparison of the injury frequency rate in matches and in practice, and 4) An analysis of the injury frequency rate in male versus female football players. The paper concludes that major national team tournaments have the highest injury frequency rate and that the probability of injury is four to five times higher in a match than in practice. The injury frequency rate in female players is lower than in male players regardless of the type of competition (national teams or leagues).

scholarly journals Revisión sistemática de investigaciones sobre videojuegos bélicos (2010-2020)

2021 ◽  
pp. 205
Author(s):  
M.-Esther Del-Moral-Pérez ◽  
Christian Rodríguez-González
Keyword(s):  
Systematic Review ◽  
Critical Thinking ◽  
Video Games ◽  
Web Of Science ◽  
Meta Analysis ◽  
Scientific Production ◽  
Google Scholar ◽  
Educational Video ◽  
Revisión Sistemática ◽  
The Face

Resumen: Se analiza la producción científica sobre videojuegos bélicos. La metodología se sustenta en una revisión sistemática de estudios extraídos de bases de datos (Scopus, Web Of Science y Google Scholar), mediante un meta-análisis, siguiendo criterios de PRISMA-P2015 para identificar los enfoques y metodologías empleadas. Se encontraron 37 estudios entre 2010-2020 en cuatro ámbitos: educativo, psicológico, sociológico o antropológico y tecnológico. Los resultados ofrecen un panorama polarizado, un sector los considera plataformas de propaganda militarista; otro apuesta por utilizarlos como un recurso didáctico, permitiendo la inmersión virtual en acontecimientos históricos; y los técnicos señalan la conveniencia de diseñar videojuegos educativos con el asesoramiento de historiadores para dotarlos de mayor fiabilidad, además de incorporar misiones gamificadas que potencien su jugabilidad. Sin embargo, se precisan estudios que profundicen en la oportunidad que ofrecen estos instrumentos para impulsar el pensamiento crítico y la reflexión frente a la guerra y el sufrimiento de las víctimas.Abstract: Scientific production on war videogames is analyzed. The methodology is based on a systematic review of studies extracted from databases (Scopus, Web of Science and Google Scholar), through a meta-analysis, following the criteria of PRISMA-P2015 to identify the approaches and methodologies used. Thirty-seven studies were found between 2010-2020 in four areas: educational, psychological, sociological or anthropological and technological. The results offer a polarized panorama, one sector considers them militarist propaganda platforms; another is committed to using them as a didactic resource, allowing virtual immersion in historical events; and the technicians point out the convenience of designing educational video games with the advice of historians to make them more reliable, in addition to incorporating gamified missions that enhance their playability. However, studies are needed to delve into the opportunity offered by these instruments to promote critical thinking and reflection in the face of war and the suffering of the victims.

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