scholarly journals Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 256
Author(s):  
Amir Vahedian-Azimi ◽  
Mitra Abbasifard ◽  
Farshid Rahimi-Bashar ◽  
Paul C. Guest ◽  
Muhammed Majeed ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Clinical Settings ◽  
Curcumin Treatment ◽  
Partial Restoration ◽  
Beneficial Effects ◽  
Disease Outcomes ◽  
Duration Of Hospitalization ◽  
Anti Inflammatory ◽  
Related Compounds

Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (p < 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant (p < 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.

scholarly journals NIGELLA SATIVA HAS BENEFICIAL EFFECT ON OSTEOPOROSIS AND BONE HEALING. IS IT FACT OR FICTION? A SYSTEMATIC REVIEW

2017 ◽  
Vol 10 (5) ◽  
pp. 41
Author(s):  
Muhamed T Osman
Keyword(s):  
Systematic Review ◽  
Bone Healing ◽  
Web Of Science ◽  
Nigella Sativa ◽  
Experimental Studies ◽  
Molecular Targets ◽  
The Elderly ◽  
Potential Effect ◽  
Beneficial Effects ◽  
Black Seed

Osteoporosis is the most common reason for a broken bone among the elderly. Several experimental studies have been reported that Nigella sativa(NS) and/or its major component thymoquinone (TQ) have good effects on osteoporosis and bone healing. We conducted this systematic review toevaluate these relevant studies to prove whether NS and/or TQ has potential effect on osteoporosis and can stop pathogenesis of this disease or thismatter still just a fiction. A search on published studies was done using databases including Scopus, PubMed, Google Scholar, Web of Science, andCINAHIL. Terms searched included “Nigella sativa, black seed, TQ, osteoporosis, bone healing.” Initially, 213 articles were extracted. After reviewing their titles and abstracts, 124 articles (Medline, 43; Scopus, 67; EBSCO, 14) were retrieved for further evaluation. However, after excluding the clinical trial studies, human reviews, removal of abstracts and unrelated studies, seven studies were considered finally as eligible for our review. Finally, seven studies were considered eligible for our review. The total number of animals used was 220 (150 rats and 70 rabbits) from different experimental study. Based on the results of this systematic review, we conclude that NS or TQ extract therapy for osteoporosis cannot be recommended yet and these data will not suffice to exclude the beneficial effects of NS on bone turnover reliably. Therefore, more studies are required to explore the specific cellular and molecular targets of NS or TQ using animal osteoporosis models. Once the anti-osteoporotic effectiveness of NS or TQ will be established, human studies can be carried out.Keywords: Nigella sativa, Black seed, Thymoquinone, Osteoporosis, Bone healing.

The effect of soya consumption on inflammatory biomarkers: a systematic review and meta-analysis of clinical trials

2020 ◽  
pp. 1-12
Author(s):  
Mahsa Rezazadegan ◽  
Fatemeh Mirjalili ◽  
Cain C. T. Clark ◽  
Mohammad Hossein Rouhani
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Web Of Science ◽  
Meta Analysis ◽  
Inflammatory Biomarkers ◽  
Beneficial Effects ◽  
Isi Web Of Science ◽  
Subgroup Analyses ◽  
Study Heterogeneity ◽  
High Doses

Abstract Inflammation is a major cause of chronic diseases. Several studies have investigated the effects of soya intake on inflammatory biomarkers; however, the results are equivocal. The aim of this study was to conduct a systematic review and meta-analysis of clinical trials that evaluated the effect of soya consumption on inflammatory biomarkers. Medline, Scopus, ISI Web of Science and Google Scholar were systematically searched, up to and including May 2020, for clinical trials that evaluated the effects of soya and soya products on TNF-α, IL-6, IL-2, IL-1β and interferon γ (IFN-γ) in adults. A random effects method was used to calculate overall effects, and subgroup analyses were performed to discern probable sources of inter-study heterogeneity. A total of twenty-eight clinical trials were included. Although soya consumption reduced TNF-α (Hedges’ g = –0·28; 95 % CI –0·49, –0·07), it had no significant effect on IL-6 (Hedges’ g = 0·07, 95 % CI –0·14, 0·28), IL-2 (mean difference (MD) = –1·38 pg/ml; 95 % CI –3·07, 0·31), IL-1β (MD = –0·02 pg/ml; 95 % CI –0·08, 0·03) and IFN-γ (MD = 1685·82 pg/ml; 95 % CI –1604·86, 4976·50). Subgroup analysis illustrated a reduction in TNF-α in parallel designed studies, at dosages ≥100 mg of isoflavones, and in unhealthy subjects. The present study showed that high doses of isoflavones in unhealthy subjects may yield beneficial effects on TNF-α.

scholarly journals Observer-based tools for non-technical skills assessment in simulated and real clinical environments in healthcare: a systematic review

2019 ◽  
Vol 28 (8) ◽  
pp. 672-686 ◽  
Author(s):  
Helen Higham ◽  
Paul R Greig ◽  
John Rutherford ◽  
Laura Vincent ◽  
Duncan Young ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Grey Literature ◽  
Technical Skills ◽  
Clinical Settings ◽  
Eligibility Criteria ◽  
The Past ◽  
Technical Skills Assessment ◽  
Study Selection ◽  
Clinical Environments

BackgroundOver the past three decades multiple tools have been developed for the assessment of non-technical skills (NTS) in healthcare. This study was designed primarily to analyse how they have been designed and tested but also to consider guidance on how to select them.ObjectivesTo analyse the context of use, method of development, evidence of validity (including reliability) and usability of tools for the observer-based assessment of NTS in healthcare.DesignSystematic review.Data sourcesSearch of electronic resources, including PubMed, Embase, CINAHL, ERIC, PsycNet, Scopus, Google Scholar and Web of Science. Additional records identified through searching grey literature (OpenGrey, ProQuest, AHRQ, King’s Fund, Health Foundation).Study selectionStudies of observer-based tools for NTS assessment in healthcare professionals (or undergraduates) were included if they: were available in English; published between January 1990 and March 2018; assessed two or more NTS; were designed for simulated or real clinical settings and had provided evidence of validity plus or minus usability. 11,101 articles were identified. After limits were applied, 576 were retrieved for evaluation and 118 articles included in this review.ResultsOne hundred and eighteen studies describing 76 tools for assessment of NTS in healthcare met the eligibility criteria. There was substantial variation in the method of design of the tools and the extent of validity, and usability testing. There was considerable overlap in the skills assessed, and the contexts of use of the tools.ConclusionThis study suggests a need for rationalisation and standardisation of the way we assess NTS in healthcare and greater consistency in how tools are developed and deployed.

A systematic Review of Aloe vera and its Properties

2021 ◽  
pp. 257-259
Author(s):  
Farha Fatma ◽  
Anil Kumar
Keyword(s):  
Systematic Review ◽  
Medicinal Plant ◽  
Review Paper ◽  
Therapeutic Potential ◽  
Aloe Vera ◽  
Paper Properties ◽  
Beneficial Effects ◽  
Aloe Vera Gel ◽  
Anti Inflammatory ◽  
Pharmaceutical Uses

Aloe vera is one of the oldest medicinal plant ever known, commonly known as Ghrit Kumari. It is well known for its therapeutic potential. Some of its beneficial effects include anticancer, hypoglycemic, antifungal, anti-inflammatory, burn healing properties. Phytochemistry of Aloe vera gel has revealed presence of bioactive chemicals. In this review paper, properties of Aloe vera, its composition, its beneficial effects and pharmaceutical uses, its application in foods and cosmetics etc. have been summarized.

scholarly journals Mindfulness for patients with rheumatoid arthritis: systematic review

2021 ◽  
Vol 10 (2) ◽  
pp. e2610212047
Author(s):  
Ledjane Neves Oliveira ◽  
André Telis de Vilela Araújo ◽  
João Nelson Rodrigues Branco ◽  
João Carlos Marchiori de Claudio ◽  
Jeanne Liliane Marlene Michel ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Clinical Practice ◽  
Web Of Science ◽  
Well Being ◽  
Complementary Therapy ◽  
Assessment Instrument ◽  
Controlled Trials ◽  
Beneficial Effects ◽  
Randomized Controlled

Objectives: To evaluate the effectiveness of mindfulness as a complementary therapy in patients with rheumatoid arthritis. Method: Protocol numbered CRD42017080108 on the PROSPERO platform. Manual searches and the Cochrane Collation assessment instrument were performed for systematic reviews in the databases CENTRAL, MEDLINE, PEDro, PsycoINFO, LILACS, Web of Science, clinical trials.gov, WHO-ICTRP and Open Gray. Randomized controlled trials were included without language restrictions or mindfulness temporality compared to placebo, psychotherapy or another equivalent strategy in patients with rheumatoid arthritis. Results: Four primary studies included (249 participants), which compared mindfulness with waiting lists, cognitive therapy and education. They presented better scores of disease activities, depressive symptoms, psychological distress, well-being, pain catastrophization, although they were classified as having a high risk of occurrence in at least one domain of the instrument used, presenting the need for robust clinical trials, proving the effectiveness of mindfulness in clinical practice. Conclusions: Beneficial effects of mindfulness in patients with rheumatoid arthritis are shown to present important results of changes in outcomes that affect the biopsychosocial dimensions in patients with. However, the evidence from the studies evaluated is of low quality, making it difficult to recommend intervention in clinical practice.

scholarly journals BIOACTIVITIES OF GUETTARDA SPECIOSA L. EXTRACTS

2020 ◽  
Vol 5 (1) ◽  
pp. 20-22
Author(s):  
Saravanan Vivekanandarajah Sathasivampillai ◽  
Moon Jain ◽  
Pholtan Rajeev Sebastian Rajamanoharan
Keyword(s):  
Systematic Review ◽  
Plant Species ◽  
Web Of Science ◽  
Antioxidant Activities ◽  
Bioactive Compound ◽  
Scientific Data ◽  
Anti Inflammatory

Guettarda speciosa L. is a tree of the Rubiaceae family. G. specious has been used to treat diarrhea, abscesses, wounds, epilepsy, and malaria in ethnomedicinal systems. So far, there is no systematic review for the bioactivities of G. speciosa. Therefore, the purpose of this minireview is to analyze, summarize and document the reported bioactivities of G. speciosa. Major electronic databases (Web of Science, Scopus, ScienceDirect, PubMed, and Semantic Scholar) were used to identify related studies from 1900 to January 2021. So far, in vivo and in vitro scientific data are available for the bioactivities of this plant species. Studies have reported that G. speciosa contains antidiarrheal, antiepileptic, anti-inflammatory, anti-ulcer, antimalarial, antineurodegenerative, and antioxidant activities. Furthermore, no bioactive compound of G. speciosa has been isolated. This work will be useful for researchers interested in bioactivity and phytochemical researches.

scholarly journals Beneficial effects of legumes on parameters of the metabolic syndrome: a systematic review of trials in animal models

2016 ◽  
Vol 116 (3) ◽  
pp. 402-424 ◽  
Author(s):  
Rosario Martínez ◽  
María López-Jurado ◽  
Carmina Wanden-Berghe ◽  
Javier Sanz-Valero ◽  
Jesús María Porres ◽  
...  
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
Metabolic Pathways ◽  
Web Of Science ◽  
Cochrane Library ◽  
Acetyl Coa ◽  
Beneficial Effects ◽  
Glucose And Lipid Metabolism ◽  
The Metabolic Syndrome ◽  
Acetyl Coa Synthesis

AbstractLegume consumption plays a pivotal role in the prevention and treatment of the metabolic syndrome (MetS). This systematic review aimed to highlight the beneficial effects of legume interventions for the prevention and/or improvement of parameters related to the MetS and the implicated metabolic pathways so far reported. The methodology involved a search in four electronic databases (Medline, Web of Science, Scopus, Cochrane Library) from January 2007 to December 2014, considering as descriptors ‘Metabolic Syndrome’ and ‘Fabaceae’ and adequately adjusting the equation in each one of them. In total, forty-one studies were finally included. The majority of the studies described a regulating effect on glucose and lipid metabolism due to legume administration, whereas effects on blood pressure and renal parameters are not fully described. Regarding the metabolic pathways involved, they include the up-regulation of genes related to β-oxidation and acetyl-CoA degradation and the down-regulation of glycolytic and lipogenesis genes, as well as those associated with the acetyl-CoA synthesis. The ameliorating effects of legume consumption on the alterations associated with the MetS are clearly reported and coincide with changes in the expression of protein and genes involved in lipid and glucose metabolism. More research needs to be conducted including more legume species that are highly consumed as part of a healthy dietary pattern.

scholarly journals Anti-inflammatory, antibacterial and immunomodulatory treatment in children with symptoms corresponding to the research condition PANS (Pediatric Acute-onset Neuropsychiatric Syndrome): A systematic review

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0253844
Author(s):  
Mats Johnson ◽  
Stephan Ehlers ◽  
Elisabeth Fernell ◽  
Parisa Hajjari ◽  
Constanze Wartenberg ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Plasma Exchange ◽  
Acute Onset ◽  
Cochrane Library ◽  
Diagnostic Systems ◽  
Beneficial Effects ◽  
Level Of Functioning ◽  
Penicillin V ◽  
Anti Inflammatory

Objective To assess effects of treatment against a hypothesized neuroinflammation in children with symptoms corresponding to the research condition Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) which is not included in current diagnostic systems. Methods Systematic literature searches were performed (1998 to June 2020) in PubMed, Embase, the Cochrane Library, CINAHL, PsycInfo, and HTA databases. Inclusion criteria: patients (P) were children (<18 years) with PANS; intervention (I)/comparison (C) was use of, versus no use of, anti-inflammatory, antibacterial or immunomodulating treatments; outcomes (O) were health-related quality of life (HRQL), level of functioning, symptom change, and complications. Results Four randomised controlled trials (RCTs) and three non-RCTs, including 23 to 98 patients, fulfilled the PICO. HRQL was not investigated in any study. Regarding level of functioning, two RCTs investigated antibiotics (penicillin V, azithromycin) and one RCT investigated immunomodulating treatments (intravenous immunoglobulins (IVIG), plasma exchange). Regarding symptoms, two non-RCTs investigated anti-inflammatory treatment (cyclooxygenase (COX) inhibitors, corticosteroids), two RCTs and one non-RCT investigated antibiotics (penicillin V, azithromycin), and two RCTs investigated immunomodulating treatments (IVIG, plasma exchange). Complications, reported in five studies, were consistent with those listed in the summary of products characteristics (SPC). All studies were assessed to have some or major problems regarding directness, the absence of an established diagnosis contributing to clinical diversity in the studied populations. All studies were assessed to have major risk of bias, including selection and detection biases. Due to clinical and methodological diversity, meta-analyses were not performed. Conclusion This systematic review reveals very low certainty of evidence of beneficial effects, and moderate certainty of evidence of adverse effects, of anti-inflammatory, antibacterial or immunomodulating treatments in patients with symptoms corresponding to the research condition PANS. Available evidence neither supports nor excludes potential beneficial effects, but supports that such treatment can result in adverse effects. Registration PROSPERO (CRD42020155714).

scholarly journals Serotonergic hallucinogens and recognition of facial emotion expressions: a systematic review of the literature

2019 ◽  
Vol 9 ◽  
pp. 204512531984577 ◽  
Author(s):  
Juliana M. Rocha ◽  
Flávia L. Osório ◽  
José Alexandre S. Crippa ◽  
José Carlos Bouso ◽  
Giordano N. Rossi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Negative Emotions ◽  
Small Sample ◽  
Lysergic Acid ◽  
Facial Emotion ◽  
Review Of The Literature ◽  
Beneficial Effects ◽  
Amygdala Activity ◽  
Small Sample Sizes

Background: Recognition of emotions in facial expressions (REFE) is a key aspect of social cognition. Anxiety and mood disorders are associated with deficits in REFE, and anxiolytics and antidepressants reverse these deficits. Recent studies have shown that serotonergic hallucinogens (i.e. ayahuasca, dimethyltryptamine, psilocybin, lysergic acid diethylamide [LSD], and mescaline) have anxiolytic and antidepressant properties, but their effects on REFE are not well understood. The purpose of the study was to conduct a systematic review analyzing the effects of serotonergic hallucinogens on REFE in humans. Methods: Studies published in the PubMed, PsycINFO, and Web of Science databases until 19 October 2018 which analyzed the effects of serotonergic hallucinogens on REFE in humans were included. Results: Of the 62 studies identified, 8 studies were included. Included studies involved the administration of a single or a few doses of LSD or psilocybin, and most trials were randomized and controlled with placebo. LSD and psilocybin reduced the recognition of negative emotions in most studies and modulated amygdala activity to these stimuli, which was correlated with antidepressive effects in patients. Both drugs were well tolerated. Conclusions: Serotonergic hallucinogens reduced the recognition of negative emotions by modulating amygdala activity. Despite the small sample sizes, results suggest that serotonergic hallucinogens show promising beneficial effects on deficits in REFE.

scholarly journals Laser Therapy for the Treatment of Morphea: A Systematic Review of Literature

2021 ◽  
Vol 10 (15) ◽  
pp. 3409
Author(s):  
Paulina Szczepanik-Kułak ◽  
Małgorzata Michalska-Jakubus ◽  
Dorota Krasowska
Keyword(s):  
Systematic Review ◽  
Laser Therapy ◽  
Web Of Science ◽  
Skin Diseases ◽  
Google Scholar ◽  
Localized Scleroderma ◽  
Psychosocial Impairment ◽  
Beneficial Effects ◽  
Limited Effectiveness ◽  
Life Therapy

Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients’ quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects. Due to the advances in the application of lasers and their possible beneficial effects, the aim of this study is to review the reported usage of laser in morphea. We present a systematic review of available literature, performed with MEDLINE, Cinahl, Central, Scopus, Web of Science, and Google Scholar databases. We identified a total of twenty relevant studies (MEDLINE n = 10, Cinahl n = 1, Central n = 0, Scopus n = 2, Web of Science n = 5, Google Scholar n = 2) using laser therapy for LoS. Eight studies were focused on the use of PDL, six on fractional lasers (CO2 and Er:YAG), four on excimer, and two on either alexandrite or Nd:YAG.

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