scholarly journals The Auto-Brewery Syndrome: A Perfect Metabolic “Storm” with Clinical and Forensic Implications

2021 ◽  
Vol 10 (20) ◽  
pp. 4637
Author(s):  
Ricardo Jorge Dinis-Oliveira
Keyword(s):  
Challenge Test ◽  
Human Microbiome ◽  
Modern Medicine ◽  
Antifungal Drugs ◽  
Confirmatory Test ◽  
Blood Alcohol ◽  
Glucose Challenge Test ◽  
Glucose Challenge ◽  
Shed Light ◽  
Test Treatment

Auto-brewery syndrome (ABS) is a rare, unstudied, unknown, and underreported phenomenon in modern medicine. Patients with this syndrome become inebriated and may suffer the medical and social implications of alcoholism, including arrest for inebriated driving. The pathophysiology of ABS is reportedly due to a fungal type dysbiosis of the gut that ferments some carbohydrates into ethanol and may mimic a food allergy or intolerance. This syndrome should be considered in patients with chronic obstruction or hypomotility presenting with elevated breath and blood alcohol concentrations, especially after a high carbohydrate intake. A glucose challenge test should be performed as the confirmatory test. Treatment typically includes antifungal drugs combined with changes in lifestyle and nutrition. Additional studies are particularly needed on the human microbiome to shed light on how imbalances of commensal bacteria in the gut allow yeast to colonize on a pathological level.

scholarly journals Comparative Study of Fasting Plasma Glucose Concentration and Glucose Challenge Test for Screening Gestational Diabetes Mellitus

2014 ◽  
Vol 6 (2) ◽  
pp. 75-78
Author(s):  
Sujaya Sham ◽  
B Poornima R Bhat ◽  
Aruna Kamath
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glucose Concentration ◽  
Challenge Test ◽  
Plasma Glucose Concentration ◽  
Fasting Plasma ◽  
Glucose Challenge Test ◽  
Glucose Challenge ◽  
Fasting Plasma Glucose Concentration

ABSTRACT Background To compare the sensitivity and specificity of fasting plasma glucose (FPG) with that of standard glucose challenge test (GCT). Materials and methods Eighty-nine eligible pregnant women underwent GCT between 24th and 28th gestational week, followed by a diagnostic 3 hours 100 gm oral glucose tolerance test within 1 week. Out patient clinic in Father Muller Medical College Hospital, Mangalore. Data was analyzed for significance by chi-square test. Results Fasting plasma glucose concentration at a threshold value of 90 mg/dl and GCT at recommended standard threshold of 140 mg/dl yielded sensitivities of 66.7% and 100% respectively and specificities of 87.3% and 46.5% respectively. Reducing the threshold value of FPG to 80 mg/dl increased the sensitivity of test to 91.7% with specificity of 54.9% which was comparable to standard GCT, in our study. Conclusion Measuring FPG concentration using a cut-off of. 80 mg/dl is an easier, tolerable and more cost effective procedure than GCT for detecting more severe cases of GDM, i.e. the diabetes mellitus group. In resource poor settings with population belonging to average risk or high risk category, FPG at a cut-off of 90 mg/dl can be used to screen GDM. How to cite this article Sham S, Bhat BPR, Kamath A. Comparative Study of Fasting Plasma Glucose Concentration and Glucose Challenge Test for Screening Gestational Diabetes Mellitus. J South Asian Feder Obst Gynae 2014;6(2):75-78.

scholarly journals Glucose challenge test screening for prediabetes and undiagnosed diabetes

Diabetologia ◽  
2009 ◽  
Vol 52 (9) ◽  
pp. 1798-1807 ◽  
Author(s):  
L. S. Phillips ◽  
D. C. Ziemer ◽  
P. Kolm ◽  
W. S. Weintraub ◽  
V. Vaccarino ◽  
...  
Keyword(s):  
Challenge Test ◽  
Undiagnosed Diabetes ◽  
Glucose Challenge Test ◽  
Glucose Challenge

Accuracy of 50-g glucose challenge test to detect International Association of Diabetes and Pregnancy Study Groups criteria-defined hyperglycemia

2017 ◽  
Vol 139 (3) ◽  
pp. 312-317 ◽  
Author(s):  
Biodun N. Olagbuji ◽  
Adeniyi K. Aderoba ◽  
Oluwatosin O. Kayode ◽  
Christianah O. Awe ◽  
Adesina L. Akintan ◽  
...  
Keyword(s):  
International Association ◽  
Challenge Test ◽  
Study Groups ◽  
Glucose Challenge Test ◽  
Glucose Challenge ◽  
Diabetes And Pregnancy

Challenging the Glucose Challenge Test

2011 ◽  
Vol 66 (7) ◽  
pp. 394-396
Author(s):  
Jenny Huynh ◽  
Sujiva Ratnaike ◽  
Catherine Bartalotta ◽  
Michael Permezel ◽  
Christine Houlihan
Keyword(s):  
Challenge Test ◽  
Glucose Challenge Test ◽  
Glucose Challenge

scholarly journals The application of 50g oral glucose challenge test in screening for gestational diabetes mellitus in patients attending antenatal care OPD

2017 ◽  
Vol 6 (5) ◽  
pp. 1952
Author(s):  
Disha Andhiwal Rajput ◽  
Jaya Kundan Gedam
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Plasma Glucose ◽  
Gestational Hypertension ◽  
Challenge Test ◽  
Oral Glucose ◽  
Average Risk ◽  
Glucose Challenge Test ◽  
Glucose Challenge

Background: To screen patients at average risk for Gestational Diabetes using 50g Glucose Challenge test, to ascertain the prevalence of Gestational diabetes through further diagnostic testing and to prevent and manage complications. Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity with onset or first recognition during pregnancy. Women with GDM are at risk for maternal and foetal complications, so it is important to screen all the pregnant woman.Methods: This study was conducted in 198 patients between 24 and 28 weeks of gestation, attending the Antenatal clinic. 50g oral glucose is administered irrespective of time of the last meal and plasma glucose is measured one hour later. Patients with plasma glucose levels more than 140 mg/dl were subjected to a 100g oral glucose tolerance test, patients with two or more abnormal reading were labelled as GDM and managed accordingly.Results: Prevalence of GDM in our study was 9.59%. Maternal complications like gestational hypertension, vaginal infections and foetal complications were much higher in GDM patients as compare to non GDM group.Conclusions: GDM is a disease which adversely affects both mother as well as foetus. It is concluded that 50 gm glucose challenge test at 24-28 weeks of gestation with a cut-off value of 140 mg/dl is a reliable screening test for GDM. This test offers the best combination of ease and economy of use and reproducibility in screening for gestational diabetes mellitus in average risk patients.

scholarly journals Is an isolated abnormal 1-hour glucose challenge test associated with adverse pregnancy outcomes?

2022 ◽  
Vol 226 (1) ◽  
pp. S149
Author(s):  
Hillary Hosier ◽  
Lisbet S. Lundsberg ◽  
Jennifer F. Culhane ◽  
Caitlin Partridge ◽  
Moeun Son
Keyword(s):  
Pregnancy Outcomes ◽  
Challenge Test ◽  
Adverse Pregnancy Outcomes ◽  
Glucose Challenge Test ◽  
Glucose Challenge ◽  
Adverse Pregnancy

scholarly journals Association of risk factors of GDM with outcome of GCT in obstetrical population

2016 ◽  
Vol 10 (1) ◽  
Author(s):  
Rubina Sohail ◽  
Tahir Bashir ◽  
Khalida Javaid ◽  
Farrukh Zaman
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Risk Factor ◽  
Gestational Diabetes ◽  
Predictive Value ◽  
Challenge Test ◽  
Antenatal Clinic ◽  
Factor Group ◽  
Glucose Challenge Test ◽  
Glucose Challenge

Objective: To determine the association of risk factors of Gestational Diabetes Mellitus (GDM) to outcome of Glucose Challenge Test (GCT). Place and Duration of Study: From February 2000 to October 2000 at the antenatal clinic of Unit-II at Services Hospital. Subject and Methods: One thousand pregnant women attending antenatal clinic at 24-28 weeks of gestation at Services Hospital were included. Glucose challenge test was performed after a history with special reference to diabetic risk factors. Results: Risk factors were identified in 198 (19.8%); while there were no risk factors in 802 (80.2%) women. An oral glucose tolerance test (OGTT) was carried out in all glucose challenge test positive patients. Out of 198 women with risk factors, 50 women were glucose challenge test positive while 148 were screen negative. Out of 802 women without risk factors 54 were GCT positive while 748 were screen negative. The positive predictive value was 48% and the negative predictive value was 83% Out of ten gestational diabetic women, six (3%) belonged to the risk factor group While four (0.5%) were in the no risk factor group. Conclusion: pregnant women with positive risk factors for diabetes mellitus were found to have a six times greater chance of developing gestational diabetes as compared to those with no risk factors.

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