Comparing Advanced with Basic Telerehabilitation Technologies for Patients with Rett Syndrome—A Pilot Study on Behavioral Parameters

The aim of this study is to compare the performances of patients with Rett syndrome that were undergoing advanced telerehabilitation (ATR) and patients that were undergoing basic telerehabilitation (BTR). It was hypothesized that patients that were undergoing ATR training would have better improvement in nearly all the motor and cognitive scale scoring activities that were administered, thus showing reduced disability. A total of 20 young girls and women with a diagnosis of RTT, ranging from age 4 to 31 years old (Median: 12.50; IQR: 9.50–17.25) underwent a pre-test, treatment post-test 1, treatment, and post-test 2 procedure. The treatment consisted of either ATR or BTR, lasting 10 weeks with three sessions a week of about an hour. The results showed that the group with advanced telerehabilitation improved their performance better than the control group only in some neuropsychological measurements. The results are discussed in the light of critical factors of telerehabilitation.

Modern approach to the diagnosis and treatment of thrombocytopenia

Normally, the number of platelets in a healthy adult is in the range of 150-320 x 10⁹. A condition in which their number falls below 150x10⁹ is called thrombocytopenia. It can be both associated with a violation of the process of platelet formation in the bone marrow (in particular, with aplastic anemia, hemoblastosis, thrombocytopenic purpura), and be a concomitant pathology, for example, be a consequence of drug treatment of a number of somatic diseases. In the pathogenesis of thrombocytopenia, three main directions are distinguished: a decrease in platelet production, an acceleration of their decay and a violation of the distribution of the platelet pool with their sequestration in the spleen. Most often, drug thrombocytopenia develops against the background of the use of cytostatics, chloramphenicol, antithyroid drugs, NSAIDs. The decrease in the number of platelets can also be influenced by the regular use of alcohol, some infectious diseases, and immunodeficiency states. The main clinical manifestation of thrombocytopenia is hemorrhagic syndrome, proceeding as petechial rashes or ecchymosis, however, in some cases, clinical manifestations may be absent, and then the diagnosis is made on the basis of a clinical blood test. Treatment of thrombocytopenia is carried out taking into account the etiological factor that caused it.

Developing environmental integration teaching materials to improve cognitive flexibility

This study aims to develop an innovative model of environmental integration learning in boosting cognitive flexibility. The research method used a Research & Development with the Dick and Carey development model. The sampling technique uses random sampling techniques. There are two groups of teachers. Data analysis used descriptive statistics and t-test to verify product differences and effectiveness. The output is in the form of teaching materials for environmental education learning strategies. Results showed that there was a very significant difference between the post-pre-test treatment score 19.68, higher than the post-pre-test score of the control 9,12. There was an increase in teachers' cognitive flexibility about environmental integration learning effectively and significantly after reading the teaching materials.

The Auto-Brewery Syndrome: A Perfect Metabolic “Storm” with Clinical and Forensic Implications

Auto-brewery syndrome (ABS) is a rare, unstudied, unknown, and underreported phenomenon in modern medicine. Patients with this syndrome become inebriated and may suffer the medical and social implications of alcoholism, including arrest for inebriated driving. The pathophysiology of ABS is reportedly due to a fungal type dysbiosis of the gut that ferments some carbohydrates into ethanol and may mimic a food allergy or intolerance. This syndrome should be considered in patients with chronic obstruction or hypomotility presenting with elevated breath and blood alcohol concentrations, especially after a high carbohydrate intake. A glucose challenge test should be performed as the confirmatory test. Treatment typically includes antifungal drugs combined with changes in lifestyle and nutrition. Additional studies are particularly needed on the human microbiome to shed light on how imbalances of commensal bacteria in the gut allow yeast to colonize on a pathological level.

Review of current controversial issues in clinical trials

In clinical development, adequate and well-controlled randomised clinical trials are usually conducted to evaluate the safety and efficacy of test treatment under investigation. The purpose is to ensure that there is an accurate and reliable assessment of test treatment under study. In practice, however, some controversial issues inevitably appear despite the compliance of good clinical practice. These debatable issues include, but are not limited to, (1) appropriateness of hypotheses for clinical investigation, (2) feasibility of power calculation for sample size requirement, (3) integrity of randomisation/blinding, (4) strategy for clinical endpoint selection, (5) demonstrating effectiveness or ineffectiveness, (6) impact of protocol amendments and (7) independence of independent data monitoring committee. In this article, these controversial issues are discussed. The impact of these issues in evaluating the safety and efficacy of the test treatment under investigation is also assessed. Recommendations regarding possible resolutions to these issues are provided whenever possible.

Detergent waste treatment through the modification of biofilter reactors

The use of detergent in households is practiced by almost all people. These conditions make the quality of the environment, especially water bodies, more disturbed when the detergent waste disposal without prior processing. Hazard by detergent can interfere with human health such as digestive system disorders, skin irritation, and even one of the causes of cancer. The aimed of this research was to design a modified biofilter reactor to reduce levels of detergent and other organic substances in domestic wastewater. This research was a pre-experimental design research with designs used is pre-test, treatment, and post-test. The research media used were bioball because bioball has more space on its surface for bacterial growth that will form bacterial phylum, while activated carbon serves to increase efficiency in reducing levels of organic matter and to reduce the concentration of surfactants dissolved. The process is more effective if given a treatment with a process of coagulation, flocculation, and sedimentation. The results showed a decrease in detergent content from 14.56 mg/L to 0.86 mg/L (94.1%). These results indicate that the Bio Filter reactor was effective in reducing detergent levels to meet the detergent waste standard requirements based on East Java Governor Regulation No. 72/2013.

Perbedaan Hasil Belajar Sejarah dengan Menggunakan Model Pembelajaran Student Facilitator and Explaining dan Mind Mapping Kelas X Di SMA Plus Bina Satria Rupit

This study aims to determine the differences in the results of learning history using the Student Facilitator And Explaining and Mind Mapping Class X learning model at SMA Plus Bina Satria Rupit. The research method used in this study was a quasi-experimental with random sampling method. The average result of the pre-test in the experimental class I was 55.18 and in the experimental class II was 54.3. while the post-test average value in the experimental class I after being given post-test treatment using the Student Facilitator And Expalinning model was 81.32, and in the experimental class II given Mind Mapping learning was 76.53. Based on the results of data analysis using the average difference test (Paired sample T test) obtained the final test value in sig. (2-Tiled) = 0.00 < 0.05, then Ho is rejected, Ha is accepted. Thus, it can be concluded that there are differences in the results of learning history using the Student Facilitator And Explaining and Mind Mapping Class X learning model at SMA Plus Bina Satria Rupit.

THE EFFECTIVENES OF ROLE PLAY IN IMPROVINGENGLISH SPEAKING SKILLTO THE TENTH GRADE STUDENTS OF MA NIDA’UL KHAIRAAT POMBEWE

This study aims to determine the process of improving speaking skill through role play for tenth grade students of MANida'ul Khairaat Pombewe in the academic year 2020/2021. This study used pre-experimental design research methods. The researcher chose class 10thas a sample consisting of 10 students. In collecting the data, researchers used four types of instruments, namely: pre-test, treatment, post-test and documentation. The result of the data calculation showed that mean score of the students’ pre-test was 40.9, it was lower than the mean score of post-test 52.6. In analyzing the data the researchers used the 0.05 and 0.01 degree of significance and df (degree of freedom) N-1. This study has two hypothesis which are the null hypothesis or Ho (there is no improvement of using role play to the students’ speaking skill, and the alternative hypothesis or Ha (there is improvement of using role play to the students’ speaking skill). It can be concluded that Ho was rejected and Ha was accepted. The use of role play was effective to improve the students speaking skill at the tenth grade of students in MA Nida’ul Khairaat Pombewe.

Pengaruh Pembelajaran Kooperatif Terhadap Hasil Belajar Keterampilan Chest Pass Bola Basket di SMPN 1 Rengasdengklok

Tujuan dari pembuatan skripsi ini adalah untuk mengetahui pengaruh model pembelajaran kooperatif terhadap hasil belajar keterampilan chest pass bola basket pada peserta didik kelas VII SMP Negeri I Rengasdengklok. Untuk menjawab rumusan masalah penelitian yang telah di rumuskan, penulis menggunakan pendekatan kuantitatif dengan metode eksperimen. Penelitian ini di lakukan di SMP Negeri 1 Rengasdengklok dengan mengambil satu kelas sebagai sampel penelitian yaitu kelas VII I yang berjumlah total 43 responden. Terdapat tiga tahapan pada penelitian ini, yaitu : pre-test, treatment dan post-test. Pre-test dilakukan untuk mengetahui hasil belajar keterampilan chest pass bola basket sebelum mendapatkan treatment. Setelah dilakukan pre-test, peneliti memberikan treatment kepada responden yaitu dengan memberikan model pembelajaran kooperatif. Setelah diberikan treatment, selanjutnya peneliti melakukan post-test untuk mengetahui adakah pengaruh model pembelajaran kooperatif terhadap hasil belajar keterampilan chest pass bola basket pada responden. Penelitian diolah dengan menggunakan T-hitung dan dibandingkan dengan T-tabel. Hasil penelitian menunjukan bahwa pembelajaran kooperatif memiliki pengaruh terhadap hasil belajar keterampilan chest pass bola basket pada peserta didik kelas VII SMP Negeri I Rengasdengklok dengan hasil perhitungan T-hitung sebesar 21,75 dan dibandingkan T-tabel 2,018.

Speed, Agility, and Quickness (SAQ) training of the circuit system: How does it affect kick speed and agility of junior taekwondo athletes?

The study is conducted based on a trainer's difficulty in improving the speed of kicks and agility of taekwondo junior athletes. This condition is a consideration for trainers to develop a proper and measurable cirquit SAQ training program to improve kick speed and agility for taekwondo novice athletes. This study aims to find out the effect of SAQ cirquit exercises with kick speed and agility. The research method used is an experimental method with equivalent time series design research design. The research is conducted for 6 weeks with a frequency of 1 week 3 exercises and consists of 3 series. Every 4 weeks it is done postest with design; (1) pre-test-treatment-portest stage 1, and (2) pre test-postest-postest stage 2. Data analysis technique uses t test with significance level 0.05. The results conclude that; (1) there is a significant influence between cirquit SAQ exercises on the kick speed of taekwondo junior athletes. (2) there is a significant influence between cirquit SAQ exercises on the agility of taekwondo junior athletes. From the results of this study, researchers expect that there will be recommendations to be used as further considerations for the future so that this study is more in-depth related to SAQ exercises, and hopefully this study can be a reference material for other researchers who want to research about the influence of SAQ exercises.