scholarly journals Association between Severity of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of Other Spinal Ligaments in Patients with Ossification of the Posterior Longitudinal Ligament

2021 ◽  
Vol 10 (20) ◽  
pp. 4690
Author(s):  
Soraya Nishimura ◽  
Takashi Hirai ◽  
Narihito Nagoshi ◽  
Toshitaka Yoshii ◽  
Jun Hashimoto ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ligamentum Flavum ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Posterior Longitudinal Ligament ◽  
Computed Tomography Images ◽  
Prevalence Level ◽  
High Prevalence ◽  
Spinal Ligaments ◽  
Grade 3 ◽  
Whole Spine

Background: Although diffuse idiopathic skeletal hyperostosis (DISH) is known to coexist with the ossification of spinal ligaments (OSLs), details of the radiographic relationship remain unclear. Methods: We prospectively collected data of 239 patients with symptomatic cervical ossification of the posterior longitudinal ligament (OPLL) and analyzed the DISH severity on whole-spine computed tomography images, using the following grades: grade 0, no DISH; grade 1, DISH at T3–T10; grade 2, DISH at both T3–T10 and C6–T2 and/or T11–L2; and grade 3, DISH beyond C5 and/or L3. Ossification indices were calculated as the sum of vertebral and intervertebral levels with OSL for each patient. Results: DISH was found in 107 patients (44.8%), 65 (60.7%) of whom had grade 2 DISH. We found significant associations of DISH grade with the indices for cervical OPLL (r = 0.45, p < 0.0001), thoracic ossification of the ligamentum flavum (OLF; r = 0.41, p < 0.0001) and thoracic ossification of the supra/interspinous ligaments (OSIL; r = 0.53, p < 0.0001). DISH grade was also correlated with the index for each OSL in the whole spine (OPLL: r = 0.29, p < 0.0001; OLF: r = 0.40, p < 0.0001; OSIL: r = 0.50, p < 0.0001). Conclusion: The DISH grade correlated with the indices of OSL at each high-prevalence level as well as the whole spine.

scholarly journals Associations between Clinical Findings and Severity of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Ossification of the Posterior Longitudinal Ligament

2021 ◽  
Vol 10 (18) ◽  
pp. 4137
Author(s):  
Takashi Hirai ◽  
Soraya Nishimura ◽  
Toshitaka Yoshii ◽  
Narihito Nagoshi ◽  
Jun Hashimoto ◽  
...  
Keyword(s):  
Back Pain ◽  
Neck Pain ◽  
Clinical Symptoms ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Posterior Longitudinal Ligament ◽  
Clinical Findings ◽  
Cross Sectional ◽  
Computed Tomography Images ◽  
Significant Difference ◽  
Whole Spine

Background: This study investigated how diffuse idiopathic skeletal hyperostosis (DISH) influences clinical characteristics in patients with cervical ossification of the posterior longitudinal ligament (OPLL). Although DISH is considered unlikely to promote neurologic dysfunction, this relationship remains unclear. Methods: Patient data were prospectively collected from 16 Japanese institutions. In total, 239 patients with cervical OPLL were enrolled who had whole-spine computed tomography images available. The primary outcomes were visual analog scale pain scores and the results of other self-reported clinical questionnaires. Correlations were sought between clinical symptoms and DISH using the following grading system: 1, DISH at T3-T10; 2, DISH at both T3–10 and C6–T2 and/or T11–L2; and 3, DISH beyond the C5 and/or L3 levels. Results: DISH was absent in 132 cases, grade 1 in 23, grade 2 in 65, and grade 3 in 19. There were no significant correlations between DISH grade and clinical scores. However, there was a significant difference in the prevalence of neck pain (but not in back pain or low back pain) among the three grades. Interestingly, DISH localized in the thoracic spine (grade 1) may create overload at the cervical spine and lead to neck pain in patients with cervical OPLL. Conclusion: This study is the first prospective multicenter cross-sectional comparison of subjective outcomes in patients with cervical OPLL according to the presence or absence of DISH. The severity of DISH was partially associated with the prevalence of neck pain.

scholarly journals Ossification of the ligamentum flavum: a unique report of a Hispanic woman

2011 ◽  
Vol 30 (3) ◽  
pp. E15 ◽  
Author(s):  
Lana D. Christiano ◽  
Rachid Assina ◽  
Ira M. Goldstein
Keyword(s):  
Genetic Basis ◽  
Ligamentum Flavum ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Mass Effect ◽  
Posterior Longitudinal Ligament ◽  
Thoracic Region ◽  
Unique Case ◽  
Common Region ◽  
Ectopic Bone ◽  
Male Preponderance

Ossification of the ligamentum flavum (OLF) is a disease of ectopic bone formation within the ligamentum flavum, which may result in mass effect and neurological compromise. The low thoracic region is the most common region of occurrence, and this is followed by the cervical, then lumbar, spine. The prevalence of OLF is significantly higher in the Japanese population compared with other nationalities and has a male preponderance. Ossification of the ligamentum flavum has been reported in association with the more common ligamentous pathological entities—ossification of the posterior longitudinal ligament and diffuse idiopathic skeletal hyperostosis. These latter two conditions have been linked to several metabolic processes, and a possible genetic basis has been hypothesized. Here, the authors present a unique case of OLF of the cervical spine in a patient with idiopathic hypercalcemia.

scholarly journals Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) assessed with whole-spine computed tomography in 1479 subjects

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Akihiko Hiyama ◽  
Hiroyuki Katoh ◽  
Daisuke Sakai ◽  
Masato Sato ◽  
Masahiro Tanaka ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Whole Spine

Ossification of the ligamentum flavum in a Caucasian man

2008 ◽  
Vol 9 (5) ◽  
pp. 427-437 ◽  
Author(s):  
Risheng Xu ◽  
Daniel M. Sciubba ◽  
Ziya L. Gokaslan ◽  
Ali Bydon
Keyword(s):  
Thoracic Spine ◽  
Clinical Presentation ◽  
Ligamentum Flavum ◽  
East Asian ◽  
Posterior Longitudinal Ligament ◽  
Documented Case ◽  
Asian Populations ◽  
Imaging Characteristics ◽  
Spinal Ligaments

Abnormal ossification of spinal ligaments is a well-known cause of myelopathy in East Asian populations, with ossification of the ligamentum flavum (OLF) and the posterior longitudinal ligament being the most prevalent. In Caucasian populations, OLF is rare, and there has been only 1 documented case of the disease affecting more than 5 spinal levels. In this report, the authors describe the clinical presentation, imaging characteristics, and management of the second published case of a Caucasian man with OLF affecting almost the entire thoracic spine. The literature is then reviewed with regard to OLF epidemiology, pathogenesis, presentation, and treatment.

scholarly journals Ossification of Posterior Longitudinal Ligament in Cervical Spine and Its Association With Ossified Lesions in the Whole Spine: A Cross-Sectional Study of 2500 CT Scans

2021 ◽  
pp. 219256822199344
Author(s):  
Neerav Anand Singh ◽  
Ajoy Prasad Shetty ◽  
Sridhar Jakkepally ◽  
Dinesh Kumarasamy ◽  
Rishi Mukesh Kanna ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Prevalence Rate ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Posterior Longitudinal Ligament ◽  
Cross Sectional Study ◽  
Ct Scans ◽  
Chi Square ◽  
Cross Sectional ◽  
Ossified Posterior Longitudinal Ligament ◽  
Whole Spine

Study Design: A retrospective study. Objective: To identify the prevalence and characteristics of ossified posterior longitudinal ligament (OPLL) in the cervical spine and its association with other spinal ligament ossifications. Method: This study is a retrospective review of whole spine CT scans of polytrauma patients from 2009 to 2018. Patients were screened for cervical OPLL (C-OPLL), thoracolumbar OPLL, thoracic ossified ligamentum flavum (OLF), cervical and thoracolumbar ossified anterior longitudinal ligament (C-OALL AND T-L OALL), ossified nuchal ligament (ONL) and, diffuse idiopathic skeletal hyperostosis (DISH) using CT scans. Their prevalence and distributions were assessed using statistical tools. Chi-square tests were used to determine statistical association between the categorical parameters. Results: Out of 2500 patients, 128 had C-OPLL with a prevalence rate of 5.12% with mean age of 55.89 year. The most commonly affected level was C5, followed by C6, and C4. The segmental OPLL was highest in number (77.7%), followed by localized type (14.8%). While the prevalence rate of thoracic OPLL was 0.56%, OLF was 9.9%. Ossifications that coexisted along with C-OPLL were thoracic OPLL (7.81%), thoracic OLF (36.71%), cervical OALL (29.68%), thoracolumbar OALL (37.5%), DISH (27.34%) and, ONL (7.03%). Conclusion: Our study indicated a prevalence rate of 5.12% for C-OPLL with a predominance of segmental OPLL (77.7%). Among these patients, approximately 36% had coexisting thoracic OLF. In patients with symptomatic OPLL induced cervical myelopathy, MRI analysis of whole spine with relevant CT correlation may help in detecting additional ossification sites of compression.

scholarly journals Prevalence of Diffuse Idiopathic Skeletal Hyperostosis Diagnosed by Whole Spine Computed Tomography: A Preliminary Study

2018 ◽  
Vol 10 (1) ◽  
pp. 41 ◽  
Author(s):  
Bum-Soo Kim ◽  
Myung-Sang Moon ◽  
Min Geun Yoon ◽  
Seong-Tae Kim ◽  
Sang-Jae Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Preliminary Study ◽  
Whole Spine

scholarly journals Diffuse Idiopathic Skeletal Hyperostosis: An Anatomical Case Report

2021 ◽  
Author(s):  
Anjali Singal ◽  
Tulika Gupta ◽  
Daisy Sahni
Keyword(s):  
Case Report ◽  
Ligamentum Flavum ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Lumbar Vertebrae ◽  
Thoracic Vertebrae ◽  
Anterior Longitudinal Ligament ◽  
Thoracic Pain ◽  
Male Cadaver ◽  
Spinal Ligaments ◽  
Ossification Of Ligamentum Flavum

Diffuse Idiopathic Skeletal Hyperostosis (DISH) is a noninflammatory disease of unknown cause characterised by osteophytic calcification or ossification of ligaments and enthesis; especially spinal. Authors hereby present a case report of a 65-year-old male cadaver, in whom the fusion of contiguous nine vertebrae from fifth thoracic to first lumbar vertebrae, because of ossification of the Anterior Longitudinal Ligament (ALL) was noticed. The tenth and eleventh thoracic vertebrae seemed to be affected worse, as maximum osseous anterior outgrowth (12 mm) of ossified ALL, ossification of Ligamentum Flavum (LF) and supraspinous ligament was also observed at this level. The Ossification of Anterior Longitudinal Ligament (OALL) along with the involvement of LF has not been classically reported. Ossification of spinal ligaments may cause local thoracic pain, stiffness and slowly progressive myelopathy. Ossified LF at the level of joint between tenth and eleventh thoracic vertebrae may result in compression of spinal cord at this level.

Sign in / Sign up

Export Citation Format

Share Document