Colchicine Improves Clinical Outcomes and Quality of Life in Hidradenitis Suppurativa Patients: A Retrospective Study

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of the follicular epithelium. The aim of the study was to investigate the effectiveness of colchicine on the clinical outcomes of HS patients, and to evaluate wither colchicine as monotherapy or in combination with doxycycline would provide better outcomes. Methods: A retrospective study was conducted including 44 patients with established HS, divided into three groups. The first group (n = 15 patients) received colchicine as monotherapy, the second group (n = 14 patients) received colchicine and doxycycline 100 mg/d, while the third group (n = 15 patients) received colchicine and doxycycline 40 mg/d. Disease severity during treatment was assessed at baseline and follow-up, using the Hurley Scoring System and the International Hidradenitis Suppurativa Severity Score System (IHS4). All patients were also asked to complete a Dermatology Life Quality Index (DLQI) questionnaire. These scores were compared among the study groups. Results: The DLQI and IHS4 scores significantly improved after treatment with colchicine (p < 0.001) in all groups. All colchicine regimes, including the single colchicine regime, colchicine plus doxycycline 100 mg regime, and colchicine plus doxycycline 40 mg regime, resulted in significant improvements in the DLQI and IHS4 scores (p < 0.001). Clinical improvement based on DLQI and IHS4 scores was similar in all groups. None of the patients had to discontinue the treatment due to adverse events. Discussion: In conclusion, our findings suggest that colchicine may improve clinical severity and quality of life in HS patients, either as monotherapy or in combination with doxycycline, both at antimicrobial (100 mg) and sub-antimicrobial (40 mg) doses.

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Quality-of-Life Impairment among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study of 1795 Patients

Life ◽

10.3390/life11010034 ◽

2021 ◽

Vol 11 (1) ◽

pp. 34

Author(s):

Piotr K. Krajewski ◽

Łukasz Matusiak ◽

Esther von Stebut ◽

Michael Schultheis ◽

Uwe Kirschner ◽

...

Keyword(s):

Quality Of Life ◽

Hidradenitis Suppurativa ◽

Demographic Data ◽

Life Quality ◽

Cross Sectional Study ◽

Cross Sectional ◽

Score System ◽

Holistic Management ◽

Inflammatory Skin Disorder

The chronic, inflammatory skin disorder hidradenitis suppurativa (HS) is associated well documented negative influences on patients’ quality of life (QoL). The aim of this study was to present more robust data on patients’ QoL impairment by demographic data and its correlation with well-known HS risk factors on a cohort of 1795 German patients. The instrument used for measuring QoL in this study was the Dermatology Life Quality Index (DLQI). Overall, patients reported a very large effect of HS on their QoL (mean DLQI: 13.2 ± 8.1 points), and 22% of the analyzed population even reported to consider the effect as extremely large. Women tended to experience significantly higher impairment than men (p < 0.001). QoL impairment correlated positively with pain (r = 0.581, p < 0.001), HS severity (measured by the International Hidradenitis Suppurativa Severity Score System (IHS4)) as well as Hurley. Neck involvement tended to decrease QoL significantly more than any other location (14.7 ± 8.3 points). This study confirms the enormous influence of HS on patients’ QoL in a large cohort. Knowledge of QoL impairment in such patients is crucial for proper understanding and holistic management of this disease.

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Trends in Hidradenitis Suppurativa Disease Severity and Quality of Life Outcome Measures: A Systematic Review (Preprint)

10.2196/preprints.27869 ◽

2021 ◽

Author(s):

Jalal Maghfour ◽

Torunn Elise Sivesind ◽

Cory A. Dunnick ◽

Robert Paul Dellavalle

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Disease Severity ◽

Outcome Measures ◽

Hidradenitis Suppurativa ◽

Life Quality ◽

Clinical Score ◽

Validity And Reliability ◽

Patient Reported

BACKGROUND While there has been an increase in the number of randomized, controlled trials (RCTs) evaluating treatment efficacy for HS, instrument measurements of disease severity and quality of life (QoL) are varied, making compilation of data and comparison between studies a challenge for clinicians. OBJECTIVE The aim of this review is to evaluate trends in disease severity scales and patient reported outcome measures used in RCTs assessing treatment interventions among HS patients. METHODS A primary systematic literature review was conducted in August 2020. PubMed/MEDLINE, Embase, Web of Science, and Cochrane databases were used to identify all articles published from January 1964 to July 2020. The study was prospectively registered with PROSPERO (ID: 209582). Twenty-five articles were included in the systematic review. RESULTS Sartorius and modified Sartorius scores (n=8), and Hidradenitis Suppurativa Clinical score (HiSCs) (n=8) were the most commonly used instruments for disease severity. Participants’ pain, followed by Dermatology Life Quality Index (DLQI), were the most common QoL measures used in the reviewed studies. CONCLUSIONS Heterogeneity of data characterizing both the validity and reliability of existing outcome measures hinders interpretation and translation of the results from RCTs into clinical practice. Many of the QoL measures identified were not specific to HS and may not be representative of all factors impacting patients.

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Efficacy of adalimumab in moderate to severe hidradenitis suppurativa: Real life data

Dermatology Reports ◽

10.4081/dr.2018.7859 ◽

2018 ◽

Vol 10 (2) ◽

Cited By ~ 8

Author(s):

Aikaterini Kyriakou ◽

Anastasia Trigoni ◽

Nikiforos Galanis ◽

Dimitrios Sotiriadis ◽

Aikaterini Patsatsi

Keyword(s):

Quality Of Life ◽

Hidradenitis Suppurativa ◽

Therapeutic Potential ◽

Therapeutic Option ◽

Real Life ◽

Life Quality ◽

Global Assessment Scale ◽

Friedman's Test ◽

Adalimumab Treatment

Hidradenitis suppurativa (HS) is a relapsing, inflammatory disease characterized by painful nodules, abscesses, sinuses track formation and scarring. HS has a great impact on patients’ quality of life and its treatment may be really challenging. Adalimumab provides a new therapeutic option for HS. Our aim was to assess the therapeutic potential of adalimumab on patients with HS based on the data from the daily clinical practice of an HS Outpatient Clinic. 19 patients with clinically evident moderate to severe HS, under adalimumab treatment for at least 24 week, participated in this observational, retrospective study. The Hidradenitis Suppurativa Physician’s Global Assessment scale, Modified Santorius scale and Dermatology Life Quality Index (DLQI) at baseline, week 4, week 12 and week 24 were retrieved from the records. Both Modified Santorius score and DLQI were significantly decreased during the weeks of evaluation (Friedman’s test; P < 0.001). The proportion of patients who achieved clinical response was 10.5% (n = 2) at week 4, 42.1% (n = 8) at week 12 and 63.2% (n = 12) at week 24. Treatment with adalimumab was linked with both clinical remission of HS and improvement of patients’ quality of life.

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Quality of Life in Cohabitants of Patients with Hidradenitis Suppurativa: A Cross-sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17166000 ◽

2020 ◽

Vol 17 (16) ◽

pp. 6000 ◽

Cited By ~ 1

Author(s):

Carmen Ramos-Alejos-Pita ◽

Salvador Arias-Santiago ◽

Alejandro Molina-Leyva

Keyword(s):

Quality Of Life ◽

Dermatology Life Quality Index ◽

Quality Index ◽

Hidradenitis Suppurativa ◽

Life Quality ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Type D

Hidradenitis suppurativa (HS) is a chronic inflammatory disease that impairs patients’ physical and mental health. However, few studies have considered the consequences of HS on cohabitants. The aims of this study were to explore the impact of HS on the quality of life (QOL) of cohabitants and to assess potentially associated factors. A cross-sectional study was conducted and patients with HS and their cohabitants were invited to participate. Validated questionnaires were used to measure QOL, anxiety and depression, type D personality and sexual dysfunction. The clinical variables of patients and the demographic characteristics of cohabitants were also collected. Twenty-seven patients and 27 cohabitants were included for analysis. Patients and cohabitants presented significant QOL impairment. A direct association was found between the Dermatology Life Quality Index (DLQI) and the Familiar Dermatology Life Quality Index (FDLQI). DLQI scores were associated with the presence of negative affectivity, a trait typical of type D personality, as well as with cohabitants’ anxiety. FDLQI scores were associated with cohabitant anxiety and patient depression. Hidradenitis suppurativa damages quality of life in patients and cohabitants. Identifying potential psychological factors could help us to recognize at-risk patients and apply personalized treatments for them and their environment.

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The Use of HSQoL-24 in an Assessment of Quality-of-Life Impairment among Hidradenitis Suppurativa Patients: First Look at Real-Life Data

Journal of Clinical Medicine ◽

10.3390/jcm10225446 ◽

2021 ◽

Vol 10 (22) ◽

pp. 5446

Author(s):

Piotr K. Krajewski ◽

Servando E. Marrón ◽

Manuel Gomez-Barrera ◽

Lucía Tomas-Aragones ◽

Yolanda Gilaberte-Calzada ◽

...

Keyword(s):

Quality Of Life ◽

Hidradenitis Suppurativa ◽

Disease Onset ◽

Real Life ◽

Clinical Settings ◽

Life Data ◽

Real Life Data ◽

Inflammatory Skin Disorder ◽

Family House

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with well-documented effects on patients’ quality of life (QoL). The aim of this study was to evaluate the QoL of patients with HS via the use of a newly developed questionnaire: Hidradenitis Suppurativa Quality of Life-24 (HSQoL-24). This study was performed on a population of 342 HS patients. Their QoL was assessed via the HSQoL-24 questionnaire. The perceived impairment of QoL due to HS in the studied group was considered to be serious (mean HSQoL-24 score: 58.3 ± 21.0 points). Women tended to experience a significantly higher impact from the disease than men (61.6 ± 19.2 points vs. 51.1 ± 23.1 points, p < 0.001). The HS severity had an effect on the perceived QoL, with statistically significant differences being evident between the self-assessed HS severity groups. The level of QoL impairment correlated positively with the number of affected body areas (r = 0.285, p < 0.001) and the duration of the disease (r = 0.173, p = 0.001), while the patients’ age at disease onset correlated negatively with the HSQoL-24 global score (r = −0.182, p = 0.001). Patients living in their family house scored higher than other groups. The least affected were patients who lived alone. The study shows that the HSQoL-24 questionnaire is a reliable, HS-specific tool for measuring the QoL among patients with HS in real-life clinical settings.

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Pruritus and Malodour in Patients with Hidradenitis Suppurativa: Impact on Quality of Life and Clinical Features Associated with Symptom Severity

Dermatology ◽

10.1159/000502139 ◽

2019 ◽

Vol 236 (1) ◽

pp. 59-65 ◽

Cited By ~ 2

Author(s):

Alejandro Molina-Leyva ◽

Carlos Cuenca-Barrales

Keyword(s):

Quality Of Life ◽

Clinical Features ◽

Hidradenitis Suppurativa ◽

Rating Scale ◽

Life Quality ◽

Numeric Rating Scale ◽

Cross Sectional Study ◽

Cross Sectional ◽

The Impact

Background: Patients with hidradenitis suppurativa (HS) suffer from symptoms such as pruritus and malodour which can significantly impair their quality of life. Objectives: (1) To analyse the impact of pruritus and malodour on the quality of life of patients with HS and (2) to explore the potential association between clinical features and the severity of these symptoms. Patients and Methods: This is a cross-sectional study. The Numeric Rating Scale (NRS) was used to assess pruritus and malodour. Quality of life was assessed by means of the Dermatology Life Quality Index (DLQI). Results: Two hundred and thirty-three patients were included in the study. Both pruritus and malodour positively correlated with worse quality of life (p < 0.05). Pruritus intensity was associated with the number of regions affected by HS, female sex, the intensity of suppuration, and the presence of comorbid Crohn’s disease. Statin use was associated with lower levels of pruritus. Malodour intensity was associated with higher body mass index, disease duration, the number of regions affected, Hurley stage, and intensity of suppuration. Conclusions: The results of our study show that pruritus and malodour are key symptoms in patients with HS which have a great impact on their quality of life. We have identified clinical features potentially associated with the intensity of these symptoms which could be useful to identify higher-risk patients and may influence treatment decisions.

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Peculiarities of psychoemotional violations and quality of life depending on the severity and the form of acne in women with infertility

HEALTH OF WOMAN ◽

10.15574/hw.2017.123.72 ◽

2017 ◽

pp. 72-76

Author(s):

A.I. Litus ◽

◽

O.I. Zadnipryanaya ◽

Keyword(s):

Quality Of Life ◽

Comparison Group ◽

Minimum Degree ◽

Life Quality ◽

Depression Scale ◽

Clinical Severity ◽

Social Effect ◽

Morphological Form ◽

Infertile Women

The objective: the study of the psychoemotional status of women with infertility and acne, depending on its severity and clinical-morphological form. Patients and methods. The study included 184 women: 111 were the main group (infertile women with acne), 40 – the comparison group of A (women with acne and normal reproductive function), 33 – the comparison group B (infertile women without dermatological problems). Were analyzed such factors as anamnesis, dermatological and gynecological status, hormonal background analysis, assessment of the psychoemotional state (HADS – Hospital Anxiety and Depression scale), quality of life (DLQI – Dermatological Life Quality Index), psychological and social effect of acne (APSEA – Assessment of Phsychological and Social Effects of Acne). Results. In the course of the study, a reliable direct dependence of the severity of psychoemotional disorders and the degree of disruption of the quality of life on the severity of acne, as well as its clinical and morphological form, was traced. Even with a minimum degree of severity of acne and with a mild comedonal form of the disease, psychoemotional disorders reached a degree of clinical severity, and dermatosis strongly influenced the quality of life of patients (in accordance with DLQI values), had a strong psychological and social effect on daily activity and self-esteem (APSEA) of patients. Conclusion. Thus, the study confirmed the comorbidity of psychoemotional disorders and acne, as well as the dependence of the severity of psychoemotional disorders and a decrease in the quality of life of infertile women with acne due to the severity of the acne and its clinical and morphological form. Key words: women with acne and infertility, quality of life, psychoemotional disorders, psychological and social effect of acne, severity of acne, acne form.

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Correlation between Depression, Quality of Life and Clinical Severity in Patients with Hidradenitis Suppurativa

Acta Dermato Venereologica ◽

10.2340/00015555-3647 ◽

2020 ◽

pp. 0

Author(s):

F Sampogna ◽

L Fania ◽

S Mastroeni ◽

R Fusari ◽

M Napolitano ◽

...

Keyword(s):

Quality Of Life ◽

Hidradenitis Suppurativa ◽

Clinical Severity

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The Broad-Spectrum Impact of Hidradenitis Suppurativa on Quality of Life: A Comparison with Psoriasis

Dermatology ◽

10.1159/000496604 ◽

2019 ◽

Vol 235 (4) ◽

pp. 308-314 ◽

Cited By ~ 2

Author(s):

Francesca Sampogna ◽

Luca Fania ◽

Cinzia Mazzanti ◽

Alessio Caggiati ◽

Sabatino Pallotta ◽

...

Keyword(s):

Quality Of Life ◽

Broad Spectrum ◽

Hidradenitis Suppurativa ◽

Clinical Severity ◽

The Mean ◽

Low Levels ◽

Chronic Skin ◽

Skin Conditions ◽

Chronic Skin Disease

Background/Aim: Hidradenitis suppurativa (HS) is a chronic skin disease with a heavy impact on patients’ quality of life (QoL). The aim of this study was to evaluate in detail the QoL impact of HS comparing it with other skin conditions, and in particular with psoriasis. Methods: Patients with a diagnosis of HS were recruited. QoL was measured using the Skindex-17 questionnaire. Results: Data were available for 69 HS patients. HS had the worst QoL among several skin conditions. Compared to psoriasis the mean symptom score was 69.4 versus 53.7, and the mean psychosocial score was 56.1 versus 32.7. Overall, the scores of patients with HS were higher than those of psoriasis patients on 16 of the 17 items of the Skindex-17. Conclusions: When compared to many different skin conditions, and in particular to psoriasis, HS was the most impairing condition, even at low levels of clinical severity.

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The Contribution of Malodour in Quality of Life of Patients With Hidradenitis Suppurativa

Journal of Cutaneous Medicine and Surgery ◽

10.1177/1203475417745826 ◽

2017 ◽

Vol 22 (2) ◽

pp. 166-174 ◽

Cited By ~ 16

Author(s):

Afsaneh Alavi ◽

Delaram Farzanfar ◽

Rosa Kyuwon Lee ◽

Dalal Almutairi

Keyword(s):

Quality Of Life ◽

Interpersonal Relationships ◽

Hidradenitis Suppurativa ◽

Social Stigma ◽

Bacterial Colonization ◽

Life Quality ◽

Common Symptom ◽

College Hospital ◽

Cross Sectional

Background: Malodourous discharge in patients with hidradenitis suppurativa (HS) has a strong psychosocial impact and is often reported as a source of embarrassment, low self-esteem, social stigma, and barriers to interpersonal relationships. Malodour is a maker of bacterial colonization, and its role in HS is understudied. Objectives: The aim of this study is to assess the relationship between severity of malodourous discharge and quality-of-life impairment in patients with HS. Methods: This is a cross-sectional study of 51 patients recruited from the Women’s College Hospital and the York Dermatology Centre. Quality of life was assessed using both the Dermatology Life Quality Index (DLQI) and the Skindex-29 instruments. Results: Severity of odour significantly predicts the total Skindex score after controlling for disease severity as measured by the Hurley stage and Sartorius score ( R2 = 0.39, F = 8.11, P < .0001). However, odour severity is not a predictor of DLQI ( R2 = 0.17, F = 2.63, P = .064). There was no difference in mean DLQI scores for the low- vs high-odour groups, but patients with high odour had a greater quality of life impairment as measured by the Skindex tool ( t = −4.19, df = 43, P < .0001, mean difference = −18.87). Conclusion: Malodour is a common symptom that significantly impairs quality of life in patients with HS. The fact that this effect is captured in Skindex and not the DLQI may be attributed to the nonspecificity of the DLQI in terms of unique disease characteristics. It is important to address odour in the management of patients with HS.

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