scholarly journals Update on Pulmonary Ossifications in the Differential Diagnosis of Solitary Pulmonary Nodules

2021 ◽  
Vol 10 (20) ◽  
pp. 4795
Author(s):  
Jan F. Gielis ◽  
Lawek Berzenji ◽  
Vasiliki Siozopoulou ◽  
Marloes Luijks ◽  
Paul E. Y. Van Schil
Keyword(s):  
Differential Diagnosis ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Lower Lobe ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Pulmonary Surgery ◽  
Pubmed Database ◽  
Post Mortem Findings ◽  
The Right

Pulmonary ossifications have often been regarded as rare, post-mortem findings without any clinical significance. We have investigated the occurrence of pulmonary ossifications in patients undergoing thoracic procedures, and how this may affect the differential diagnosis of solitary pulmonary nodules. In addition, we have performed a literature search on the occurrence and possible pathogenesis of these ossifications. From January 2008 until August 2019, we identified pulmonary ossifications in 34 patients who underwent elective pulmonary surgery. Pre-operative imaging was unable to differentiate these ossifications from solid tumors. A definitive diagnosis was made by an experienced pathologist (VS, ML). The PubMed database was researched in December 2019 with the search terms “pulmonary ossifications”; “heterotopic ossifications”; and “solitary pulmonary nodule”. In total, 27 patients were male, with a mean age of 63 ± 12 years (age 41 to 82 on diagnosis). All lesions were identified on thoracic CT and marked for resection by a multidisciplinary team. A total of 17 patients were diagnosed with malignancy concurrent with ossifications. There was a clear predilection for the right lower lobe (12 cases, 35.3%) and most ossifications had a nodular form (70.6%). We could not identify a clear association with any other pathology, either cancerous or non-cancerous in origin. Oncologic or pulmonary comorbidities did not influence patient survival. Pulmonary ossifications are not as seldom as thought and are not just a curiosity finding by pathologists. These formations may be mistaken for a malignant space-occupying lesion, both pre-and perioperatively, as they are indistinguishable in imaging. We propose these ossifications as an underestimated addition to the differential diagnosis of a solitary pulmonary nodule.

scholarly journals Malignant melanoma without primary, presenting as solitary pulmonary nodule: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
George Tsaknis ◽  
Muhammad Naeem ◽  
Advitya Singh ◽  
Siddharth Vijayakumar
Keyword(s):  
Lung Cancer ◽  
Malignant Melanoma ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Past History ◽  
White Male ◽  
Pulmonary Nodules ◽  
Metastatic Malignant Melanoma ◽  
Unknown Primary ◽  
Solitary Pulmonary Nodules

Abstract Background Solitary pulmonary nodules are the most common incidental finding on chest imaging. Their management is very well defined by several guidelines, with risk calculators for lung cancer being the gold standard. Solitary intramuscular metastasis combined with a solitary pulmonary nodule from malignant melanoma without a primary site is rare. Case presentation A 57-year-old white male was referred to our lung cancer service with solitary pulmonary nodule. After positron-emission tomography, we performed an ultrasound-guided core needle biopsy of an intramuscular solitary lesion, not identified on computed tomography scan, and diagnosed metastatic malignant melanoma. The solitary pulmonary nodule was resected and also confirmed metastatic melanoma. There was no primary skin lesion. The patient received oral targeted therapy and is disease-free 5 years later. Conclusions Clinicians dealing with solitary pulmonary nodules must remain vigilant for other extrathoracic malignancies even in the absence of obvious past history. Lung metastasectomy may have a role in metastatic malignant melanoma with unknown primary.

scholarly journals An approach to the solitary pulmonary nodule

2016 ◽  
Vol 22 (3) ◽  
pp. 54 ◽  
Author(s):  
S Abraham ◽  
M J Vorster ◽  
S S Roy ◽  
C F N Koegelenberg
Keyword(s):  
Lung Cancer ◽  
South Africa ◽  
Risk Stratification ◽  
Current Literature ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Imaging Techniques ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Structured Approach

<p>Solitary pulmonary nodules may represent early lung cancer, which is potentially curable. The advent of improved imaging techniques, together with the worldwide implementation of screening programmes, has intensified the need for a structured approach to the management <br />of pulmonary nodules. We present an overview of the current literature on risk stratification, characteristics and management of pulmonary <br />nodules that are relevant to practitioners in South Africa.</p>

scholarly journals Solitary pulmonary nodule and 18F-FDG PET/CT. Part 2: accuracy, cost-effectiveness, and current recommendations

2016 ◽  
Vol 49 (2) ◽  
pp. 104-111 ◽  
Author(s):  
Marcos Pretto Mosmann ◽  
Marcelle Alves Borba ◽  
Francisco Pires Negromonte de Macedo ◽  
Adriano de Araujo Lima Liguori ◽  
Arthur Villarim Neto ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Radiographic Finding ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Positron Emission ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract A solitary pulmonary nodule is a common, often incidental, radiographic finding. The investigation and differential diagnosis of solitary pulmonary nodules remain complex, because there are overlaps between the characteristics of benign and malignant processes. There are currently many strategies for evaluating solitary pulmonary nodules. The main objective is to identify benign lesions, in order to avoid exposing patients to the risks of invasive methods, and to detect cases of lung cancer accurately, in order to avoid delaying potentially curative treatment. The focus of this study was to review the evaluation of solitary pulmonary nodules, to discuss the current role of 18F-fluorodeoxyglucose positron-emission tomography, addressing its accuracy and cost-effectiveness, and to detail the current recommendations for the examination in this scenario.

SAVI SCOUT as a Novel Localization and Surgical Navigation System for More Accurate Localization and Resection of Pulmonary Nodules

2019 ◽  
Vol 26 (4) ◽  
pp. 469-472 ◽  
Author(s):  
Katie N. Cornella ◽  
Brian A. Palafox ◽  
Mahmood K. Razavi ◽  
Christopher T. Loh ◽  
Kelly M. Markle ◽  
...  
Keyword(s):  
Interventional Radiology ◽  
Pulmonary Nodule ◽  
Surgical Navigation ◽  
Lung Resection ◽  
Lung Nodule ◽  
Lower Lobe ◽  
Pulmonary Nodules ◽  
Ease Of Use ◽  
Accurate Localization ◽  
The Right

Background. Current techniques for localization and resection of lung nodules carry many intraoperative challenges for surgeons. This article proposes a new localization method for diagnosis and treatment of pulmonary nodules, which provides a navigational system for more accurate lung resection. Methods. We report the case of a 77-year-old female with a pulmonary nodule of the right lower lobe. A nonradioactive localization technology, known as SAVI SCOUT (Cianna Medical Inc, Aliso Viejo, CA), was placed by interventional radiology under computed tomography guidance preoperatively. Using the SCOUT Wire-Free Radar Localization System, the pulmonary nodule was robotically localized and resected. SCOUT removal was confirmed using the Trident Specimen Radiology System. The efficacy of this procedure was evaluated in terms of ease of use and procedure time by interventional radiology, surgical resection accuracy, diagnostic accuracy, simplicity, and ease to implement this technology in an existing hospital. Results. The SCOUT system allowed for the first reported case of successful SCOUT placement in lung tissue, targeted the pulmonary nodule intraoperatively, and facilitated accurate lung resection. Conclusions. The SCOUT system shows promising advancements in the ability to eliminate many challenges currently seen with lung nodule localization and resection.

scholarly journals Solitary pulmonary nodule and 18F-FDG PET/CT. Part 1: epidemiology, morphological evaluation and cancer probability

2016 ◽  
Vol 49 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Marcos Pretto Mosmann ◽  
Marcelle Alves Borba ◽  
Francisco Pires Negromonte de Macedo ◽  
Adriano de Araujo Lima Liguori ◽  
Arthur Villarim Neto ◽  
...  
Keyword(s):  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Radiographic Finding ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Benign Lesions ◽  
Morphological Evaluation ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Solitary pulmonary nodule corresponds to a common radiographic finding, which is frequently detected incidentally. The investigation of this entity remains complex, since characteristics of benign and malignant processes overlap in the differential diagnosis. Currently, many strategies are available to evaluate solitary pulmonary nodules with the main objective of characterizing benign lesions as best as possible, while avoiding to expose patients to the risks inherent to invasive methods, besides correctly detecting cases of lung cancer so as the potential curative treatment is not delayed. This first part of the study focuses on the epidemiology, the morfological evaluation and the methods to determine the likelihood of cancer in cases of indeterminate solitary pulmonary nodule.

Study the value of lung low dose computed tomography in early detection the malignant pulmonary nodule

2020 ◽  
pp. 7-15
Author(s):  
Ha Hoang ◽  
Tien Doan Dung ◽  
Khoan Le Trong
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Early Detection ◽  
Pulmonary Nodule ◽  
Pulmonary Nodules ◽  
Diagnostic Value ◽  
Cross Sectional Study ◽  
Solitary Pulmonary Nodules ◽  
Cross Sectional ◽  
The Right

Background: Early diagnosis of the malignant pulmonary nodules plays an important role in decreasing the mortality, increasing the lifetime and considering as early detection of lung cancer. Objectives: To describe the characteristics and diagnostic value of the malignant suspected signs of pulmonary nodule. Materials and methods: A descriptive cross-sectional study on 33 patients with localized pulmonary nodule which has indications of biopsy or surgery at Hospital of Hue University of Medicine and Pharmacy from 05/2017 to 08/2018. Results: A majority of pulmonary nodules were found in the right upper lobe with 42.4%; solitary pulmonary nodules made up the majority of 75.8%. (Nodules > 21.5 mm: 57.6%; nodules ≤ 21.5 mm: 42.4%; solid nodules: 97% and mixed nodules: 3%, round shape: 42.4% and polygons: 57.6%; irregular margin: 78.8%; regular margin: 21.2%; eccentric and stippled calcification: 18.2%; non-calcification: 81.8%; air-bronchogram in nodules: 39.4%; air-bronchogram (-): 60.6%; fat containing pulmonary nodules: 6.1%, malignant and benign confirmed by biopsy: 39.3% and 60.7% respectively. The sensitivity and specificity of features included size > 21.5 mm; air-bronchogram in nodules, polygons for malignant nodules diagnosis are 81.6%; 92.3%; 76.9% and 60%, 65%, 85% respectively. Conclusions: Three features of nodules: Size ≥ 21.5 mm; air-bronchogram and polygons are suggestive malignant characteristics. The combination of two or more characteristics have the sensitive 92.3% and specific 80% Keywords: pulmonary nodule, thoracic computed tomography, lung cancer.

scholarly journals Management of the Solitary Pulmonary Nodule

2016 ◽  
Vol 141 (7) ◽  
pp. 927-931 ◽  
Author(s):  
Edward Y. Chan ◽  
Puja Gaur ◽  
Yimin Ge ◽  
Lisa Kopas ◽  
Jose F. Santacruz ◽  
...  
Keyword(s):  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Malignant Tumors ◽  
Early Stage ◽  
Pulmonary Nodules ◽  
Extensive Literature ◽  
Solitary Pulmonary Nodules ◽  
Early Stage Lung Cancer ◽  
Appropriate Treatment ◽  
Benign Nodules

Context.— Optimal management of the patient with a solitary pulmonary nodule entails early diagnosis and appropriate treatment for patients with malignant tumors, and minimization of unnecessary interventions and procedures for those with ultimately benign nodules. With the growing number of high-resolution imaging modalities and studies available, incidentally found solitary pulmonary nodules are an increasingly common occurrence. Objective.— To provide guidance to clinicians involved in the management of patients with a solitary pulmonary nodule, including aspects of risk stratification, workup, diagnosis, and management. Data Sources.— Data for this review were gathered from an extensive literature review on the topic. Conclusions.— Logical evaluation and management pathways for a patient with a solitary pulmonary nodule will allow providers to diagnose and treat individuals with early stage lung cancer and minimize morbidity from invasive procedures for patients with benign lesions.

scholarly journals Alveolar adenoma: A rare lung tumor

2007 ◽  
Vol 135 (7-8) ◽  
pp. 461-464 ◽  
Author(s):  
Jelena Stojsic ◽  
Branislava Milenkovic ◽  
Jelena Radojicic ◽  
Malina Percinkovski
Keyword(s):  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Lung Tumor ◽  
Fibrous Tissue ◽  
Surgical Excision ◽  
Middle Lobe ◽  
Benign Lung Tumor ◽  
Right Middle Lobe ◽  
Malignant Alteration ◽  
The Right

Introduction Alveolar adenoma belongs to the group of benign epithelial tumors. Histogenesis of alveolar adenoma is a combination of proliferation of alveolar pneumocytes and fibrous tissue originating from septal mesenchyma. Case outline A sixty-nine-year old female patient was hospitalized for clinical examination and surgery of well defined and homogenous timorous lesion in the right middle lobe causing pleural pain. Bronchoscopic examination with biopsy did not resolve etiology of the disease. Tumorectomy was performed. Timorous nodule had a multicystic appearance and histologically, histochemically and immunohistochemically, an alveolar adenoma was estimated. Five years after surgery, the patient feels well, without respiratory symptoms and signs of recurrence or malignant alteration, respectively. Conclusion Alveolar adenoma is a rare benign lung tumor, most frequently presented as a solitary pulmonary nodule. After complete surgery, the tumor neither relapses nor malignantly alters. Surgical excision is curative. It is necessary to take into consideration alveolar adenoma, too, when a solitary pulmonary nodule is diagnosed.

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