scholarly journals Malignant Pleural Mesothelioma Nodal Status: Where Are We at?

2021 ◽  
Vol 10 (21) ◽  
pp. 5177
Author(s):  
Sara Ricciardi ◽  
Francesco Carleo ◽  
Massimo O. Jaus ◽  
Marco Di Martino ◽  
Luigi Carbone ◽  
...  
Keyword(s):  
Lymph Node ◽  
Malignant Pleural Mesothelioma ◽  
Relevant Literature ◽  
Prospective Trial ◽  
High Volume ◽  
Lymph Node Status ◽  
Lymph Node Staging ◽  
Pleural Mesothelioma ◽  
Node Positive ◽  
Pre Treatment

Due to the lack of both prospective trial and high-volume retrospective studies, the management of clinical N+ malignant pleural mesothelioma (MPM) patients remains highly debated. Node positive patients show poor survival compared with node-negative ones; thus, lymph node staging appears crucial in determining treatment strategy. Notwithstanding the improvement in pre-treatment staging and the update on lymph node classification in the 8th edition of TNM, several open controversies remain on N parameter. How should we stage suspected N+ patients? How should we treat node positive patients? Which is the definition of a “resectable patient”? Is the site or the number the main prognostic factor for node positive patients? The aim of our narrative review is to analyse the existing relevant literature on lymph node status in MPM.

Management of Clinically Lymph Node-Positive Malignant Pleural Mesothelioma

2020 ◽  
Vol 32 (4) ◽  
pp. 1125-1132 ◽  
Author(s):  
Vivek Verma ◽  
Rodney E. Wegner ◽  
Sebastian Adeberg ◽  
Zachary D. Horne ◽  
Surbhi Grover ◽  
...  
Keyword(s):  
Lymph Node ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Node Positive ◽  
Lymph Node Positive

scholarly journals PROGNOSTIC VALUES OF MIDKINE, SYNDECAN-1, HYALURONAN SYNTHASE-2, SESTRIN-1, LAMININ SUBUNIT ALPHA-4 AND FIBULIN-3 FOR MALIGNANT PLEURAL MESOTHELIOMA

2021 ◽  
Author(s):  
HAKAN AKGUN ◽  
Selma Metintas ◽  
Guntulu Ak ◽  
Secil Demirkol ◽  
Murat Isbilen ◽  
...  
Keyword(s):  
Survival Time ◽  
Malignant Pleural Mesothelioma ◽  
Multivariate Analyses ◽  
Ex Vivo ◽  
Relevant Literature ◽  
Good Prognosis ◽  
Hyaluronan Synthase ◽  
Pleural Mesothelioma ◽  
Analysis Tool ◽  
Hyaluronan Synthase 2

IntroductionThe prognosis of malignant pleural mesothelioma (MPM) is poor with a limited survival time. In this study, we aimed to examine expression levels of genes selected from relevant literature and to utilize in silico methods to determine genes whose expression could reflect the prognosis of the patients with MPM by ex-vivo validation experimentsMaterial and methodsThe study group consisted of 54 MPM patients treated by chemotherapy. Expression of 6 genes; midkine (MDK), syndecan 1 (SDC1), hyaluronan synthase 2 (HAS2), sestrin 1 (SESN1), laminin subunit alpha 4 (LAMA4), and fibulin 3 (FBLN3) were examined by qPCR in tumor tissues. SESN1 and LAMA4 were identified using an in house R-based script “Unsupervised Survival Analysis Tool." MDK, SDC1, HAS2, and FBLN3 were selected from current literature. We used two housekeeping genes; glucose-6-phosphate dehydrogenase and TATA-box binding protein as controls.ResultsOf the patients, 43 (79.6%) had epithelioid mesothelioma. The median survival for all patients was 10 (±1.2 SE) months (CI 95%; 7.7-12.3). In multivariate analyses, MDK (p=0.007), HAS2 (p=0.008) and SESN1 (p=0.014) expression were related with survival time in whole group. In epithelioid type MPM patients, MDK (p=0.014), FBLN3 (p=0.029), HAS2 (p=0.014) and SESN1 (p=0.045) expression was related with survival time by multivariate analyses.ConclusionsHigh HAS2 and SESN1 expressions and low MDK are potential biomarkers of good prognosis in MPM. High HAS2 and SESN1 expression and low MDK and FBLN3 can also be utilized as biomarkers of good prognosis for epithelioid MPM. Those results should be further investigated in sera, plasma, and pleural effusions

Lymph node status assessment in head and neck squamous cell carcinoma in patients with clinically non palpable lymph nodes: Meta-analysis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hany Riad ◽  
Samer Ibrahim ◽  
Amr Gouda ◽  
Ossama Mustafa ◽  
Heba Mohamed
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Lymph Node Status ◽  
Lymph Node Staging ◽  
Pet Ct

Abstract Background The most important prognostic factor in squamous cell carcinoma of the head and neck (HNSCC) is the presence or absence of clinically involved neck nodes. The presence of metastases in a lymph node is said to reduce the 5-years survival rate by about 50%. The appropriate diagnosis of the presence of metastatic node is very important for the management of HNSCC Aim To compare difTerent diagnostic modalities for assessment of the clinically non palpable lymph nodes in HNSCC including by meta-analysis: CT, MRI, US, USFNAC and PET/CT for the proper cervical lymph node staging. Methods Met-analysis study on patients with HNSCC of clinically non palpable lymph nodes (cN0). Results Analysis was divided in 6 groups .Each group contain analysis of one modality according to available studies per patient, per level and per lesion .US is fair test per patient and per lesion.CT is good test per patient and excellent test per lesion.MRI is poor test per patient and fair test per lesion.CT-MRl combined is fair per patient and excellent per level.PET/CT is good per patient, fair per lesion and excellent per level. USFNAC is excellent per lesion. Conclusion CT, CT-MRI combined, PET/CT and USFNAC proved to be excellent in detecting cN0.MRI was poor test in detecting cN0.US was a fair test in detecting cN0 if used alone.

Prevalence and Pattern of Lymph Node Metastasis in Malignant Pleural Mesothelioma

2008 ◽  
Vol 86 (2) ◽  
pp. 391-395 ◽  
Author(s):  
Abdel Rahman M. Abdel Rahman ◽  
Rabab M. Gaafar ◽  
Hoda A. Baki ◽  
Hesham M. El Hosieny ◽  
Fatma Aboulkasem ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Node Metastasis

scholarly journals Comparative analysis of clinical and pathological lymph node staging data in head and neck squamous cell carcinoma patients treated at the General Hospital Vienna

2018 ◽  
Vol 52 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Christina Eder-Czembirek ◽  
Birgit Erlacher ◽  
Dietmar Thurnher ◽  
Boban M. Erovic ◽  
Edgar Selzer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Correlation Coefficient ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Clinical Staging ◽  
Lymph Node Status ◽  
Lymph Node Staging

Abstract Background Results from publications evaluating discrepancies between clinical staging data in relation to pathological findings demonstrate that a significant number of head and neck squamous cell carcinoma (HNSCC) patients are not correctly staged. The aim of this retrospective study was to analyze potential discrepancies of radiological assessment versus pathological data of regional lymph node involvement and to compare the results with data published in the literature. Patients and methods In a retrospective analysis we focused on patients with HNSCC routinely treated by surgery plus postoperative radiotherapy between 2002 and 2012. For inclusion, complete pre-operative clinical staging information with lymph node status and patho-histological information on involved lymph node regions as well as survival outcome data were mandatory. We included 87 patients (UICC stage III-IV 90.8%) for which the aforementioned data obtained by CT or MRI were available. Overall survival rates were estimated by the Kaplan–Meier method. The Pearson correlation coefficient and Spearman’s rank correlation coefficient (non-linear relationship) was calculated. Results Discrepancies at the level of overall tumour stage assessment were noticed in 27.5% of all cases. Thereof, 5.7% were assigned to patho-histological up-staging or down-staging of the primary tumour. At the lymph node level, 11.5% of the patients were downstaged, and 10.3% were upstaged. Conclusions The study showed that in approximately one-fifth (21.8%) of the patients, lymph node assessment by CT or MRI differs from the pathologic staging, an outcome that corresponds well with those published by several other groups in this field.

scholarly journals P1-105: Prevalence and pattern of lymph node metastasis in malignant pleural mesothelioma

2007 ◽  
Vol 2 (8) ◽  
pp. S591-S592
Author(s):  
Mohamed Abdel Rahman ◽  
Rabab M. Gaafar ◽  
Hoda A. Baki ◽  
Hesham M. Elhosini ◽  
Fatma A. Kasem
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Node Metastasis
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