Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study

This multicenter cohort study investigated the differences between coronavirus disease 2019 (COVID-19) related symptoms and post-COVID symptoms between male and female COVID-19 survivors. Clinical and hospitalization data were collected from hospital medical records in a sample of individuals recovered from COVID-19 at five public hospitals in Spain. A predefined list of post-COVID symptoms was systematically assessed, but patients were free to report any symptom. Anxiety/depressive levels and sleep quality were also assessed. Adjusted multivariate logistic regressions were used to identify the association of sex with post-COVID related-symptoms. A total of 1969 individuals (age: 61, SD: 16 years, 46.4% women) were assessed 8.4 months after discharge. No overall significant sex differences in COVID-19 onset symptoms at hospital admission were found. Post-COVID symptoms were present in up to 60% of hospitalized COVID-19 survivors eight months after the infection. The number of post-COVID symptoms was 2.25 for females and 1.5 for males. After adjusting by all variables, female sex was associated with ≥3 post-COVID symptoms (adj OR 2.54, 95%CI 1.671–3.865, p < 0.001), the presence of post-COVID fatigue (adj OR 1.514, 95%CI 1.040–2.205), dyspnea (rest: adj OR 1.428, 95%CI 1.081–1.886, exertion: adj OR 1.409, 95%CI 1.109–1.791), pain (adj OR 1.349, 95%CI 1.059–1.720), hair loss (adj OR 4.529, 95%CI 2.784–7.368), ocular problems (adj OR 1.981, 95%CI 1.185–3.312), depressive levels (adj OR 1.606, 95%CI 1.002–2.572) and worse sleep quality (adj OR 1.634, 95%CI 1.097–2.434). Female sex was a risk factor for the development of some long-term post-COVID symptoms including mood disorders. Healthcare systems should consider sex differences in the management of long haulers.

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One-Year Age Increment and Sex Differences in the Relationship between Long-Term Exposure to PM 2.5 and Fasting Plasma Glucose Levels in Chinese Children and Adolescents Aged 6-17 Years: Exploring an Independent Risk Factor and Precise Intervention Time Clues

SSRN Electronic Journal ◽

10.2139/ssrn.3416701 ◽

2019 ◽

Author(s):

Mao Wang ◽

Lijuan Gong ◽

Aili Jiang ◽

Yinglin Wu ◽

Ruijie Wang ◽

...

Keyword(s):

Sex Differences ◽

Risk Factor ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Independent Risk Factor ◽

Glucose Levels ◽

One Year ◽

The Relationship ◽

Chinese Children And Adolescents

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Preoperative Anemia is Associated With Worse Long-Term Survival After Lung Cancer Resection: A Multicenter Cohort Study of 5,029 Patients

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1053/j.jvca.2021.08.029 ◽

2021 ◽

Author(s):

Marcus Taylor ◽

Udo Abah ◽

Tim Hayes ◽

Thomas Eadington ◽

Matthew Smith ◽

...

Keyword(s):

Lung Cancer ◽

Cohort Study ◽

Preoperative Anemia ◽

Multicenter Cohort Study ◽

Term Survival ◽

Long Term Survival ◽

Cancer Resection ◽

Multicenter Cohort

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Long-Term Central Venous Catheter Infection in HIV-infected and Cancer Patients: A Multicenter Cohort Study

Infection Control and Hospital Epidemiology ◽

10.1086/501658 ◽

1999 ◽

Vol 20 (7) ◽

pp. 494-498 ◽

Cited By ~ 25

Author(s):

Pascal Astagneau ◽

Sylvie Maugat ◽

Tuan Tran-Minh ◽

Marie-Cécile Douard ◽

Pascale Longuet ◽

...

Keyword(s):

Cohort Study ◽

Central Venous Catheter ◽

Cancer Patients ◽

Venous Catheter ◽

Central Venous ◽

Hiv Patients ◽

Multicenter Cohort Study ◽

Multicenter Cohort ◽

Hiv And Cancer

Objectives:To evaluate and compare the risk of long-term central venous catheter (CVC) infection in human immunodeficiency virus (HIV)-infected and cancer patients.Design:Prospective multicenter cohort study based on active surveillance of long-term CVC manipulations and patient outcome over a 6-month period.Setting:Services of infectious diseases and oncology of 12 university hospitals in Paris, France.Participants:In 1995, all HIV and cancer patients with solid malignancy were included at the time of long-term CVC implantation.Results:Overall, 31.6% of long-term CVC infections were identified in 32% of 201 HIV and 5% of 255 cancer patients. Most were associated with bacteremia, most commonly coagulase-negative staphylococci. The long-term CVC time-related infection risk was greater in HIV than in cancer patients (3.78 vs 0.39 infections per 1,000 long-term CVC days; P<.001). The independent risk factors of long-term CVC infection were as follows: in HIV patients, frequency of long-term CVC handling and neutropenia; in cancer patients, poor Karnofsky performance status; in both HIV and cancer patients, recent history of bacterial infection. The risk of long-term CVC infection was similar for tunneled catheters and venous access ports in each population.Conclusions:Prevention of long-term CVC infection should focus first on better sterile precautions while handling long-term CVC, especially in HIV patients who have frequent and daily use of the long-term CVC.

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Mo1886 Mid- to Long-Term Stability and Associated Prognostic Factors of Adalimumab Treatment for 1189 Patients With Crohn's Disease: A Multicenter Cohort Study

Gastroenterology ◽

10.1016/s0016-5085(16)32728-7 ◽

2016 ◽

Vol 150 (4) ◽

pp. S806

Author(s):

Hiroki Tanaka ◽

Noriko Kamata ◽

Akihiro Yamada ◽

Katsuya Endo ◽

Toshimitsu Fujii ◽

...

Keyword(s):

Cohort Study ◽

Crohn’S Disease ◽

Prognostic Factors ◽

Crohn's Disease ◽

Multicenter Cohort Study ◽

Term Stability ◽

Long Term Stability ◽

Multicenter Cohort ◽

Adalimumab Treatment

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Sex differences in clinical outcomes of patients with stable coronary artery disease after percutaneous coronary intervention

Current Pharmaceutical Design ◽

10.2174/1381612827666210303142901 ◽

2021 ◽

Vol 27 ◽

Author(s):

Emmanuel P. Vardas ◽

Evangelos Oikonomou ◽

Gerasimos Siasos ◽

Panagiotis Theofilis ◽

Polychronis Dilaveris ◽

...

Keyword(s):

Coronary Artery Disease ◽

Risk Factor ◽

Coronary Artery ◽

Independent Risk Factor ◽

Stable Coronary Artery Disease ◽

Coronary Intervention ◽

Female Sex ◽

Percutaneous Coronary ◽

Artery Disease

: Potential sex-related differences in the periprocedural and long-term postprocedural outcomes of coronary angioplasty in patients with stable coronary artery disease have been studied thoroughly over the last few decades, to determine whether female sex should be regarded as an independent risk factor that affects clinical outcomes. Based on a significant number of observational studies and meta-analyses, sex has not yet emerged as an independent risk factor for either mortality or major cardiac and cerebrovascular events, despite the fact that in the early 1980s, for several reasons, female sex was associated with unfavourable outcomes. Therefore, it remains debatable whether female sex should be considered as an independent risk factor for periprocedural and long-term bleeding events. The pharmacological and technological advancements that support current coronary angioplasty procedures, as well as the non-delayed treatment of coronary artery disease in females have certainly lessened the outcome differences between the two sexes. However, females show fluctuations in blood coagulability through their lifetime and higher prevalence of bleeding episodes associated with the antithrombotic treatment, following transcatheter coronary reperfusion interventions. In conclusion, the clinical results of percutaneous coronary intervention in patients with stable coronary artery disease, during the periprocedural and long-term postprocedural periods, appear to show no significant differences between the two sexes, except for bleeding rates, which seem to be higher in females, a difference that mandates further systematic research.

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