scholarly journals Comparative Assessment and External Validation of Hepatic Steatosis Formulae in a Community-Based Setting

2020 ◽  
Vol 9 (9) ◽  
pp. 2851
Author(s):  
Tae Yang Jung ◽  
Myung Sub Kim ◽  
Hyun Pyo Hong ◽  
Kyung A Kang ◽  
Dae Won Jun
Keyword(s):  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Diagnostic Performance ◽  
Liver Fat ◽  
Community Based ◽  
Alcoholic Fatty Liver ◽  
Gold Standard Method ◽  
Fat Score ◽  
Zju Index ◽  
Nafld Liver Fat Score

Several hepatic steatosis formulae have been validated in various cohorts using ultrasonography. However, none of these studies has been validated in a community-based setting using the gold standard method. Thus, the aim of this study was to externally validate hepatic steatosis formulae in community-based settings using magnetic resonance imaging (MRI). A total of 1301 community-based health checkup subjects who underwent liver fat quantification with MRI were enrolled in this study. Diagnostic performance was assessed using the area under the receiver operating characteristic curve (AUROC). Non-alcoholic fatty liver disease (NAFLD) liver fat score showed the highest diagnostic performance with an AUROC of 0.72, followed by Framingham steatosis index (0.70), hepatic steatosis index (HSI, 0.69), ZJU index (0.69), and fatty liver index (FLI, 0.68). There were considerable gray zones in three fatty liver prediction models using two cutoffs (FLI, 28.9%; HSI, 48.9%; and ZJU index, 53.6%). The diagnostic performance of NAFLD liver fat score for detecting steatosis was comparable to that of ultrasonography. The diagnostic agreement was 72.7% between NAFLD liver fat score and 70.9% between ultrasound and MRI. In conclusion, the NAFLD liver fat score showed the best diagnostic performance for detecting hepatic steatosis. Its diagnostic performance was comparable to that of ultrasonography in a community-based setting.

scholarly journals Effect of Short Term Intensive Lifestyle Intervention on Hepatic Steatosis Indexes in Adults with Obesity and/or Type 2 Diabetes

2019 ◽  
Vol 8 (6) ◽  
pp. 851 ◽  
Author(s):  
Elisa Reginato ◽  
Roberto Pippi ◽  
Cristina Aiello ◽  
Emilia Sbroma Tomaro ◽  
Claudia Ranucci ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Lifestyle Intervention ◽  
Intervention Program ◽  
Liver Fat ◽  
Alcoholic Fatty Liver ◽  
Lifestyle Intervention Program ◽  
Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) has an estimated prevalence of 20–30% in the general population and even higher in individuals with metabolic risk factors. The aim of this study was to evaluate the effect of a lifestyle intervention program on surrogate markers of hepatic steatosis in obesity and/or type 2 diabetes patients, enrolled in the C.U.R.I.A.Mo. (Centro Universitario di Ricerca Interdipartimentale Attività Motoria) trial. Methods: 102 subjects (56 females and 46 males, aged between 23 and 78) with type 2 diabetes, obesity or a BMI of at least 25 kg/m2 with comorbidities, participated in the intensive phase of a multidisciplinary lifestyle intervention program at the Healthy Lifestyle Institute of the University of Perugia (C.U.R.I.A.Mo.). Six indices related to NAFLD (Visceral Adiposity Index, Fatty Liver index, Non-Alcoholic Fatty Liver Disease liver fat score and liver fat equation, hepatic steatosis index and TyG index) were calculated before and after a three-month multidisciplinary lifestyle intervention. Results: The intervention improved the anthropometric and clinical parameters in the total population, the obese and/or diabetics. Data showed a significant weight loss, a reduced waist circumference, triglycerides, and an improvement in Mediterranean diet adherence. Hepatic steatosis indices were significantly reduced in the total population and in different subgroups (males, females, obesity and diabetes).

scholarly journals Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate

2020 ◽  
Vol 11 ◽  
Author(s):  
Terry D. Hinds ◽  
Justin F. Creeden ◽  
Darren M. Gordon ◽  
Donald F. Stec ◽  
Matthew C. Donald ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Liver Fat ◽  
Alcoholic Fatty Liver ◽  
Fat Accumulation ◽  
Fat Utilization ◽  
Hepatic Fat ◽  
Alcoholic Fatty Liver Disease

The inverse relationship of plasma bilirubin levels with liver fat accumulation has prompted the possibility of bilirubin as a therapeutic for non-alcoholic fatty liver disease. Here, we used diet-induced obese mice with non-alcoholic fatty liver disease treated with pegylated bilirubin (bilirubin nanoparticles) or vehicle control to determine the impact on hepatic lipid accumulation. The bilirubin nanoparticles significantly reduced hepatic fat, triglyceride accumulation, de novo lipogenesis, and serum levels of liver dysfunction marker aspartate transaminase and ApoB100 containing very-low-density lipoprotein. The bilirubin nanoparticles improved liver function and activated the hepatic β-oxidation pathway by increasing PPARα and acyl-coenzyme A oxidase 1. The bilirubin nanoparticles also significantly elevated plasma levels of the ketone β-hydroxybutyrate and lowered liver fat accumulation. This study demonstrates that bilirubin nanoparticles induce hepatic fat utilization, raise plasma ketones, and reduce hepatic steatosis, opening new therapeutic avenues for NAFLD.

scholarly journals Dietary Sources of Fructose and Its Association with Fatty Liver in Mexican Young Adults

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 522 ◽  
Author(s):  
Alejandra Cantoral ◽  
Alejandra Contreras-Manzano ◽  
Lynda Luna-Villa ◽  
Carolina Batis ◽  
Ernesto Roldán-Valadez ◽  
...  
Keyword(s):  
Young Adults ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Liver Fat ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Sweetened Beverages ◽  
Fatty Liver Index ◽  
Hepatic Steatosis Index ◽  
Sectional Analysis

Fructose intake has been associated with non-alcoholic fatty liver disease (NAFLD). The objective of this study was to assess the consumption of dietary fructose according to: 1) classification of hepatic steatosis by two indexes and 2) diagnosis of NAFLD by MRI. We conducted a cross-sectional analysis among 100 young adults from Mexico City. The Hepatic Steatosis Index (HSI) and the Fatty Liver Index (FLI) were estimated using Body Mass Index (BMI), waist circumference, and fasting concentrations of glucose, triglycerides, and hepatic enzymes (ALT, AST, GGT). A semi-quantitative food frequency questionnaire was administered to obtain dietary sources of fructose. We estimated the concordance between the hepatic indices and NAFLD and the correlation between the index scores and the percentage of liver fat. Eighteen percent presented NAFLD; 44% and 46% were classified with hepatic steatosis according to HSI and FLI, respectively. We compared dietary intake of fructose by each outcome: HSI, FLI, and NAFLD. Sugar-sweetened beverages (SSB) and juices were consumed significantly more by those with steatosis by FLI and NAFLD suggesting that SSB intake is linked to metabolic alterations that predict the risk of having NAFLD at a young age.

Prevalence of non-alcoholic fatty liver disease in patients with chronic kidney disease: a case-control study

2021 ◽  
Author(s):  
Therese Adrian ◽  
Ida M H Sørensen ◽  
Filip K Knop ◽  
Susanne Bro ◽  
Ellen L F Ballegaard ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Liver Disease ◽  
Kidney Disease ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

ABSTRACT Background Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and represents a wide spectrum ranging from mild steatosis over non-alcoholic steatohepatitis with and without fibrosis to overt cirrhosis. Patients with NAFLD have a high risk of developing cardiovascular disease and chronic kidney disease (CKD). So far, there is scarce evidence of the prevalence of NAFLD among patients with CKD. We investigated the prevalence of moderate-to-severe hepatic steatosis graded according to the definition of NAFLD in a cohort of patients with CKD. Methods Hepatic liver fat content was evaluated by computed tomography (CT) scan in 291 patients from the Copenhagen Chronic Kidney Disease Cohort Study and in 866 age- and sex-matched individuals with normal kidney function from the Copenhagen General Population Study. Liver attenuation density <48 Hounsfield units was used as cut-off value for moderate-to-severe hepatic steatosis. Results The prevalence of moderate-to-severe hepatic steatosis was 7.9% and 10.7% (P = 0.177) among patients with CKD and controls, respectively. No association between liver fat content and CKD stage was found. In the pooled data set from both cohorts, adjusted odds ratios for moderate-to-severe hepatic steatosis among persons with diabetes, overweight and obesity amounted to 3.1 (95% confidence interval (CI) 1.6-5.9), 14.8 (95% CI 4.6-47.9) and 42.0 (95% CI 12.9-136.6), respectively. Conclusions In a cohort of 291 patients with CKD, kidney function was not associated with the prevalence of moderate-to-severe hepatic steatosis as assessed by CT scan.

scholarly journals MON-597 Non-Alcoholic Fatty Liver Disease Determined by MRI and Its Association with Metabolic Variables in Non-Diabetic Subjects

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Debora Gonçalves Da Silva ◽  
Josue Da Silva Brito ◽  
Beatriz Francisco Barbosa Rodrigues ◽  
Daniele Martins Afonso ◽  
Angelica Amorim Amato
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Serum Levels ◽  
Liver Fat ◽  
Alcoholic Fatty Liver ◽  
Biochemical Variables ◽  
Metabolic Variables ◽  
Alcoholic Fatty Liver Disease

Abstract Non-alcoholic fatty liver disease determined by MRI and its association with metabolic variables in non-diabetic subjects Background: Non-alcoholic fatty liver disease (NAFLD) is defined as the presence of hepatic steatosis (liver fat accumulation higher than 5% of liver weight) in the absence of other causes. Liver biopsy is recognized as a gold standard for diagnosis, but it is limited by the risks of serious complications. Besides that, the increasing prevalence of NASH led to improved imaging methods, such as Magnetic Resonance Imaging (MRI), that enable quantitative assessment of steatosis by quantifying the hepatic fat fraction (HFF), even with steatosis levels as low as 5.56%. Objective: The aim of this study was to evaluate the metabolic profile of patients without T2DM according to hepatic steatosis measured by MRI. Methods: This was cross-sectional study conducted in an Endocrinology Unity in Minas Gerais, Brazil. The study complied with the WMA Declaration of Helsinki and was approved by the Ethical Committee on Human Subject Research from the Faculty Patos de Minas. We recruited non-diabetic subjects aged above 20 years with hepatic steatosis detected by liver sonography. Exclusion criteria were alcohol consumption of more than 20 grams/day for female and 30 grams/day for male, ferritin serum levels above 1000 mg/dL, positive serology for hepatitis B or C and intake of medications known to produce hepatic steatosis. Included subjects underwent HFF quantification by MRI, and the degree of liver fatty infiltration was estimated by using chemical shift imaging. The following biochemical variables were assessed: fasting glucose and HbA1c, HOMA-IR, lipids, AST, ALT and GGT. Analysis: we grouped individuals according to the quartile of HFF and compared clinical and biochemical variables between the groups. Results: A total of 30 subjects (18 male and 12 females) were included. All subjects were overweight (10% overweight and 90% obese); 7 (23.3%) had 3 criteria and 16 (53.3%) had two criteria for MS. The only variable assessed herein that was different between males and females was HDL-c (40.5 vs 50.5 mg/dL, respectively, p=0.0255). ALT serum levels were significantly higher in subjects in the fourth quartile of HFF, when compared to those in the third quartile (76 vs 47 UI/L, respectively, p=0.037). The other clinical of biochemical variables assessed did not differ between the quartiles of HFF. Conclusion: our preliminary findings indicate that the biochemical variables related to metabolic homeostasis are poor predictors of the degree of liver fat in overweight non-diabetic subjects. Although screening for NAFLD is still a matter of debate, our results suggest that future discussions about this should take into account that excess body weight per se, independently from biochemical abnormalities, should be considered in the recommendations for screening non-diabetic subjects.

scholarly journals Non-alcoholic fatty liver disease (NAFLD): C.U.R.I.A.Mo. lifestyle intervention and hepatic steatosis indexes

2020 ◽  
Author(s):  
Roberto Pippi
Keyword(s):  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Lifestyle Intervention ◽  
Intervention Program ◽  
Total Population ◽  
Liver Fat ◽  
Alcoholic Fatty Liver ◽  
Lifestyle Intervention Program ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) has an estimated prevalence of 20–30% in the general population and even higher in individuals with metabolic risk factors. The aim of this study was to evaluate the effect of a lifestyle intervention program on surrogate markers of hepatic steatosis in obesity and/or type 2 diabetes patients, enrolled in the C.U.R.I.A.Mo.(Centro Universitario di Ricerca Interdipartimentale Attività Motoria) trial. 102 subjects with type 2 diabetes, obesity or a BMI of at least 25 kg/m2 with comorbidities, participated in the intensive phase of a multidisciplinary lifestyle intervention program at the Healthy Lifestyle Institute of the University of Perugia (C.U.R.I.A.Mo.).Six indices related to NAFLD (Visceral Adiposity Index, Fatty Liver index, Non-Alcoholic Fatty LiverDisease liver fat score and liver fat equation, hepatic steatosis index and TyG index) were calculated before and after a three-month multidisciplinary lifestyle intervention. The intervention improved the anthropometric and clinical parameters in the total population, the obese and/or diabetics. Data showed a significant weight loss, a reduced waist circumference, triglycerides, and an improvement in Mediterranean diet adherence. Hepatic steatosis indices were significantly reduced in the total population and in different subgroups (males, females, obesity and diabetes).

scholarly journals CLUSTER ANALYSIS OF THE PATHOGENETIC RELATIONSHIPS OF METABOLIC PARAMETERS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE ON THE BACKGROUND OF HYPERTENSION

World Science ◽  
2019 ◽  
Vol 1 (10(50)) ◽  
pp. 30-36
Author(s):  
Oleg Babak ◽  
Anna Bashkirova
Keyword(s):  
Cluster Analysis ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Metabolic Parameters ◽  
Liver Fat ◽  
Endothelial Lipase ◽  
Alcoholic Fatty Liver ◽  
Fat Score ◽  
Alcoholic Fatty Liver Disease

The aim of the study was to conduct a cluster analysis of pathogenetic relationships between metabolic parameters, endothelial lipase levels, the severity of steatosis, and clinical parameters in patients with non-alcoholic fatty liver disease with hypertension. To analyze pathogenetic relationships, a cluster analysis was performed with the distribution of parameters into 4 clusters using the Ward's method. The most dense metabolic link by cluster analysis endothelial lipase forms with NAFLD liver fat score (2.639 cu), HbA1C (2.084 cu), total cholesterol (2.272 cu), and alcohol units (2.797 cu).

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