scholarly journals Long- and Short-Term Exposures to PM10 Can Shorten Telomere Length in Individuals Affected by Overweight and Obesity

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 808
Author(s):  
Michele Carugno ◽  
Elisa Borroni ◽  
Luca Fedrizzi ◽  
Mirjam Hoxha ◽  
Luisella Vigna ◽  
...  
Keyword(s):  
Air Pollution ◽  
Telomere Length ◽  
Linear Models ◽  
Meteorological Data ◽  
Overweight And Obesity ◽  
Random Intercept ◽  
Age Related ◽  
Increased Risk ◽  
Air Pollution Exposure ◽  
Pollution Exposure

Reduced telomere length (TL) has been associated with increased risk of age-related diseases, most likely through oxidative stress and inflammation, which have also been claimed as mechanisms underlying health effects of air pollution exposure. We aimed to verify whether exposure to particulate matter with diameter ≤10 µm (PM10) affects TL. We recruited 1792 participants with overweight/obesity in Milan (Italy) in 2010–2015 who completed a structured questionnaire on sociodemographic data, gave a blood sample for TL measurement by real-time PCR, and were assigned air pollution and meteorological data of their residential address. In multivariate mixed-effects linear models (with a random intercept on PCR plate), we observed a −0.51% change in TL (95% confidence interval (CI): −0.98; −0.05)) per 10 µg/m3 increase in PM10 at the day of recruitment. A similar decreasing trend in TL was observed up to two weeks before withdrawal, with percentage changes as low as −1.53% (average exposure of the 12 days before recruitment). Mean annual exposure to PM10 was associated with −2.57% TL reduction (95%CI: −5.06; −0.08). By showing consistent associations between short- and long-term PM10 exposures and reduced TL, our findings shed light on the potential mechanisms responsible for the excess of age-related diseases associated with air pollution exposure.

scholarly journals Air pollution exposure associates with increased risk of neonatal jaundice

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Liqiang Zhang ◽  
Weiwei Liu ◽  
Kun Hou ◽  
Jintai Lin ◽  
Changqing Song ◽  
...  
Keyword(s):  
Air Pollution ◽  
Neonatal Jaundice ◽  
Increased Risk ◽  
Air Pollution Exposure ◽  
Pollution Exposure

scholarly journals Air pollution and the development of asthma from birth until young adulthood

2020 ◽  
Vol 56 (1) ◽  
pp. 2000147 ◽  
Author(s):  
Ulrike Gehring ◽  
Alet H. Wijga ◽  
Gerard H. Koppelman ◽  
Judith M. Vonk ◽  
Henriette A. Smit ◽  
...  
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Early Adulthood ◽  
Childhood And Adolescence ◽  
Asthma Incidence ◽  
Mite Allergy ◽  
Increased Risk ◽  
Air Pollution Exposure ◽  
Pollution Exposure ◽  
The Impact

BackgroundAir pollution is associated with asthma development in children and adults, but the impact on asthma development during the transition from adolescence to adulthood is unclear. Adult studies lack historical exposures and consequently cannot assess the relevance of exposure during different periods of life. We assessed the relevance of early-life and more recent air pollution exposure for asthma development from birth until early adulthood.MethodsWe used data of 3687 participants of the prospective Dutch PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort and linked asthma incidence until age 20 years to estimated concentrations of nitrogen dioxide (NO2), particulate matter with a diameter <2.5 μm (PM2.5), <10 μm (PM10), and 2.5–10 μm, and PM2.5 absorbance (“soot”) at the residential address. We assessed overall and age-specific associations with air pollution exposure with discrete time-hazard models, adjusting for potential confounders.ResultsOverall, we found higher incidence of asthma until the age of 20 years with higher exposure to all pollutants at the birth address (adjusted odds ratio (95% CI) ranging from 1.09 (1.01–1.18) for PM10 to 1.20 (1.10–1.32) for NO2) per interquartile range increase) that were rather persistent with age. Similar associations were observed with more recent exposure defined as exposure at the current home address. In two-pollutant models with particulate matter, associations with NO2 persisted.ConclusionsExposure to air pollution, especially from motorised traffic, early in life may have long-term consequences for asthma development, as it is associated with an increased risk of developing asthma through childhood and adolescence into early adulthood.

AIR POLLUTION EXPOSURE AND TELOMERE LENGTH IN HIGHLY EXPOSED SUBJECTS IN BEIJING, CHINA

2011 ◽  
Vol 2011 (1) ◽  
Author(s):  
Lifang Hou ◽  
Chang Dou ◽  
Umakanth Avula ◽  
Sheng Wang ◽  
Yue Yu ◽  
...  
Keyword(s):  
Air Pollution ◽  
Telomere Length ◽  
Air Pollution Exposure ◽  
Pollution Exposure ◽  
Beijing China

scholarly journals Air pollution exposure during pregnancy and spontaneous abortion and stillbirth

2018 ◽  
Vol 33 (3) ◽  
pp. 247-264 ◽  
Author(s):  
Alexandra Grippo ◽  
Jun Zhang ◽  
Li Chu ◽  
Yanjun Guo ◽  
Lihua Qiao ◽  
...  
Keyword(s):  
Air Pollution ◽  
Spontaneous Abortion ◽  
Air Pollutants ◽  
Pregnancy Loss ◽  
Third Trimester ◽  
The Third ◽  
Increased Risk ◽  
Air Pollution Exposure ◽  
Exposure During Pregnancy ◽  
Pollution Exposure

Abstract The developing fetus is particularly susceptible to environmental pollutants, and evidence has shown adverse effects of air pollutants on pregnancy and birth outcomes. Pregnancy loss, including spontaneous abortion (miscarriage) and stillbirth, is the most severe adverse pregnancy outcome. This review focuses on air pollution exposure during pregnancy in relation to spontaneous abortion and stillbirth. A total of 43 studies are included in this review, including 35 human studies and eight animal studies. Overall, these studies suggest that exposure to air pollutants such as particulate matter (PM), carbon monoxide (CO) and cooking smoke may be associated with higher risk for stillbirth and spontaneous abortion. PM10 exposure during an entire pregnancy was associated with increased risk of spontaneous abortion, and exposure to PM2.5 and PM10 in the third trimester might increase the risk of stillbirth. CO exposure during the first trimester of pregnancy was associated with an increased risk of spontaneous abortion and exposure during the third trimester was associated with an increased risk of stillbirth. Cooking smoke was found to increase the risk of stillbirths, and the evidence was consistent. Insufficient and conflicting evidence was found for various other pollutants, such as NO2 and SO2. Studies did not show clear evidence for associations between pregnancy loss and others pollutants such as heavy metals, organochlorine compounds, PAH and total dust count. Further research is warranted to better understand the relationship between air pollution exposure and pregnancy loss.

scholarly journals Prenatal Household Air Pollution Exposure, Cord Blood Mononuclear Cell Telomere Length and Age Four Blood Pressure: Evidence from a Ghanaian Pregnancy Cohort

Toxics ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 169
Author(s):  
Seyram Kaali ◽  
Darby Jack ◽  
Jones Opoku-Mensah ◽  
Tessa Bloomquist ◽  
Joseph Aanaro ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Air Pollution ◽  
Cord Blood ◽  
Telomere Length ◽  
Mononuclear Cells ◽  
Disease Risk ◽  
Household Air Pollution ◽  
Biomass Stove ◽  
Air Pollution Exposure ◽  
Pollution Exposure

Background: Associations between prenatal household air pollution exposure (HAP), newborn telomere length and early childhood blood pressure are unknown. Methods: Pregnant women were randomized to liquefied petroleum gas (LPG) stove, improved biomass stove or control (traditional, open fire cook stove). HAP was measured by personal carbon monoxide (CO) (n = 97) and fine particulate matter (PM2.5) (n = 60). At birth, cord blood mononuclear cells (CBMCs) were collected for telomere length (TL) analyses. At child age four years, we measured resting blood pressure (BP) (n = 97). We employed multivariable linear regression to determine associations between prenatal HAP and cookstove arm and assessed CBMC relative to TL separately. We then examined associations between CBMC TL and resting BP. Results: Higher prenatal PM2.5 exposure was associated with reduced TL (β = −4.9% (95% CI −8.6, −0.4), p = 0.03, per 10 ug/m3 increase in PM2.5). Infants born to mothers randomized to the LPG cookstove had longer TL (β = 55.3% (95% CI 16.2, 109.6), p < 0.01)) compared with control. In all children, shorter TL was associated with higher systolic BP (SBP) (β = 0.35 mmHg (95% CI 0.001, 0.71), p = 0.05, per 10% decrease in TL). Conclusions: Increased prenatal HAP exposure is associated with shorter TL at birth. Shorter TL at birth is associated with higher age four BP, suggesting that TL at birth may be a biomarker of HAP-associated disease risk.

scholarly journals Effects of long-term particulate matter exposure on platelet counts in adults of Northeast China

2020 ◽  
Author(s):  
Hehua Zhang ◽  
Yuhong Zhao
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Northeast China ◽  
Linear Models ◽  
Platelet Counts ◽  
Asian Populations ◽  
Han Ethnicity ◽  
Air Pollution Exposure ◽  
Pollution Exposure

Abstract Associations between air pollution exposure and platelet counts have been inconsistent in previous studies, and there have been few studies of effects of long-term exposure in Asian populations. We explored the associations between long-term PM2.5 (particulate matter < 2.5 µm) exposure and platelet counts using a prospective cohort study in Northeast China. We used a logistic regression model to analyze the effects of different PM2.5 increments and platelet count elevation. Mixed linear models were used to analyze the association between PM2.5 concentration and platelet counts. Interaction and stratified analyses were also conducted. Results showed that every 1 µg/m3 increment of PM2.5 exposure was associated with 0.29% (95%CI: 0.25–0.32%) increase in platelet counts and 10% (95%CI: 8–12%) higher risk of platelet elevation. Effects of long-term PM2.5 exposure on platelet elevation were stronger in male participants, of Han ethnicity, and without diabetes. Our findings add more evidence to the potential biological mechanisms responsible for the effect of air pollution exposure on cardiovascular disease.

scholarly journals Long- and short-term air pollution exposure shortens telomere length in a population of hypersusceptible subjects

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Michele Carugno ◽  
Elisa Borroni ◽  
Luca Fedrizzi ◽  
Mirjam Hoxha ◽  
Luisella Vigna ◽  
...  
Keyword(s):  
Air Pollution ◽  
Telomere Length ◽  
Short Term ◽  
Air Pollution Exposure ◽  
Pollution Exposure

The Association between Long-term Exposure to Ambient Air Pollution and Bone Strength in China

2021 ◽  
Author(s):  
Jialong Wu ◽  
Bing Guo ◽  
Han Guan ◽  
Fei Mi ◽  
Jingru Xu ◽  
...  
Keyword(s):  
Air Pollution ◽  
Bone Strength ◽  
Quantitative Ultrasound ◽  
Linear Models ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Middle Income ◽  
Air Pollution Exposure ◽  
Pollution Exposure

Abstract Context Evidence regarding the association of long-term exposure to air pollution on bone strength or osteoporosis is rare, especially in high polluted low- and middle-income countries. Little is known about whether the association between air pollution and bone strength changes at different bone strength distributions. Objective Using the baseline data from the China Multi-Ethnic Cohort, we investigated the association between long-term air pollution exposure and bone strength. Methods We used multiple linear models to estimate the association between air pollution and bone strength. And we conducted quantile regression models to investigate the variation of this association in the distribution of bone strength. The 3-year concentrations of PM1, PM2.5, PM10, and NO2 for each participant were assessed using spatial statistical models. Bone strength was expressed by the calcaneus quantitative ultrasound index (QUI) measured by quantitative ultrasound, with higher QUI values indicating greater bone strength. Result A total of 66,598 participants were included. Our analysis shows that every 10 μg/m 3 increase in 3-year average PM1, PM2.5, PM10, and NO2 was associated with -5.38 units (95% CI: -6.17, -4.60), -1.89 units (95% CI: -2.33, -1.44), -0.77 units (95% CI: -1.08, -0.47), and -2.02 units (95% CI: -2.32, -1.71) changes in the QUI, respectively. In addition, populations with higher bone strength may more susceptible to air pollution. Conclusions Long-term exposure to PM1, PM2.5, PM10, and NO2 was significantly associated with decreased bone strength in southwestern China adults. Air pollution exposure has a more substantial adverse effect on bones among populations with higher bone strength.

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