scholarly journals Production and Physicochemical Characterization of Cu-Doped Silicate Bioceramic Scaffolds

Materials ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 1524 ◽  
Author(s):  
Francesco Baino ◽  
Isabel Potestio ◽  
Chiara Vitale-Brovarone

Development of ion-releasing implantable biomaterials is a valuable approach for advanced medical therapies. In the effort of tackling this challenge, we explored the feasibility of porous bioceramic scaffolds releasing copper ions, which are potentially able to elicit angiogenetic and antibacterial effects. First, small amounts of CuO were incorporated in the base silicate glass during melting and the obtained powders were further processed to fabricate glass–ceramic scaffolds by sponge replica method followed by sinter crystallization. As the release of copper ions from these foams in simulated body fluid (SBF) was very limited, a second processing strategy was developed. Silicate glass–ceramic scaffolds were coated with a layer of Cu-doped mesoporous glass, which exhibited favorable textural properties (ultrahigh specific surface area >200 m2/g, mesopore size about 5 nm) for modulating the release of copper. All the produced scaffolds, containing biocompatible crystals of wollastonite (CaSiO3), revealed high stability in a biological environment. Furthermore, the materials had adequate compressive strength (>10 MPa) for allowing safe manipulation during surgery. Overall, the results achieved in the present work suggest that these Cu-doped glass-derived scaffolds show promise for biomedical application and motivate further investigation of their suitability from a biological viewpoint.

2014 ◽  
Vol 16 (29) ◽  
pp. 15053-15067 ◽  
Author(s):  
L. Treuel ◽  
K. A. Eslahian ◽  
D. Docter ◽  
T. Lang ◽  
R. Zellner ◽  
...  

Whilst the physical and chemical properties of nanoparticles in the gas or idealized solvent phase can nowadays be characterized with sufficient accuracy, this is no longer the case for particles in the presence of a complex biological environment.


2016 ◽  
Vol 25 (8) ◽  
pp. 3398-3408 ◽  
Author(s):  
Fatemeh Baghbani ◽  
Fathollah Moztarzadeh ◽  
Masoud Mozafari ◽  
Majid Raz ◽  
Hamideh Rezvani

2013 ◽  
Vol 3 (6) ◽  
pp. 884 ◽  
Author(s):  
Indumathi Kamma ◽  
Monday Mbila ◽  
Karen E. Steege Gall ◽  
B. Rami Reddy

2019 ◽  
Vol 38 (2) ◽  
pp. 385 ◽  
Author(s):  
Marwa M. El-Naggar ◽  
Wael S. I. Abou-Elmagd ◽  
Ashraf Suloma ◽  
Hamza A. El-Shabaka ◽  
Magdy T. Khalil ◽  
...  

Author(s):  
Kumar P ◽  
S Kumar ◽  
A Kumar ◽  
M Chander

The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.


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