scholarly journals Monodisperse Fe3O4/SiO2 and Fe3O4/SiO2/PPy Core-Shell Composite Nanospheres for IBU Loading and Release

Materials ◽  
2019 ◽  
Vol 12 (5) ◽  
pp. 828 ◽  
Author(s):  
Lazhen Shen ◽  
Bei Li ◽  
Yongsheng Qiao ◽  
Jinping Song
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Fe3o4 Nanoparticles ◽  
Shell Structure ◽  
Solvothermal Method ◽  
Drug Loading ◽  
Core Shell ◽  
Prepared Nanoparticles ◽  
Sio2 Shell ◽  
Core Shell Structure

The magnetic targeting drug delivery system is an effective way of targeting therapy. In this study, the monodisperse Fe3O4 nanoparticles with a particles size of about 180 nm were first prepared via a solvothermal method. Subsequently, the core-shell structure Fe3O4/SiO2 and Fe3O4/SiO2/polypyrrole (PPy) composite nanospheres were successfully synthesized by coating Fe3O4 nanoparticles with SiO2 shell layer using the Stöber method and PPy shell by solvothermal method in turn. The as-prepared nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), and Ultraviolet-Visible spectrophotometer (UV-Vis). The results indicated that the as-prepared composite nanospheres displayed a well-defined core-shell structure and monodispersity. The thicknesses of SiO2 shell and PPy shell were ~6 nm and ~19 nm, respectively. Additionally, the as-prepared nanoparticles exhibited high saturation magnetization of 104 emu/g, 77 emu/g, and 24 emu/g, and have great potential applications in drug delivery. The drug loading and drug release of the Fe3O4/SiO2 and Fe3O4/SiO2/PPy composite nanospheres to ibuprofen (IBU) under stirring and ultrasonication were investigated. Their drug loading efficiency and drug release efficiency under ultrasonication were all higher than 33% and 90%, respectively. The drug release analyses showed sustained release of IBU from nanospheres and followed the Korsmeyer-Peppas model.

PREPARATION AND CHARACTERIZATION OF SURFACE-FUNCTIONALIZATION OF SILICA-COATED MAGNETITE NANOPARTICLES FOR DRUG DELIVERY

NANO ◽  
2014 ◽  
Vol 09 (04) ◽  
pp. 1450042 ◽  
Author(s):  
CONG-WANG ZHANG ◽  
CHANG-CHUN ZENG ◽  
YING XU
Keyword(s):  
Drug Delivery ◽  
Shell Structure ◽  
Drug Carrier ◽  
Point Of View ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
The Core ◽  
Application Potential ◽  
Core Shell Structure ◽  
Core Shell Nanoparticles

Fe 3 O 4– SiO 2 core–shell structure nanoparticles containing magnetic properties were investigated for their potential use in drug delivery. The Fe 3 O 4– SiO 2 core–shell structure nanoparticles were successfully synthesized by a simple and convenient way. The Fe 3 O 4– SiO 2 nanoparticles showed superparamagnetic behavior, indicating a great application potential in separation technologies. From the application point of view, the prepared nanoparticles were found to act as an efficient drug carrier. Specifically, the surface of the core–shell nanoparticles was modified with amino groups by use of silane coupling agent 3-aminopropyltriethoxysilane (APTS). Doxorubicin (DOX) was successfully grafted to the surface of the core–shell nanoparticles after the decoration with the carboxyl acid groups on the surface of amino-modified core–shell structure nanoparticles. Moreover, the nanocomposite showed a good drug delivery performance in the DOX-loading efficiency and drug release experiments, confirming that the materials had a great application potential in drug delivery. It is envisioned that the prepared materials are the ideal agent for application in medical diagnosis and therapy.

scholarly journals Core-shell structure microcapsules with dual pH-responsive drug release function

2014 ◽  
Vol 35 (18) ◽  
pp. NA-NA
Author(s):  
Chih-Hui Yang ◽  
Chih-Yu Wang ◽  
Alexandru Mihai Grumezescu ◽  
Andrew H.-J. Wang ◽  
Ching-Ju Hsiao ◽  
...  
Keyword(s):  
Drug Release ◽  
Shell Structure ◽  
Core Shell ◽  
Ph Responsive ◽  
Core Shell Structure

Core-shell structure microcapsules with dual pH-responsive drug release function

2014 ◽  
Vol 35 (18) ◽  
pp. 2673-2680 ◽  
Author(s):  
Chih-Hui Yang ◽  
Chih-Yu Wang ◽  
Alexandru Mihai Grumezescu ◽  
Andrew H.-J. Wang ◽  
Ching-Ju Hsiao ◽  
...  
Keyword(s):  
Drug Release ◽  
Shell Structure ◽  
Core Shell ◽  
Ph Responsive ◽  
Core Shell Structure

Synthesis and photocatalytic activity of N-K2Ti4O9/UiO-66 composites

RSC Advances ◽  
2015 ◽  
Vol 5 (66) ◽  
pp. 53198-53206 ◽  
Author(s):  
Sunfeng Li ◽  
Xing Wang ◽  
Qi Chen ◽  
Qinqin He ◽  
Mengmeng Lv ◽  
...  
Keyword(s):  
Photocatalytic Activity ◽  
Shell Structure ◽  
Solvothermal Method ◽  
Core Shell ◽  
Core Shell Structure ◽  
Facile Solvothermal Method

N-K2Ti4O9/UiO-66 composites synthesized by a facile solvothermal method possess a hierarchical core–shell structure with UiO-66 forming the shell around the N-K2Ti4O9 core.

Coaxial solution blown core-shell structure nanofibers for drug delivery

2012 ◽  
Vol 21 (4) ◽  
pp. 346-348 ◽  
Author(s):  
Xupin Zhuang ◽  
Lei Shi ◽  
Bo Zhang ◽  
Bowen Cheng ◽  
Weimin Kang
Keyword(s):  
Drug Delivery ◽  
Shell Structure ◽  
Core Shell ◽  
Core Shell Structure

scholarly journals Multifunctional Polymeric Nanogels for Biomedical Applications

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 228
Author(s):  
Tisana Kaewruethai ◽  
Chavee Laomeephol ◽  
Yue Pan ◽  
Jittima Amie Luckanagul
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Shell Structure ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Functionalized Polymers ◽  
Core Shell ◽  
Structural Components ◽  
Bioactive Substances ◽  
Core Shell Structure

Currently, research in nanoparticles as a drug delivery system has broadened to include their use as a delivery system for bioactive substances and a diagnostic or theranostic system. Nanogels, nanoparticles containing a high amount of water, have gained attention due to their advantages of colloidal stability, core-shell structure, and adjustable structural components. These advantages provide the potential to design and fabricate multifunctional nanosystems for various biomedical applications. Modified or functionalized polymers and some metals are components that markedly enhance the features of the nanogels, such as tunable amphiphilicity, biocompatibility, stimuli-responsiveness, or sensing moieties, leading to specificity, stability, and tracking abilities. Here, we review the diverse designs of core-shell structure nanogels along with studies on the fabrication and demonstration of the responsiveness of nanogels to different stimuli, temperature, pH, reductive environment, or radiation. Furthermore, additional biomedical applications are presented to illustrate the versatility of the nanogels.

scholarly journals In-Vitro Cytotoxicity and Anticancer Drug Release Behavior of Methionine - Coated Magnetite Nanoparticles As Carriers.

2021 ◽  
Author(s):  
Faten Eshrati Yeganeh ◽  
Amir Eshrati Yeganeh ◽  
Bahareh Farasati Far ◽  
Iman Akbarzadeh ◽  
Sameer Quazi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acid ◽  
Drug Release ◽  
Drug Loading ◽  
Average Particle Size ◽  
Mcf10a Cell ◽  
Core Shell ◽  
Average Particle ◽  
Release Behavior

Abstract An innovative and customized drug delivery system for in vitro cancer treatment has been developed successfully by a simple one-step method. A CoFe2O4@Methionine core-shell nanoparticle was prepared by the reflux assay, in which amino acid on the surface makes the ferrite biocompatible, enhances the chemical stability of the compound, and increases the drug loading capacity. The synthesized nanoparticles were evaluated using SEM, TEM, FTIR, and VSM, while XRD and TGA analysis verified the presence of a coating amino acid on the surface of CoFe2O4. The appearance of a new peak for C≡N in the FTIR spectrum validates the synthesis of a letrozole-loaded carrier. Both uncoated CoFe2O4 and methionine-coated CoFe2O4 nanoparticles behave super-paramagnetically at room temperature, with saturation values of 46 emu/g and 16.8 emu/g, respectively. SEM and TEM were used to characterize the morphology and size of samples, revealing that the average particle size was around 28–29 nm. The loading of Letrozole and the effect of pH (5, 7.4) on the release behavior of the carrier were studied. The result of the drug release in pH (5) was about 88% higher than pH (7.4). Also, the preparation has been evaluated for determining its cytotoxicity using MCF-7, MDA-MB-231, and MCF10A cell lines as an in vitro model, and the results of in vitro experiments showed that CoFe2O4@Methionine could significantly reduce cancer in the cell model. These results demonstrate that core-shell nanoparticles were prepared that are biocompatible and have potential use as drug delivery.

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