scholarly journals Evaluation of the Mechanical, Physical, and Anti-Fungal Properties of Flax Laboratory Papersheets with the Nanoparticles Treatment

Materials ◽  
2020 ◽  
Vol 13 (2) ◽  
pp. 363 ◽  
Author(s):  
Wael A. A. Abo Elgat ◽  
Ayman S. Taha ◽  
Martin Böhm ◽  
Eva Vejmelková ◽  
Wael S. Mohamed ◽  
...  
Keyword(s):  
Aspergillus Flavus ◽  
Technological Properties ◽  
Fungal Inhibition ◽  
Anti Fungal

In the present study, novel mixed additives of Chitosan or Paraloid B-72 combined with nanoparticles (NPs) of Ag, ZnO, or cellulose (NCL) were examined for their effects on the mechanical, optical, and fungal inhibition properties of the papersheets produced. The highest tensile, tear, and burst indices of the papersheets were observed for flax pulp treated with additives of Paraloid B-72 + ZnO NP (1%), Chitosan + ZnO NP (3%), and Chitosan + NCL (3%) at levels of 59.93 N·m/g, 18.45 mN·m2/g, and 6.47 kPa·m2/g, respectively. Chitosan + ZnO NP (1%) added to flax pulp showed the highest fungal mycelial inhibition (FMI) (1.85%) against Aspergillus flavus. Chitosan + Ag NP (1%) exhibited the highest FMI percentage (11.48%) when added to pulp against A. terreus. Pulp treated with Paraloid B-72 + Ag NP (1%) exhibited the highest activity against Stemphylium solani with an FMI value of 3.7%. The results indicate that the technological properties of the papersheets were enhanced with the addition of novel mixtures to the pulp.

Anti-Fungal Activity of Cressa cretica, Leptadenia pyrotechnica and Pulicaria crispa, indigenous plants of Cholistan desert, Pakistan

2020 ◽  
Vol 18 ◽  
Author(s):  
Faheem Hadi ◽  
Tahir Maqbool ◽  
Sameera Khurshid ◽  
Aisha Nawaz ◽  
Saira Aftab ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Aspergillus Flavus ◽  
Fungal Infections ◽  
Fungal Species ◽  
Fungal Activity ◽  
Aspergillus Ustus ◽  
Mother Tincture ◽  
Anti Fungal

Background: Fungal infections have always remain a problem and they are getting worse with passage of each year due to their resistance against available antibiotics. Natural ways of treatment with homoeopathic medicines made of mother tinctures of plants have no reported side effects and have been proved effective against many bacterial and fungal infections. Materials & Methods: Preparation of mother tinctures of plants Cressa cretica, Leptadenia pyrotechnica and Pulicaria crispa was done and used to evaluate the anti-fungal potential of these plants against potentially pathogenic fungal species like Aspergillus niger, Aspergillus flavus, Aspergillus ustus and Candida albicans by agar disc diffusion method. Each tincture was evaluated at 0.25 ml, 0.5 ml and 1 ml volume per disc and zone of inhibition was measured in millimetres and compared with commercial drug Fluconazole (2 mg/ml) which was used as standard. Results: The results showed that satisfactory anti-fungal activity of these plants in comparison to standard drug Fluconazole. The ratio of antifungal activity of Cressa cretica measured as the zone of growth inhibition of these cultures against Aspergillus niger, Aspergillus flavus, Aspergillus ustus and Candida albicans was 24 mm / 27 mm, 30mm / 28 mm, 23 mm/ 30 mm and 32 mm/ 30 mm respectively. In the case of Leptadenia pyrotechnica, the mother tincture’s antifungal activity was 32 mm / 27 mm, 30 mm / 28 mm, 17 mm/ 30 mm and 24 mm/ 30 mm. In case of our third plant Pulicaria crispa, antifungal activity came out to be 23 mm/ 27 mm, 26 mm/ 28 mm, 26 mm / 30 mm and 24 mm/ 30 mm. Conclusion: Our study proved that mother tincture of these plants can be a potential new therapy to treat fungal infections and has the potential to rule out fungal problems. Further research using mother tincture of these plants against other fungal species has the potential to prove them a safer and widespread anti-fungal homoeopathic medicine.

scholarly journals Assessment of the antifungal activity of Spirulina platensis phenolic extract against Aspergillus flavus

2011 ◽  
Vol 35 (6) ◽  
pp. 1050-1058 ◽  
Author(s):  
Michele Moraes de Souza ◽  
Luciana Prietto ◽  
Anelise Christ Ribeiro ◽  
Taiana Denardi de Souza ◽  
Eliana Badiale-Furlong
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Flavus ◽  
Spirulina Platensis ◽  
Food Protection ◽  
Natural Substances ◽  
Natural Defense ◽  
Methanolic Extracts ◽  
Fungal Inhibition ◽  
Phenolic Extract ◽  
Safe Food

The production of safe food has stimulated the search for natural substances that possess antifungal activity. The indirect methods of estimating fungal biomass are based on the measurement of glucosamine, ergosterol and protein - typical compounds produced during the development of biomass. The aim of the study was to assess the effect of the phenolic extract from Spirulina platensis on the production of structural compounds in Aspergillus flavus, in order to identify its action on fungal inhibition. The Spirulina platensis methanolic extracts presented 1.15 mg phenolic compound/g Spirulina platensis, which showed an antifungal effect against Aspergillus flavus, inhibiting the glucosamine production up to 56%. Therefore, it may be employed as natural defense when food protection is necessary.

scholarly journals In vitro antifungal activity of Desmodium intortum and D. uncinatum root extracts against growth of toxigenic Fusarium verticillioides and Aspergillus flavus

2020 ◽  
pp. 1942-1948
Author(s):  
Nancy Karimi Njeru ◽  
Charles Aura Odhiambo Midega ◽  
James Wanjohi Muthomi ◽  
John Maina Wagacha ◽  
Zeyaur Rahman Khan
Keyword(s):  
Aspergillus Flavus ◽  
Radial Growth ◽  
Cropping Systems ◽  
Fusarium Verticillioides ◽  
Fine Powder ◽  
Cropping System ◽  
Inhibitory Effect ◽  
Root Extracts ◽  
Anti Fungal

Maize grown under push-pull cropping system has been reported to contain lower concentrations of fumonisin and aflatoxin than maize monocrop. This study determined the inhibitory effect of desmodium root extracts on spore germination and radial growth of toxigenic Aspergillus flavus and Fusarium verticillioides. Aspergillus flavus and F. verticillioides were isolated from maize and soil and tested for ability to produce aflatoxin and fumonisin by inoculation on mycotoxin-free maize. Aflatoxin and fuminisin were detected and quantified by direct competitive ELISA. Desmodium roots were dried, ground to fine powder and extracted with methanol and dichloromethane and evaluated for anti-fungal activity by inhibition of spores of A. flavus and F. verticillioides potato dextrose agar (PDA) medium. Isolates of F. verticillioides produced up to 599,741 µg/kg fumonisin while isolates of A. flavus produced up to 199,184 µg/kg aflatoxin. Desmodium root extracts reduced germination of A. flavus spores and F. verticillioides by 9.6% and 43.8%, respectively and reduced their respective colony radial growth by 15% and 57%. The results suggested that desmodium roots contain chemical compounds that inhibit growth of A. flavus and F. verticillioides. This may explain the reduction in infection of maize with mycotoxin-producing fungi before harvest in push-pull cropping systems by reducing the pathogen inoculum in the soils. Determination of the active compounds in the root exudates is recommended

scholarly journals Nano-Vesicle Based Anti-Fungal Formulation Shows Higher Stability, Skin Diffusion, Biosafety and Anti-Fungal Efficacy In Vitro

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 516
Author(s):  
Isaac G. Deaguero ◽  
Md Nurul Huda ◽  
Victor Rodriguez ◽  
Jade Zicari ◽  
Taslim A. Al-Hilal ◽  
...  
Keyword(s):  
Treatment Approach ◽  
Fungal Infections ◽  
Dermal Fibroblast ◽  
Human Dermal Fibroblast ◽  
Over The Counter ◽  
Fungal Inhibition ◽  
Cell Survival Rate ◽  
Cytotoxicity Studies ◽  
Anti Fungal

Opportunistic fungal infections are responsible for over 1.5 million deaths per year. This has created a need for highly effective antifungal medication to be as potent as possible. In this study, we improved the efficacy of a common over the counter (OTC) antifungal skin medication, miconazole, by encapsulating nano-molecules of the drug in cholesterol/sodium oleate nano-vesicles. These nano-vesicles were characterized to optimize their size, zeta potential, polydispersity index and encapsulation efficiency. Furthermore, these nano-vesicles were compared to a conventional miconazole-based commercially available cream to determine potential improvements via permeation through the stratum corneum, cytotoxicity, and antifungal capabilities. Our results found that the vesicle size was within the nano range (~300 nm), with moderate polydispersity and stability. When compared with the commercially available cream, Actavis, as well as free miconazole, the miconazole nano-vesicle formulation displayed enhanced fungal inhibition by a factor of three or more when compared to free miconazole. Furthermore, with smaller nanoparticle (NP) sizes, higher percentages of miconazole may be delivered, further enhancing the efficacy of miconazole’s antifungal capability. Cytotoxicity studies conducted with human dermal fibroblast cells confirm its biosafety and biocompatibility, as cell survival rate was observed to be twofold higher in nano-vesicle formulation than free miconazole. This formulation has the potential to treat fungal infections through increasing the retention time in the skin, improving the treatment approach, and by enhancing the efficacy via the use of nano-vesicles.

scholarly journals Anti-Fungal Efficacy and Secondary Metabolite Analysis of the Methanolic Extract from Colpomenia peregrina towards Opportunistic Fungal Pathogens

2021 ◽  
pp. 89-100
Keyword(s):  
Candida Albicans ◽  
Aspergillus Fumigatus ◽  
Cryptococcus Neoformans ◽  
Aspergillus Flavus ◽  
Fungal Pathogens ◽  
Methanolic Extract ◽  
Chemical Shifts ◽  
Brown Seaweed ◽  
Microsporum Gypseum ◽  
Anti Fungal

The present study illustrates the antifungal efficacy of methanolic extract from marine brown seaweed Colopomenia peregrina gathered from Leepuram coast, South India, towards opportunistic fungal pathogens comprising of dermatophytes, non-dermatophytes, and yeasts. The opportunistic fungal pathogens used in the study are Aspergillus flavus (ATCC 27692), Aspergillus fumigatus (ATCC 19673), Microsporum gypseum (ATCC 24102), Cryptococcus neoformans (ATCC 14116), and Candida albicans (ATCC14053) which are commonly responsible for nosocomial infections. The NMR analysis revealed the presence of various chemical shifts showing the presence of protons containing Hydroxyl, Methoxy, Methyl groups, and –COO-CH2 groups.The presence of phytochemicals from the extract of seaweed confirmed the nutritional profile. The results revealed greater efficacy of methanolic extract towards Aspergillus fumigatus, Microsporum gypseum, Cryptococcus neoformans, and lower activity with Aspergillus flavus and Candida albicans compared with the standard anti-fungal fluconazole.

Systemic aspergillosis caused by an aflatoxin-producing strain of Aspergillus flavus

1998 ◽  
Vol 36 (2) ◽  
pp. 107-112 ◽  
Author(s):  
T. MORI ◽  
M. MATSUMURA ◽  
K. YAMADA ◽  
S. IRIE ◽  
K. OSHIMI ◽  
...  
Keyword(s):  
Aspergillus Flavus

In vitro anti-fungal activity of a plant-based ear gel and its essential oils

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
JK Ketzis ◽  
N Nolard ◽  
NS Ryder
Keyword(s):  
Essential Oils ◽  
Fungal Activity ◽  
Anti Fungal
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